Slide 1
... • Appreciate the levels of evidence supporting different drug-herb interactions • Be able to compare scientific information to assess the significance of potential drug-herb interactions, in particularly cardiovascular drugs – herbs interactions ...
... • Appreciate the levels of evidence supporting different drug-herb interactions • Be able to compare scientific information to assess the significance of potential drug-herb interactions, in particularly cardiovascular drugs – herbs interactions ...
Chapter Sixteen: Using Drugs Responsibly
... All recreational drugs contain psychoactive substances that affect moods, perceptions, and thoughts. Humans have always sought ways to change states of consciousness. No one really understands why people seek and use psychoactive drugs. For some, these drugs increase pleasurable sensations and feeli ...
... All recreational drugs contain psychoactive substances that affect moods, perceptions, and thoughts. Humans have always sought ways to change states of consciousness. No one really understands why people seek and use psychoactive drugs. For some, these drugs increase pleasurable sensations and feeli ...
Presentation
... Optimising anti-bacterial activities for complex peptides & carbohydrates Transforming an anti-Gram (+) compound into an anti-Gram (-) compound ...
... Optimising anti-bacterial activities for complex peptides & carbohydrates Transforming an anti-Gram (+) compound into an anti-Gram (-) compound ...
article pdf - ONdrugDelivery
... atrophy of the retina. Although this process can be very slow, it leads to irreversible loss of vision. There are no FDA-approved treatments for dry-AMD, the most prevalent incidence of AMD. In approximately 15% of cases, new blood vessels grow under and through the RPE, which are leaky and fragile, ...
... atrophy of the retina. Although this process can be very slow, it leads to irreversible loss of vision. There are no FDA-approved treatments for dry-AMD, the most prevalent incidence of AMD. In approximately 15% of cases, new blood vessels grow under and through the RPE, which are leaky and fragile, ...
dose-effect relationship
... colchicine, an anti-inflammatory agent). Traditionally, drug binding was used to identify or purify receptors from tissue extracts; However, advances in molecular biology and genome sequencing have begun to reverse this order. Now receptors are being discovered by predicted structure or sequence hom ...
... colchicine, an anti-inflammatory agent). Traditionally, drug binding was used to identify or purify receptors from tissue extracts; However, advances in molecular biology and genome sequencing have begun to reverse this order. Now receptors are being discovered by predicted structure or sequence hom ...
Perspectives in MicroRNA Therapeutics
... target sites, located in the 3’ UTR of messenger RNAs, are often imperfectly matched to the microRNA sequence. MicroRNAs do not require perfect complementarity for target recognition, so a single microRNA is able to regulate multiple messenger RNAs. Although microRNAs exert subtle effects on each in ...
... target sites, located in the 3’ UTR of messenger RNAs, are often imperfectly matched to the microRNA sequence. MicroRNAs do not require perfect complementarity for target recognition, so a single microRNA is able to regulate multiple messenger RNAs. Although microRNAs exert subtle effects on each in ...
DEVELOPMENT AND VALIDATION OF A NOVEL SPECTROPHOTOMETRIC ANALYTICAL
... Angiotensin II receptor blockers. It is a prodrug and is rapidly deesterifies during absorption to form olmesartan, the active metabolite2-3. Olmesartan is more effective than other angiotensin II receptor blockers (candesartan,irbesartan, losartan and valsartan) tested at their recommended doses, i ...
... Angiotensin II receptor blockers. It is a prodrug and is rapidly deesterifies during absorption to form olmesartan, the active metabolite2-3. Olmesartan is more effective than other angiotensin II receptor blockers (candesartan,irbesartan, losartan and valsartan) tested at their recommended doses, i ...
Drugs that increase the INR and risk of bleed Drugs that decrease
... on warfarin. This list is not exhaustive - refer to the British National Formulary (BNF) for further information. If any of the drugs below are to be started in these patients then the use of alternatives in the same therapeutic class may be considered. If this is not possible then the patient’s INR ...
... on warfarin. This list is not exhaustive - refer to the British National Formulary (BNF) for further information. If any of the drugs below are to be started in these patients then the use of alternatives in the same therapeutic class may be considered. If this is not possible then the patient’s INR ...
