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Registration process of API - International Journal of Pharma
Registration process of API - International Journal of Pharma

... intended to be used in the manufacture of a drug (medicinal) product and that, when used in the production of a drug, becomes an active ingredient of the drug product. Such substances are intended to furnish pharmacological activity or other direct effect in the diagnosis, cure, mitigation, treatmen ...
Antithyroid Drugs
Antithyroid Drugs

... therapy that radioiodine and surgery provide. For example, antithyroid drugs might be preferable in patients with severe Graves’ eye disease, in whom radioiodine therapy has been associated with worsening ophthalmopathy.33 The preference of the patient is paramount in the decision process. A prospec ...
DEVELOPMENT AND VALIDATION OF NEWER ANALYTICAL METHODS FOR THE ESTIMATION
DEVELOPMENT AND VALIDATION OF NEWER ANALYTICAL METHODS FOR THE ESTIMATION

... Deferasirox belongs to the class Antidote. Chemical name is 4-[3,5bis (2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-benzoic acid. Deferasirox is an oral iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving long term blood transfusions for conditions such as beta th ...
Cholinergics and Anticholinergics
Cholinergics and Anticholinergics

... Toxicity of Cholinergic Drugs  Atropine is the specific antidote to cholinergic agents  Atropine reverses only the muscarinic effects of ...
Drug Awareness - South Fayette Township
Drug Awareness - South Fayette Township

... is a very effective cough suppressant. When taken at much higher doses, however, it acts as a disassociative anesthetic, similar to PCP and ketamine. At these high doses, DXM is also a central nervous system depressant. DXM is often used in combination with other drugs such as marijuana, ecstasy, or ...
A Review on Benzylpiperazine and Trifluoromethylphenypiperazine
A Review on Benzylpiperazine and Trifluoromethylphenypiperazine

... transporters (Baumann, Clark et al. 2005). It is also reported that both the drugs acts in a synergy effect on each other, releasing far larger amount of dopamine than each drug induces alone (Baumann, Clark et al. 2005). And as such, the pill with its stimulating, hallucinogenic and euphoric proper ...
NEW SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS DETERMINATION OF  AMLODIPINE BESYLATE AND ATORVASTATIN CALCIUM IN TABLET DOSAGE FORMS  
NEW SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS DETERMINATION OF  AMLODIPINE BESYLATE AND ATORVASTATIN CALCIUM IN TABLET DOSAGE FORMS  

... dihydropyridine  derivative  with  calcium  antagonist  activity2.  It  is  used  in  the  management  of  hypertension,  chronic  stable  angina  pectoris  and  prinzmetal  variant  angina3.  Amlodipine  acts  by  inhibiting  the  transmembrane  influx  of  calcium  ions  into  vascular  smooth mus ...
Antibiotic Update
Antibiotic Update

... Spectrum of Activity • Drugs vary widely regarding spectrum of activity, and detailed knowledge of this will require much study and/or experience – Even within same class, spectrum can be quite different ...
protocol - Rajiv Gandhi University of Health Sciences
protocol - Rajiv Gandhi University of Health Sciences

... different stimuli, a method of diminishing the overall response to one stimulus would be to introduce a second stimulus. This is based upon the assumption that differences among responses to stimuli are not so much a distinction between firing and non-firing of the neurons, but instead the differenc ...
hydrogels: a review - Global Research Online
hydrogels: a review - Global Research Online

... due to hydrophilicity, thus differing in their release mechanisms from hydrophobic polymers. Various models have been developed to predict the release of an active agent from a hydrogel device as a function of time. These models are based on the rate limiting step for controlled release and are divi ...
Attention-Deficit Hyperactivity Disorder (ADHD) Drug
Attention-Deficit Hyperactivity Disorder (ADHD) Drug

... Remillard (PharmD, College of Pharmacy, U of S.), C. Evans (BSP,PHD Cand ) & the RxFiles Advisory Committee. Prepared by: Monica Lee PharmD Cand L. Regier BSP, BA, B. Jensen BSP DISCLAIMER: The content of this newsletter represents the research, experience and opinions of the authors and not those o ...
Sabiduría  Spring 2015 Table of Contents
Sabiduría Spring 2015 Table of Contents

