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03/05 PPT
03/05 PPT

... • Different cells respond to the same guidance cues in different ways • Chemical cues exist at many points along the axon guidance pathway e.g the optic tectum and optic tract ...
ANS VS PNS
ANS VS PNS

... AUTOMATIC NERVOUS SYSTEM Controlled and part of PNS  Involuntary Muscle Movements  Regulates glands, cardiac, and smooth muscle by returning them back to homeostasis; just like the reflex arc ...
The Scientist » Magazine » Lab Tools
The Scientist » Magazine » Lab Tools

... use for imaging glial activity. For instance, users found that it was difficult to image signaling in astrocytes’ narrow processes, as the GCaMP molecules gathered primarily in the cell body. So Bergles and his colleagues generated mice whose astrocytes tether GCaMP molecules to their cell membranes ...
Role of Astrocytes, Soluble Factors, Cells Adhesion Molecules and
Role of Astrocytes, Soluble Factors, Cells Adhesion Molecules and

... Synapses are highly asymmetric cellular junctions designed for rapid and repetitive signaling between neurons and their targets. A synapse comprises of 3 distinct components: a pre-synaptic specialization, a synaptic cleft, and a post-synaptic specialization (Fig. (1)). The pre-synaptic specializati ...
The Nervous System
The Nervous System

... Relays information to/from brain Processes some information on its own Starts at end of brain stem (C1) Ends at the conus medullaris (around L2) • Terminal group of nerves = cauda equina • Anchored by the filum terminale – Extension of the dura mater descending to the coccyx ...
Shaping dendrites with machinery borrowed from
Shaping dendrites with machinery borrowed from

... well as sensory epithelia [49,50]. Likewise, the C. elegans homolog SAX-7 was identified for a neuronal role in axon guidance [51], but is also expressed in epithelia where it acts at sites of cell contact to maintain tissue attachment [52,53]. Recent work has shown that SAX-7 acts in concert with t ...
G - Computer Science - University of Memphis
G - Computer Science - University of Memphis

... some species of the great apes can use rudimentary language (Savage-Rumbaugh, ...
Functional Anatomy of the Peripheral Nervous System
Functional Anatomy of the Peripheral Nervous System

... – Several dendrites – Brain & SC ...
52 Nerve Tissue
52 Nerve Tissue

... A neuron has only one axon, which conducts impulses away from the parent neuron to other functionally related neurons or effector organs. The axon arises from the axon hillock, an elevation on the surface of the perikaryon that lacks Nissl substance. Occasionally, axons may arise from the base of a ...
Propagation of cortical synfire activity: survival probability in single
Propagation of cortical synfire activity: survival probability in single

... If all neurons in the ®rst group are activated synchronously, they will cause the neurons of the second group to ®re synchronously and so on. Thus, each activated group will pass a spike volley on to the next group. This process will continue, until either the chain comes to an end, or other (e.g. i ...
Dopamine Neurons Mediate a Fast Excitatory Signal
Dopamine Neurons Mediate a Fast Excitatory Signal

... lidocaine N-ethyl bromide (QX-314; Sigma-RBI) was added to the internal solution. The liquid junction potential was ⬃15 mV and was corrected offline. Cells were voltage-clamped at ⫺85 mV, unless otherwise noted, using an Axopatch 200 amplifier (Axon Instruments). Series resistances were 20 – 45 M⍀ a ...
Extended PDF
Extended PDF

... SS, somatosensory cortex; MO, motor cortex; AUD, auditory cortex; VISal, visual cortex; PTLp, posterior parietal association areas; Medial, including anterior cingulate area, dorsal peduncular area, infralimbic area, prelimbic area, and retrosplenial area. Data are presented as mean ± SEM. n.s., not ...
Neural Substrate Expansion for the Restoration of Brain
Neural Substrate Expansion for the Restoration of Brain

... damage is one of the principal objectives of modern translational neuroscience. Electrical stimulation approaches, such as deep-brain stimulation, have achieved the most clinical success, but they ultimately may be limited by the computational capacity of the residual cerebral circuitry. An alternat ...
An Optogenetic Approach to Understanding the Neural Circuits of Fear
An Optogenetic Approach to Understanding the Neural Circuits of Fear

