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Migraine
Migraine

... rizatriptan, naratriptan, zolmitriptan, almotriptan, frovatriptan, eletriptan Side effects: nausea, dizziness, muscle weakness. Coronary vasoconstriction, heart attack and rarely stroke ...
Effects of Tamoxifen Therapy on Plasma Lipid Profile in
Effects of Tamoxifen Therapy on Plasma Lipid Profile in

... HDL levels in both pre-menopausal and postmenopausal patients. No alteration in VLDL-c was observed in both pre-menopausal and postmenopausal. Similar observation has been made on pre-menopausal women by Caleffi et al.10 Comparison of the effects of tamoxifen in premenopausal and postmenopausal pati ...
Inheritance Lecture Notes - Instruction.greenriver.edu
Inheritance Lecture Notes - Instruction.greenriver.edu

... (normal); Kd, 0.21 nmol/L; normal range, 0.03–0.13 nmol/L]. In trans-activation assays, the mutant 712F-AR showed considerable deficiency at low concentrations of testosterone (0.01–0.1 nmol/L) or dihydrotestosterone (0.01 nmol/L). Remarkably, this could be fully neutralized by testosterone concentr ...
SERIES: ‘‘GENETICS OF ASTHMA AND COPD IN THE POSTGENOME ERA’’
SERIES: ‘‘GENETICS OF ASTHMA AND COPD IN THE POSTGENOME ERA’’

... The gene for the a chain of tumour necrosis factor has a promoter polymorphism G-308A. The G allele has been associated with asthma in Australian children [30]. This allele was present in 90.1% of a Gambian population and 77% of an English cohort [4]. The evidence that multiple genes show consistent ...
chapter 23 - Scranton Prep Biology
chapter 23 - Scranton Prep Biology

... are more likely to interbreedwith others from their population center (see Campbell, Figure 23.2). Gene flow between the two population centers is thus reducedby the intermediaterange. Genepool : The total aggregateof genesin a population at any one time ...
Phospholipid Complex Technique for Superior Bioavailability of
Phospholipid Complex Technique for Superior Bioavailability of

... complexed actives are safer than its original form1 and can even serve as a better targeting agents to deliver these encapsulated agents at specific sites there by proving promising candidates in various medical fields for improving health aspects. This technique can be applied for both herbal and c ...
Xifaxan - Salix Pharmaceuticals
Xifaxan - Salix Pharmaceuticals

... 5.2 Clostridium difficile-Associated Diarrhea Clostridium difficile-associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including XIFAXAN, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flor ...
Novel Antimicrobial Agents
Novel Antimicrobial Agents

... We welcome you to the Robert Gordon University today for what promises to be a very interesting conference. Having assembled the programme over the last few months, it is pleasing to have gathered such a prestigious grouping of people who will be discussing their work on novel antimicrobials. We wou ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.

... was used [25]. The preparation and evaluation of fast disintegrating tablets by using different concentrations of natural superdisintegrant that is plantago ovata mucilage was studied. The reason for selecting plantago ovate mucilage is it has high swelling index. Mucilage of plantago ovata has vari ...
enclosure-v
enclosure-v

... when compared to that of the pure drug. They have observed mechanisms for increase in dissolution rate may be concluded that, reduction of crystallite size, solubilization effect of the carrier, absence of aggregation of drug crystallites, improved wettability and dispersbility.9 (2011) Bobe et al. ...
Sedative-hypnotics
Sedative-hypnotics

... “Complex sleep-related behavior”: driving, talking on the phone, eating, etc., with no memory of the event ...
Effects of Solubility and Dissolution Characteristics on Oral
Effects of Solubility and Dissolution Characteristics on Oral

... development goal is come up with a product in similar lines as innovator in record time.None of the shortlisted ingredients had shown any significant drop in the drug content during the study period. Therefore, these excipients were used for further development work with reasonable amount of confide ...
IMPAACT P1093: Phase I/II, Multi-Center, Open
IMPAACT P1093: Phase I/II, Multi-Center, Open

