
Pharmacophore screening of the Protein Data Bank for specific
... A simple computational approach was developed to screen the Protein Data Bank (PDB) for putative pockets possessing a specific binding site chemistry and geometry. The method employs two commonly used 3D screening technologies, namely identification of cavities in protein structures and pharmacophor ...
... A simple computational approach was developed to screen the Protein Data Bank (PDB) for putative pockets possessing a specific binding site chemistry and geometry. The method employs two commonly used 3D screening technologies, namely identification of cavities in protein structures and pharmacophor ...
Mechanistic Pharmacokinetic Modeling for the Prediction of
... The passive diffusion component was parameterized as unbound distribution CL (CLint, u, pass) within the model. Active uptake was parameterized in the ...
... The passive diffusion component was parameterized as unbound distribution CL (CLint, u, pass) within the model. Active uptake was parameterized in the ...
pharmacy technician certification examination content outline......
... It is very important for technicians to know when to answer a patient’s question and when to refer the patient to the pharmacist. Technicians SHOULD NOT interpret a patient-specific question or provide information that may require professional judgment. The technician is not the one to tell the pati ...
... It is very important for technicians to know when to answer a patient’s question and when to refer the patient to the pharmacist. Technicians SHOULD NOT interpret a patient-specific question or provide information that may require professional judgment. The technician is not the one to tell the pati ...
The use of compound topical anesthetics
... -unregulated. Some compounding pharmacies bypass the new FDA drug approval process, which is based on reliable scientific data and ensures that a marketed drug is safe, effective, properly manufactured and accurately labeled. Two deaths have been attributed to the lay use of compound topical anesthe ...
... -unregulated. Some compounding pharmacies bypass the new FDA drug approval process, which is based on reliable scientific data and ensures that a marketed drug is safe, effective, properly manufactured and accurately labeled. Two deaths have been attributed to the lay use of compound topical anesthe ...
uncorrected proof
... and available biochemical data on actin binding domains suggest that two calponin homology domains come in a closed conformation in the native apo-form, and that conformational changes involving the relative orientation of the two calponin homology domains are required for efficient binding to actin ...
... and available biochemical data on actin binding domains suggest that two calponin homology domains come in a closed conformation in the native apo-form, and that conformational changes involving the relative orientation of the two calponin homology domains are required for efficient binding to actin ...
Analytical Method Validation Develop Protocols that Survive the
... • Identify critical process steps and related assays • Is this used for characterization only? – Or will this lead to a testing requirement and be held to a specification? • How important is continued characterization testing? – Do they need to be ongoing as part of release or used for process check ...
... • Identify critical process steps and related assays • Is this used for characterization only? – Or will this lead to a testing requirement and be held to a specification? • How important is continued characterization testing? – Do they need to be ongoing as part of release or used for process check ...
Pharmacology of Antiepileptic Drugs
... • Atonic seizures: sudden loss of postural tone; most often in children but may be seen in adults • Tonic-clonic seizures (grand mal): tonic rigidity of all extremities followed in 15-30 sec by tremor that is actually an interruption of the tonus by relaxation; relaxation proceeds to clonic phase wi ...
... • Atonic seizures: sudden loss of postural tone; most often in children but may be seen in adults • Tonic-clonic seizures (grand mal): tonic rigidity of all extremities followed in 15-30 sec by tremor that is actually an interruption of the tonus by relaxation; relaxation proceeds to clonic phase wi ...
Ada_Dekhtyar
... administer such drug; or (C) is limited by an approved application under section 505 to use under the professional supervision of a practitioner licensed by law to administer such drug. ...
... administer such drug; or (C) is limited by an approved application under section 505 to use under the professional supervision of a practitioner licensed by law to administer such drug. ...
Optimization of Protein Therapies by Polymer
... HO-(CH2CH2O)n-H, where functionalization of PEG is restricted to the utilization of the terminal primary OH groups [39]. From this viewpoint, modifiable polymeric modifiers are needed to control the biopharmaceutical characteristics of conjugated drugs. Therefore, we assessed the pharmacokinetic pro ...
