Pharmacology
... Non competitive antagonism: The noncompetitive antagonist binds irreversibly to the receptor site or to another site that inhibits the response to the agonist. For example, drugs such as Verapamil and Nifedipine prevent the influx of calcium ions through the cell membrane and thus block non-specifi ...
... Non competitive antagonism: The noncompetitive antagonist binds irreversibly to the receptor site or to another site that inhibits the response to the agonist. For example, drugs such as Verapamil and Nifedipine prevent the influx of calcium ions through the cell membrane and thus block non-specifi ...
Psychology - Cloudfront.net
... Hypnotic Amnesia • Inability to remember what happened during hypnosis because the hypnotist suggests that the subject will have no memory of that period of time ...
... Hypnotic Amnesia • Inability to remember what happened during hypnosis because the hypnotist suggests that the subject will have no memory of that period of time ...
PRONIOSOMAL GEL AS A CARRIER FOR TRANSDERMAL DRUG DELIVERY OF... Research Article ASTHA MISHRA*, ANUPRIYA KAPOOR, SHILPI BHARGAVA
... were prepared using different non-ionic surfactants such as Span 60, Span 40, Brij 72 and Tween 80 and characterized by light microscopy, S.E.M, assessed for their rate of spontaneity, drug entrapment, and stability. The release through cellulose membrane and hairless mice skin was also carried out. ...
... were prepared using different non-ionic surfactants such as Span 60, Span 40, Brij 72 and Tween 80 and characterized by light microscopy, S.E.M, assessed for their rate of spontaneity, drug entrapment, and stability. The release through cellulose membrane and hairless mice skin was also carried out. ...
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF DILTIAZEM HYDROCHLORIDE
... permeable) drug with extensive and highly variable hepatic first pass metabolism following oral administration, with systemic bioavailability of between 36-50% and half life of 3.5 ± 1.2 hours. When such a drug administered in conventional immediate release dosage form, the frequency of administrati ...
... permeable) drug with extensive and highly variable hepatic first pass metabolism following oral administration, with systemic bioavailability of between 36-50% and half life of 3.5 ± 1.2 hours. When such a drug administered in conventional immediate release dosage form, the frequency of administrati ...
Slide ()
... shifted to the right. Maximal responsiveness is preserved, however, because the remaining available receptors are still in excess of the number required. In curve C, produced after treatment with a larger concentration of antagonist, the available receptors are no longer “spare”; instead, they are j ...
... shifted to the right. Maximal responsiveness is preserved, however, because the remaining available receptors are still in excess of the number required. In curve C, produced after treatment with a larger concentration of antagonist, the available receptors are no longer “spare”; instead, they are j ...
Health Canada - Isomer Design
... US: Kynurenine is not listed specifically in the Schedules to the US Controlled Substances Act and is not mentioned anywhere on the DEA website. United Nations: The substance is not listed on the Yellow List - List of Narcotic Drugs under International Control, the Green List - List of Psychotropic ...
... US: Kynurenine is not listed specifically in the Schedules to the US Controlled Substances Act and is not mentioned anywhere on the DEA website. United Nations: The substance is not listed on the Yellow List - List of Narcotic Drugs under International Control, the Green List - List of Psychotropic ...
Shoppers Drug Mart discovers energy savings in
... installed Carbon Dioxide (CO2) sensors on their rooftop units at select stores. CO2 sensors are a type of DemandControlled-Ventilation strategy that helps ensure proper indoor air quality, decreases the demand on a building’s HVAC system, and improves a building’s energy efficiency by controlling th ...
... installed Carbon Dioxide (CO2) sensors on their rooftop units at select stores. CO2 sensors are a type of DemandControlled-Ventilation strategy that helps ensure proper indoor air quality, decreases the demand on a building’s HVAC system, and improves a building’s energy efficiency by controlling th ...
