Macrolides and ketolides: azithromycin, clarithromycin, telithromycin * Jerry M. Zuckerman, MD
... The macrolides and ketolides are lipophilic and are extensively distributed in body fluids and tissues. Mean tissue concentrations are 2- to 20-fold greater than serum concentrations for clarithromycin and are 10- to 100fold greater than serum concentrations for azithromycin [14,26]. Tissue concentra ...
... The macrolides and ketolides are lipophilic and are extensively distributed in body fluids and tissues. Mean tissue concentrations are 2- to 20-fold greater than serum concentrations for clarithromycin and are 10- to 100fold greater than serum concentrations for azithromycin [14,26]. Tissue concentra ...
Sedation, Analgesia, and Neuromuscular Blockade in
... Initiation- Loading infusion of up to 1 mcg/kg over 10 to 20 minutes, if needed. Maintenance- Adults generally require a maintenance infusion of 0.2-0.7 mcg/kg/hr. Conscious Sedation Clinically effective onset of sedation 10 to 15 minutes after start of infusion Initiation- Loading infusion ...
... Initiation- Loading infusion of up to 1 mcg/kg over 10 to 20 minutes, if needed. Maintenance- Adults generally require a maintenance infusion of 0.2-0.7 mcg/kg/hr. Conscious Sedation Clinically effective onset of sedation 10 to 15 minutes after start of infusion Initiation- Loading infusion ...
How Well Does Methadone Maintenance
... treatment outcomes of people on 40 mgs of methadone a day and those who were taking 75 mgs of methadone a day. They found that higher doses of methadone are associated with significantly higher treatment retention (in this case a doubling between those who take 40 mgs and day and those who ...
... treatment outcomes of people on 40 mgs of methadone a day and those who were taking 75 mgs of methadone a day. They found that higher doses of methadone are associated with significantly higher treatment retention (in this case a doubling between those who take 40 mgs and day and those who ...
Fall Newsletter September 2015
... It shouldn’t come as a surprise that diabetes is a prevalent disease for members of Gold Coast Health Plan (GCHP) and for costs to the Plan. In terms of pharmacy costs, diabetes is the most expensive disease. In the first six months of 2015, GCHP spent $11.1 million on providing medications and supp ...
... It shouldn’t come as a surprise that diabetes is a prevalent disease for members of Gold Coast Health Plan (GCHP) and for costs to the Plan. In terms of pharmacy costs, diabetes is the most expensive disease. In the first six months of 2015, GCHP spent $11.1 million on providing medications and supp ...
Parazoanthoxanthin A blocks Torpedo nicotinic acetylcholine
... ParaA and tacrine are structurally similar, and both substances are anticholinesterase agents. It is also possible that they could similarly modify nAChR responses. This view is supported by the observation that tacrine shortens the open time of nAChR, meaning that it is an open channel blocker [20] ...
... ParaA and tacrine are structurally similar, and both substances are anticholinesterase agents. It is also possible that they could similarly modify nAChR responses. This view is supported by the observation that tacrine shortens the open time of nAChR, meaning that it is an open channel blocker [20] ...
Management of bipolar disorder - Mental Health and Family Medicine
... safety and tolerability profiles compared with typical antipsychotics, but side-effects associated with some of the newer agents, such as weight gain and metabolic disturbance, should be taken into consideration when formulating a patient’s treatment plan.27,33 The characteristic properties of medic ...
... safety and tolerability profiles compared with typical antipsychotics, but side-effects associated with some of the newer agents, such as weight gain and metabolic disturbance, should be taken into consideration when formulating a patient’s treatment plan.27,33 The characteristic properties of medic ...
MCQ - North West Urology
... A) Lamm’s protocol use 28 doses BCG over a period of 3 years-F (27 doses over 3 yrs) B) SWOG trial protocol uses maintenance BCG for 1 year only-F (used Lamm’s) C) BCG maintenance drop out rate is as high as 84% according to SWOG trial-T D) There is good evidence to suggest that Immuncyst BCG is mor ...
... A) Lamm’s protocol use 28 doses BCG over a period of 3 years-F (27 doses over 3 yrs) B) SWOG trial protocol uses maintenance BCG for 1 year only-F (used Lamm’s) C) BCG maintenance drop out rate is as high as 84% according to SWOG trial-T D) There is good evidence to suggest that Immuncyst BCG is mor ...
Desmopressin Acetate Nasal Spray, 10 mcg per 0.1 mL
... be performed with caution. Carcinogenes is , Mutagenes is , Impairment of Fertility Studies with Desmopressin Acetate have not been performed to evaluate carcinogenic potential, mutagenic potential or effects on fertility. Pregnancy Category B Fertility studies have not been done. Teratology studie ...
... be performed with caution. Carcinogenes is , Mutagenes is , Impairment of Fertility Studies with Desmopressin Acetate have not been performed to evaluate carcinogenic potential, mutagenic potential or effects on fertility. Pregnancy Category B Fertility studies have not been done. Teratology studie ...
Patient Registries and Participating in Clinical Trials
... Is a larger study worth doing, will there be problems? ...
... Is a larger study worth doing, will there be problems? ...
Local anesthetics Part I
... oxidation of the vasoconstrictor (4). Methylparaben was previously used as a preservative in anesthetic carpules but due to its high potential for allergic reactions, it was removed from single dose cartridges and currently is found only in multidose anesthetic vials (1,4). The addition of vasoconst ...
