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Antibiotics in the management of shigellosis in children : what role
Antibiotics in the management of shigellosis in children : what role

... to be active in vitro against Shigella (and Campylobacrer species, another important cause of dysentery in young children), and limited evidence suggests that they are also effective in vivo. (3) Nalidixic acid, which shares all the cartilage toxicity of the fluoroquinolones, is licensed for use in ...
Medical Emergencies in the Dental Surgery
Medical Emergencies in the Dental Surgery

... Midazolam Buccal Liquid, midazolam 5mg/ml for use in dental surgeries to help with the management of epileptic seizures. The medication comes in 2ml vials and should only be given if the seizures are prolonged (more than 5 mins) or repeated rapidly. The midazolam buccal liquid should be given by the ...
Formulary Updates Volume 13, Issue 3 · March 2015
Formulary Updates Volume 13, Issue 3 · March 2015

... Type 2 Diabetes (available at: http://www.universityhealthsystem.com/clinical-pathways-and-guidelines/). This medication is available for CareLink members through a BULK MAP, which allows same day availability for eligible patients. 4. Levofloxacin (Levaquin)- all dosage forms were added to formular ...
Levosimendan vs Dobutamine for Patients With Acute
Levosimendan vs Dobutamine for Patients With Acute

... Results All-cause mortality at 180 days occurred in 173 (26%) patients in the levosimendan group and 185 (28%) patients in the dobutamine group (hazard ratio, 0.91; 95% confidence interval, 0.74-1.13; P=.40). The levosimendan group had greater decreases in B-type natriuretic peptide level at 24 hour ...
THIRTY -SIXTH  ANNUAL  REPORT RESEARCH  ADVISORY  PANEL 2006
THIRTY -SIXTH ANNUAL REPORT RESEARCH ADVISORY PANEL 2006

... a cutaneous heat stimulation procedure and the heat/capsaicin sensitization model. Results: Fifty patients completed the entire trial. Smoked cannabis reduced daily pain by 34% vs 17%with placebo (p = 0. 03). Greater than 30% reduction in pain was reported by 52% in the cannabis group and by 24% in ...
EffEcts of MEMantinE on Pain in PatiEnts REtRosPEctivE study M
EffEcts of MEMantinE on Pain in PatiEnts REtRosPEctivE study M

... at least two months with 40mg QHS from 2007 until 2009. Results: 34 females and 22 male patients. Age-46.0+/-9.7 years. Number of years with CRPS-9.24 ± 5.7 years. Mean age-46.0+/-9.7 years. Memantine was started at 5 or 10mg QHS, before being increased by 5 or 10mg every 4-7 days, as tolerated, to ...
Buprenorphine for Pain and for Addiction
Buprenorphine for Pain and for Addiction

... DSM IV Substance Dependence A maladaptive pattern of substance use, with 3 or more of: • Tolerance • Withdrawal • Using larger amounts or for a longer time than intended • Persistent desire or lack of control • A great deal of time spent obtaining, using, recovering from • Important activities give ...
Document
Document

... gg= ...
443 - The AIDS InfoNet
443 - The AIDS InfoNet

... Many new copies of HIV are mutations. They are slightly different from the original virus. Some mutations can keep multiplying even when you are taking an ARV. When this happens, the drug will stop working. This is called “developing resistance” to the drug. See Fact Sheet 126 for more information o ...
Vascular Medicine
Vascular Medicine

... therapy, for the treatment of acute proximal deep-vein thrombosis (DVT). This proof-of-concept study was planned to assess the ability of rivaroxaban to treat existing clots, because previous studies have shown that short-term anticoagulation with rivaroxaban, for up to 10 days, can prevent VTE afte ...
12 January 2007 - Scottish Medicines Consortium
12 January 2007 - Scottish Medicines Consortium

... in patients with advanced non-small-cell lung cancer (NSCLC) previously treated with chemotherapy. Patients were aged ≥ 18 years with histological or cytological confirmation of NSCLC with locally advanced or metastatic disease (stage III or IV) not amenable to curative therapy. Patients had to have ...
Obesity - PHG Foundation
Obesity - PHG Foundation

... large deletion have been implicated in monogenic disorders in which obesity is the primary feature. These gene discoveries have contributed to our understanding of the biological mechanisms involved in the development of obesity, as all play a role in the central regulation of energy intake. Mutatio ...
Caspary T, Anderson KV. Dev Dyn. 2006 Sep;235(9):2412-23. Uncovering the uncharacterized and unexpected: unbiased phenotype-driven screens in the mouse. (Review)
Caspary T, Anderson KV. Dev Dyn. 2006 Sep;235(9):2412-23. Uncovering the uncharacterized and unexpected: unbiased phenotype-driven screens in the mouse. (Review)

