Prescribing Information - Aegerion Pharmaceuticals
... JUXTAPID can cause elevations in transaminases. In the JUXTAPID clinical trial, 10 (34%) of the 29 patients treated with JUXTAPID had at least one elevation in alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥3x upper limit of normal (ULN). There were no concomitant clinically mea ...
... JUXTAPID can cause elevations in transaminases. In the JUXTAPID clinical trial, 10 (34%) of the 29 patients treated with JUXTAPID had at least one elevation in alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥3x upper limit of normal (ULN). There were no concomitant clinically mea ...
The Rational Use of Drugs - Part 4
... When the assumption of linearity does not hold, the EC50 no longer approximates the KD. For example, the EC50 will be much smaller than the KD when “spare receptors” are present. A tissue is said to express “spare receptors” when only a small fraction of the receptor population must be occupied by d ...
... When the assumption of linearity does not hold, the EC50 no longer approximates the KD. For example, the EC50 will be much smaller than the KD when “spare receptors” are present. A tissue is said to express “spare receptors” when only a small fraction of the receptor population must be occupied by d ...
Trends in methylamphetamine availability, use and treatment: 2003
... Alcohol and other drug treatment services (AODTS) play an important role in efforts to reduce the recent trends in methylamphetamine use (AIHW 2011). This report presents data on the use, availability and market activity of methylamphetamine over the period 2003–04 to 2013–14 and compares these with ...
... Alcohol and other drug treatment services (AODTS) play an important role in efforts to reduce the recent trends in methylamphetamine use (AIHW 2011). This report presents data on the use, availability and market activity of methylamphetamine over the period 2003–04 to 2013–14 and compares these with ...
Article - New Zealand Institute of Chemistry
... marshmallow, blue lotus and rosehip.1 The wording on the packets to describe the contents often uses phrases like “natural organic extracts” and “100% legal herbs”. Most of the packets are labeled “R18” and also inform the user to use in a well ventilated room. The packaging of herbal blends general ...
... marshmallow, blue lotus and rosehip.1 The wording on the packets to describe the contents often uses phrases like “natural organic extracts” and “100% legal herbs”. Most of the packets are labeled “R18” and also inform the user to use in a well ventilated room. The packaging of herbal blends general ...
The pharmacologic treatment of Dravet syndrome
... further long-lasting seizures, the parents should be encouraged to administer oral/nasal/rectal benzodiazepine–diazepam or midazolam for any seizure lasting more than a few minutes. However, repetition of the seizures permits the diagnosis to be considered, and to no longer consider complicated febr ...
... further long-lasting seizures, the parents should be encouraged to administer oral/nasal/rectal benzodiazepine–diazepam or midazolam for any seizure lasting more than a few minutes. However, repetition of the seizures permits the diagnosis to be considered, and to no longer consider complicated febr ...
the cost of comprehensive hiv treatment in kenya
... and also received routine CD4 count tests to monitor disease progression. More than 90.0% of all ART patients were adults, and almost all were on a triple combination antiretroviral (ARV) regimen of two nucleoside reverse transcriptase inhibitors and a non-nucleoside reverse transcriptase inhibitor ...
... and also received routine CD4 count tests to monitor disease progression. More than 90.0% of all ART patients were adults, and almost all were on a triple combination antiretroviral (ARV) regimen of two nucleoside reverse transcriptase inhibitors and a non-nucleoside reverse transcriptase inhibitor ...
Introduction to the WHO Drug Dictionary
... possible to retrieve all information about the drug when assessing and analysing the data. It also makes it possible to produce reports – regulatory reports or internal. An important reason for coding clinical data is to be able to optimize the analysis of the data – and to make the best decisions. ...
... possible to retrieve all information about the drug when assessing and analysing the data. It also makes it possible to produce reports – regulatory reports or internal. An important reason for coding clinical data is to be able to optimize the analysis of the data – and to make the best decisions. ...
PREPARATION AND EVALUATION OF NOVEL TOPICAL GEL PREPARATIONS FOR WOUND
... Diabetes mellitus is one of the metabolic disorders that impedes normal steps of wound healing process. Recently, statins have been shown to have anticoagulant, immunosuppressive and antiproliferative effects that could conceivably affect wound healing or the risk of wound complications after surger ...
