DETERMINATION OF LEVOCETIRIZINE CONFIGURATIONAL STABILITY IN TABLETS USING CHIRAL HPLC METHOD Research Article
... (racemates). In many cases the two enantiomers differ in their pharmacokinetic and pharmacodynamic properties. Replacing existing racemates with single isomers has resulted in improved safety and/or efficacy profile of various racemates1,2. Many optically active enantiomers ...
... (racemates). In many cases the two enantiomers differ in their pharmacokinetic and pharmacodynamic properties. Replacing existing racemates with single isomers has resulted in improved safety and/or efficacy profile of various racemates1,2. Many optically active enantiomers ...
Positron Emission Tomography Imaging: A Quantitative Biomarker in
... Quantitative Modeling Analysis of PET Data Tracer kinetic modeling has been used for over 50 years as a tool to measure the uptake, retention, and metabolism of radiotracers [4]. These modeling approaches depend upon the tracer assumption, i.e., that the mass concentration of the radiotracer is minu ...
... Quantitative Modeling Analysis of PET Data Tracer kinetic modeling has been used for over 50 years as a tool to measure the uptake, retention, and metabolism of radiotracers [4]. These modeling approaches depend upon the tracer assumption, i.e., that the mass concentration of the radiotracer is minu ...
Antifungals - ACH Pediatric Residents
... Large Vd, extensive tissue distribution, lipid soluble ...
... Large Vd, extensive tissue distribution, lipid soluble ...
Serotonin-Norepinephrine Reuptake Inhibitors
... Activity on norepinephrine reuptake is thought necessary for an antidepressant to be effective on neuropathic pain, a property shared with the older tricyclic antidepressants but not with the SSRIs. It has been theorized that depression corresponds with a reduction in communication and connectivity ...
... Activity on norepinephrine reuptake is thought necessary for an antidepressant to be effective on neuropathic pain, a property shared with the older tricyclic antidepressants but not with the SSRIs. It has been theorized that depression corresponds with a reduction in communication and connectivity ...
PERCUTANEOUS DRUG DELIVERY SYSTEMS FOR IMPROVING ANTIFUNGAL THERAPY EFFECTIVENESS: A REVIEW
... only the ones related with fungi but also with Leishmania parasites that grow in skin layers. Azoles are the most commonly used antifungals in clinical treatment of superficial fungal infections, but their physicochemical properties limit their bioavailability; consequently most of the azoleloaded d ...
... only the ones related with fungi but also with Leishmania parasites that grow in skin layers. Azoles are the most commonly used antifungals in clinical treatment of superficial fungal infections, but their physicochemical properties limit their bioavailability; consequently most of the azoleloaded d ...
DEVELOPMENT AND VALIDATION OF SIMULTANEOUS EQUATION METHOD FOR
... 4dihydropyridine-3, 5-dicarboxylate (Fig.1), is a long-acting calcium channel blocker used in the management of hypertension by inhibiting the inward movement of calcium by binding to L-Type calcium channels in the heart and in smooth muscle of the coronary and peripheral vasculature relaxing the sm ...
... 4dihydropyridine-3, 5-dicarboxylate (Fig.1), is a long-acting calcium channel blocker used in the management of hypertension by inhibiting the inward movement of calcium by binding to L-Type calcium channels in the heart and in smooth muscle of the coronary and peripheral vasculature relaxing the sm ...
Thesis - CiteSeerX
... psychological symptoms of dementia, but the use of these drugs has been associated with increased morbidity and mortality. Efforts have therefore been made to reduce the prescribing of antipsychotic drugs to older adults with dementia. We found a higher use of antipsychotic drugs among persons with ...
... psychological symptoms of dementia, but the use of these drugs has been associated with increased morbidity and mortality. Efforts have therefore been made to reduce the prescribing of antipsychotic drugs to older adults with dementia. We found a higher use of antipsychotic drugs among persons with ...
The use of animals for research in the
... physiology, extending established scientific traditions of using animals in research. New potential medicines were not directed at a specific target such as a cell receptor, as they are today. Rather, the effect of medicines was measured in relation to the general physiological response of an animal ...