... HO-(CH2CH2O)n-H, where functionalization of PEG is restricted to the utilization of the terminal primary OH groups [39]. From this viewpoint, modifiable polymeric modifiers are needed to control the biopharmaceutical characteristics of conjugated drugs. Therefore, we assessed the pharmacokinetic pro ...
t.5
... of desipramine can be expected to plateau relatively rapidly but full response will not be evident for several weeks. If at the end of the 1st week of therapy A.R. is having no SE, the dose may be ↑ed. 75-100mg, even though the full therapeutic benefit is from the initial dose is unlikely to be evid ...
... of desipramine can be expected to plateau relatively rapidly but full response will not be evident for several weeks. If at the end of the 1st week of therapy A.R. is having no SE, the dose may be ↑ed. 75-100mg, even though the full therapeutic benefit is from the initial dose is unlikely to be evid ...
How fast and how often: The pharmacokinetics of drug use are
... phenomena. The first is the ‘abstinence period’, which can last for days or weeks. The second is the inter-dosing interval within a bout of intoxication. Drug users adopt intermittent patterns of use, and this is seen both within and between a bout of intoxication. The notion of intermittent drug us ...
... phenomena. The first is the ‘abstinence period’, which can last for days or weeks. The second is the inter-dosing interval within a bout of intoxication. Drug users adopt intermittent patterns of use, and this is seen both within and between a bout of intoxication. The notion of intermittent drug us ...
Pharmacy Law Review 2010
... (b)(1) A drug intended for use by man which— (A) because of its toxicity or other potentiality for harmful effect, or the method of its use, or the collateral measures necessary to its use, is not safe for use except under the supervision of a practitioner licensed by law to administer such drug; or ...
... (b)(1) A drug intended for use by man which— (A) because of its toxicity or other potentiality for harmful effect, or the method of its use, or the collateral measures necessary to its use, is not safe for use except under the supervision of a practitioner licensed by law to administer such drug; or ...
American Geriatrics Society Updated Beers Criteria for
... comes. Estimates from past studies in ambulatory and longterm care settings found that 27% of adverse drug events (ADEs) in primary care and 42% of ADEs in long-term care were preventable, with most problems occurring at the ordering and monitoring stages of care.1,2 In a study of the 2000/2001 Medi ...
... comes. Estimates from past studies in ambulatory and longterm care settings found that 27% of adverse drug events (ADEs) in primary care and 42% of ADEs in long-term care were preventable, with most problems occurring at the ordering and monitoring stages of care.1,2 In a study of the 2000/2001 Medi ...
Original Article Inhibitory effects of 19 antiprotozoal drugs and
... every 2 or 3 days until 28–30 days post-infection. Blood without detectable parasitemia on 3 consecutive days was considered as negative. All the experiments were repeated three times. Observation on the pathogenicity of blood from BALB/c mice with self-limited infection The pathogenicity of blood w ...
... every 2 or 3 days until 28–30 days post-infection. Blood without detectable parasitemia on 3 consecutive days was considered as negative. All the experiments were repeated three times. Observation on the pathogenicity of blood from BALB/c mice with self-limited infection The pathogenicity of blood w ...
Formulation and evaluation of fluconazole and ichthammol ointment
... Ointment was removed from each tube and each empty tube was washed with methanol. The empty tubes were dried and their weight was taken. The difference between two weights was calculated as net weight of the ointment of tube. The average of net weight of ointment of ten tubes was noted. ...
... Ointment was removed from each tube and each empty tube was washed with methanol. The empty tubes were dried and their weight was taken. The difference between two weights was calculated as net weight of the ointment of tube. The average of net weight of ointment of ten tubes was noted. ...
DEVELOPMENT OF DIRECTLY COMPRESSIBLE CO-PROCESSED EXCIPIENTS FOR ORALLY
... dosing, better stability compared with oral liquids, and because it is more tamper proof than capsules [2]. Over the decade, the demand for the development of orally disintegrating tablets (ODTs) has enormously increased as it has notable impact on the patient compliance. ODTs are designed to disint ...