... the past five years from a potential approach to a practical tool. This change has been driven by the relative ease of identifying causative mutations now that the complete genome sequence is available. These unbiased screens make it possible to identify genes, gene functions and processes that are ...
Efficacy, Compliance & Cost-Effectiveness in the Treatment of Glaucoma
Efficacy, Compliance & Cost-Effectiveness in the Treatment of Glaucoma

... glaucoma, and in patients treated previously with ALT. (11, 26) These studies individually demonstrate that SLT is a superior and more cost-effective treatment compared to medication and other glaucoma therapies, not merely from the cost perspective, but also from the several relative advantages tha ...
Phenotype-genotype correlation in 20 deletion and 20 non
Phenotype-genotype correlation in 20 deletion and 20 non

... activity in seven cases; three of them became seizurefree 2–3 years after treatment initiation. The three remaining child cases were more severe. In the adolescent and adult group, epilepsy never improved in four cases, and the frequency and duration of epileptic seizures became worse in adult age. ...
methyl salicylate topical
methyl salicylate topical

... resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug ...
Cayratia carnosa Wight) Gagnep. IN PARACETAMOL INDUCED HEPATOTOXICITY IN ALBINO RATS
Cayratia carnosa Wight) Gagnep. IN PARACETAMOL INDUCED HEPATOTOXICITY IN ALBINO RATS

... Group-I = Normal control (Normal saline 10 ml/kg) Group-II = Paracetamol 2.5 kg/kg. Group-III = Silymarin (25 mg/kg) Group-IV = Ethanolic extract 200 mg/kg Group-V = Aqueous extract 200 mg/kg Group-VI = Total Aqueous extract 200 mg/kg Group-VII = Ethanolic extract 400 mg/kg Group-VIII = Aqueous extr ...
NATURAL POPULATIONS OF DROSOPHZLA PSEUDOOBSCURAl
NATURAL POPULATIONS OF DROSOPHZLA PSEUDOOBSCURAl

... of genic variation segregating in all of the populations studied and that the real variation in these populations must be greater than we are able to demonstrate. This study does not make clear what balance of forces is responsible for the genetic variation observed, but it does make clear the kind ...
09:45 PATO: An Ontology of Phenotypic Qualities
09:45 PATO: An Ontology of Phenotypic Qualities

...  Annotate 11 human disease genes, and their homologs  Develop search algorithm that utilizes the ontologies for comparison  Test search algorithm by asking, “given a set of phenotypic descriptions (EQ stmts), can we find…” alleles of the same gene homologs in different organisms members of a p ...
Psychotropics and Sudden Cardiac Death
Psychotropics and Sudden Cardiac Death

... prolongation which is considered a marker for increased risk of sudden cardiac death due to malignant arrhythmias such as Torsades de pointes (TdP). Psychotropics rarely lead to sudden death in healthy individuals on a single QTc prolonging medication. However, factors such polypharmacy, recent init ...
RECENT MAJOR CHANGES
RECENT MAJOR CHANGES

... The dosage and duration of CANCIDAS treatment for each indication are as follows: Empirical Therapy for Presumed Fungal Infections in Febrile Neutropenic Patients Administer a single 70-mg loading dose on Day 1, followed by 50 mg once daily thereafter. Duration of treatment should be based on the pa ...
JDP Featured in BioCentury
JDP Featured in BioCentury

... injectable antihistamine can become standard of care for hospitalized patients suffering acute allergic reactions. By avoiding IV diphenhydramine’s multiple doses and heavy sedative effects, the company is proposing its products will improve quality of care while producing cost savings for the healt ...
Alendronat 1A Farma 70 mg film
Alendronat 1A Farma 70 mg film

... Alendronate is not recommended for patients with impaired renal function if the creatinine clearance is less than 35 ml/min (see section 4.2). Bone and mineral metabolism Causes of osteoporosis other than oestrogen deficiency and ageing should be considered. Hypocalcaemia must be corrected before tr ...
Vol. 19, No. 2 To P.O. B12 or Not to P.O. B12 - medSask
Vol. 19, No. 2 To P.O. B12 or Not to P.O. B12 - medSask

... patients relapsed or had a low serum cobalamin level.(7) Following this study, oral cobalamin became an alternative first-line treatment for B12 deficiency in Sweden and has been widely used in that country for the past thirty years.(8) Currently, approximately 40% of Swedish patients with perniciou ...
product information
product information

... has not been established, in some reports the association cannot be excluded. Patients being treated with CHAMPIX and their families should be alerted to the need to monitor for neuropsychiatric symptoms including changes in behaviour or thinking, anxiety, psychosis, mood swings, agitation, aggressi ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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