... physiology, extending established scientific traditions of using animals in research. New potential medicines were not directed at a specific target such as a cell receptor, as they are today. Rather, the effect of medicines was measured in relation to the general physiological response of an animal ...
Diuretics and Synthetic Hypoglycemic Drugs
... The hypoglycemic(降血糖)effect of salicylates(水杨酸 盐)has been known for 100 years. Clinical use of salicylates was not feasible, since the very large doses required produced intolerable side effects. The hypoglycemic effects of the thiadiazole sulfonamide known as IPTD, used to treat typhoid (伤 寒症)f ...
... The hypoglycemic(降血糖)effect of salicylates(水杨酸 盐)has been known for 100 years. Clinical use of salicylates was not feasible, since the very large doses required produced intolerable side effects. The hypoglycemic effects of the thiadiazole sulfonamide known as IPTD, used to treat typhoid (伤 寒症)f ...
TrendsRx® Alert
... As many as one-third of patients seen in the primary care setting may experience trouble sleeping from time to time, and 10 percent of those may have chronic sleep problems.3 About 30 percent to 40 percent of adults report some level of insomnia within any given year, and about 10 percent to 15 perc ...
... As many as one-third of patients seen in the primary care setting may experience trouble sleeping from time to time, and 10 percent of those may have chronic sleep problems.3 About 30 percent to 40 percent of adults report some level of insomnia within any given year, and about 10 percent to 15 perc ...
Status Epilepticus was defined by the International Classification of
... Women with epilepsy who are planning a pregnancy should take folic acid 5 mg/day in the preconception period and throughout the pregnancy; vitamin K should be used in the last month of pregnancy in women on enzyme-inducing AEDs. The use of phenytoin, valproate, carbamazepine, lamotrigine, and phenob ...
... Women with epilepsy who are planning a pregnancy should take folic acid 5 mg/day in the preconception period and throughout the pregnancy; vitamin K should be used in the last month of pregnancy in women on enzyme-inducing AEDs. The use of phenytoin, valproate, carbamazepine, lamotrigine, and phenob ...
transdermal approach to pain relief: present and future
... → evaluate analgesic efficacy after 24 h ( other analgesia required during ...
... → evaluate analgesic efficacy after 24 h ( other analgesia required during ...
Suggestion from clinicians
... treatments, because it encompasses efficacy and tolerability.7,8 In our analysis, the results paralleled the efficacy findings in that the most effective drugs also had the lowest discontinuation rates (although haloperidol, the worst drug with respect to all-cause discontinuation, had a middle rank ...
... treatments, because it encompasses efficacy and tolerability.7,8 In our analysis, the results paralleled the efficacy findings in that the most effective drugs also had the lowest discontinuation rates (although haloperidol, the worst drug with respect to all-cause discontinuation, had a middle rank ...
Extreme value modelling: A novel approach to the analysis of
... Phase 2 – more patients, finding right dose Phase 3 – many patients, confirming efficacy ...
... Phase 2 – more patients, finding right dose Phase 3 – many patients, confirming efficacy ...
Prodrugs II
... significant levels of the active agent. The targeting of drugs for a specific site in the body by conversion to a prodrug is plausible when the physicochemical properties of prodrug are optimal for the target site. It should be kept in mind, however, that when the lipophilicity of a drug is increase ...
... significant levels of the active agent. The targeting of drugs for a specific site in the body by conversion to a prodrug is plausible when the physicochemical properties of prodrug are optimal for the target site. It should be kept in mind, however, that when the lipophilicity of a drug is increase ...
Prescribing information for paediatric medicines
... a. X is not recommended for use in children
age Y due to data
on safety and/or efficacy (the age should be specified)’
b. The experience in children is limited. There is no
experience in children.
c. ‘Use in children – there is no relevant indication for u ...
... a. X is not recommended for use in children
Clindoxyl Gel For The Treatment Of Acne Vulgaris
... inhibition of lipase production via protein synthesis inhibition, antimicrobials also result in a reduction of skin surface sebum fatty acid composition.1 ...
... inhibition of lipase production via protein synthesis inhibition, antimicrobials also result in a reduction of skin surface sebum fatty acid composition.1 ...