Computational protein design
... conditions, or to perform entirely new functions, • knowledge obtained is likely to be linked to a more complete understanding of the forces underlying protein folding, enabling more rapid interpretation of the wealthof genomic information being amassed. ...
... conditions, or to perform entirely new functions, • knowledge obtained is likely to be linked to a more complete understanding of the forces underlying protein folding, enabling more rapid interpretation of the wealthof genomic information being amassed. ...
herbal nebulizer
... Gk, izein- to cause Nebulization is the process of medication administration via inhalation. It utilizes a nebulizer which transports medications to the lungs by means of mist inhalation. It is a method of administration of drug by spraying it into the respiratory passage of the patient. The medicat ...
... Gk, izein- to cause Nebulization is the process of medication administration via inhalation. It utilizes a nebulizer which transports medications to the lungs by means of mist inhalation. It is a method of administration of drug by spraying it into the respiratory passage of the patient. The medicat ...
Drug interactions and lethal drug combinations
... occurs commonly. Metoclopramide increases the rate of gastric emptying, particularly in patients in whom it is delayed, and has been shown to shorten the time to peak plasma concentration of paracetamol and aspirin (Prescott, 1974; Volans, 1974). Some drugs may interact chemically in the gut, leadin ...
... occurs commonly. Metoclopramide increases the rate of gastric emptying, particularly in patients in whom it is delayed, and has been shown to shorten the time to peak plasma concentration of paracetamol and aspirin (Prescott, 1974; Volans, 1974). Some drugs may interact chemically in the gut, leadin ...
Design of colon specific drug delivery systems.
... containing an anti-inflammatory drug for the treatment of inflammatory bowel diseases. Oral route is the most preferred route for drug administration, especially for chronic therapies where repeated administration is required. In addition, greater convenience, less pain, higher compliance, reduced r ...
... containing an anti-inflammatory drug for the treatment of inflammatory bowel diseases. Oral route is the most preferred route for drug administration, especially for chronic therapies where repeated administration is required. In addition, greater convenience, less pain, higher compliance, reduced r ...
Chronobiology: Pulsatile Drug Delivery System
... existing molecules rather going for new drug discovery as because of inherent hurdles posed in drug discovery and development process. Traditionally drug discovery was meant for getting a simple chemical absorbed from the site of absorption. The second generation drug delivery goes for a continuous ...
... existing molecules rather going for new drug discovery as because of inherent hurdles posed in drug discovery and development process. Traditionally drug discovery was meant for getting a simple chemical absorbed from the site of absorption. The second generation drug delivery goes for a continuous ...
PRESCRIBING OPIOIDS for OFFICE BASED OPIOID TREATMENT
... What can ___ do now? What could ___ do before this ____? What does the family hope ___ will be able to do if we can help? Has ___ Cutback on use of alcohol or other drugs? Has ___ been Annoyed by comments re: alc / drug use? Has ___ felt Guilty or embarrassed about actions/words when using? ...
... What can ___ do now? What could ___ do before this ____? What does the family hope ___ will be able to do if we can help? Has ___ Cutback on use of alcohol or other drugs? Has ___ been Annoyed by comments re: alc / drug use? Has ___ felt Guilty or embarrassed about actions/words when using? ...
Heroin Opium, morphine and heroin are all derived from the opium
... materials as caffeine (a stimulant), paracetamol (an analgesic/antipyretic), chlorpheniramine (an antihistamine), theophylline (a bronchodilator), antipyrine (an antipyretic), carbetapentane (an antitussive), phenobarbitone (a sedative), midazolam (a tranquillizer) and estazolam (a tranquillizer) in ...
... materials as caffeine (a stimulant), paracetamol (an analgesic/antipyretic), chlorpheniramine (an antihistamine), theophylline (a bronchodilator), antipyrine (an antipyretic), carbetapentane (an antitussive), phenobarbitone (a sedative), midazolam (a tranquillizer) and estazolam (a tranquillizer) in ...