Hypnosis - AP Psychology
... unless you are resistant to the idea • Hypnotizability is associated with bright, imaginative people. One of the more frequent correlates of an individual's ability to be hypnotized is whether he/she had an imaginary friend as a child. It is also thought that a willingness to suspend belief is relat ...
... unless you are resistant to the idea • Hypnotizability is associated with bright, imaginative people. One of the more frequent correlates of an individual's ability to be hypnotized is whether he/she had an imaginary friend as a child. It is also thought that a willingness to suspend belief is relat ...
annexure – ii
... transport across a biological membrane, is the product of permeability and solubility. According to the biopharmaceutics classification system (BCS), aqueous solubility and permeability are the most important parameters affecting drug bioavailability. Retrospective studies show that greater than 40% ...
... transport across a biological membrane, is the product of permeability and solubility. According to the biopharmaceutics classification system (BCS), aqueous solubility and permeability are the most important parameters affecting drug bioavailability. Retrospective studies show that greater than 40% ...
Neurobiology of Drug Addiction - National Center for State Courts
... involved in the rewarding effects of drugs of abuse. Composed of central nucleus of the amygdala, bed nucleus of the stria terminalis, and a transition zone in the medial part of the nucleus accumbens Corticotropin-Releasing Factor — “brain stress” neurotransmitter, 41 amino acid polypeptide that co ...
... involved in the rewarding effects of drugs of abuse. Composed of central nucleus of the amygdala, bed nucleus of the stria terminalis, and a transition zone in the medial part of the nucleus accumbens Corticotropin-Releasing Factor — “brain stress” neurotransmitter, 41 amino acid polypeptide that co ...
Endocrinology Drug List
... radioactive half life = 8 days must be isolated to avoid pregnant women and children ...
... radioactive half life = 8 days must be isolated to avoid pregnant women and children ...
hypnosis and drugs
... •Hidden observer; Ernest Hilgard determined that a person has a split consciousness that involuntarily knows what is happening; dissociation •Distinctive brain activity does accompany hypnosis •Hypnotic pain relief may result from selective attention; PET scans do show reduced activity in pain proce ...
... •Hidden observer; Ernest Hilgard determined that a person has a split consciousness that involuntarily knows what is happening; dissociation •Distinctive brain activity does accompany hypnosis •Hypnotic pain relief may result from selective attention; PET scans do show reduced activity in pain proce ...
Therapeutic drug monitoring
... patient’s serum creatinine concentration and the rate of urinary excretion of creatinine. The approach is similar to that used in the determination of drug clearance. In practice, the rate of urinary excretion of creatinine is measured by the entire day to obtain a reliable excretion rate. The s ...
... patient’s serum creatinine concentration and the rate of urinary excretion of creatinine. The approach is similar to that used in the determination of drug clearance. In practice, the rate of urinary excretion of creatinine is measured by the entire day to obtain a reliable excretion rate. The s ...
Chemical Biology -2014-15.indd - Indian Institute of Chemical Biology
... Gene expression and Mass spectroscopy data analysis: analysis of DNA microarray data (especially clustering approaches) and correlation of gene expression data to biological processes. In silico tools for analysis of proteomics data (Tools available at ExPASy Proteomics server); computational method ...
... Gene expression and Mass spectroscopy data analysis: analysis of DNA microarray data (especially clustering approaches) and correlation of gene expression data to biological processes. In silico tools for analysis of proteomics data (Tools available at ExPASy Proteomics server); computational method ...
4a-Pharmacodynamics,ADRs (Lec.1 & 2)
... Explain drug combinations Describe therapeutic index of a drug Discuss the significance of therapeutic index Identify different types of drug actions Explain mechanisms of drug actions Describe the receptor theory of drug actions Determine the different factors modifying drug action Discuss toleranc ...
... Explain drug combinations Describe therapeutic index of a drug Discuss the significance of therapeutic index Identify different types of drug actions Explain mechanisms of drug actions Describe the receptor theory of drug actions Determine the different factors modifying drug action Discuss toleranc ...
