NIDA Research Report - Heroin
... to receive pharmacotherapy for their heroin addiction, detoxification from opiates during pregnancy can be accomplished with relative safety, although the likelihood of relapse to heroin use should be considered. Why are heroin users at special risk for contracting HIV/AIDS and hepatitis B and C? er ...
... to receive pharmacotherapy for their heroin addiction, detoxification from opiates during pregnancy can be accomplished with relative safety, although the likelihood of relapse to heroin use should be considered. Why are heroin users at special risk for contracting HIV/AIDS and hepatitis B and C? er ...
PRODUCT MONOGRAPH INHIBACE PLUS cilazapril and
... This medicine does not cure high blood pressure. It helps to control it. Therefore, it is important to continue taking INHIBACE PLUS regularly even if you feel fine. When it should not be used: Do not take INHIBACE PLUS if you: Are allergic to cilazapril or hydrochlorothiazide or to any non-medici ...
... This medicine does not cure high blood pressure. It helps to control it. Therefore, it is important to continue taking INHIBACE PLUS regularly even if you feel fine. When it should not be used: Do not take INHIBACE PLUS if you: Are allergic to cilazapril or hydrochlorothiazide or to any non-medici ...
eeg
... • qEEG has even face- and construct- validity for the effects of drugs in several target indications (insomnia, epilepsy) • there is increasing evidence for the use of qEEG as : • a prognostic biomarker for the cognitive deficits in MCI and Alzheimer, • a drug-response biomarker in major depressive ...
... • qEEG has even face- and construct- validity for the effects of drugs in several target indications (insomnia, epilepsy) • there is increasing evidence for the use of qEEG as : • a prognostic biomarker for the cognitive deficits in MCI and Alzheimer, • a drug-response biomarker in major depressive ...
FORMULATION AND EVALUATION OF OLMESARTAN MEDOXOMIL FLOATING TABLETS
... antagonist use in the treatment of mild –moderate hypertension. This drug is weakly basic, lipophilic and having very less oral bioavailability of about 26%. Olmesartan Medoxomil inhibits type I angiotensin II receptor in the rennin angiotensin system, there by producing best antihypertensive action ...
... antagonist use in the treatment of mild –moderate hypertension. This drug is weakly basic, lipophilic and having very less oral bioavailability of about 26%. Olmesartan Medoxomil inhibits type I angiotensin II receptor in the rennin angiotensin system, there by producing best antihypertensive action ...
1. introduction
... In determining the flux of a material through human skin is the molecular size plays an important role. Molecular weight is generally taken as an approximation of molecular size for simplicity. It was observed that an inverse relationship existed between transdermal flux and molecular weight of the ...
... In determining the flux of a material through human skin is the molecular size plays an important role. Molecular weight is generally taken as an approximation of molecular size for simplicity. It was observed that an inverse relationship existed between transdermal flux and molecular weight of the ...
Drugs and nutrition Drug disposition in obesity and protein–energy
... bloodstream to the site(s) of effect are determined by several factors related to the drug (e.g. lipophilicity, plasma protein binding, degree of ionization and tissue affinity) and to the body (e.g. body composition, blood flow, tissue size and permeability)(1,10,11). As a result, the distribution ...
... bloodstream to the site(s) of effect are determined by several factors related to the drug (e.g. lipophilicity, plasma protein binding, degree of ionization and tissue affinity) and to the body (e.g. body composition, blood flow, tissue size and permeability)(1,10,11). As a result, the distribution ...
Review of Principles
... Some tissues have more receptors than are necessary to produce a maximal response. – Dependent on tissue, measure of response and intrinsic efficacy of the drug. ...
... Some tissues have more receptors than are necessary to produce a maximal response. – Dependent on tissue, measure of response and intrinsic efficacy of the drug. ...
Antibiotics in Endodontics
... Although some patients may experience moderate to severe pain after endodontic treatment ,very few experience what is now commonly referred to as Flare-up : a postoperative problem requiring an unscheduled ...
... Although some patients may experience moderate to severe pain after endodontic treatment ,very few experience what is now commonly referred to as Flare-up : a postoperative problem requiring an unscheduled ...
Chapter_005
... Fig. 5-2. Dose-response curves demonstrating efficacy and potency. A, Efficacy, or “maximal efficacy,” is an index of the maximal response a drug can produce. The efficacy of a drug is indicated by the height of its dose-response curve. In this example, meperidine has greater efficacy than pentazoc ...