... Another area of pharmacy science where calculus is applied is nanoscience. In this arena, ...
Determining Frequency of Prescription, Administration and
Determining Frequency of Prescription, Administration and

... Previous research and results of our directobservation-based studies proves that occurrences of errors in direct observation method compared with volunteer-based reporting are more accurate [12, 14]. Another limitation is lack of any standard for determining MES. As a result we were not able to inve ...
Preservative-Free Ophthalmic Products - Scope e
Preservative-Free Ophthalmic Products - Scope e

... become a key component in ophthalmic solutions such as prostaglandin analogues, first-line drugs used in the management of glaucoma, IOP-lowering drugs, artificial tears and antibiotics. Though preservatives help keep the containers sterile over the course of multiple uses, they cause ocular irritat ...
Young Innovators 2009
Young Innovators 2009

... INTRODUCTION: CHEMOGENOMICS Chemogenomics is a new interdisciplinary field, which exploits multi-receptor chemical profiling to identify specific ligands for all targets. The term chemogenomics is applied to a multiplicity of approaches that use chemical compound libraries to probe biological syste ...
Stevens Johnson Syndrome
Stevens Johnson Syndrome

... to be most strongly associated with recently started drugs9 . Therefore, we least 3 years in the US between 1980 and 1997 . also separately considered drugs started within 8 weeks of onset and those Statistical methods. For the International Case-Control Study, data were used for longer periods. ana ...
amphetamines and other stimulants history
amphetamines and other stimulants history

... Every drug in the amphetamine group is a psychostimulant (a drug that increases the activity of the brain). Unlike many other frequently abused drugs, amphetamines are not natural, but can only be made in a chemical laboratory (Lukas, 1989, p. 9). Amphetamines were originally made in 1887 by a Germa ...
Neyroleptiklər
Neyroleptiklər

... antagonists. Although they are also effective antagonists at ACh, 5HT, NE receptors. ...
Blue with White Corner
Blue with White Corner

... • AUC/dose gives an average extent of bioavailability. • The rate of absorption is usually also important for the onset of drug action. • The time of peak plasma concentration is used often as a measure of the rate of drug absorption. • The peak plasma concentration is also an important parameter - ...
Molecular imaging with SPECT as a tool for drug
Molecular imaging with SPECT as a tool for drug

... of the high failure rate of new drug candidates that occurs during clinical trials and for the prolonged timeline and associated high costs [2,3]. The situation is rather common with the development of the new so-called molecularly targeted agents for cancer treatment, whereas the availability of va ...
challenges in adc development
challenges in adc development

... leukemia (AML) who were not candidates for cytotoxic chemotherapy  In 2010, results of a post-approval phase III study showed no clinical benefit. In fact, patients in the GO arm had a higher risk of fatal AEs – This trial led to the retraction of its FDA licence approval (Petersdorf et al, 2013). ...
Treating Anxiety, ADHD, Depression, Insomnia, and PTSD | Off
Treating Anxiety, ADHD, Depression, Insomnia, and PTSD | Off

... effective as augmentation therapy for treating resistant depression. Given the possible side effects they can cause, antipsychotic drugs aren’t the best choice for this use for most people. Other options, such as increasing the dose of your standard antidepressant or switching to a different one, ar ...
LABEL Infopest Verified
LABEL Infopest Verified

... As a class, cyclooxygenase inhibitory NSAIDs may be associated with gastrointestinal and renal toxicity. Effects may result from decreased prostaglandin production and inhibition of the enzyme cyclooxygenase, which is responsible for the formation of prostaglandins from arachidonic acid. When NSAIDs ...
Review: New oral anticoagulants reduced stroke and systemic
Review: New oral anticoagulants reduced stroke and systemic

... the new anticoagulants during bleeding events, although dabigatran may be dialyzable and prothrombin complex concentrates to reverse apixaban and rivaroxaban are being evaluated.  Individualized drug selection is important and can be achieved by using risk stratification schemes for thrombosis (CHA ...
Clinical Discussion of Special Populations - M
Clinical Discussion of Special Populations - M

... – new indication, new dosage form, new route of administration, new dosing regimen, or new active ingredient ...
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