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Somaclonal Variation
Somaclonal Variation

... Somaclonal Variation • Possible causes – the "culture environment" • the hypothesis – that tissue culture is inherently stressful to cultured plant cells • environmental stress is known to cause: – DNA methylation – the methylation of cytosine is known to cause gene inactivation; this may occur dur ...
2.1 Selective breeding
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Cell - David Page Lab
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... branches. To quote the authors, “thus, during recent human history, gene conversion in C/T chromosomes has used either the C copy or the T copy as a template.” Similar observations were made at two other duplicated sites that displayed sequence variation. Moreover, an analysis of the ampliconic sequ ...
Alleles and Genotypes in Populations that Mate at Random Three
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Genome Questions
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Zoo/Bot 3333
Zoo/Bot 3333

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Complex Germline Architecture: Two Genes
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Genomics 1 The Genome

... From one individual to the next there are variations in the sequences of base pairs. Variations can be due to 1. A change in one base pair, where A changes to G, or G changes to C, 2. A few base pairs are missing between animals, 3. A few extra base pairs are added between two animals, or 4. The ord ...
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Chapter 15 Power Point Slides

... human genome and use that info to map all human genes. (The HGP also set out to map the genomes of other species commonly used in scientific research.)  Mutant genes are the basis of genetic disorders—in humans and other organisms. Mutations were studied and cataloged, providing insight into genome ...
SEGMENTAL VARIATION
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Gene set enrichment analysis (GSEA)
Gene set enrichment analysis (GSEA)

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Gene Section FGA7 (Fused Gene 7 to AML1) in Oncology and Haematology
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Lecture 12
Lecture 12

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Copy-number variation



Copy-number variations (CNVs)—a form of structural variation—are alterations of the DNA of a genome that results in the cell having an abnormal or, for certain genes, a normal variation in the number of copies of one or more sections of the DNA. CNVs correspond to relatively large regions of the genome that have been deleted (fewer than the normal number) or duplicated (more than the normal number) on certain chromosomes. For example, the chromosome that normally has sections in order as A-B-C-D might instead have sections A-B-C-C-D (a duplication of ""C"") or A-B-D (a deletion of ""C"").This variation accounts for roughly 13% of human genomic DNA and each variation may range from about one kilobase (1,000 nucleotide bases) to several megabases in size. CNVs contrast with single-nucleotide polymorphisms (SNPs), which affect only one single nucleotide base.
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