Histamine receptor antagonists
... Both neutral H1 antagonists and inverse H1 agonists reduce or block the actions of histamine by reversible competitive binding to the H1 receptor. Several have been clearly shown to be inverse agonists, and it is possible that all act by this mechanism. They have negligible potency at the H2 recepto ...
... Both neutral H1 antagonists and inverse H1 agonists reduce or block the actions of histamine by reversible competitive binding to the H1 receptor. Several have been clearly shown to be inverse agonists, and it is possible that all act by this mechanism. They have negligible potency at the H2 recepto ...
, English, Pages 205
... bisphosphonates, which prevent the transcellular transport across intestinal epithelium and favor the paracellular route (4–5). Higher localized concentration of bisphosphonates has resulted in severe gastro-intestinal side effects such as dysphagia, esophagitis and gastric ulceration (6). To improv ...
... bisphosphonates, which prevent the transcellular transport across intestinal epithelium and favor the paracellular route (4–5). Higher localized concentration of bisphosphonates has resulted in severe gastro-intestinal side effects such as dysphagia, esophagitis and gastric ulceration (6). To improv ...
Guidance for Industry Acne Vulgaris: Developing Drugs for Treatment DRAFT GUIDANCE
... for labeling purposes. Dermal irritation and sensitization (allergenicity) studies can be combined as long as a sufficient number of subjects are included for sensitization evaluation. Phototoxicity and photosensitization studies may be waived if there is no absorption of the drug product by UVB, UV ...
... for labeling purposes. Dermal irritation and sensitization (allergenicity) studies can be combined as long as a sufficient number of subjects are included for sensitization evaluation. Phototoxicity and photosensitization studies may be waived if there is no absorption of the drug product by UVB, UV ...
PRODUCT MONOGRAPH PrMatulane® Procarbazine
... Pediatric use: Appropriate prospective controlled studies in the pediatric population have not been performed. Undue toxicity, evidenced by tremors, coma and convulsions, has occurred in a few cases. Dosage, therefore, should be individualized. Very close monitoring is mandatory. Monitoring and Labo ...
... Pediatric use: Appropriate prospective controlled studies in the pediatric population have not been performed. Undue toxicity, evidenced by tremors, coma and convulsions, has occurred in a few cases. Dosage, therefore, should be individualized. Very close monitoring is mandatory. Monitoring and Labo ...
Is there an interaction between erythromycin and statins?
... isoenzyme 3A4 (i.e. atorvastatin and simvastatin), but in practice not all patients are affected [13]. Simvastatin is contra-indicted in patients taking erythromycin and should be withdrawn if the antibiotic is required [8, 13, 15, 16. 26, 27]. Atorvastatin and erythromycin should be used together w ...
... isoenzyme 3A4 (i.e. atorvastatin and simvastatin), but in practice not all patients are affected [13]. Simvastatin is contra-indicted in patients taking erythromycin and should be withdrawn if the antibiotic is required [8, 13, 15, 16. 26, 27]. Atorvastatin and erythromycin should be used together w ...
Pharmacokinetic/Pharmacodynamic Parameters: Rationale
... duration of time that the levels exceeded the MIC. The 24hour AUC/MIC ratio for the two regimens would be the same. Such study designs are rarely used in human clinical trials but are easily performed with animal infection models. Several investigators have used multiple dosage regimens in animal in ...
... duration of time that the levels exceeded the MIC. The 24hour AUC/MIC ratio for the two regimens would be the same. Such study designs are rarely used in human clinical trials but are easily performed with animal infection models. Several investigators have used multiple dosage regimens in animal in ...
Methamphetamine — Effects on Human Performance and Behavior
... ether, and is extracted in most common protocols designed to isolate alkaloidal and basic drugs. It also readily back-extracts into acid, and back into organic solvents without significant loss. Because of its volatility, however, it can be lost during a dry-down or evaporation step if that is part ...
... ether, and is extracted in most common protocols designed to isolate alkaloidal and basic drugs. It also readily back-extracts into acid, and back into organic solvents without significant loss. Because of its volatility, however, it can be lost during a dry-down or evaporation step if that is part ...
Development of a Common Cyclobenzaprine
... made them uniquely suitable for blinding a new drug and its positive comparators in early clinical trials. The trials are usually designed to compare one medication with another to evaluate the relative safety and/or efficacy of the new drug. In those tests, it is a common practice to blind the medi ...
