Accelerating antimalarial drug discovery through repositioning Holly
... I certify that this thesis, which I submit to the University of Salford a partial fulfilment of the requirements for a Degree of Doctor of Philosophy, is a presentation of my own research work. Wherever contributions of others are involved, every effort is made to indicate this clearly with due refe ...
... I certify that this thesis, which I submit to the University of Salford a partial fulfilment of the requirements for a Degree of Doctor of Philosophy, is a presentation of my own research work. Wherever contributions of others are involved, every effort is made to indicate this clearly with due refe ...
Dear Sir/Madam - University of Michigan College of Pharmacy
... pharmacokinetics (POPPK), (2) interspecies scaling and human PK projection, (3) blood-brain barrier (BBB) penetration and quantitative structure-BBB penetration relationship. Served as a consultant for young scientists at Pfizer in pharmaceutical sciences, produced method sheets as guidance for re ...
... pharmacokinetics (POPPK), (2) interspecies scaling and human PK projection, (3) blood-brain barrier (BBB) penetration and quantitative structure-BBB penetration relationship. Served as a consultant for young scientists at Pfizer in pharmaceutical sciences, produced method sheets as guidance for re ...
impact of advertising on customer purchase
... OTC drugs, due to extensive advertising by companies. The present study intends to explore advertising effectiveness of OTC drugs and Prescription drugs amongst consumers and Doctors. Although there are different means of providing the consumers with drug information, advertising seems to be one of ...
... OTC drugs, due to extensive advertising by companies. The present study intends to explore advertising effectiveness of OTC drugs and Prescription drugs amongst consumers and Doctors. Although there are different means of providing the consumers with drug information, advertising seems to be one of ...
Campus Location: Wilmington Effective Date: 2018
... Core Course Performance Objectives (CCPOs): 1. Identify the general principles of pharmacology. (CCC 1) 2. Examine selected medications that affect the peripheral nervous system and skeletal muscle. (CCC 1, 5, 6) 3. Examine selected medications that influence the central nervous system. (CCC 1, 5, 6 ...
... Core Course Performance Objectives (CCPOs): 1. Identify the general principles of pharmacology. (CCC 1) 2. Examine selected medications that affect the peripheral nervous system and skeletal muscle. (CCC 1, 5, 6) 3. Examine selected medications that influence the central nervous system. (CCC 1, 5, 6 ...
Review of cough and cold medicines in children
... definite diagnosis, and for cough and other symptoms believed by a parent to be due to the common cold. The brief discussion to follow refers to causes of these symptoms and to symptom patterns associated with common respiratory illnesses in childhood. This is relevant to the question – does it matt ...
... definite diagnosis, and for cough and other symptoms believed by a parent to be due to the common cold. The brief discussion to follow refers to causes of these symptoms and to symptom patterns associated with common respiratory illnesses in childhood. This is relevant to the question – does it matt ...
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
... The objective of this guidance is to recommend acceptable amounts for residual solvents in pharmaceuticals for the safety of the patient. The guidance recommends use of less toxic solvents and describes levels considered to be toxicologically acceptable for some residual solvents. Residual solvents ...
... The objective of this guidance is to recommend acceptable amounts for residual solvents in pharmaceuticals for the safety of the patient. The guidance recommends use of less toxic solvents and describes levels considered to be toxicologically acceptable for some residual solvents. Residual solvents ...
Development of a facile antibody–drug conjugate
... the latter being unstable during circulation.6 While heterogeneous ADCs have unpredictable safety and PK proles and show batch-to-batch variability, the instability of maleimide chemistry results in off-target toxicity.4 These shortcomings with current linker technologies have hindered the concept o ...
... the latter being unstable during circulation.6 While heterogeneous ADCs have unpredictable safety and PK proles and show batch-to-batch variability, the instability of maleimide chemistry results in off-target toxicity.4 These shortcomings with current linker technologies have hindered the concept o ...
A bitter pill. Overview of ecstasy (MDMA, MDA) related
... 2003b). The serotonin syndrome seems to be the direct consequence of MDMA-induced 5-HT1-like and 5-HT2 receptor stimulation, which results in a marked increase of central serotonin levels (Liechti and Vollenweider 2001). Some of the MDMA acute effects (tachycardia, overarousal and hypertension) may ...