... Neural circuits underlie our ability to interact in the world and to learn adaptively from experience. Understanding neural circuits and how circuit structure gives rise to neural firing patterns or computations is fundamental to our understanding of human experience and behavior. Fear conditioning ...
Electrical Properties of Hypothalamic Neuroendocrine Cells
Electrical Properties of Hypothalamic Neuroendocrine Cells

... neuroendocrine cell resembles that of non-endocrine neurons or of nonnervous glandular cells (12, 21, 28). 1 The preoptic nucleus of lower vertebrates, which differentiates into the supraoptic and paraventricular nuclei in higher forms, produces the hormones of the neural lobe of the pituitary (40). ...
Chapter 3
Chapter 3

... The major sequence of events that allow communication between neurons across the synapse are as follows: 1. The neuron synthesizes chemicals that serve as neurotransmitters. 2. Neurons store neurotransmitters in axon terminals or transport them there. 3. An action potential triggers the release of n ...
Brain Research - Dana Foundation
Brain Research - Dana Foundation

... The outermost layer, the cerebral cortex, is a fraction of an inch thick but contains 70 percent of all neurons. This most evolved part of the brain is divided into lobes specialized to regulate ...
Synapse Formation
Synapse Formation

... Agrin is release by the presynaptic terminal and activates a receptor complex that includes MuSK At the intracellular side of the postsynaptic membrane, rapsyn is required for agrin-mediated clustering ...
Lecture 22 clustering (3)
Lecture 22 clustering (3)

... • Both SOM and LVQ are proposed by T. Kohonen. • Biological motivations: Different regions of a brain (cerebral cortex) seem to tune into different tasks. Particular location of the neural response of the "map" often directly corresponds to specific modality and quality of sensory signal. • SOM is a ...
35-2 The Nervous System
35-2 The Nervous System

... The largest part of a typical neuron is the cell body. It contains the nucleus and much of the cytoplasm. ...
Target-cell-specific concentration of a metabotropic glutamate
Target-cell-specific concentration of a metabotropic glutamate

... terminals is regulated by presynaptic receptors responding to transmitters released fro m the same nerve terminal or from terminals of other neurons. The release of glutamate, the major excitatory neurotransmitter, is suppressed by presynaptic auto· receptors'-J. Here we show that a metabotropic glu ...
Minimal model of strategy switching in the plus
Minimal model of strategy switching in the plus

... These results suggest that different strategies are indeed encoded in the activities of the strategy-selective cells in our model, in a manner resembling the strategy encoding by the rat PFC neurons [8]. It is interesting to see what predictions can be derived from this simple model. The principal f ...
Rapid Neural Coding in the Retina with Relative Spike Latencies
Rapid Neural Coding in the Retina with Relative Spike Latencies

... measured the spatiotemporal filter in a separate reverse-correlation experiment (fig. S1) (14), whereas the threshold remained as a single free parameter. In using this model to process grating stimuli, one quickly finds that it cannot account for the observed responses. Because the stimulus is inte ...
Chapter 5
Chapter 5

... The serious developmental delays seen in institutionalized children who are severely deprived of experiences with motor activity demonstrate that environmental factors are also crucial for proper motor development. Some types of experiences may promote the acquisition of motor milestones. Cross-Cul ...
Artificial Neural Networks - A Science in Trouble
Artificial Neural Networks - A Science in Trouble

... The notion that each neuron or cell in the brain is an "autonomous/independent learner" is one of the fundamental notions of this field. Under this notion, it is construed that individual cells modify their synaptic strengths (connection weights) solely on the basis of their "input and output behavi ...
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Nervous system network models

Network of human nervous system comprises nodes (for example, neurons) that are connected by links (for example, synapses). The connectivity may be viewed anatomically, functionally, or electrophysiologically. These are presented in several Wikipedia articles that include Connectionism (a.k.a. Parallel Distributed Processing (PDP)), Biological neural network, Artificial neural network (a.k.a. Neural network), Computational neuroscience, as well as in several books by Ascoli, G. A. (2002), Sterratt, D., Graham, B., Gillies, A., & Willshaw, D. (2011), Gerstner, W., & Kistler, W. (2002), and Rumelhart, J. L., McClelland, J. L., and PDP Research Group (1986) among others. The focus of this article is a comprehensive view of modeling a neural network (technically neuronal network based on neuron model). Once an approach based on the perspective and connectivity is chosen, the models are developed at microscopic (ion and neuron), mesoscopic (functional or population), or macroscopic (system) levels. Computational modeling refers to models that are developed using computing tools.
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