EFFECT OF TWO DIFFERENT DILUENTS ON RELEASE PROFILE OF ACECLOFENAC FROM SUSTAINED RELEASE MATRIX TABLETS USING GUM DAMAR AS RELEASE RETARDANT
... In the present work the effect of two different diluents namely dicalcium phosphate (DCP) and maize starch (MS) on the release of aceclofenac from sustained release matrix tablets has been studied. Gum damar (GD), a hydrophobic polymer with significant binding property was used as a release retard ...
... In the present work the effect of two different diluents namely dicalcium phosphate (DCP) and maize starch (MS) on the release of aceclofenac from sustained release matrix tablets has been studied. Gum damar (GD), a hydrophobic polymer with significant binding property was used as a release retard ...
The Effect of Peppermint Oil on Symptomatic Treatment of Pruritus in
... Itching is one of the most common skin symptoms. Generalized pruritus occurs in 1-8% of pregnant women. It can create unpleasant feeling for these women especially at nights. Most pregnant women avoid using synthetic drugs because of their side effects. Peppermint is a plant which has been used as a ...
... Itching is one of the most common skin symptoms. Generalized pruritus occurs in 1-8% of pregnant women. It can create unpleasant feeling for these women especially at nights. Most pregnant women avoid using synthetic drugs because of their side effects. Peppermint is a plant which has been used as a ...
Tetracycline group in children
... oral dose absorbed on an empty stomach is low for chlortetracyclines (30%); intermediate for oxytetracycline, demeclocycline, tetracycline (60% to 80%); and high for doxycycline (95%) and minocycline (100%). High lipid solubility of doxycycline and minocycline contribute to this. Food, including dai ...
... oral dose absorbed on an empty stomach is low for chlortetracyclines (30%); intermediate for oxytetracycline, demeclocycline, tetracycline (60% to 80%); and high for doxycycline (95%) and minocycline (100%). High lipid solubility of doxycycline and minocycline contribute to this. Food, including dai ...
COMPARATIVE BIOAVAILABILITY OF TWO LISINOPRIL
... is prolonged. Older patients, on average, have (approximately doubled) higher blood levels and area under the plasma concentration time (AUC) than younger patients. Lisinopril can be removed by hemodialysis11,12. To compare the rate and extent of absorption of lisinopril in both formulations, the fo ...
... is prolonged. Older patients, on average, have (approximately doubled) higher blood levels and area under the plasma concentration time (AUC) than younger patients. Lisinopril can be removed by hemodialysis11,12. To compare the rate and extent of absorption of lisinopril in both formulations, the fo ...
An Epidemic of Clandestine Labs and Health Risk
... apparent and the task of its synthesis was given to a British UCLA graduate student named Gordon Alles. Alles attempt to synthesize ephedrine was unsuccessful, but on the way he discovered the properties of a product later called dextroamphetamine. He found this substance to have potential for incre ...
... apparent and the task of its synthesis was given to a British UCLA graduate student named Gordon Alles. Alles attempt to synthesize ephedrine was unsuccessful, but on the way he discovered the properties of a product later called dextroamphetamine. He found this substance to have potential for incre ...
20810 AlleRx DF.indd
... assess the long-term carcinogenic and mutagenic potential or the effect on fertility in animals or humans have not been performed. Pregnancy Category C: It is not known whether AlleRx can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. AlleRx should be giv ...
... assess the long-term carcinogenic and mutagenic potential or the effect on fertility in animals or humans have not been performed. Pregnancy Category C: It is not known whether AlleRx can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. AlleRx should be giv ...
Issues of Access to Cancer Drugs in Canada
... Biologics and Genetic Therapies Directorate (BGTD) handles products derived from biotechnology. In regulatory terminology, “new drugs” refers not only to the first time a drug is licensed for marketing, but also the first time it is used in a different indication, or disease state. Regulatory approv ...
... Biologics and Genetic Therapies Directorate (BGTD) handles products derived from biotechnology. In regulatory terminology, “new drugs” refers not only to the first time a drug is licensed for marketing, but also the first time it is used in a different indication, or disease state. Regulatory approv ...
pdf - Drug Discovery World
... including: 1) limited success of target-based drug discovery, typically with the protein target in solution or over expressed in the cell; 2) the need to minimise the risk of late stage attrition due to poor efficacy or off-target activities; 3) the realisation that many of today’s first-in-class dr ...