... 2003b). The serotonin syndrome seems to be the direct consequence of MDMA-induced 5-HT1-like and 5-HT2 receptor stimulation, which results in a marked increase of central serotonin levels (Liechti and Vollenweider 2001). Some of the MDMA acute effects (tachycardia, overarousal and hypertension) may ...
Common Medication prescribed in pediatric dentistry.
... miniaturized version of his adult counter part. child physiology and anatomy significantly differ from those of adults. • Pediatric dentist must consider this differences when making therapeutic choices about young patient. ...
... miniaturized version of his adult counter part. child physiology and anatomy significantly differ from those of adults. • Pediatric dentist must consider this differences when making therapeutic choices about young patient. ...
VA Medicaid PDL List (effective 07/01/2011)
... Not all medications listed are covered by all DMAS programs. Check individual program coverage. For program drug coverage information, visit the following: http://www.VirginiaMedicaidPharmacyServices.com All new products included in a PDL class are automatically non-preferred until reviewed by the P ...
... Not all medications listed are covered by all DMAS programs. Check individual program coverage. For program drug coverage information, visit the following: http://www.VirginiaMedicaidPharmacyServices.com All new products included in a PDL class are automatically non-preferred until reviewed by the P ...
SALT SOLID DISPERSIONS
... Improving oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Pharmaceutical salt formation is a widely accepted approach to improve dissolution rate of poorly water-soluble ionic drugs. Nevertheless, the salt formation process is often ...
... Improving oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Pharmaceutical salt formation is a widely accepted approach to improve dissolution rate of poorly water-soluble ionic drugs. Nevertheless, the salt formation process is often ...
Antibody–drug conjugates nonclinical support: from early to late
... In general, during the early drug discovery stage, where research teams are working with large number of similar compounds for a given target, the availability of critical reagents, time and resources may be limited. As a result, flexible ‘fit-for-purpose’ assay development approaches and generic re ...
... In general, during the early drug discovery stage, where research teams are working with large number of similar compounds for a given target, the availability of critical reagents, time and resources may be limited. As a result, flexible ‘fit-for-purpose’ assay development approaches and generic re ...
Patient Registries and Participating in Clinical Trials
... drugs and using biomarkers). • What is the rationale for excluding certain patients? Can those excluded be used in other ways? Parallel or ...
... drugs and using biomarkers). • What is the rationale for excluding certain patients? Can those excluded be used in other ways? Parallel or ...
PhD thesis
... disrupting compounds (EDCs) on humans. However, pharmaceuticals have not received much attention as potential EDCs, even though several classes of drugs e.g. antiepileptic drugs (AEDs), selective serotonin reuptake inhibitors (SSRIs) and fungicides have adverse effects on the reproductive system, ...
... disrupting compounds (EDCs) on humans. However, pharmaceuticals have not received much attention as potential EDCs, even though several classes of drugs e.g. antiepileptic drugs (AEDs), selective serotonin reuptake inhibitors (SSRIs) and fungicides have adverse effects on the reproductive system, ...
Citizen Petition to Investigate Polyethylene Glycol 3350
... Based on its own findings and the soaring number of adverse events reported to the Food and Drug Administration, we are asking the FDA to reopen its investigation of polyethylene glycol products in pediatric patients, as the safety of PEG 3350 use in children has not been established by the FDA and, ...
... Based on its own findings and the soaring number of adverse events reported to the Food and Drug Administration, we are asking the FDA to reopen its investigation of polyethylene glycol products in pediatric patients, as the safety of PEG 3350 use in children has not been established by the FDA and, ...
Simulation Based Assessment of Limited Sampling Strategies
... LSS is generally evaluated through the calculation of their bias and precision [17]. Though these criteria inform a certain validity of the LSS, their predictive power and transferability should not be taken for granted when different patient subpopulations and contexts are involved [18]. This fact ...