... dosing, better stability compared with oral liquids, and because it is more tamper proof than capsules [2]. Over the decade, the demand for the development of orally disintegrating tablets (ODTs) has enormously increased as it has notable impact on the patient compliance. ODTs are designed to disint ...
In vitro, in vivo and ex vivo models for studying particle deposition
... of the currently used models adequately reproduces various features of the respiratory apparatus. Therefore, it is important to identify the limitations of existing models and propose novel strategies to address those limitations. In this review, we have discussed various in vitro, ex vivo and in vi ...
... of the currently used models adequately reproduces various features of the respiratory apparatus. Therefore, it is important to identify the limitations of existing models and propose novel strategies to address those limitations. In this review, we have discussed various in vitro, ex vivo and in vi ...
Functional Group Characteristics and Roles
... group. As shown in Figure 2-1, bethanechol and simvastatin have an additional methyl group as compared to acetylcholine and lovastatin, respectively. The methyl group in bethanchol offers several advantages for bethanechol over acetylcholine as acetylcholine non-selectively interacts with both musca ...
... group. As shown in Figure 2-1, bethanechol and simvastatin have an additional methyl group as compared to acetylcholine and lovastatin, respectively. The methyl group in bethanchol offers several advantages for bethanechol over acetylcholine as acetylcholine non-selectively interacts with both musca ...
Positive and negative ion mode ESI-MS and MS/MS for - ORBi
... free energy ΔG°obs results from the additive contributions of five terms [8]: ΔG°conf (contribution from conformational changes upon complex formation), ΔG°t+r (losses in translational and rotational degrees of freedom), ΔG°hyd (hydrophobic transfer of drug from the solution into its DNA binding sit ...
... free energy ΔG°obs results from the additive contributions of five terms [8]: ΔG°conf (contribution from conformational changes upon complex formation), ΔG°t+r (losses in translational and rotational degrees of freedom), ΔG°hyd (hydrophobic transfer of drug from the solution into its DNA binding sit ...
Development and validation of desvenlafaxine succinate in bulk an
... Department of Pharmaceutical Chemistry, Smt. Kashibai Navale College of Pharmacy, Kondhwa (B.k.), Pune, Maharashtra, India _____________________________________________________________________________________________ ABSTRACT Desvenlafaxine succinate is a serotonin-nor serotonin epinephrine reuptake ...
... Department of Pharmaceutical Chemistry, Smt. Kashibai Navale College of Pharmacy, Kondhwa (B.k.), Pune, Maharashtra, India _____________________________________________________________________________________________ ABSTRACT Desvenlafaxine succinate is a serotonin-nor serotonin epinephrine reuptake ...
Implications for policy, prevention, and treatment
... decreasing. Internet Web sites offering to sell S. divinorum in a variety of forms, including whole plants, seeds, dried and fresh leaves, and extracts, have appeared (DEA, 2005). Other Web sites offer firsthand experiential reports, information on plant cultivation, dosage instructions, and suggest ...
... decreasing. Internet Web sites offering to sell S. divinorum in a variety of forms, including whole plants, seeds, dried and fresh leaves, and extracts, have appeared (DEA, 2005). Other Web sites offer firsthand experiential reports, information on plant cultivation, dosage instructions, and suggest ...
Prodrugs: A challenge for the drug development
... The basic aim of prodrug design is to mask undesirable drug properties, such as low solubility in water or lipid membranes, low target selectivity, chemical instability, undesirable taste, irritation or pain after local administration, presystemic metabolism and toxicity [54, 70, 74]. In general, th ...
... The basic aim of prodrug design is to mask undesirable drug properties, such as low solubility in water or lipid membranes, low target selectivity, chemical instability, undesirable taste, irritation or pain after local administration, presystemic metabolism and toxicity [54, 70, 74]. In general, th ...
Aminoglycoside
... apnea. Have Ca gluconate or pyridostigmine available to reverse such effect Monitor patient's neurologic status if the drug is given for ...
... apnea. Have Ca gluconate or pyridostigmine available to reverse such effect Monitor patient's neurologic status if the drug is given for ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.