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St.eroid Anesthetics: Old Compounds, New Drugs
St.eroid Anesthetics: Old Compounds, New Drugs

... thereby maintaining a coupling between metabolism and blood flow. A number of open studies have defined ED,, induction doses in both benzodiazepine and opioid-premeditated patients as between 0.33 mg/kg and 0.46 mg/kg.4g-51 Induction resulted in minimal hemodynamic depression, the main side effects ...
Beta-Lactam Antibiotics and Vancomycin Beta
Beta-Lactam Antibiotics and Vancomycin Beta

... enzymes. The fungi (penicillium and cephalosporium molds) are the sources of many ß-lactam antibiotics and are soil organisms which in nature grow in the same ecological niche as many bacteria. Thus, the bacteria evolved mechanisms to deal with the presence of these natural antimicrobial products, ...
POWERPOINT SPECIALS
POWERPOINT SPECIALS

... extent to which COX-2 users were taking OTC pain relievers – negating COX-2 therapeutic advantage ...
ENHANCEMENT OF DISSOLUTION OF NIFEDIPINE BY SURFACE SOLID DISPERSION  TECHNIQUE  Research Article   
ENHANCEMENT OF DISSOLUTION OF NIFEDIPINE BY SURFACE SOLID DISPERSION  TECHNIQUE  Research Article   

... out to increase the dissolution rate of drugs [1]. One such study was  solid  dispersion  which  has  shown  promising  results  in  improving  solubility, wettability, dissolution  rate of  drug and  subsequently  its  bioavailability  [2].  The  mechanism  by  which  solid  dispersion  enhances  t ...
Antidepressant drug overdoses in dogs
Antidepressant drug overdoses in dogs

... With the rising number of people and animals receiving antidepressant medications, it’s not surprising that the number of accidental ingestions of these drugs has also increased. Since 1998, the ASPCA Animal Poison Control Center (APCC) has received more than 1,075 calls concerning antidepressant me ...
Ensuring availability of controlled medications for the relief of pain
Ensuring availability of controlled medications for the relief of pain

... drug treatment: “Reducing the adverse health and social consequences of drug abuse: a comprehensive approach”;19 and “Principles of drug dependence treatment”.20 The tragedy of the inadequate availability of opioid analgesics is well expressed by the INCB: “Although medical science has the capacity ...
University of Groningen Merits and demerits of the converting
University of Groningen Merits and demerits of the converting

... the renal vasculature,often in combination with a suppressedRAS. It is therefore no surprise that thesecategoriesof patients with EH showeda different renal responseto captopril. No conclusiveanswer can be supplied as to whether changesin renal function contributeto the hypotensiveaction of the drug ...
RIVOTRIL Product Monograph
RIVOTRIL Product Monograph

... of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Porphyria In patients with porphyria, clonazepam has to be used with care because it may have a porphyrogenic effect. Dependence and Tolerance With long-term RIVOTRIL treatment at ...
Can Drugs Cause Depression? A Review of the Evidence
Can Drugs Cause Depression? A Review of the Evidence

... compared a group of patients selected because they were taking propranolol with a group of volunteers, and the possibility of selection bias makes interpretation of these results difficult. Another study found that propranolol was not associated with depressive symptoms in a clinical trial evaluatin ...
Neyroleptiklər
Neyroleptiklər

... Is a rare but serious side effect of neuroleptic (antipsychotic) therapy that can be lethal. It can arise at any time in the course of treatment and shows no predilection for age, duration of treatment, antipsychotic medication, or dose. ...
FORMULATION AND EVALUATION OF OXICONAZOLE NITRATE
FORMULATION AND EVALUATION OF OXICONAZOLE NITRATE

... increase the residence time of OXZ in the vagina. This purpose can be achieved by gelling of the OXZ using bioadhesive gelling agent. A gel can be described as the cross-linked material that retains a large amount of solvent inside its medium and if the solvent retained in organic one, such material ...
Diphenhydramine Hydrochloride Injection, USPRx only
Diphenhydramine Hydrochloride Injection, USPRx only

... For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated. M ...
Indonesia - K4Health
Indonesia - K4Health

... 1. In what proportion of deliveries is AMTSL used nationally? 2. What practices are in place that do not conform with the ICM/FIGO definition of AMTSL? 3. What are the facility- and policy-level barriers and facilitators to the use of AMTSL? To answer these questions, a nationally-representative sam ...
document - medSask
document - medSask

... shortage, physicians should consider whether an alternative medication could be used at least initially. The clobazam shortage could last many months, based on currently available information, and a widespread shortage is anticipated. Patients currently taking clobazam If all supply avenues have bee ...
History of Cannabis as a Medicine By Lester Grinspoon, M.D.
History of Cannabis as a Medicine By Lester Grinspoon, M.D.