... Diabetes mellitus is one of the metabolic disorders that impedes normal steps of wound healing process. Recently, statins have been shown to have anticoagulant, immunosuppressive and antiproliferative effects that could conceivably affect wound healing or the risk of wound complications after surger ...
... Long term studies with disease modifying drugs in rheumatoid arthritis are rather complicated owing to a relatively high drop out rate due to side effects, spontaneous fluctuations of activity during a long term study, and low sensitivity of some clinical and laboratory tests. In our study we used a ...
(HIV)–Infected Adults Receiving A
... mg/dL, respectively), but increases in the triglyceride level were significantly greater with lopinavir-ritonavir than with nelfinavir (125 and 47 mg/dL, respectively) [32]. Lipid abnormalities tend to be most marked with ritonavir [16] and lopinavirritonavir [33, 34]. Amprenavir [29] and nelfinavir ...
... mg/dL, respectively), but increases in the triglyceride level were significantly greater with lopinavir-ritonavir than with nelfinavir (125 and 47 mg/dL, respectively) [32]. Lipid abnormalities tend to be most marked with ritonavir [16] and lopinavirritonavir [33, 34]. Amprenavir [29] and nelfinavir ...
UKMI Guidance: Temazepam Shortage
... dose together with 7.5mg zopiclone for 10 days, followed by 18 days of zopiclone 7.5mg alone at night, after which the zopiclone was discontinued. A total of 566 patients completed the study and at the end, 21% had ceased hypnotic use. The second study4 recruited 134 patients (average age 50), who w ...
... dose together with 7.5mg zopiclone for 10 days, followed by 18 days of zopiclone 7.5mg alone at night, after which the zopiclone was discontinued. A total of 566 patients completed the study and at the end, 21% had ceased hypnotic use. The second study4 recruited 134 patients (average age 50), who w ...
Urine Opiate Tests for Pain Management 2/15/2014
... immunoassay which has a higher cutoff or detection limit compared to a liquid chromatography tandem mass spectrometry-based assay (LC-MS/MS). In this study, Mikel and colleagues took the urine of pain management patients and tested it using both an immunoassay and a LC- tandem mass spec assay. The u ...
... immunoassay which has a higher cutoff or detection limit compared to a liquid chromatography tandem mass spectrometry-based assay (LC-MS/MS). In this study, Mikel and colleagues took the urine of pain management patients and tested it using both an immunoassay and a LC- tandem mass spec assay. The u ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... Plants have always been a common source of med icament either in the form of t raditional preparat ion or pure active principles. Synthetic products of the modern civilizat ion have overshadowed the usage of herbal med icines. But once having realized their serious side effects people are going back ...
... Plants have always been a common source of med icament either in the form of t raditional preparat ion or pure active principles. Synthetic products of the modern civilizat ion have overshadowed the usage of herbal med icines. But once having realized their serious side effects people are going back ...
Tutorial Planner - Collegiate Medical Centre
... outpatients who are unable to absorb oral agents because of gastric atony or vomiting. Injectables are used in the emergency room or inpatient settings. The new agents are used when all else fails. Some antihistamines commonly used as vestibular suppressants have significant antiemetic properties (e ...
... outpatients who are unable to absorb oral agents because of gastric atony or vomiting. Injectables are used in the emergency room or inpatient settings. The new agents are used when all else fails. Some antihistamines commonly used as vestibular suppressants have significant antiemetic properties (e ...
IN-VITRO STUDIES OF EFAVIRENZ FORMULATION BY RP-HPLC Research Article
... A reverse phase stability indicating HPLC method was developed for the analysis of efavirenz bulk and pharmaceutical formulations. The developed method was also utilized for in-vitro dissolution studies of efavirenz formulations. Acetonitrile and acetate buffer pH 3.4 was the mobile phase (75:25% v/ ...
... A reverse phase stability indicating HPLC method was developed for the analysis of efavirenz bulk and pharmaceutical formulations. The developed method was also utilized for in-vitro dissolution studies of efavirenz formulations. Acetonitrile and acetate buffer pH 3.4 was the mobile phase (75:25% v/ ...
Protocol version 1 05/03/2010 Text S2 PARTICIPATING
... We have developed high performance liquid chromatography assays for lumefantrine, naphthoquine and pyronaridine, but now have access to liquid chromatography-mass spectrometry which allows greater assay sensitivity with a smaller sample volume and increased throughput. Day 7 and follow-up samples on ...
