• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Genetic Load
Genetic Load

... “It is altogether unlikely that two genes would have identical selective values under all the conditions under which they may coexist in a population. … cases of neutral polymorphism do not exist … it appears probable that random fixation is of negligible evolutionary importance” ⎯Ernst Mayr ...
LAB 14 API LAB 2 Hardy
LAB 14 API LAB 2 Hardy

... 1. What does the Hardy-Weinberg equation predict for the new p and q? 2. Do the results you obtained in this simulation agree? If not, why not? 3. What major assumption(s) were not strictly followed in this simulation? CASE B (Selection- Lethal Allele) In this Case, you will modify the simulation to ...
The Ethics of Regulatory Mandates for Pediatric Research
The Ethics of Regulatory Mandates for Pediatric Research

... for a significant portion of pediatric drug dosing.7 The phrase “off-label” is simply a way of stating that a drug is given to a person or group for a use that has not undergone the full scientific and regulatory rigor available for a so-called “on-label” use. While this may seem innocuous, the pote ...
for Chronic Stable Angina
for Chronic Stable Angina

... The MARISA trial12 was a dose-comparison study. Compared with placebo, treatment with ranolazine significantly improved total exercise duration, time to angina, and time to 1 mm ST-segment depression. The results were consistent in subgroup analyses for diabetes, gender, history of heart failure, an ...
unusual medication
unusual medication

... Propranolol is known to mask hyperthyroidism, and to change thyroid function tests, especially for the breakdown of T 4 and T 3 . My colleagues and I have seen one patient in whom propranolol therapy caused an apparent hypothyroid condition over a six-week period. When admitted to another hospital t ...
Amphadase® Professional Prescribing Information
Amphadase® Professional Prescribing Information

... Administration of hyaluronidase during labor was reported to cause no complications: no increase in blood loss or differences in cervical trauma were observed. 8.3 Nursing Mothers It is not known whether hyaluronidase is excreted in human milk. Because many drugs are excreted in human milk, caution ...
Saquinavir/low dose ritonavir - WHO archives
Saquinavir/low dose ritonavir - WHO archives

... prospective observational cohort study was undertaken to assess the feasibility, effectiveness, adherence, toxicity and viral resistance of antiretroviral therapy. The clinical and biological results of the study were comparable to those seen in western cohorts, despite differences in HIV-1 subtype ...
Drug Awareness - South Fayette Township
Drug Awareness - South Fayette Township

... Sudden cessation of long term, extensive alcohol intake is likely to produce withdrawal symptoms, including severe anxiety, tremors, hallucinations, and convulsions. Long-term effects of consuming large quantities of alcohol can lead to: • permanent damage to vital organs • several different types o ...
Hey Dude! How Did I Get Here?
Hey Dude! How Did I Get Here?

...  Tolerance and physiological withdrawal have been reported ...
comparing quantitative trait loci and gene expression data
comparing quantitative trait loci and gene expression data

... made by a third cut immediately in front of the optic chiasm or approximately 2.0 mm from the second cut. Finally, the third slab contained the MBH, corresponding to plates 15-16, was cut from the brain by making two cuts at the beginning and end of the median eminence, respectively. From the first ...
Using of medicine in clinical practice_1
Using of medicine in clinical practice_1

... 36 Angina pectoris is: A. Severe constricting chest pain, often radiating from the precordium to the left shoulder and down the arm, due to insufficient blood supply to the heart that is usually caused by coronary disease B. An often fatal form of arrhythmia characterized by rapid, irregular fibrill ...
Extravasation Policy
Extravasation Policy

... Aims and Objectives Two strategies for the treatment of extravasation injuries are described in the literature. The first approach requires the parenteral and local application of antidotes for all extravasation injuries. The second approach involves a flush out technique carried out by plastic surg ...
PART 2, VOLUME 3 - UPGRADES PAGE 7 Under B) FREE SKIN
PART 2, VOLUME 3 - UPGRADES PAGE 7 Under B) FREE SKIN

... in combination with other anaesthetics, eg. acetylpromazine, medetomidine, ketamine etc. Its main effect is sedation, but it does provide a degree of INTRAOPERATIVE and POSTOPERATIVE ANALGESIA. 6) FENTANYL (Sublimaze) This is a potent short-acting analgesic. Given during an operation it works within ...
Abuse of Prescription drugs
Abuse of Prescription drugs

... 281. Over the years, the Board has repeatedly drawn the attention of Governments to the increasing abuse of prescription drugs containing controlled substances. In its annual report for 2009, in particular, the Board devoted a special topic to this problem to highlight the need for Governments to gi ...
Name: Date: ______ Mendel`s Work Gregor Mendel was curious
Name: Date: ______ Mendel`s Work Gregor Mendel was curious

... Pea plants are useful for studying heredity because they have many traits that exist in only two forms. They also produce large numbers of offspring, making it easy to collect large amounts of data. Their flower structure makes it easy to set up crosses between specific plants. Mendel crossed two pe ...
contraindications table
contraindications table



... but some studies have indicated that they can provide control of mild-to-moderate asthma comparable with that of 400 µg·day-1 of BDP [7, 8]. Nedocromil sodium appears to be more effective than sodium cromoglycate [9]. Bone discussed anti-inflammatory treatment for moderate-tosevere asthma, for which ...
High Risk IV Medication Dosing Limits Guidelines
High Risk IV Medication Dosing Limits Guidelines

... Tim Vanderveen, PharmD, MS ...
Making the Grade: Testing for Human Genetic Disorders
Making the Grade: Testing for Human Genetic Disorders

... possibility of a mistaken diagnosis raises questions regarding the distribution of the risks and benefits of an imperfect testing procedure. 9 Nevertheless, this Article assumes, for the purposes of this discussion, that the tests are flawless, since it is important to look at the ethical issues ari ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington

... Vary according to drug used Stem from their nonselective blockade of various receptors ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington

...  Vary according to drug used  Stem from their nonselective blockade of various ...
PDF
PDF

... system the parasites evade both the acquired and innate immune systems, predominantly by antigenic variation, changing the variant surface glycoprotein (VSG) expressed on their surface to avoid antibody-mediated responses (Gadelha et al., 2011). During the second stage of infection, in the CNS, they ...
Study Objectives
Study Objectives

... 18. Summarize some of the research findings by Carroll (1993) using a behavioral economics approach to investigate PCP consumption in rhesus monkeys. McKim, Chapter 6 Alcohol 1. Describe examples of alcohol use in human history. 2. Define BAC and explain how it is typically expressed. 3. Identify at ...
what is now known as the Hatch-Waxman Act.
what is now known as the Hatch-Waxman Act.

... Briefly, this section provides that inventors of pioneer drugs may have their patent terms extended by an amount of time equal to one-half of the FDA’s investigational new drug period. The maximum term of extension is five years, but the effective market exclusivity may not exceed fourteen years. ...
cardiopulmonary resuscitation - Cornell University Veterinary
cardiopulmonary resuscitation - Cornell University Veterinary

... with hypovolemia, but can potentially worsen perfusion in euvolemic patients by increasing venous pressure. Electrical defibrillation is indicated only in patients with documented ventricular fibrillation. The goal is to use a high current to depolarize myocardial cells simultaneously and put them i ...
< 1 ... 380 381 382 383 384 385 386 387 388 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report