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179: ekg signs of disordered impulse formation or conduction
179: ekg signs of disordered impulse formation or conduction

... Mobitz type II; characterised by occasional non-conducted P waves. The PR interval constant for conducted beats 2:1 AV block; characterised by a fixed ratio of conducted to nonconducted P waves, where two P waves are seen for every one QRS complex. The PR interval constant for conducted beats and th ...
Guidelines for the perioperative management of patients with
Guidelines for the perioperative management of patients with

... About implantable pacemakers and cardioverter defibrillators Pacemakers/ICDs are highly sophisticated electronic medical implants which monitor and respond to very small electrical signals sensed within the heart. Although some pacemakers treat bradycardia, some are also able to treat heart arrhythm ...
VBWG - Policlinico di Monza
VBWG - Policlinico di Monza

... Overall prevalence of Heart Failure, and the Age- and SexSpecific Prevalences of DHF and SHF - EPICA Study ...
Secondary prevention after myocardial infarction
Secondary prevention after myocardial infarction

... in CHD6 showed that statin therapy compared from placebo was associated with reduction in all cause mortality (RR 0.79), cardiovascular mortality (RR 0.75), coronary disease mortality (RR 0.72), fatal MI (RR 0.57), unstable angina (RR 0.82), nonfatal stroke (RR 0.75), intermittent claudication (RR 0 ...
Medical Management of Atrial Fibrillation
Medical Management of Atrial Fibrillation

... No significant difference in quality of life No difference in mortality However, both trials allowed for stopping anticoagulation 4 weeks after restoring sinus rhythm ...
Integrated care of patients with atrial fibrillation: the - Heart
Integrated care of patients with atrial fibrillation: the - Heart

... with AF, from ECG screening to surgical procedures to prevent recurrent AF. While these improvements provide tools to improve outcomes and quality of life in affected patients, they often need multidisciplinary input into patient management. It therefore seems timely that the European Society of Car ...
heart and vascular center - UVA Health Foundation
heart and vascular center - UVA Health Foundation

... across the country to receive a new, minimally invasive procedure offered at UVA. He had an excellent result with a MitraClip procedure, designed to treat a leaky heart valve without surgery. UVA is one of the few medical centers in the nation to offer this procedure, along with other minimally inva ...
Mexiletine guidelines
Mexiletine guidelines

... pharmacotherapy (e.g. omeprazole) to facilitate reaching sufficient mexiletine dose for adequate treatment trial (200mg TDS). 4.2 In refractory cases and where adverse effects allow, consider further dose titration to a total of 800mg mexiletine daily. However, patients should be counselled about th ...
Tissue Doppler Imaging and Early Myocardial Dysfunction In Poorly
Tissue Doppler Imaging and Early Myocardial Dysfunction In Poorly

... INTRODUCTION AND AIM OF THE WORK: Beta thalassemia major is the most common chronic hemolytic anemia among children and adolescents across the world.(1) In Egypt  thalassemia is the most common hereditary hemolytic anemia. The rate of new births with thalassemia is 1000 per year. (2) The regular b ...
A Study of Mean Electrical Axis (QRS
A Study of Mean Electrical Axis (QRS

... and thus throughout depolarisation phase apex of heart remains positive in respect to the base. Average direction of this depolarisation wave through ventricles is called QRSaxis and this mean electrical axis (QRS-axis) of normal ventrical is +59o.1 Variation of this mean electrical axis is due to a ...
Philips Announces System with PiezoCrystal Transducer
Philips Announces System with PiezoCrystal Transducer

... help make treatment decisions and monitor their success. The iE33 intelligent echocardiography system features extraordinary levels of 2D image quality, powerful 2D and 3D measurement of cardiac function and anatomy, Live 3D imaging of the beating heart, and user centered ergonomics. The iE33 system ...
Phospholipid Composition of Myocardium in
Phospholipid Composition of Myocardium in

... lysophospholipids might also originate from the process of tissue sampling during the surgery. We observed ...
Severe Tricuspid Valve Regurgitation Is Not an Innocent Finding to
Severe Tricuspid Valve Regurgitation Is Not an Innocent Finding to