... • Clinical evidence of pancreatitis • Use of disallowed medications at the time of screening (section 4.32) • Integrase inhibitor experienced (incl mother prior to delivery) • Pregnancy • Active TB /disease and/or requirement for treatment that includes rifampin at the time of the screening visit. H ...
Name: LAB 3 ANTH 2101 MENDELIAN TRAITS and INHERITANCE
Name: LAB 3 ANTH 2101 MENDELIAN TRAITS and INHERITANCE

S07.NSAIDS-brief#PART2
S07.NSAIDS-brief#PART2

... GI bleeding or other GI adverse effects did not find an increase in GI toxicity when bisphosphonates were combined with NSAIDs, compared with NSAIDs alone. Explain !!! ...
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06 NSAIDS-brief

... GI bleeding or other GI adverse effects did not find an increase in GI toxicity when bisphosphonates were combined with NSAIDs, compared with NSAIDs alone. Explain !!! ...
FATMA POST OP PAIN MANEGEMENT
FATMA POST OP PAIN MANEGEMENT

... There are many different techniques,nonpharmacological &pharmacological , both regional and non-regional to provide post op ...
Follow the Script_ Spring 2015
Follow the Script_ Spring 2015

... increased by 203 per cent between 2000 and 2010… From 2004 to 2009 in Ontario, admissions to treatment programs for prescription opioids doubled. In 2005–2006, 10.6 per cent of individuals seeking addiction treatment in Ontario did so for prescription opioids; by 2010–2011, this percentage had incre ...
HerbClip™
HerbClip™

... incarnata/clonidine regimen were better able to manage anxiety, irritability, cravings, etc. In the second study, 36 patients with generalized anxiety disorder were treated with either the antianxiety drug oxazepam plus a placebo liquid or P. incarnata extract plus a placebo tablet. Patients receivi ...
Alglucosidase alfa: first available treatment for Pompe disease
Alglucosidase alfa: first available treatment for Pompe disease

... patients survived to the age of 18 months) [20]. All patients with repeated cardiac measurements showed reversal of cardiomyopathy, this positive effect of alglucosidase alfa certainly contributing to the significant increase in lifespan. The majority of patients maintained normal growth and exhibit ...
formulation and evaluation of bilayer tablet of
formulation and evaluation of bilayer tablet of

... The study of drug–excipients compatibility represents an important phase in the preformulation stage for the development of all dosage forms. In fact, potential physical and chemical interactions between drugs and excipients can affect the chemical nature, stability and bioavailability of drugs and, ...
PREPARATION AND STANDARDIZATION ANTICANCER FORMULATION
PREPARATION AND STANDARDIZATION ANTICANCER FORMULATION

... tested 500 µg/ml showed maximum absorbance of 0.53±0.01. The data obtained in the present study revealed that the test drug Veera Mezhugu has good reducing capacity. To sum up from the data generated in the present study, It is concluded that Siddha formulation, Veera Mezhugu possess both antioxidan ...
Rapid detection of multidrug-resistant tuberculosis
Rapid detection of multidrug-resistant tuberculosis

... eye, and stored using any simple word-processing programme. Strain-typing itself does not provide direct information about drug susceptibility, but a register of spoligotypes from known MDR isolates may be particularly useful in providing early warning of possible infection with these strains. Whils ...
5.2 Dominant, Recessive, Heterozygous
5.2 Dominant, Recessive, Heterozygous

...  Reginald has one allele for green eyes, and one allele for brown eyes. He is heterozygous for eye color. ...
AusPAR: Emtricitabine / rilpivirine / tenofovir disoproxil fumarate
AusPAR: Emtricitabine / rilpivirine / tenofovir disoproxil fumarate

... >100,000 to <500,000 copies/mL, the clinical evaluator does not think other important factors need to be considered. First high viral load above 100,000 is associated with an increased risk of virological failure with Eviplera (and this finding is consistent with the earlier registration studies). I ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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