Biomarkers of Acute Coronary Syndrome and Heart Failure
... close communication with local physician and other caregivers, as well as with the administrators responsible for each area. Collaboration with manufacturers and communication of clinical need as articulated in the guidelines are also critical for proper implementation. Many of these issues are of p ...
... close communication with local physician and other caregivers, as well as with the administrators responsible for each area. Collaboration with manufacturers and communication of clinical need as articulated in the guidelines are also critical for proper implementation. Many of these issues are of p ...
QT interval variability in body surface ECG
... Methodology Measurement principles QT interval measurement Under normal conditions, beat-to-beat QT interval changes are minimal, detectable by computerized high-resolution ECG. Accurate delineation of T wave end (Tend) is challenging, and most commercial systems measure the average, rate-corrected ...
... Methodology Measurement principles QT interval measurement Under normal conditions, beat-to-beat QT interval changes are minimal, detectable by computerized high-resolution ECG. Accurate delineation of T wave end (Tend) is challenging, and most commercial systems measure the average, rate-corrected ...
Should All Patients With Heart Block Receive Biventricular Pacing?
... (AVN) ablation. Overall, they showed that for patients with normal LV function preimplantation, there were no changes in LVEF after 12 to 20 months of RV pacing.1,3 Moreover, 8% to 15% of patients experienced a decline in LVEF or developed HF after 4 to 8 years of pacing.3,4 It is apparent from thes ...
... (AVN) ablation. Overall, they showed that for patients with normal LV function preimplantation, there were no changes in LVEF after 12 to 20 months of RV pacing.1,3 Moreover, 8% to 15% of patients experienced a decline in LVEF or developed HF after 4 to 8 years of pacing.3,4 It is apparent from thes ...
Aortic involvement in patients with a bicuspid aortic valve
... with BAVs if the diameter of the aortic root or ascending aorta is >5.0 cm or if the rate of increase in diameter is 0.5 cm/year or more, and to consider lower threshold values for patients of small stature of either gender.17 These recommendations are based on consensus opinion by a group of expert ...
... with BAVs if the diameter of the aortic root or ascending aorta is >5.0 cm or if the rate of increase in diameter is 0.5 cm/year or more, and to consider lower threshold values for patients of small stature of either gender.17 These recommendations are based on consensus opinion by a group of expert ...
Capítulo 1: Descrição geral da tese - RUN
... Patients with the same inclusion criteria, who did not accept exercise intervention or living far, without other exclusion criteria were additionally studied as a prospective cohort for evaluation of CRT intervention effects and mechanisms. During the period from January 2012 to March 2015, all pati ...
... Patients with the same inclusion criteria, who did not accept exercise intervention or living far, without other exclusion criteria were additionally studied as a prospective cohort for evaluation of CRT intervention effects and mechanisms. During the period from January 2012 to March 2015, all pati ...
Arrhythmia/Electrophysiology
... with implantable cardioverter-defibrillators, and it is controversial whether nonarrhythmogenic syncope is associated with increased mortality. Methods and Results—The Multicenter Automatic Defibrillator Implantation Trial–Reduce Inappropriate Therapy (MADIT-RIT) randomized 1500 patients to 3 differ ...
... with implantable cardioverter-defibrillators, and it is controversial whether nonarrhythmogenic syncope is associated with increased mortality. Methods and Results—The Multicenter Automatic Defibrillator Implantation Trial–Reduce Inappropriate Therapy (MADIT-RIT) randomized 1500 patients to 3 differ ...
Molecular distinction between physiological and pathological
... physiological adaptation to chronic training. Though, with attention from media reports of sudden death in young athletes, it has been questioned whether highly trained athletes develop pathological conditions. Notably, there is currently no evidence in the healthy population (excluding persons with ...
... physiological adaptation to chronic training. Though, with attention from media reports of sudden death in young athletes, it has been questioned whether highly trained athletes develop pathological conditions. Notably, there is currently no evidence in the healthy population (excluding persons with ...
Developing a global fluid-structure interaction
... and hemodynamic variations, they have gained considerable attention in assessing the hemodynamic conditions associated with cardiovascular diseases. In recent clinical studies, it was established that regional pathologies of the aortic valve can alter the structural and hemodynamic function of the v ...
... and hemodynamic variations, they have gained considerable attention in assessing the hemodynamic conditions associated with cardiovascular diseases. In recent clinical studies, it was established that regional pathologies of the aortic valve can alter the structural and hemodynamic function of the v ...
The distribution of the cardiac veins in the New Zealand White
... This vein opened into the left circumflex vein, and curved towards left ventricular border, extended along this border and ended near apex cordis. Along its course to apex cordis, it collected multiple branches from the wall of the left ventricle. Its terminal branches were seen to reach the subatri ...
