High-performance genetically targetable optical neural silencing by
... We estimated the tissue volumes that could be silenced, using in vitro experiments and computational modeling. In cultured neurons expressing Arch or a trafficking-improved variant of Halo, eNpHR7,8, we somatically injected brief current pulses at magnitudes chosen to mimic the current drives of neu ...
... We estimated the tissue volumes that could be silenced, using in vitro experiments and computational modeling. In cultured neurons expressing Arch or a trafficking-improved variant of Halo, eNpHR7,8, we somatically injected brief current pulses at magnitudes chosen to mimic the current drives of neu ...
Discontinuity in evolution: how different levels of organization imply
... target area, +1 point for each movement forward, and -1 point for each cycle spent outside the 20x20 cell area. At the end of their lives (2400 actions) Os are allowed to reproduce. However, only the 20 individuals which have accumulated the most fitness are allowed to reproduce by generating 5 copi ...
... target area, +1 point for each movement forward, and -1 point for each cycle spent outside the 20x20 cell area. At the end of their lives (2400 actions) Os are allowed to reproduce. However, only the 20 individuals which have accumulated the most fitness are allowed to reproduce by generating 5 copi ...
how different levels of organization imply pre
... target area, +1 point for each movement forward, and -1 point for each cycle spent outside the 20x20 cell area. At the end of their lives (2400 actions) Os are allowed to reproduce. However, only the 20 individuals which have accumulated the most fitness are allowed to reproduce by generating 5 copi ...
... target area, +1 point for each movement forward, and -1 point for each cycle spent outside the 20x20 cell area. At the end of their lives (2400 actions) Os are allowed to reproduce. However, only the 20 individuals which have accumulated the most fitness are allowed to reproduce by generating 5 copi ...
Poster Example
... • Glia support neurons in several ways. A few of their functions involve supplying nutrients1, regulating synaptic transmission1 3 and long term potentiation (LTP)3, neurotransmitter reuptake1 3 5 and synapse pruning during development1 4. • Glial processes are closely intertwined with neuronal proc ...
... • Glia support neurons in several ways. A few of their functions involve supplying nutrients1, regulating synaptic transmission1 3 and long term potentiation (LTP)3, neurotransmitter reuptake1 3 5 and synapse pruning during development1 4. • Glial processes are closely intertwined with neuronal proc ...
Neuronal circuitries involved in thermoregulation
... Received 16 May 2000; accepted 18 August 2000 ...
... Received 16 May 2000; accepted 18 August 2000 ...
Compete to Compute
... a recurrent on-center, off-surround anatomy, wherein cells provide excitatory feedback to nearby cells, while scattering inhibitory signals over a broader range. Biological modeling has since tried to uncover the functional properties of this sort of organization, and its role in the behavioral succ ...
... a recurrent on-center, off-surround anatomy, wherein cells provide excitatory feedback to nearby cells, while scattering inhibitory signals over a broader range. Biological modeling has since tried to uncover the functional properties of this sort of organization, and its role in the behavioral succ ...
The Nervous System - Gordon State College
... Motor neurons: send commands from the brain to glands, muscles, and organs Interneurons: connect other neurons to one another ...
... Motor neurons: send commands from the brain to glands, muscles, and organs Interneurons: connect other neurons to one another ...
I. Nervous System
... The nervous system can be characterized according to the functional and anatomical principles. According to the functional principle the nervous system (NS) consists of: 1. the somatic nervous system which is responsible for coordinating voluntary body movements (i.e. activities that are under consc ...
... The nervous system can be characterized according to the functional and anatomical principles. According to the functional principle the nervous system (NS) consists of: 1. the somatic nervous system which is responsible for coordinating voluntary body movements (i.e. activities that are under consc ...
Induced pluripotent stem cells in Parkinson`s disease
... A recent paper on clinicopathological correlations of PD highlighted the need to develop new methods to improve diagnostic accuracy of early PD.21 iPSCs derived from patients may serve this need if the phenotypes shown in iPSC-derived neurons can recapitulate the pathological features in PD, includi ...
... A recent paper on clinicopathological correlations of PD highlighted the need to develop new methods to improve diagnostic accuracy of early PD.21 iPSCs derived from patients may serve this need if the phenotypes shown in iPSC-derived neurons can recapitulate the pathological features in PD, includi ...
Is this a brain which I see before me? Modeling human neural
... The human brain is arguably the most complex structure among living organisms. However, the specific mechanisms leading to this complexity remain incompletely understood, primarily because of the poor experimental accessibility of the human embryonic brain. Over recent years, technologies based on p ...
... The human brain is arguably the most complex structure among living organisms. However, the specific mechanisms leading to this complexity remain incompletely understood, primarily because of the poor experimental accessibility of the human embryonic brain. Over recent years, technologies based on p ...
1 - UPenn School of Engineering and Applied Science
... death and result in a net loss in the total number of cells. Experimentally, several types of cells have been used to encourage neuronal cell survival in animal models. They include fetal tissue grafts, embryonic stem cells, multi-potent stem cells (from adults), Schwann cells (that are normally fou ...
... death and result in a net loss in the total number of cells. Experimentally, several types of cells have been used to encourage neuronal cell survival in animal models. They include fetal tissue grafts, embryonic stem cells, multi-potent stem cells (from adults), Schwann cells (that are normally fou ...
pdf - Llano Lab
... receive receptive field information from one cortical area and relay it to another (Guillery, 1995). In contrast to the higher-order nuclei, primary sensory nuclei receive receptive field information from the sensory periphery and relay this information to the cortex, and have been referred to as ‘‘fir ...