... capacity of hemp to subdue restlessness and anxiety and distract a patient's mind in terminal illness. In these circumstances, he wrote, "The patient, whose most painful symptom has been mental trepidation, may become more happy or even hilarious." He believed cannabis to be as effective a pain reli ...
Advances in molecular modeling and docking as a tool for modern
Advances in molecular modeling and docking as a tool for modern

... The process of discovery of a new drug is a very difficult task. Pharmaceutical and biotechnology companies need to make huge investments in the discovery of a single drug that may cure a disease or simply alleviate the symptoms of another. These are businesses like any other, where profits fuel the ...
3.4: Speeding up the response: A global review of the harm
3.4: Speeding up the response: A global review of the harm

... depression that can lead to cardiac failure, whereas alcohol and methamphetamine increase blood pressure and thus the risk of cardiovascular crisis. Methamphetamine masks the effects of alcohol and opiates, allowing people to underestimate their intoxication and increasing the risk of accidents and ...
preclinical evaluation of central nervous system stimulant agents
preclinical evaluation of central nervous system stimulant agents

... Central nervous system (CNS) stimulants are agents that speed up physical and mental processes. The middle of the 20th centuries identifies a pivotal period in the treatment of mentally ill. Since the 1950's the development of psychopharmacology has expanded to include wide spread use of antipsychot ...
ASHP Technical Assistance Bulletin on Compounding Nonsterile
ASHP Technical Assistance Bulletin on Compounding Nonsterile

... is not available, the pharmacist should use professional judgment and may have to obtain the highest-grade chemical possible. Chemical grades that may be considered in this situation are ACS grade (meeting or exceeding specifications listed for reagent chemicals by the American Chemical Society) and ...
Drug action
Drug action

... Some material was previously published. ...
Stable drug encapsulation in micelles and microemulsions
Stable drug encapsulation in micelles and microemulsions

... Oral absorption of hydrophobic drugs can be significantly improved using lipid-based non-particulate drug delivery systems, which avoid the dissolution step. Micellar and microemulsion systems, being the most dispersed of all, appear the most promising. While these systems show high drug entrapment ...
Central Nervous System Activity Studies of Baptisia tinctoria (L.) R
Central Nervous System Activity Studies of Baptisia tinctoria (L.) R

... Abstract. The present investigations were undertaken with a view to evaluate Baptisia tinctoria roots (Wild Indigo; family – Fabaceae) systematically for neuropharmacological activities. The methanol extract (ME) of plant was prepared by extracting properly identified plant in a Soxhlet apparatus wi ...
Treating Anxiety, ADHD, Depression, Insomnia, and PTSD | Off
Treating Anxiety, ADHD, Depression, Insomnia, and PTSD | Off

... effectiveness and safety of those medications when used to treat the “off-label” conditions listed above, so it’s unclear whether any potential benefit outweighs the risk of side effects. The antipsychotic drugs we evaluate in this report can cause several possible side effects, including muscle rig ...
This PDF is a selection from a published volume from... Research Volume Title: Regulation vs. Litigation: Perspectives from Economics and Law
This PDF is a selection from a published volume from... Research Volume Title: Regulation vs. Litigation: Perspectives from Economics and Law

... and suggestions. Sun gratefully acknowledges funding from the Medical Scientist Training Program at the University of Chicago (NIGMS Grant number 5 T32 GM07281). 1. Vioxx, a selective COX-2 inhibitor, was withdrawn from the U.S. market in 2004 after several high profile lawsuits alleging that the dr ...
navigating the fda
navigating the fda

... • Clinical data not supportive of indications for use – need more data •Inadequacy on how people respond to various dosages – need more data •“Approvable” – probably be approved, provided certain issues get resolved •Labeling •Safety issues •Manufacturing issues – can delay or deny application. Prod ...
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Pharmaceutical industry



The pharmaceutical industry develops, produces, and markets drugs or pharmaceuticals for use as medications. Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy and marketing of drugs.
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