... made them uniquely suitable for blinding a new drug and its positive comparators in early clinical trials. The trials are usually designed to compare one medication with another to evaluate the relative safety and/or efficacy of the new drug. In those tests, it is a common practice to blind the medi ...
PDF - Problems of Forensic Sciences
... that clonazepam was used mainly for medical purposes (in the treatment of epileptic states of different aetiology and also as a sedative), and it was administered to this end in 27 cases. Clonazepam was also used by persons addicted to substances of abuse (e.g. morphine, amphetamine and its derivati ...
... that clonazepam was used mainly for medical purposes (in the treatment of epileptic states of different aetiology and also as a sedative), and it was administered to this end in 27 cases. Clonazepam was also used by persons addicted to substances of abuse (e.g. morphine, amphetamine and its derivati ...
Natural products as starting points for future anti
... assays using live parasites in erythrocytes are higher those often found screening many classes of molecular targets. The live parasite approach is also one step ahead of target based approaches, in that the hits are already known to kill parasites, so have addressed cellular permeability question. ...
... assays using live parasites in erythrocytes are higher those often found screening many classes of molecular targets. The live parasite approach is also one step ahead of target based approaches, in that the hits are already known to kill parasites, so have addressed cellular permeability question. ...
Aalborg Universitet The medication process in a psychiatric hospital Mainz, Jan
... drugs, and physicians prescribing drugs, but the observational unit was the individual handling of medication (prescribing, dispensing, and administering). It is common in Denmark that each ward has its own stock ward system where nurses dispense drugs. The term “dispensing” refers to nurses identi ...
... drugs, and physicians prescribing drugs, but the observational unit was the individual handling of medication (prescribing, dispensing, and administering). It is common in Denmark that each ward has its own stock ward system where nurses dispense drugs. The term “dispensing” refers to nurses identi ...
13: Skin - Gateshead Health NHS Foundation Trust
... These products, apart from white soft paraffin 50%/liquid paraffin 50%, may be used as soap substitutes by firstly wetting the skin, washing with the cream or ointment, then rinsing off. ...
... These products, apart from white soft paraffin 50%/liquid paraffin 50%, may be used as soap substitutes by firstly wetting the skin, washing with the cream or ointment, then rinsing off. ...
Identification and Analysis of Synthetic Cathinones in Seized Materials
... ing strategy is aggressive and involves giving those substances catchy product names such as “miaow miaow”, “top cat”, “bubbles” and “ivory wave”. Online retailers can often provide ambiguous descriptions of their items, which are commonly sold as research chemicals, room odourizers, plant food, or ...
... ing strategy is aggressive and involves giving those substances catchy product names such as “miaow miaow”, “top cat”, “bubbles” and “ivory wave”. Online retailers can often provide ambiguous descriptions of their items, which are commonly sold as research chemicals, room odourizers, plant food, or ...
(NSAIDs) classification, diagnosis and management
... hypersensitivity may reach 25.6% (9). Cutaneous manifestations to NSAIDs may affect 0.3% of general population (5), and the prevalence of aspirin hypersensitivity may be as high as 27–35% in patients with chronic urticaria (10). NSAIDs have been reported to be the major (11) or the second group of d ...
... hypersensitivity may reach 25.6% (9). Cutaneous manifestations to NSAIDs may affect 0.3% of general population (5), and the prevalence of aspirin hypersensitivity may be as high as 27–35% in patients with chronic urticaria (10). NSAIDs have been reported to be the major (11) or the second group of d ...
SEIKO ABUBAKARI - Kwame Nkrumah University of Science
... Malaria is a public health problem worldwide, especially in tropical Africa where it kills around a million of people a year, of which 75% are children under 5 years of age, drug assessment in this group is lower which complicate the choice of appropriate treatment. Quinine is re-emerging as an impo ...
... Malaria is a public health problem worldwide, especially in tropical Africa where it kills around a million of people a year, of which 75% are children under 5 years of age, drug assessment in this group is lower which complicate the choice of appropriate treatment. Quinine is re-emerging as an impo ...
The Seventh Report of the Joint National Committee on
... most patients with uncomplicated hypertension, either alone or combined with drugs from other classes. Certain high-risk conditions are compelling indications for the initial use of other antihypertensive drug classes (angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, -blocke ...
... most patients with uncomplicated hypertension, either alone or combined with drugs from other classes. Certain high-risk conditions are compelling indications for the initial use of other antihypertensive drug classes (angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, -blocke ...