... receive receptive field information from one cortical area and relay it to another (Guillery, 1995). In contrast to the higher-order nuclei, primary sensory nuclei receive receptive field information from the sensory periphery and relay this information to the cortex, and have been referred to as ‘‘fir ...
emboj2008265-sup
... 10 µM of BOC-LM-CMAC (Molecular Probes) was added to living neurons 10 minutes prior to visualization of Calpain activity. For each sample, a pair of coverslips (control and treatment) were used and imaged in parallel under UV light by inverting the coverslips over a microscope slide. Exposure times ...
... 10 µM of BOC-LM-CMAC (Molecular Probes) was added to living neurons 10 minutes prior to visualization of Calpain activity. For each sample, a pair of coverslips (control and treatment) were used and imaged in parallel under UV light by inverting the coverslips over a microscope slide. Exposure times ...
Spinal Cord Tutorial 101
... Although spinal cord injury causes complex damage, a surprising amount of the basic circuitry to control movement and process information can remain intact. This is because the spinal cord is arranged in layers of circuitry. Many of the connections and neuronal cell bodies forming this circuitry abo ...
... Although spinal cord injury causes complex damage, a surprising amount of the basic circuitry to control movement and process information can remain intact. This is because the spinal cord is arranged in layers of circuitry. Many of the connections and neuronal cell bodies forming this circuitry abo ...
1Induct Neurul
... glial fibers, neural crest cells “crawl along” independently (like fibroblasts). Motility is promoted by integrins – bind cell surface to ECM (how does this contrast with cadherins?) Prominent ECM components along neural crest cell pathway: fibronectin, laminin, collagen. The ECM provides attractive ...
... glial fibers, neural crest cells “crawl along” independently (like fibroblasts). Motility is promoted by integrins – bind cell surface to ECM (how does this contrast with cadherins?) Prominent ECM components along neural crest cell pathway: fibronectin, laminin, collagen. The ECM provides attractive ...
High-performance genetically targetable optical neural
... highlight how proton pump ecological and genomic diversity may support new innovation, we show that the blue–green lightdrivable proton pump from the fungus Leptosphaeria maculans4 (Mac) can, when expressed in neurons, enable neural silencing by blue light, thus enabling alongside other developed re ...
... highlight how proton pump ecological and genomic diversity may support new innovation, we show that the blue–green lightdrivable proton pump from the fungus Leptosphaeria maculans4 (Mac) can, when expressed in neurons, enable neural silencing by blue light, thus enabling alongside other developed re ...
Spiking Neurons with Boltzmann-like Properties to
... increases the strength when the neurons co-fire (see sections 2.2 and 4). One biological requirement, from Hebbian learning, is that neurons need to fire to positively influence neural circuits. However, in many computational models only neurons that are directly linked to sensors fire, and in mamma ...
... increases the strength when the neurons co-fire (see sections 2.2 and 4). One biological requirement, from Hebbian learning, is that neurons need to fire to positively influence neural circuits. However, in many computational models only neurons that are directly linked to sensors fire, and in mamma ...
The neuronal structure of the globus pallidus in the rabbit — Nissl
... a wavy route. The dendritic arbour of the large pallidal nerve cells is varied. In a single neuron, the dendrites may be covered with dendritic swellings, not numerous spines or may be completely smooth. In addition, the different portions of the same dendrite may show all of these characteristics. ...
... a wavy route. The dendritic arbour of the large pallidal nerve cells is varied. In a single neuron, the dendrites may be covered with dendritic swellings, not numerous spines or may be completely smooth. In addition, the different portions of the same dendrite may show all of these characteristics. ...
`Genotypes` for neural networks - laral
... (c) The "branching angle gene" and the "segment length gene" determine the angle of branching of the neuron's axon and the length of the branching segments. While angle of branching and segment length can vary from one neuron to another in the same network, all the branchings of the axon of a given ...
... (c) The "branching angle gene" and the "segment length gene" determine the angle of branching of the neuron's axon and the length of the branching segments. While angle of branching and segment length can vary from one neuron to another in the same network, all the branchings of the axon of a given ...
Inferring functional connections between neurons
... for a wide variety of signals ranging from fMRI and PET imaging to simultaneous recordings of many single neurons [1–3,4,5]. In this review we focus on the ideas underlying new techniques for the inference of functional connectivity from spike data. It has long been known that neurons, even when th ...
... for a wide variety of signals ranging from fMRI and PET imaging to simultaneous recordings of many single neurons [1–3,4,5]. In this review we focus on the ideas underlying new techniques for the inference of functional connectivity from spike data. It has long been known that neurons, even when th ...
Axonal conduction properties of antidromically identified neurons in
... Extracellular single unit recordings were obtained using tungsten or glass microelectrodes (5± 10 MV ), positioned over the barrel cortex and advanced perpendicular to the pial surface using a stepping microdrive equipped with a digital counter. Antidromically identified units could be found reliabl ...
... Extracellular single unit recordings were obtained using tungsten or glass microelectrodes (5± 10 MV ), positioned over the barrel cortex and advanced perpendicular to the pial surface using a stepping microdrive equipped with a digital counter. Antidromically identified units could be found reliabl ...
Membrane Potential Fluctuations in Neural Integrator
... the calculus sense) transient saccadic and vestibular signals into permanent changes in eye position. We use in vivo whole-cell intracellular recordings of integrator neurons in awake goldfish to temporally resolve individual excitatory postsynaptic potentials (EPSPs). We discovered that the EPSP ra ...
... the calculus sense) transient saccadic and vestibular signals into permanent changes in eye position. We use in vivo whole-cell intracellular recordings of integrator neurons in awake goldfish to temporally resolve individual excitatory postsynaptic potentials (EPSPs). We discovered that the EPSP ra ...