... We have developed high performance liquid chromatography assays for lumefantrine, naphthoquine and pyronaridine, but now have access to liquid chromatography-mass spectrometry which allows greater assay sensitivity with a smaller sample volume and increased throughput. Day 7 and follow-up samples on ...
How to Deliver Respiratory Treatments to Neonates by
... levels in respiratory secretions, which are higher than those achieved after systemic administration.6 Anti-Inflammatories Few studies are published regarding the efficacy of inhaled corticosteroids in veterinary medicine, although the benefits of systemic corticosteroids in cases of equine airway dise ...
... levels in respiratory secretions, which are higher than those achieved after systemic administration.6 Anti-Inflammatories Few studies are published regarding the efficacy of inhaled corticosteroids in veterinary medicine, although the benefits of systemic corticosteroids in cases of equine airway dise ...
“medical” marijuana
... motivation, memory, AND learning. • Because youth with an average grade of D or below were more than four times as likely to have used marijuana in the past year than youth with an average grade of A. National Institute on Drug Abuse, “Marijuana: Facts Parents Need to Know.” 2011. Available: ...
... motivation, memory, AND learning. • Because youth with an average grade of D or below were more than four times as likely to have used marijuana in the past year than youth with an average grade of A. National Institute on Drug Abuse, “Marijuana: Facts Parents Need to Know.” 2011. Available: ...
Hyperlipidemia
... fasting lipoprotein profile and risk factor assessment be used in the initial classification of adults. ...
... fasting lipoprotein profile and risk factor assessment be used in the initial classification of adults. ...
What is the prognosis for new centrally-acting anti
... In this review, we discuss the challenges for the development of centrally-acting anti-obesity drugs arising from a conservative regulatory environment, difficult marketing conditions and unrealistic patient expectations. We also critically assess the three drug candidates that are currently at the p ...
... In this review, we discuss the challenges for the development of centrally-acting anti-obesity drugs arising from a conservative regulatory environment, difficult marketing conditions and unrealistic patient expectations. We also critically assess the three drug candidates that are currently at the p ...
Division of Clinical Pharmacology Department of Medicine and Health Sciences Linköping University
... Drugs have been used successfully to treat and prevent illnesses for long time and have revolutionised health care. Today drug treatment is the most important intervention for curing diseases and maintaining mankind’s well being. The number of drugs used per individual has successively increased ove ...
... Drugs have been used successfully to treat and prevent illnesses for long time and have revolutionised health care. Today drug treatment is the most important intervention for curing diseases and maintaining mankind’s well being. The number of drugs used per individual has successively increased ove ...
- Journal of Allergy and Clinical Immunology
... enrolled. After 32,430 injections during 2736 patient years of observation, 57 of 1790 patients (3.2%) had an allergic reaction, and 4 of these reactions were anaphylactic (incidence of 0.2%; 1.2 cases/10,000 injections).11 Despite the fact that penicillin-induced anaphylaxis is rare, this drug cont ...
... enrolled. After 32,430 injections during 2736 patient years of observation, 57 of 1790 patients (3.2%) had an allergic reaction, and 4 of these reactions were anaphylactic (incidence of 0.2%; 1.2 cases/10,000 injections).11 Despite the fact that penicillin-induced anaphylaxis is rare, this drug cont ...
Aflibercept for the treatment of wet age
... the treating physician and may be more frequent than the scheduled injections (8). For ranibizumab, the manufacturers recommend monthly monitoring and hence 12 visits would be expected over a year but in practice there is suggestion that monitoring intervals may be extended to 6 weeks after the init ...
... the treating physician and may be more frequent than the scheduled injections (8). For ranibizumab, the manufacturers recommend monthly monitoring and hence 12 visits would be expected over a year but in practice there is suggestion that monitoring intervals may be extended to 6 weeks after the init ...
IPR2016-01186
... required, if, and only if, the declarant is on the same document, warned that willful false statements and the like are punishable by fine or imprisonment, or both (18 U.S.C. 1001) and may jeopardize the validity of the application or any patent issuing thereon. The declarant must set forth in the b ...
... required, if, and only if, the declarant is on the same document, warned that willful false statements and the like are punishable by fine or imprisonment, or both (18 U.S.C. 1001) and may jeopardize the validity of the application or any patent issuing thereon. The declarant must set forth in the b ...