SPECTROPHOTOMETRIC ESTIMATION OF LEVOSULPIRIDE IN BULK DRUG AND FORMULATIONS Research Article
... derivative spectrum in Methanol at 282.4 nm with n=1 (Method C). Linearity range was found to be 25‐125 µg/ml in all the three methods. The apparent molar absorptivity was found to be 2.14 X 103 lmol‐1cm‐1 (Method A), 2.39 X 103 lmol‐1cm‐1 (Method B) and 2.07 X 103 lmol‐1cm‐1 (Method C). T ...
... derivative spectrum in Methanol at 282.4 nm with n=1 (Method C). Linearity range was found to be 25‐125 µg/ml in all the three methods. The apparent molar absorptivity was found to be 2.14 X 103 lmol‐1cm‐1 (Method A), 2.39 X 103 lmol‐1cm‐1 (Method B) and 2.07 X 103 lmol‐1cm‐1 (Method C). T ...
1 HST-151 Principles of Clinical Cancer Chemotherapy and Drug
... (colon, lung cancer) may therefore be similar to those associated with acquired resistance to anti-neoplastic agents. 10. Drugs such as verapamil, diltiazem and quinidine have been found to overcome multidrug resistance in cell culture and in some animal experiments. For example, verapamil has been ...
... (colon, lung cancer) may therefore be similar to those associated with acquired resistance to anti-neoplastic agents. 10. Drugs such as verapamil, diltiazem and quinidine have been found to overcome multidrug resistance in cell culture and in some animal experiments. For example, verapamil has been ...
BVGH - Who We Are - BIO Ventures for Global Health
... these macromolecules are broken down, electrons are released. The electrons are funneled into electron acceptors and passed through a series of membrane-associated electron carriers, known as the electron transport chain. The electron transport chain generates a proton gradient whereby the concentra ...
... these macromolecules are broken down, electrons are released. The electrons are funneled into electron acceptors and passed through a series of membrane-associated electron carriers, known as the electron transport chain. The electron transport chain generates a proton gradient whereby the concentra ...
I.2 New Prospects for Drug Discovery (IV)
... bind to the extracellular part of the receptor, and can interact with the TM domains, the three extracellular loops and/or the N-terminus. A significant number of GPCR binding sites for their corresponding ligands have been mapped from a combination of site-directed mutagenesis –and other biochemica ...
... bind to the extracellular part of the receptor, and can interact with the TM domains, the three extracellular loops and/or the N-terminus. A significant number of GPCR binding sites for their corresponding ligands have been mapped from a combination of site-directed mutagenesis –and other biochemica ...
酸枣仁油软胶囊的新药开发研究
... b. without or less First-pass elimination. For example Nitroglycerin given sublingually bypasses liver and enters the superior vena cava and, in turn, perfuses the coronary and systemic blood vessel, therefore it is immediately effective to relive patients with angina pectoris. ...
... b. without or less First-pass elimination. For example Nitroglycerin given sublingually bypasses liver and enters the superior vena cava and, in turn, perfuses the coronary and systemic blood vessel, therefore it is immediately effective to relive patients with angina pectoris. ...
Narcotics and OD`s Uppsala University, Sweden, November 25th
... OD and drug-related deaths in Norway: Professor Thomas Clausen, Oslo University Overdoses rates in Norway have been on a decline since its peak in 2001. This is a trend that is contrasting Sweden and Finland, as well as many other EU-countries. Although overdose rates are declining in Norway, we ha ...
... OD and drug-related deaths in Norway: Professor Thomas Clausen, Oslo University Overdoses rates in Norway have been on a decline since its peak in 2001. This is a trend that is contrasting Sweden and Finland, as well as many other EU-countries. Although overdose rates are declining in Norway, we ha ...
chebi-and-plants - Buffalo Ontology Site
... Not exactly a biological role Not a binary relationship ...
... Not exactly a biological role Not a binary relationship ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.