Drug Discovery and Development
... Finding a Lead (cont.) Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a form of ischaemic cardiovascula ...
... Finding a Lead (cont.) Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a form of ischaemic cardiovascula ...
Basic Principles of Pharmacology
... = Virtually all chemicals may be drugs = All drugs are toxins but not all toxins are drugs ...
... = Virtually all chemicals may be drugs = All drugs are toxins but not all toxins are drugs ...
substance abuse - Molloy College
... Consequences of Prescription Substance Abuse Opiate meds may lead to rapid tolerance and if abused consistently can lead to opiate withdrawal when stopped abruptly. Symptoms of opioids misuse: resp. depression and death. Drowsiness, miosis, and constipation. This side effects can be made worse when ...
... Consequences of Prescription Substance Abuse Opiate meds may lead to rapid tolerance and if abused consistently can lead to opiate withdrawal when stopped abruptly. Symptoms of opioids misuse: resp. depression and death. Drowsiness, miosis, and constipation. This side effects can be made worse when ...
Polypharmacy - Dr. Bill Dalziel
... With respect to Coumadin for atrial fibrillation and the concerns about falls in the elderly, how many falls per year do you need to = the risk of ...
... With respect to Coumadin for atrial fibrillation and the concerns about falls in the elderly, how many falls per year do you need to = the risk of ...
2011 GEM Drugs Elderly
... What are the Drug Therapy Problems (DTP) What do we hope to achieve What is the best therapeutic plan What is the monitoring plan ...
... What are the Drug Therapy Problems (DTP) What do we hope to achieve What is the best therapeutic plan What is the monitoring plan ...
week2pm
... enter intestine; penetrate lining of intestine, pass into bloodstream and reach site of action; intestine is more basic absorption favored if the drug is nonionized and more lipophilic ...
... enter intestine; penetrate lining of intestine, pass into bloodstream and reach site of action; intestine is more basic absorption favored if the drug is nonionized and more lipophilic ...
Chapter 12 Antimicrobial Therapy Antibiotics
... - selectively toxic, - nonallergenic, - reasonable half life (maintained at a constant therapeutic concentration) - unlikely to elicit resistance, - has a long shelf life, - reasonably priced. ...
... - selectively toxic, - nonallergenic, - reasonable half life (maintained at a constant therapeutic concentration) - unlikely to elicit resistance, - has a long shelf life, - reasonably priced. ...
First-pass effect
... • Noncompetitive antagonism exists when two drugs fit in the same receptor site but their intrinsic activities are not opposite of one another and the two drugs do not reverse each other. In this case one drug either combines better with the receptor or one drug alters the shape of the receptor when ...
... • Noncompetitive antagonism exists when two drugs fit in the same receptor site but their intrinsic activities are not opposite of one another and the two drugs do not reverse each other. In this case one drug either combines better with the receptor or one drug alters the shape of the receptor when ...
Click here for Illegal Drugs PowerPoint Presentation
... BUT DO NOT CONTAIN THE ACTIVE INGEDIENT OF THAT DRUG. ...
... BUT DO NOT CONTAIN THE ACTIVE INGEDIENT OF THAT DRUG. ...
Leaflet
... Interaction with other medicinal drugs and other forms of interactions. Treatment with the drug is recommended to be provided on the basis of vitamin therapy. Due to high stability of lacto bacteria to antibiotics the drug application is possible in combination with antibiotic therapy. In case of sp ...
... Interaction with other medicinal drugs and other forms of interactions. Treatment with the drug is recommended to be provided on the basis of vitamin therapy. Due to high stability of lacto bacteria to antibiotics the drug application is possible in combination with antibiotic therapy. In case of sp ...
Who made the ruling? What was the vote? What was the award?
... gangrene requiring amputation, but it did not rule out administering the drug by the “IV push” method. The Vermont trial judge instructed the jury that compliance with F.D.A. requirements did not establish that the warnings on the labels were adequate. Justice Stevens noted that the trial record con ...
... gangrene requiring amputation, but it did not rule out administering the drug by the “IV push” method. The Vermont trial judge instructed the jury that compliance with F.D.A. requirements did not establish that the warnings on the labels were adequate. Justice Stevens noted that the trial record con ...
Urine drug screening Urine drug screens
... A negative UDS does not necessarily mean the patient is diverting their drugs. It may be because the patient’s drug level was below threshold due to dose and dosing, especially if the patient is very well hydrated. A good practice is to ask when the last dose was taken when obtaining a UDS. Drug met ...
... A negative UDS does not necessarily mean the patient is diverting their drugs. It may be because the patient’s drug level was below threshold due to dose and dosing, especially if the patient is very well hydrated. A good practice is to ask when the last dose was taken when obtaining a UDS. Drug met ...
What do you know about ECSTASY?
... • Not to be confused with “Herbal ecstasy” containing ephedrine and other herbs • Reputed to be a safe “recreational” or “therapeutic” drug in a dose of 1 to 2 mg. • Deaths have been attributed to the use of MDMA – why? ...