Opiates Drug Information
... The term "opioid" refers to all drugs, natural or synthetic, with morphine-like properties. Both morphine and codeine are naturally occurring alkaloids derived from the seed pod of the opium poppy. Semi-synthetic opiates include heroin, a diacetyl derivative of morphine; hydromorphone, hydrocodone, ...
... The term "opioid" refers to all drugs, natural or synthetic, with morphine-like properties. Both morphine and codeine are naturally occurring alkaloids derived from the seed pod of the opium poppy. Semi-synthetic opiates include heroin, a diacetyl derivative of morphine; hydromorphone, hydrocodone, ...
PDF - Santen Inc.
... further support global expansion. Currently, Santen is focused on the development of two main products*: ...
... further support global expansion. Currently, Santen is focused on the development of two main products*: ...
Selective Inhibition of Human Solute Carrier Transporters by
... Eighteen MKIs were tested for the capacity to modulate substrate uptake by 13 SLC transporters expressed in HEK293 cells (Fig. 1). Initial screening at the 10 mM concentration identified a number of potent inhibitory interactions (.50% inhibition); IC50 values were determined for these interactions ...
... Eighteen MKIs were tested for the capacity to modulate substrate uptake by 13 SLC transporters expressed in HEK293 cells (Fig. 1). Initial screening at the 10 mM concentration identified a number of potent inhibitory interactions (.50% inhibition); IC50 values were determined for these interactions ...
leucovorin - Cancer Care Ontario
... Keep refrigerated; protect from light. LEUCOVORIN ORAL Oral self-administration; drug available by outpatient prescription. ...
... Keep refrigerated; protect from light. LEUCOVORIN ORAL Oral self-administration; drug available by outpatient prescription. ...
doc - 3.24 MB - Medicines for Malaria Venture
... P. vivax (0.1–1.0%) (C. Kocken, personal communication). This model was originally used in the screening that led to the discovery of the drug primaquine, and also in defining the activity of proguanil and cycloguanil against liver stage schizonts. Building on these original activities, 2guanidine i ...
... P. vivax (0.1–1.0%) (C. Kocken, personal communication). This model was originally used in the screening that led to the discovery of the drug primaquine, and also in defining the activity of proguanil and cycloguanil against liver stage schizonts. Building on these original activities, 2guanidine i ...
Journal of Legal Medicine The Need for Ibogaine in
... aversion drugs, it induces nausea, vomiting, and physical pain.26 The problems associated with these treatment methods, however, are numerous. Both require long-term treatment, which greatly increases the chance that an addict will quit treatment and return to using.27 Replacement therapy simply rep ...
... aversion drugs, it induces nausea, vomiting, and physical pain.26 The problems associated with these treatment methods, however, are numerous. Both require long-term treatment, which greatly increases the chance that an addict will quit treatment and return to using.27 Replacement therapy simply rep ...
Hypersensitivity to nonsteroidal antiinflammatory drugs (NSAIDs
... hypersensitivity may reach 25.6% (9). Cutaneous manifestations to NSAIDs may affect 0.3% of general population (5), and the prevalence of aspirin hypersensitivity may be as high as 27–35% in patients with chronic urticaria (10). NSAIDs have been reported to be the major (11) or the second group of d ...
... hypersensitivity may reach 25.6% (9). Cutaneous manifestations to NSAIDs may affect 0.3% of general population (5), and the prevalence of aspirin hypersensitivity may be as high as 27–35% in patients with chronic urticaria (10). NSAIDs have been reported to be the major (11) or the second group of d ...
Substance Related Disorders
... Behavioral Therapies • A widely used behavioral treatment is aversion therapy, an approach based on classical conditioning principles – Individuals are repeatedly presented with an unpleasant stimulus at the very moment they are taking a drug – After repeated pairings, they are expected to react ne ...
... Behavioral Therapies • A widely used behavioral treatment is aversion therapy, an approach based on classical conditioning principles – Individuals are repeatedly presented with an unpleasant stimulus at the very moment they are taking a drug – After repeated pairings, they are expected to react ne ...
TYPE OF MANUSCRIPT: ORIGINAL RESEARCH ARTICLE
... The results of various physical parameters for evaluation of the prepared herbal gel Formulation are reported below. The physical parameter such as color, appearance, and feel on application are observed and shown in Table No 4. From the physical evaluation the color of prepared herbal gels was dark ...
... The results of various physical parameters for evaluation of the prepared herbal gel Formulation are reported below. The physical parameter such as color, appearance, and feel on application are observed and shown in Table No 4. From the physical evaluation the color of prepared herbal gels was dark ...