• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Med-Psych Drug-Drug Interactions Update Triptans
Med-Psych Drug-Drug Interactions Update Triptans

... et al., no significant clinical events occurred, and the authors suggested that no dose adjustment was necessary. These modest findings reflect almotriptan’s multiple avenues of metabolism, which allow the drug to be biotransformed despite “roadblocks” at some of its metabolic sites. We could not fi ...
Pay Attention: Ritalin Acts Much Like Cocaine
Pay Attention: Ritalin Acts Much Like Cocaine

Translational Safety in Drug Development
Translational Safety in Drug Development

... individual subject factors with a focus on populations and variability, Toxicometrics is defined as the science that quantifies drug, toxicity and clinical trial information to aid efficient drug development, regulatory decisions and rational drug treatment in patients. Toxicometric-based drug model ...
Viktor`s Notes * Barbiturates
Viktor`s Notes * Barbiturates

... 2. Drug hangover (residual CNS depression) - feeling of tiredness (± nausea and dizziness) for many hours after patient awakes. 3. High potential for physical dependence & addiction (abrupt withdrawal → severe tremors, anxiety, weakness, restlessness, nausea & vomiting, grand mal seizures, delirium ...
INTERACTION STUDY OF CURCULIGOSIDE A AND ITS AGLYCONE AS CYCLOOXYGENASE
INTERACTION STUDY OF CURCULIGOSIDE A AND ITS AGLYCONE AS CYCLOOXYGENASE

... (Fig. 4) through the formation of hydrogen bonds between the hydrogen of the aromatic group (HB donor) and Gln192 (HB acceptor), the hydrogen of the glucose group (HB donor) and Val349 and Tyr355 (HB acceptor), the oxygen of the glucose group (HB acceptor) and Arg120 and Tyr355 (HB donor), as well a ...
Doctoral theses MÁRIA TÓTH MD. Semmelweis University
Doctoral theses MÁRIA TÓTH MD. Semmelweis University

... kidney function due to the familiar renal toxic effect of drugs belong to calcineurine-inhibitors. According to the several authors, the temporary reduction in graft function may affect on the long term succes of kidney transplantation. The avoidance the drug-drug interaction during treatment of tra ...
Herb-Drug Interactions: What Clinicians Need to Know.
Herb-Drug Interactions: What Clinicians Need to Know.

... The majority of data on herb-drug interactions are theoretical and based on case reports, in vitro assays, animal studies, and/or speculation.6 Case reports are frequently cited as unequivocal evidence of dangerous interactions, despite the fact that “published case reports are often incomplete” and ...
Impurities in new drug products, Q3B (R2)
Impurities in new drug products, Q3B (R2)

... amount of the degradation product; and (3) other safety factors, as appropriate. If the qualification thresholds given in Attachment 1 are exceeded and data are unavailable to qualify the proposed acceptance criterion of a degradation product, additional studies to obtain such data can be appropriat ...
投影片 1
投影片 1

... A substituent is alpha when the substituent is below the plane of the molecule. It is represented by a dashed line in a 2D drawing. Examples in this molecule are: H-5, H-9, H-14, etc. A substituent is beta when the substituent is above the plane of the molecule. It is represented by a bold line in ...
Prodrugs for Amines
Prodrugs for Amines

... hydrolysis of a pentyl carbamate mediated by liver carboxylesterase (CES-1). Significant species differences were observed when a panel of homologous carbamates was subjected to hydrolysis by human, monkey and mouse carboxylesterases and the discovery scientists point out that the correct analogue w ...
process development and optimization for moisture activated dry
process development and optimization for moisture activated dry

... typically have a size range between 0.2 and 4.0 mm, depending on their subsequent use.2 Granulation method can be broadly classified into two types: Wet granulation and Dry granulation. Wet granulation technique is receiving great significance, because direct compression method is not most suitable ...
CTI - Tech Transfer Central
CTI - Tech Transfer Central

... Partner with PIs to enable development of preclinical discovery into the clinic (Phase I) Focus on protein therapeutics Parallel development of Translational Medicine approach – understanding patient heterogeneity and patient stratification Focus on Mechanisms - across all disease areas ...
Bulletin #106
Bulletin #106