... including: 1) limited success of target-based drug discovery, typically with the protein target in solution or over expressed in the cell; 2) the need to minimise the risk of late stage attrition due to poor efficacy or off-target activities; 3) the realisation that many of today’s first-in-class dr ...
Draft Guidance for Industry Drug Interaction Studies
... The desirable and undesirable effects of a drug arising from its concentrations at the sites of action are usually related either to the amount administered (dose) or to the resulting blood concentrations, which are affected by its absorption, distribution, metabolism, and/or excretion. Elimination ...
... The desirable and undesirable effects of a drug arising from its concentrations at the sites of action are usually related either to the amount administered (dose) or to the resulting blood concentrations, which are affected by its absorption, distribution, metabolism, and/or excretion. Elimination ...
with notes for guidance
... Thus a highly restrictive approach should be taken to the use of those active antibacterial ingredients whose activity spectrum and favourable resistance situation means that they are indicated for the treatment of lifethreatening infections in humans or animals and where no other sufficiently effec ...
... Thus a highly restrictive approach should be taken to the use of those active antibacterial ingredients whose activity spectrum and favourable resistance situation means that they are indicated for the treatment of lifethreatening infections in humans or animals and where no other sufficiently effec ...
Drug List - The North Carolina Office of EMS
... history of GI Bleeding (ulcers) or renal insufficiency. Not to be used in patients with allergies to aspirin or other NSAID drugs Avoid in patients currently taking anticoagulants, such as coumadin. ...
... history of GI Bleeding (ulcers) or renal insufficiency. Not to be used in patients with allergies to aspirin or other NSAID drugs Avoid in patients currently taking anticoagulants, such as coumadin. ...
Therapeutic Agents for Alzheimer`s Disease
... studied, and the majority of the drugs on the market are AChE inhibitors. In terms of structural information for the design of new inhibitors, X-ray analysis of AChE has been most helpful, as shown in (Fig. 1); AChE has a hydrophobic gorge or pocket which contains the catalytic triad (GLU327, HIS440 ...
... studied, and the majority of the drugs on the market are AChE inhibitors. In terms of structural information for the design of new inhibitors, X-ray analysis of AChE has been most helpful, as shown in (Fig. 1); AChE has a hydrophobic gorge or pocket which contains the catalytic triad (GLU327, HIS440 ...
Cardiovascular Disease Manual
... Ensure at least 8 hours between doses. Do not give second dose close to bedtime to avoid insomnia. If insomnia persists, reduce dose to 150mg AM Consider longer treatment for smokers who suffer significant mood swings or who continue to experience strong cravings after discontinuing bupropion. Safet ...
... Ensure at least 8 hours between doses. Do not give second dose close to bedtime to avoid insomnia. If insomnia persists, reduce dose to 150mg AM Consider longer treatment for smokers who suffer significant mood swings or who continue to experience strong cravings after discontinuing bupropion. Safet ...
Enhancement of psychostimulant effect and development of
... cadget unit pack and replace it with piracetam (and decrease their expenses). In an effort to assess the possibility of such pharmacological interaction, the first aim of our study was to evaluate modification of methamphetamine stimulatory effects by piracetam co-administration. The repeated admini ...
... cadget unit pack and replace it with piracetam (and decrease their expenses). In an effort to assess the possibility of such pharmacological interaction, the first aim of our study was to evaluate modification of methamphetamine stimulatory effects by piracetam co-administration. The repeated admini ...
JDP Featured in BioCentury
... Phase II testing is slated to begin by March. Du said JDP is raising about $15 million in a series A round, which should take the company through approval of the compound by YE14. She said the Phase II trial should take about 10 months, with another year and a half for Phase III testing. JDP plans t ...
... Phase II testing is slated to begin by March. Du said JDP is raising about $15 million in a series A round, which should take the company through approval of the compound by YE14. She said the Phase II trial should take about 10 months, with another year and a half for Phase III testing. JDP plans t ...
140 mmHg
... Beta-blocker / Diuretic Combination • Despite trial evidence of outcome reduction, the BB / diuretic combination favours development of diabetes and ...
... Beta-blocker / Diuretic Combination • Despite trial evidence of outcome reduction, the BB / diuretic combination favours development of diabetes and ...