... This vein opened into the left circumflex vein, and curved towards left ventricular border, extended along this border and ended near apex cordis. Along its course to apex cordis, it collected multiple branches from the wall of the left ventricle. Its terminal branches were seen to reach the subatri ...
Cardiac Thyrotropin-Releasing Hormone Mediates
... TRH-iRNA–treated SHR showed similar indices that were significantly lower compared to those of the Con-iRNA– treated SHR. These normal ratios found in the animals with the inhibition of the LV TRH were not caused by normalization of blood pressure or changes in the body weight, as we measured both v ...
... TRH-iRNA–treated SHR showed similar indices that were significantly lower compared to those of the Con-iRNA– treated SHR. These normal ratios found in the animals with the inhibition of the LV TRH were not caused by normalization of blood pressure or changes in the body weight, as we measured both v ...
Conduction Defects
... It remains uncertain whether local delay (or block) of the atrial activation can result in notching of the P-wave without an increase in its duration. On the other hand, some normal subjects, with no evidence of heart disease, do have a small notch at the peak of the P-wave, which is probably relate ...
... It remains uncertain whether local delay (or block) of the atrial activation can result in notching of the P-wave without an increase in its duration. On the other hand, some normal subjects, with no evidence of heart disease, do have a small notch at the peak of the P-wave, which is probably relate ...
Quantification of Left Ventricular Function With Premature
... For each ectopic contraction, there is a potential for 4 distinct beat types to be observed via the 2D clustering of RRi–1 and RRi. First, during normal sinus rhythm, the RRi–1 of the preceding beat and RRi of the current beat are similar, thus forming a sinus–sinus beat. Second, when a PVC occurs, ...
... For each ectopic contraction, there is a potential for 4 distinct beat types to be observed via the 2D clustering of RRi–1 and RRi. First, during normal sinus rhythm, the RRi–1 of the preceding beat and RRi of the current beat are similar, thus forming a sinus–sinus beat. Second, when a PVC occurs, ...
A Simple Guide to Thoracic Aortic Surgery
... A portion of inherited aortic diseases cannot be explained through known genetic mutations. In recent years numerous mutations have been discovered that explain these inherited aortic diseases. However, they are unique in that aortic diseases inconsistently affect patients with these mutations. It i ...
... A portion of inherited aortic diseases cannot be explained through known genetic mutations. In recent years numerous mutations have been discovered that explain these inherited aortic diseases. However, they are unique in that aortic diseases inconsistently affect patients with these mutations. It i ...
A Simple Guide to Thoracic Aortic Surgery
... Many connective tissue diseases that involve the aorta lead to the early development of aneurysms (see page 13). Patients with these diseases, ...
... Many connective tissue diseases that involve the aorta lead to the early development of aneurysms (see page 13). Patients with these diseases, ...
Venice Chart International Consensus Document on Ventricular
... Sustained ventricular arrhythmias—ventricular tachycardia (VT) and ventricular fibrillation (VF)—are important causes of morbidity and sudden death (SD), especially in patients with structural heart disease. Therapeutic options for the treatment of these arrhythmias include antiarrhythmic drugs, imp ...
... Sustained ventricular arrhythmias—ventricular tachycardia (VT) and ventricular fibrillation (VF)—are important causes of morbidity and sudden death (SD), especially in patients with structural heart disease. Therapeutic options for the treatment of these arrhythmias include antiarrhythmic drugs, imp ...
Mutations in SCN10A Are Responsible for a Large Fraction
... BACKGROUND BrS is an inherited sudden cardiac death syndrome. Less than 35% of BrS probands have genetically identified pathogenic variants. Recent evidence has implicated SCN10A, a neuronal sodium channel gene encoding Nav1.8, in the electrical function of the heart. OBJECTIVES The purpose of this s ...
... BACKGROUND BrS is an inherited sudden cardiac death syndrome. Less than 35% of BrS probands have genetically identified pathogenic variants. Recent evidence has implicated SCN10A, a neuronal sodium channel gene encoding Nav1.8, in the electrical function of the heart. OBJECTIVES The purpose of this s ...
Myocardial Extracellular Volume Fraction From T1 Measurements in
... diffuse fibrosis (5 7). The LGE technique relies on relative enhancement of an abnormal region of myocardium compared with a normal reference. In conditions such as hypertension, sleep apnea, valvular disease, diabetes, obesity, and nonischemic cardiomyopathy, the entire left ventricle may be affecte ...