... REQUIREMENTS FOR DRUGS FOR NON-APPROVED INDICATIONS Occasionally drugs are required for non-approved indications on a case by case basis. In order to conduct a timely review of these requests the drug review committees request the following information be provided by the prescriber: ● the disease or ...
tRNA aminoacylation by arginyltRNA synthetase: induced
tRNA aminoacylation by arginyltRNA synthetase: induced

... Phylogenetic analysis of the 20 aaRSs has also revealed a complex evolutionary picture (Woese et al., 2000). In this context, new structures are essential to gain structural insight from sequence block alignments and therefore to decipher the relationships between function, evolution and sequences. ...
Neuroscience and Biobehavioral Reviews SEEKING, reward, addiction, and withdrawal
Neuroscience and Biobehavioral Reviews SEEKING, reward, addiction, and withdrawal

... these phenomena and it may explain why evolutionary factors have received scant attention in addiction research compared to cultural, environmental, biological, or pathological concerns (Nesse and Berridge, 1997; Panksepp et al., 2002; Panksepp et al., 2004). It has become clear that a wide range of ...
DMID 01-553 FQ EBA Study Results
DMID 01-553 FQ EBA Study Results

... • Different doses can be evaluated to define dose for phase 2b & 3 trials • PK can be compared to bactericidal activity • Short term toxicity in humans with TB can be evaluated ...
University of Groningen Dry powder inhalation of
University of Groningen Dry powder inhalation of

... the past decades have resulted in the successful introduction of a number of biopharmaceuticals (among which many therapeutic peptides and proteins) on the market. Biopharmaceuticals are a special class of medicines in the sense that, in general, they are chemically and physically not stable. In add ...
amphetamines and other stimulants history
amphetamines and other stimulants history

... Every drug in the amphetamine group is a psychostimulant (a drug that increases the activity of the brain). Unlike many other frequently abused drugs, amphetamines are not natural, but can only be made in a chemical laboratory (Lukas, 1989, p. 9). Amphetamines were originally made in 1887 by a Germa ...
Patrick Tb Ch04
Patrick Tb Ch04

... 22) Which statement best describes the relevance of an allosteric binding site to medicinal chemistry? Feedback: Designing drugs to interact with allosteric binding site allows a method of regulating enzyme activity, other than using inhibitors which bind to the active site. Allosteric binding sites ...
ABSTRACT Title of Document:
ABSTRACT Title of Document:

... I have had the honor and privilege to work with many advisors and collaborators from the University of Maryland and the National Institutes of Health, all of whom have contributed to the successful completion of this dissertation. I am grateful for the support from my advisor, Dr. Nam Sun Wang, who ...
DESIGN AND DEVELOPMENT OF MUCOADHESIVE BUCCAL DELIVERY FOR PANTOPRAZOLE
DESIGN AND DEVELOPMENT OF MUCOADHESIVE BUCCAL DELIVERY FOR PANTOPRAZOLE

... improved using magnesium oxide due to its strong waterproofing effect. In present study attempt has been done to improve the bioavailability by formulating mucoadhesive buccal tablet as well as to improve stability of tablet in human saliva. Methods: Nine formulations were developed with varying con ...
see p. Rx1 - Viktor`s Notes for the Neurosurgery Resident
see p. Rx1 - Viktor`s Notes for the Neurosurgery Resident

... excitability. *benzodiazepines and GABA mutually increase affinity of their binding sites.  clinical effects of various benzodiazepines correlate well with each drug's binding affinity for GABAA receptor-Cl- channel complex. ...
What People Need to Know about Psychiatric Drugs
What People Need to Know about Psychiatric Drugs

... 2005, is a consumer's guide giving information on over 500 drugs, including those of limited use and ones that should be avoided. It also provides non-drug alternatives for common health issues. If finding unbiased information is difficult, then it is important to read all the available literature a ...
Carbonic Anhydrase Inhibitors and Activators: Small
Carbonic Anhydrase Inhibitors and Activators: Small

... at the molecular level, bringing also new insights into problems of ligand recognition by an enzyme active site, since it has been observed that enantiomers such as L-/D-His and L-/DPhe bind in a very different manner to hCA II, interacting with different amino acid residues from the activator bindi ...
Study Guide for Veterinary Drug Dispenser Licence
Study Guide for Veterinary Drug Dispenser Licence

... remove these agents. Immunity or resistance to disease is dependent on the presence of antibodies against a particular infectious agent. ...
< 1 ... 65 66 67 68 69 70 71 72 73 ... 391 >

Drug design



Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report