... Fig. 5-2. Dose-response curves demonstrating efficacy and potency. A, Efficacy, or “maximal efficacy,” is an index of the maximal response a drug can produce. The efficacy of a drug is indicated by the height of its dose-response curve. In this example, meperidine has greater efficacy than pentazoc ...
REVERSE PHASE HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE
... Objective: To develop a simple, precise, accurate, linear and rapid Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method for the simultaneous quantitative estimation of Troxerutin 500 mg and Calcium dobesilate 500 mg in tablets as per ICH guidelines. Methods: The method uses revers ...
... Objective: To develop a simple, precise, accurate, linear and rapid Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method for the simultaneous quantitative estimation of Troxerutin 500 mg and Calcium dobesilate 500 mg in tablets as per ICH guidelines. Methods: The method uses revers ...
gangrenous ergotism
... LSD 25 had strong uterine effect and animals became stuporous but restless ◦ nothing of special interest – set back on shelf…… ◦ 5 years later – made new batch and must have gotten tiny amount on fingers ◦ tried it again under a more controlled condition using a 0.25 mg dose (10X the dose for most t ...
... LSD 25 had strong uterine effect and animals became stuporous but restless ◦ nothing of special interest – set back on shelf…… ◦ 5 years later – made new batch and must have gotten tiny amount on fingers ◦ tried it again under a more controlled condition using a 0.25 mg dose (10X the dose for most t ...
Drug study guide for NPLEX clincal
... This list is NOT all inclusive of what is on NPLEX, but will likely have many NPLEX answers in it. I wrote this study list before taking NPLEX II examination. This list in no way tells people what specific questions were on nplex list, This list is based upon the 2009 NPLEX drug list, which may have ...
... This list is NOT all inclusive of what is on NPLEX, but will likely have many NPLEX answers in it. I wrote this study list before taking NPLEX II examination. This list in no way tells people what specific questions were on nplex list, This list is based upon the 2009 NPLEX drug list, which may have ...
The role of adherence in tuberculosis HIV-positive patients treated in
... deaths in those who receive an effective therapy are due to complications of HIV infection rather than tuberculosis [11]. In the current study, almost one-quarter of patients do not recover from tuberculosis. The mortality was 14.3%, much higher than the 4.7% for the global fatality rate of tubercul ...
... deaths in those who receive an effective therapy are due to complications of HIV infection rather than tuberculosis [11]. In the current study, almost one-quarter of patients do not recover from tuberculosis. The mortality was 14.3%, much higher than the 4.7% for the global fatality rate of tubercul ...
Development of supersaturatable self-emulsifying drug delivery system formulations for
... PNU-91325 is a lipophilic drug with a calculated Log P partition coefficient (CLogP) of 2.8 [38]. This molecule shows a U-shaped pH-solubility dependency, indicating two -log10 dissociation constant for an acid (pKa) values (a basic pKa of 2.61 and an acidic pKa of 6.85). PNU-91325 shows an almost c ...
... PNU-91325 is a lipophilic drug with a calculated Log P partition coefficient (CLogP) of 2.8 [38]. This molecule shows a U-shaped pH-solubility dependency, indicating two -log10 dissociation constant for an acid (pKa) values (a basic pKa of 2.61 and an acidic pKa of 6.85). PNU-91325 shows an almost c ...
ECX Regimen - Cancer Care Ontario
... national consensus body e.g. pan-Canadian Oncology Drug Review, pCODR). Recommendation is based on an appropriately conducted phase III clinical trial relevant to the Canadian context OR (where phase III trials are not feasible) an appropriately sized phase II trial. Regimens where one or more drug ...
... national consensus body e.g. pan-Canadian Oncology Drug Review, pCODR). Recommendation is based on an appropriately conducted phase III clinical trial relevant to the Canadian context OR (where phase III trials are not feasible) an appropriately sized phase II trial. Regimens where one or more drug ...
Histamine H2 - Receptor Antagonists
... with risk factors for gastric ulcer treatment failure such as smoking. H2RA acute dosage regimens may also exceed 8 weeks in patients with risk factors for delayed duodenal ulcer healing such as daily ethanol use, large ulcers, signs of upper GI bleeding, and/or a previous history of duodenal ulcer ...
... with risk factors for gastric ulcer treatment failure such as smoking. H2RA acute dosage regimens may also exceed 8 weeks in patients with risk factors for delayed duodenal ulcer healing such as daily ethanol use, large ulcers, signs of upper GI bleeding, and/or a previous history of duodenal ulcer ...