... diffuse fibrosis (5 7). The LGE technique relies on relative enhancement of an abnormal region of myocardium compared with a normal reference. In conditions such as hypertension, sleep apnea, valvular disease, diabetes, obesity, and nonischemic cardiomyopathy, the entire left ventricle may be affecte ...
Effectiveness of Implantable Cardioverter Defibrillators for Primary
... and are in NYHA (New York Heart Association) class II or III; patients with nonischemic dilated cardiomyopathy with LVEFs of 35% or less and who are in NYHA class II or III; or patients with left ventricular dysfunction due to previous MI who are at least 40 days post-MI, have an LVEF of 30% or less ...
... and are in NYHA (New York Heart Association) class II or III; patients with nonischemic dilated cardiomyopathy with LVEFs of 35% or less and who are in NYHA class II or III; or patients with left ventricular dysfunction due to previous MI who are at least 40 days post-MI, have an LVEF of 30% or less ...
Pulmonary hypertension caused by pulmonary venous hypertension
... Remodeling and “reversibility” of increased PVR with PVH The fact that PVR decreases over a matter of months after mitral valve intervention suggests that the decrease is partly due to favorable remodeling. Unfortunately, there is little documentation of what actually happens with the decrease in PV ...
... Remodeling and “reversibility” of increased PVR with PVH The fact that PVR decreases over a matter of months after mitral valve intervention suggests that the decrease is partly due to favorable remodeling. Unfortunately, there is little documentation of what actually happens with the decrease in PV ...
A 4-Tiered Classification of Left Ventricular Hypertrophy
... tunity to address this question because subjects underwent cardiac MRI, a modality with significant advantages over 2D echocardiography in estimating LV mass10 and volumes.11 Further, because of the extensive phenotyping of DHS subjects, we were able to compare clinical characteristics and surrogate ...
... tunity to address this question because subjects underwent cardiac MRI, a modality with significant advantages over 2D echocardiography in estimating LV mass10 and volumes.11 Further, because of the extensive phenotyping of DHS subjects, we were able to compare clinical characteristics and surrogate ...
Assessment of the 12-Lead Electrocardiogram as€a
... 8. Premature death (sudden and unexpected, or otherwise) before 50 y of age attributable to heart disease in $1 relative 9. Disability from heart disease in close relative <50 y of age 10. Hypertrophic or dilated cardiomyopathy, long-QT syndrome, or other ion channelopathies, Marfan syndrome, or cli ...
... 8. Premature death (sudden and unexpected, or otherwise) before 50 y of age attributable to heart disease in $1 relative 9. Disability from heart disease in close relative <50 y of age 10. Hypertrophic or dilated cardiomyopathy, long-QT syndrome, or other ion channelopathies, Marfan syndrome, or cli ...
Depolarization wave and mechanics in the paced heart : model and
... depolarization patterns result in deterioration of pump function and can contribute to the development of heart failure. In the clinic, pacemakers are used to maintain a normal cardiac rhythm, but during the last decade the evidence is increasing that the abnormal depolarization and contraction patt ...
... depolarization patterns result in deterioration of pump function and can contribute to the development of heart failure. In the clinic, pacemakers are used to maintain a normal cardiac rhythm, but during the last decade the evidence is increasing that the abnormal depolarization and contraction patt ...
Should All Patients With Heart Block Receive Biventricular Pacing?
... for atrial fibrillation, biventricular pacing was first proven to be superior to RV pacing, achieving better exercise capacity and LVEF, especially for those with pre-existing HF.35 These benefits were also confirmed in a later meta-analysis.36 Because the pathophysiology of complete AVB and AV node ...
... for atrial fibrillation, biventricular pacing was first proven to be superior to RV pacing, achieving better exercise capacity and LVEF, especially for those with pre-existing HF.35 These benefits were also confirmed in a later meta-analysis.36 Because the pathophysiology of complete AVB and AV node ...
CURRICULUM VITAE John Alex Elefteriades, M.D. Date of Revision
... most clinically active academic surgeons in the country. Dr. Elefteriades graduated magna cum laude with a triple major in Physics, French and Psychology from Yale University. He received his MD degree from the Yale University School of Medicine. He trained at Yale in both general surgery and cardio ...
... most clinically active academic surgeons in the country. Dr. Elefteriades graduated magna cum laude with a triple major in Physics, French and Psychology from Yale University. He received his MD degree from the Yale University School of Medicine. He trained at Yale in both general surgery and cardio ...
GK Mechanical Heart Valve GK Mechanical Heart Valve
... Chinese Journal of Thoracic and Cardiovascular Surgery February 1997, Vol. 13, No.1 ...
... Chinese Journal of Thoracic and Cardiovascular Surgery February 1997, Vol. 13, No.1 ...
Hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.