Meta-Analyses Are No Longer Required for Determining the Efficacy
... on the basis of estimated creatinine clearance values [21, 27, 28, 32]. In most cases the 24-hr mglkg dose was reduced, and the dosing interval was not extended. The majority of the studies did not address the issue. A few of the published trials do document the desired low or undetectable levels of ...
... on the basis of estimated creatinine clearance values [21, 27, 28, 32]. In most cases the 24-hr mglkg dose was reduced, and the dosing interval was not extended. The majority of the studies did not address the issue. A few of the published trials do document the desired low or undetectable levels of ...
ภาพนิ่ง 1
... “Losing wt. is difficult for most obese persons, yet longterm maintenance of a reduced wt. is even more challenging!” ...
... “Losing wt. is difficult for most obese persons, yet longterm maintenance of a reduced wt. is even more challenging!” ...
Statins induced myopathy
... hydroxy 3 methyl glutaryl coenzyme A) in the liver - 1987 : first approved for the use in treatment of hypercholesterolemia - Most effective agents for reducing plasma chol. level - Benefit in prevention of primary and secondary CHD - Reduce of mortality and morbidity - Good tolerance ...
... hydroxy 3 methyl glutaryl coenzyme A) in the liver - 1987 : first approved for the use in treatment of hypercholesterolemia - Most effective agents for reducing plasma chol. level - Benefit in prevention of primary and secondary CHD - Reduce of mortality and morbidity - Good tolerance ...
oral bioavailability and first-pass effects
... predicated on assumptions such as the dose being completely absorbed unchanged, biotransformation not occurring in the gut wall; the liver being the only drug metabolizing organ; etc. While such qualifying assumptions may be appropriate in specific situations, they detract from the general applicabi ...
... predicated on assumptions such as the dose being completely absorbed unchanged, biotransformation not occurring in the gut wall; the liver being the only drug metabolizing organ; etc. While such qualifying assumptions may be appropriate in specific situations, they detract from the general applicabi ...
Outsourcing API Manufacture to India & China A Suppliers Perspective
... Over 20 years experience 6 sites (3 in Switzerland, 1 in the United Kingdom, 1 in France and 1 in India) Over 200 chemists, with >40% Ph.D. Well over 500 projects per annum ...
... Over 20 years experience 6 sites (3 in Switzerland, 1 in the United Kingdom, 1 in France and 1 in India) Over 200 chemists, with >40% Ph.D. Well over 500 projects per annum ...
recent court decisions
... are superior to maleate salts. The Federal Circuit reviewed the evidence and held claims 1-3 of the ’303 patent invalid for obviousness. Both parties agreed that all of the ’303 patent claim limitations were found in the prior art. The two main issues addressed on appeal were (1) Was there a motivat ...
... are superior to maleate salts. The Federal Circuit reviewed the evidence and held claims 1-3 of the ’303 patent invalid for obviousness. Both parties agreed that all of the ’303 patent claim limitations were found in the prior art. The two main issues addressed on appeal were (1) Was there a motivat ...
transcutaneous drug delivery system: a comprehensive review
... The polymer controls the release of the drug from the device. Molecular weight, chemical functionality of the polymer should be such that the specific drug diffuses properly and gets released through it. The following criteria should be satisfied for a polymer to be used in transcutaneous patches. · ...
... The polymer controls the release of the drug from the device. Molecular weight, chemical functionality of the polymer should be such that the specific drug diffuses properly and gets released through it. The following criteria should be satisfied for a polymer to be used in transcutaneous patches. · ...
Garrett Peters 3/31/2013 Writing 340 Adderall: An A+ in a Bottle
... Although recreational use is a concern, the main issue regarding Adderall abuse on campuses is its use as a study drug. 34.5% of college students admitted to using Adderall in 2012 and this number continues to grow [11]. The increase in pressure for students to do well has driven nonprescription Add ...
... Although recreational use is a concern, the main issue regarding Adderall abuse on campuses is its use as a study drug. 34.5% of college students admitted to using Adderall in 2012 and this number continues to grow [11]. The increase in pressure for students to do well has driven nonprescription Add ...
Pharmaceutical industry
The pharmaceutical industry develops, produces, and markets drugs or pharmaceuticals for use as medications. Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy and marketing of drugs.