Herbal Medicine Herbal Medicine By Kenneth R. Pelletier Herbal
... billion on them. In the rest of the world, approximately 64 percent of the population relies on herbal medicines. Despite their overwhelming popularity and long history, we know relatively little about the safety and effectiveness of herbal remedies. Scientific study should make these remedies far s ...
... billion on them. In the rest of the world, approximately 64 percent of the population relies on herbal medicines. Despite their overwhelming popularity and long history, we know relatively little about the safety and effectiveness of herbal remedies. Scientific study should make these remedies far s ...
Chapter-1 Introduction 1.1 INTRODUCTION
... e. New Business opportunity comes in the market like line extension, product differentiation, patent extension and life cycle management. f. Rapid Action: Fast onset of therapeutic action as tablet gets disintegrated rapidly along with quick dissolution and absorption in oral cavity. g. Obstruction ...
... e. New Business opportunity comes in the market like line extension, product differentiation, patent extension and life cycle management. f. Rapid Action: Fast onset of therapeutic action as tablet gets disintegrated rapidly along with quick dissolution and absorption in oral cavity. g. Obstruction ...
CHOLESTEROL AND OUR LIVES الدهنيات وحياتنا
... CHD and CHD Risk Equivalents Baseline (or On-Treatment) LDL-C: 100–129 mg/dL Therapeutic Options: • LDL-lowering therapy – Initiate or intensify lifestyle therapies – Initiate or intensify LDL-lowering drugs • Treatment of metabolic syndrome – Emphasize weight reduction and increased physical activi ...
... CHD and CHD Risk Equivalents Baseline (or On-Treatment) LDL-C: 100–129 mg/dL Therapeutic Options: • LDL-lowering therapy – Initiate or intensify lifestyle therapies – Initiate or intensify LDL-lowering drugs • Treatment of metabolic syndrome – Emphasize weight reduction and increased physical activi ...
Combining antidepressants
... A recently published review (1) on this topic concluded that there is limited evidence, mostly in uncontrolled studies, supporting the efficacy of combination antidepressant treatment. As shown in the table, there are very few randomised, controlled trials and sample sizes are small. Most studies us ...
... A recently published review (1) on this topic concluded that there is limited evidence, mostly in uncontrolled studies, supporting the efficacy of combination antidepressant treatment. As shown in the table, there are very few randomised, controlled trials and sample sizes are small. Most studies us ...
Age-related differences in reporting of drug
... Report VigiBase™ database without accessing identifiable private information and was reviewed by the University of North Carolina Office of Human Research Ethics, which determined that this study does not constitute human subjects research as defined under federal regulations [45 CFR 46.102 (d or f ...
... Report VigiBase™ database without accessing identifiable private information and was reviewed by the University of North Carolina Office of Human Research Ethics, which determined that this study does not constitute human subjects research as defined under federal regulations [45 CFR 46.102 (d or f ...
Drug Delivery System based on MEMS Technology
... in this case. Another potential use of this device is for treating angina. The IRD3 could be implanted in high-risk patients to deliver vasodilators such as nitrates on demand (Aronow, 2003), without the need to carry pills (typically for sublingual delivery). In this particular case, the applicatio ...
... in this case. Another potential use of this device is for treating angina. The IRD3 could be implanted in high-risk patients to deliver vasodilators such as nitrates on demand (Aronow, 2003), without the need to carry pills (typically for sublingual delivery). In this particular case, the applicatio ...
Emerging Drug List SIBUTRAMINE
... Sibutramine is the first agent of this class approved in Canada for the treatment of obesity. It is effective in the management of obesity when used in conjunction with a calorie-restricted diet. It should also be used in conjunction with behaviour and lifestyle modifications. Patients with certain ...
... Sibutramine is the first agent of this class approved in Canada for the treatment of obesity. It is effective in the management of obesity when used in conjunction with a calorie-restricted diet. It should also be used in conjunction with behaviour and lifestyle modifications. Patients with certain ...
united states securities and exchange commission - corporate
... biopharmaceutical company developing treatments to make a difference in the lives of patients with neurological and psychiatric disorders, today announced that it has acquired exclusive, worldwide rights from Eli Lilly and Company (“Lilly”) to develop and commercialize LY3130418 (now designated as C ...
... biopharmaceutical company developing treatments to make a difference in the lives of patients with neurological and psychiatric disorders, today announced that it has acquired exclusive, worldwide rights from Eli Lilly and Company (“Lilly”) to develop and commercialize LY3130418 (now designated as C ...
Pharmaceutical industry
The pharmaceutical industry develops, produces, and markets drugs or pharmaceuticals for use as medications. Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy and marketing of drugs.