... LSS is generally evaluated through the calculation of their bias and precision [17]. Though these criteria inform a certain validity of the LSS, their predictive power and transferability should not be taken for granted when different patient subpopulations and contexts are involved [18]. This fact ...
Methamphetamine Action Plan
... and enhanced mood. The effects of methamphetamine are dose dependent, however, the following effects will occur at greater or lesser levels; euphoria, increased activity and energy levels, dis-inhibition, sense of well-being, increased confidence (often termed ‘bullet-proof’), decreased appetite and ...
... and enhanced mood. The effects of methamphetamine are dose dependent, however, the following effects will occur at greater or lesser levels; euphoria, increased activity and energy levels, dis-inhibition, sense of well-being, increased confidence (often termed ‘bullet-proof’), decreased appetite and ...
Inhibition and induction of human cytochrome P450 (CYP) enzymes
... Substrate and inhibitor selectivity From the point of view of this review, the most interesting characteristics of CY P enzymes are substrate speci® city and inhibitor selectivity and in tables 1 and 2 several ` speci® c ’ or ` diagnostic ’ substrates and inhibitors have been listed, as they are cur ...
... Substrate and inhibitor selectivity From the point of view of this review, the most interesting characteristics of CY P enzymes are substrate speci® city and inhibitor selectivity and in tables 1 and 2 several ` speci® c ’ or ` diagnostic ’ substrates and inhibitors have been listed, as they are cur ...
The PBAC agenda primarily consists of applications relating
... circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be listed in alphabetical order by drug name. There is no provision for consumer comments to the PBAC on agenda item 8 which relates to pricing matters. Pharmaceu ...
... circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be listed in alphabetical order by drug name. There is no provision for consumer comments to the PBAC on agenda item 8 which relates to pricing matters. Pharmaceu ...
March 2016 PBAC Meeting Agenda
... circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be listed in alphabetical order by drug name. There is no provision for consumer comments to the PBAC on agenda item 8 which relates to pricing matters. Pharmaceu ...
... circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be listed in alphabetical order by drug name. There is no provision for consumer comments to the PBAC on agenda item 8 which relates to pricing matters. Pharmaceu ...
Addiction neurobiology: Ethical and social implications
... holds out the prospect of providing us with some novel approaches to both the prevention and treatment of drug problems. It may also lead to developments that — if misused — could have serious negative consequences, such as the unrestricted use of sensitive screening techniques or invasive and poten ...
... holds out the prospect of providing us with some novel approaches to both the prevention and treatment of drug problems. It may also lead to developments that — if misused — could have serious negative consequences, such as the unrestricted use of sensitive screening techniques or invasive and poten ...
Enhancement of Taste Masking by A newly
... direct compression method. This might be due to good distribution of active ingredient in the tablet formulation. In wet granulation, saccharin was employed as a sweetening agent and binder. To overcome bitterness problem, saccharin was four to six times in weight to active ingredient in the efferve ...
... direct compression method. This might be due to good distribution of active ingredient in the tablet formulation. In wet granulation, saccharin was employed as a sweetening agent and binder. To overcome bitterness problem, saccharin was four to six times in weight to active ingredient in the efferve ...
Research Report Series: MDMA (Ecstasy) Abuse
... Because of its stimulant properties and the environment in which it is often taken, MDMA is associated with vigorous physical activity for extended periods. This can lead to one of the most significant, although rare, acute adverse effects -- a marked rise in body temperature (hyperthermia). Treatme ...
... Because of its stimulant properties and the environment in which it is often taken, MDMA is associated with vigorous physical activity for extended periods. This can lead to one of the most significant, although rare, acute adverse effects -- a marked rise in body temperature (hyperthermia). Treatme ...
opioid codrugs for pain management - UKnowledge
... Pain is an unpleasant sensory and emotional experience associated with actual or potential tissus damage or described in terms of such damage. Opioids are effective in treating moderate to severe pain, but opioid alone therapy is associated with several adverse effects, development of tolerance and ...
... Pain is an unpleasant sensory and emotional experience associated with actual or potential tissus damage or described in terms of such damage. Opioids are effective in treating moderate to severe pain, but opioid alone therapy is associated with several adverse effects, development of tolerance and ...