... • Not to be confused with “Herbal ecstasy” containing ephedrine and other herbs • Reputed to be a safe “recreational” or “therapeutic” drug in a dose of 1 to 2 mg. • Deaths have been attributed to the use of MDMA – why? ...
Medications - Metoprolol
... symptoms of hypoglycemia. -Monitor blood pressure frequently; drug masks common signs and symptoms of shock. -Beta blockers may mask tachycardia caused by hyperthyroidism. In patients with suspected thyrotoxicosis, taper off beta blocker to avoid thyroid storm. -Black box warning: When stopping ther ...
... symptoms of hypoglycemia. -Monitor blood pressure frequently; drug masks common signs and symptoms of shock. -Beta blockers may mask tachycardia caused by hyperthyroidism. In patients with suspected thyrotoxicosis, taper off beta blocker to avoid thyroid storm. -Black box warning: When stopping ther ...
Pharmacokinetics_200..
... Types of parenteral administration: – Intravascular: Intravenous (IV) or intraarterial (IA; rarely) • Advantage - most control over dose administered (no absorption phase, no first-pass effect – bioavailability 100%) • Disadvantage – invasive, uncomfortable, risk of introducing bacteria, inductio ...
... Types of parenteral administration: – Intravascular: Intravenous (IV) or intraarterial (IA; rarely) • Advantage - most control over dose administered (no absorption phase, no first-pass effect – bioavailability 100%) • Disadvantage – invasive, uncomfortable, risk of introducing bacteria, inductio ...
Executive Summary - BioTech Showcase News
... The leading potent opioid analgesics in use today such as Morphine, Oxycodone, Hydrocodone, Methadone, Fentanyl, etc. bind strongly to the mu receptor in the brain and then aggressively agonize that receptor, leading to a number of severe side effects including euphoria (which leads to abuse and add ...
... The leading potent opioid analgesics in use today such as Morphine, Oxycodone, Hydrocodone, Methadone, Fentanyl, etc. bind strongly to the mu receptor in the brain and then aggressively agonize that receptor, leading to a number of severe side effects including euphoria (which leads to abuse and add ...
May 9, 2013 Development of a Successful New Drug
... Also included are any previous experience with the drug in humans (often foreign use). ...
... Also included are any previous experience with the drug in humans (often foreign use). ...
Document
... In most cases drugs will show a non-exclusive preference for their target - selective. The interaction with both their intended target and other molecules can lead to undesirable effects (side effects). ...
... In most cases drugs will show a non-exclusive preference for their target - selective. The interaction with both their intended target and other molecules can lead to undesirable effects (side effects). ...
Drug Interactions
... • High Risk Drugs – Narrow therapeutic index drugs – Recognised enzyme inhibitors or inducers ...
... • High Risk Drugs – Narrow therapeutic index drugs – Recognised enzyme inhibitors or inducers ...
Pharmacology Review
... These same factors also determine the speed of absorption. Oral solutions and elixirs, which bypass need for disintegration and dissolution, are usually absorbed more rapidly. Some tablets have enteric coatings that prevent disintegration in the acidic environment of the stomach; others may have coa ...
... These same factors also determine the speed of absorption. Oral solutions and elixirs, which bypass need for disintegration and dissolution, are usually absorbed more rapidly. Some tablets have enteric coatings that prevent disintegration in the acidic environment of the stomach; others may have coa ...
Sedatives, Hypnotics & Anxiolytics
... bilirubin, induce glucuronyl transferase for glucuronide conjugation • the drugs are effective in premature infants for increased bilirubin formation or any hemolytic disease or if mothers are given sulfonamides in last trimester • even in physiological jaundice that is not resolving ...
... bilirubin, induce glucuronyl transferase for glucuronide conjugation • the drugs are effective in premature infants for increased bilirubin formation or any hemolytic disease or if mothers are given sulfonamides in last trimester • even in physiological jaundice that is not resolving ...
PRESCRIBING OPIOIDS for OFFICE BASED OPIOID TREATMENT
... SELF HARM: 40-50% of successful suicides, 40-80% of level I trauma FINANCIAL: productivity Not to mention all of the other medical complications / organ damage ...
... SELF HARM: 40-50% of successful suicides, 40-80% of level I trauma FINANCIAL: productivity Not to mention all of the other medical complications / organ damage ...
What`s Changing on the Prescription Drug List?
... PA – This drug requires prior authorization. ST – Requires other selected drugs to be tried first. QL – This drug has quantity limits on amount covered. SPRx – Specialty drug; many plans require you to get this type of drug from a Preferred Specialty Pharmacy. ...
... PA – This drug requires prior authorization. ST – Requires other selected drugs to be tried first. QL – This drug has quantity limits on amount covered. SPRx – Specialty drug; many plans require you to get this type of drug from a Preferred Specialty Pharmacy. ...