Medicines Management Programme: Preferred Medicines Angiotensin‐Converting Enzyme Inhibitors
... al (2005) found that ‘relative to those initiated on enalapril, no significant differences in the combined end point of readmission to the hospital for congestive heart failure or mortality were observed among users of lisinopril, ramipril, or other ACE inhibitors (included benazepril, captopri ...
... al (2005) found that ‘relative to those initiated on enalapril, no significant differences in the combined end point of readmission to the hospital for congestive heart failure or mortality were observed among users of lisinopril, ramipril, or other ACE inhibitors (included benazepril, captopri ...
REVIEW Chiral Toxicology: It`s the Same Thing...Only Different
... This manuscript was developed from a presentation at the American College of Medical Toxicology Spring Conference, San Diego, CA, USA, March 2008. The author has no financial interest in any commercial products mentioned nor the companies that produce them. The use of trade names and/or commercial p ...
... This manuscript was developed from a presentation at the American College of Medical Toxicology Spring Conference, San Diego, CA, USA, March 2008. The author has no financial interest in any commercial products mentioned nor the companies that produce them. The use of trade names and/or commercial p ...
Mass or Molar Units - The Royal College of Pathologists of Australasia
... and decision points are expressed in different units (see Table 1 for examples). This type of error occurs most often when a clinician, familiar with one unit, encounters a result expressed in different units without recognizing the difference. It may occur when a result is separated from its report ...
... and decision points are expressed in different units (see Table 1 for examples). This type of error occurs most often when a clinician, familiar with one unit, encounters a result expressed in different units without recognizing the difference. It may occur when a result is separated from its report ...
Chewable Tablets: A Comprehensive Review
... the end of its patent life, it is common for pharmaceutical manufacturers to develop a given drug entity in a new and improved dosage form. A new dosage form allows a manufacturer to extend market exclusivity, unique product differentiation, value added product line extension and extend patent prote ...
... the end of its patent life, it is common for pharmaceutical manufacturers to develop a given drug entity in a new and improved dosage form. A new dosage form allows a manufacturer to extend market exclusivity, unique product differentiation, value added product line extension and extend patent prote ...
Journal Club Seminar
... Osmosis :In allowing water to enter under the right circumstances, an osmotic pressure can be built up within the interior of the particle. The drug is forced out of the particle into the12 exterior through the coating. ...
... Osmosis :In allowing water to enter under the right circumstances, an osmotic pressure can be built up within the interior of the particle. The drug is forced out of the particle into the12 exterior through the coating. ...
annexure ii
... cyclooxygenase (COX). Administration of this non-selective COX inhibitor by oral route causes many gastrointestinal side effects, like nausea, vomiting, gastric irritation, peptic ulceration and bleeding that limit its clinical use . Prostaglandins are ubiquitous compounds that mediate a variety of ...
... cyclooxygenase (COX). Administration of this non-selective COX inhibitor by oral route causes many gastrointestinal side effects, like nausea, vomiting, gastric irritation, peptic ulceration and bleeding that limit its clinical use . Prostaglandins are ubiquitous compounds that mediate a variety of ...
Analysis of the Acquisition of Drug Discrimination Reveals
... than the low dose discrimination. Furthermore, only the low dose discrimination was affected by increasing the acquisition criterion. Taken together these results suggest that a higher training-dose of MDMA produced a more robust discriminative stimulus effect than the 1.5 mg/kg dose which is typica ...
... than the low dose discrimination. Furthermore, only the low dose discrimination was affected by increasing the acquisition criterion. Taken together these results suggest that a higher training-dose of MDMA produced a more robust discriminative stimulus effect than the 1.5 mg/kg dose which is typica ...
IN-VIVO SCREENING OF ANTI-INFLAMMATORY ACTIVITY IN METHANOLIC EXTRACT OF CORBICHONIA DECUMBENS
... Medicinal plant is defined as any substance with one or more of its organ containing properties that can be used for therapeutic purposes or which can be used as precursors for the synthesis of various drugs [1]. Plants have contributed lot of medicinal compounds being used today to treat diseases l ...
... Medicinal plant is defined as any substance with one or more of its organ containing properties that can be used for therapeutic purposes or which can be used as precursors for the synthesis of various drugs [1]. Plants have contributed lot of medicinal compounds being used today to treat diseases l ...
Pharmaceutical industry
The pharmaceutical industry develops, produces, and markets drugs or pharmaceuticals for use as medications. Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy and marketing of drugs.