... functional isolated TR” or they are just studying patients with “isolated TR” is unimportant. The study ...
B-type Natriuretic Peptide (BNP) Testing
B-type Natriuretic Peptide (BNP) Testing

... B-type natriuretic peptide (BNP) is a cardiac neurohormone produced mainly in the left ventricle. It is secreted in response to ventricular volume expansion and pressure overload, conditions often present in congestive heart failure (CHF). Used in conjunction with other clinical information, measure ...
ECGs of structural heart disease: Part 2
ECGs of structural heart disease: Part 2

... RBBB can occur in patients with a structurally normal heart, and the long-term outcome in this situation is good when compared to patients with underlying heart disease. In one study, it was found that 94% of patients with complete RBBB and no evidence of cardiovascular disease had good prognoses. ...
Basics of Hemodynamics and Shock
Basics of Hemodynamics and Shock

... Increased SVO2 • Most common cause is - Sepsis ...
Cardiovascular
Cardiovascular

... in early diastole the ventricles begin to contract the SA node is the pacemaker of the heart because it has the fastest rate of spontaneous depolarization all heart muscle cells are capable of spontaneous contraction pulmonary arteries carry oxygenated blood to the lungs from the right heart ...
Incremental Prognostic Value of Estimated LV€End
Incremental Prognostic Value of Estimated LV€End

... (Table 1). Using these measures, LVEDVI Estimated was calculated and compared with “true” CTCA-measured LVEDV. The correlation between measured LVEDVI and LVEDVIEstimated was very good (r ¼ 0.910, 95% confidence interval [95% CI]: 0.882 to 0.931; p < 0.0001). LVEDVI Estimated was significantly larger ...
Cardiology Revision 2014
Cardiology Revision 2014

... P2 is loud. There is a mid-diastolic rumbling murmur with an opening snap, localised to the mitral area. Best heard in left lateral and exp. PSM at left sternal edge increasing with inspiration ...
MYOCARDIAL AND
MYOCARDIAL AND

... controversial and no studies have demonstrated an improvement in left ventricular ejection fraction or survival following their use. The administration of high-dose intravenous immunoglobulin on the other hand appears to be associated with a more rapid resolution of the left ventricular dysfunction ...
Guidelines for the secondary prevention of ischaemic heart disease
Guidelines for the secondary prevention of ischaemic heart disease

... Non-rheumatic atrial fibrillation is an important risk factor for stroke, increasing the risk factor by five. It is particularly important in the elderly. This risk is largely reversed by anticoagulation, (Atrial Fibrillation Investigators,1994, European Atrial Fibrillation Trial Study Group, 1993). ...
Predicting Prognosis in dilated cardiomyopathy editOrials
Predicting Prognosis in dilated cardiomyopathy editOrials

... laboratory, electrocardiograph, echoDoppler and hemodynamic parameters were included in the analysis, with a notable exception of B-natriuretic peptide and VO2max. Lower age, lower NYHA class at presentation and higher LVEF emerged as independent predictors of event-free survival. A model based on t ...
One Weapon, Two Blows in the War Against the Thrombus
One Weapon, Two Blows in the War Against the Thrombus

... found no difference in all-cause mortality between VKA versus aspirin in 2,305 patients with left ventricular systolic dysfunction and sinus rhythm, but this may have been because the benefits of VKA therapy in reducing ischemic stroke were offset by an increase in major hemorrhage among older patien ...
versus Use of tiotropium Respimat HandiHaler and mortality in patients with COPD
versus Use of tiotropium Respimat HandiHaler and mortality in patients with COPD

... users of tiotropium in primary care. They concluded that ‘‘until further data become available, physicians should be aware that patients with arrhythmia or a history of cardiovascular disease might be particularly at risk’’ when using tiotropium Respimat [1]. Although arrhythmia, renal disease and c ...
Exercise training as effective therapy for a patient with left ventricular
Exercise training as effective therapy for a patient with left ventricular

... from other investigators that anxiety frequently coexists with depression and often exhibits a parallel increase in HADS scores (3) in people with heart disease. It is speculated that his decision to not participate in psychological sessions combined with the length of time on the device and mountin ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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