Drugs Affecting the Central Nervous System #1
... • The precursor of DA that is taken orally and converted into DA in the basal ganglia • Administered in combination with carbidopa that increases the amount of DA that enters the brain • Levodopa and carbidopa drug combination known as Sinemet • Levodopa is considered the most effective drug for the ...
... • The precursor of DA that is taken orally and converted into DA in the basal ganglia • Administered in combination with carbidopa that increases the amount of DA that enters the brain • Levodopa and carbidopa drug combination known as Sinemet • Levodopa is considered the most effective drug for the ...
Investigational New Drug (IND) Submission checklist
... Need for studies depend on the nature of the drug and the phase of human investigation, including acute, sub-acute and chronic toxicity tests, tests on reproduction and fetal effects, any special toxicity tests unique to the product’s use (e.g., dermal, inhalation, etc.) and any necessary in vitro t ...
... Need for studies depend on the nature of the drug and the phase of human investigation, including acute, sub-acute and chronic toxicity tests, tests on reproduction and fetal effects, any special toxicity tests unique to the product’s use (e.g., dermal, inhalation, etc.) and any necessary in vitro t ...
2015 Preferred Drug List Exclusions
... 2015 Preferred Drug List Exclusions The excluded medications shown below are not covered on the Express Scripts drug list. In most cases, if you fill a prescription for one of these drugs, you will pay the full retail price. Take action to avoid paying full price. If you are currently using one of t ...
... 2015 Preferred Drug List Exclusions The excluded medications shown below are not covered on the Express Scripts drug list. In most cases, if you fill a prescription for one of these drugs, you will pay the full retail price. Take action to avoid paying full price. If you are currently using one of t ...
tutorial on carbohydrates
... 12. The polymer chains of glycosaminoglycans are widely spread apart and bind large amount of water. a. What 2 functional groups of the polymer make this binding of water possible? b. What type of binding is involved? 13. In glycoproteins, what are the 3 amino acids to which the carbohydrate groups ...
... 12. The polymer chains of glycosaminoglycans are widely spread apart and bind large amount of water. a. What 2 functional groups of the polymer make this binding of water possible? b. What type of binding is involved? 13. In glycoproteins, what are the 3 amino acids to which the carbohydrate groups ...
Carbamazepine: Watch for Many Potential Drug Interactions
... patient receiving carbamazepine for CYP3A4 can affect carbamazepine, potential drug interactions. PT however, reducing its plasma concentrations. The result of an inducer on carbamazepine would be to reduce its plasma concentrations and efficacy. While more of the active metabolite of carbaFor lists ...
... patient receiving carbamazepine for CYP3A4 can affect carbamazepine, potential drug interactions. PT however, reducing its plasma concentrations. The result of an inducer on carbamazepine would be to reduce its plasma concentrations and efficacy. While more of the active metabolite of carbaFor lists ...
Prodrugs and active metabolites among antidepressive
... Knowledge-based system of pharmacokinetics and metabolism of the drugs has a high impact in understanding both the pharmacokinetic and the pharmacodynamic interactions. Cytochrome P450 isoenzymes taking part in the metabolic activity of the central nervous system is a developing area in metabolic st ...
... Knowledge-based system of pharmacokinetics and metabolism of the drugs has a high impact in understanding both the pharmacokinetic and the pharmacodynamic interactions. Cytochrome P450 isoenzymes taking part in the metabolic activity of the central nervous system is a developing area in metabolic st ...
PHARMACOLOGY IN PSYCHIATRIC CARE
... Clinical studies have not identified risk to fetus in any trimester ...
... Clinical studies have not identified risk to fetus in any trimester ...
Social Problems - American Character Builders
... health, education, family ties and social life at risk. Face your problems. Using marijuana won’t help you escape your problems, it will only create more. If you know someone with a drug problem, be a part of the solution. ...
... health, education, family ties and social life at risk. Face your problems. Using marijuana won’t help you escape your problems, it will only create more. If you know someone with a drug problem, be a part of the solution. ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.