... oxidation of the vasoconstrictor (4). Methylparaben was previously used as a preservative in anesthetic carpules but due to its high potential for allergic reactions, it was removed from single dose cartridges and currently is found only in multidose anesthetic vials (1,4). The addition of vasoconst ...
P R E S C R I B I N G I N F O R M A T I O N
... In vitro data on metabolic interactions indicate that KEPPRA XR is unlikely to produce, or be subject to, pharmacokinetic interactions. Levetiracetam and its major metabolite, at concentrations well above Cmax levels achieved within the therapeutic dose range, are neither inhibitors of nor high affi ...
... In vitro data on metabolic interactions indicate that KEPPRA XR is unlikely to produce, or be subject to, pharmacokinetic interactions. Levetiracetam and its major metabolite, at concentrations well above Cmax levels achieved within the therapeutic dose range, are neither inhibitors of nor high affi ...
Effectiveness of MTX+TNFi, MTX+DMARDs and MTX+Pred
... Objectives: To investigate the effect of MTX combining with Pred, DMARDs and TNFi to treat type-II collagen-induced arthritis (CIA) rats, respectively. Furthermore, we detected the serum of IL-17A (the characteristic cytokine of Th17) and the variation of Th17 and Tregs. Finally, whether glucocortic ...
... Objectives: To investigate the effect of MTX combining with Pred, DMARDs and TNFi to treat type-II collagen-induced arthritis (CIA) rats, respectively. Furthermore, we detected the serum of IL-17A (the characteristic cytokine of Th17) and the variation of Th17 and Tregs. Finally, whether glucocortic ...
Opioids for chronic noncancer pain
... adults,9 for chronic low back pain,10 and for neuropathic pain.11 Opioids are not recommended for use in treating tension-type headaches,12 and fewer than 20% of patients with refractory daily headache likely improve in sustained reduced pain and function.e6 In addition, the AAN, in its Choosing Wis ...
... adults,9 for chronic low back pain,10 and for neuropathic pain.11 Opioids are not recommended for use in treating tension-type headaches,12 and fewer than 20% of patients with refractory daily headache likely improve in sustained reduced pain and function.e6 In addition, the AAN, in its Choosing Wis ...
Drug utilisation sub-committee (DUSC)
... Dose and frequency of administration The recommended dose of ipilimumab is 3mg/kg administered intravenously over 90 minutes every 3 weeks for a total of 4 doses. Where there is any withholding of a dose, ipilimumab should be resumed at a dose of 3mg/kg every 3 weeks until administration of all 4 pl ...
... Dose and frequency of administration The recommended dose of ipilimumab is 3mg/kg administered intravenously over 90 minutes every 3 weeks for a total of 4 doses. Where there is any withholding of a dose, ipilimumab should be resumed at a dose of 3mg/kg every 3 weeks until administration of all 4 pl ...
Adalimumab Humira® – Abbott Laboratories Limited
... age group, the peak onset of disease is most often seen in the second or third decade. Crohn's disease is a chronic, incurable, relapsing condition. A patient is considered to be in clinical remission when there are few or no symptoms. A relapse or disease flare can be defined as the recurrence of s ...
... age group, the peak onset of disease is most often seen in the second or third decade. Crohn's disease is a chronic, incurable, relapsing condition. A patient is considered to be in clinical remission when there are few or no symptoms. A relapse or disease flare can be defined as the recurrence of s ...
Central Nervous System Mechanisms Involving GABA
... 3.3 kg were anesthetized with a-chloralose, 70-80 mg/kg, iv. A femoral artery and vein were cannulated for measurement of arterial pressure and systemic administration of drugs, respectively. The trachea was cannulated and all cats were artificially ventilated with room air. Animals then were immobi ...
... 3.3 kg were anesthetized with a-chloralose, 70-80 mg/kg, iv. A femoral artery and vein were cannulated for measurement of arterial pressure and systemic administration of drugs, respectively. The trachea was cannulated and all cats were artificially ventilated with room air. Animals then were immobi ...
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... iii. Vasospasms may play a role in CACP, the pathophysiology of cocaine toxicity is complex59 b. Cocaine + β-‐blocker →unopposed α effect i. Ramoska and Sacchetti observed that blood pressure (BP) increased ...
... iii. Vasospasms may play a role in CACP, the pathophysiology of cocaine toxicity is complex59 b. Cocaine + β-‐blocker →unopposed α effect i. Ramoska and Sacchetti observed that blood pressure (BP) increased ...
An Endocrine Society Clinical
... be repeated after a 1:100 serum sample dilution to overcome a potential hook effect. Alternatively, after prolactin binding to the first antibody, a washout could be performed to eliminate excess unbound prolactin before adding the second antibody. Modestly elevated prolactin may occur in patients w ...
... be repeated after a 1:100 serum sample dilution to overcome a potential hook effect. Alternatively, after prolactin binding to the first antibody, a washout could be performed to eliminate excess unbound prolactin before adding the second antibody. Modestly elevated prolactin may occur in patients w ...
Central Nervous System Mechanisms Involving GABA Influence
... 3.3 kg were anesthetized with a-chloralose, 70-80 mg/kg, iv. A femoral artery and vein were cannulated for measurement of arterial pressure and systemic administration of drugs, respectively. The trachea was cannulated and all cats were artificially ventilated with room air. Animals then were immobi ...
... 3.3 kg were anesthetized with a-chloralose, 70-80 mg/kg, iv. A femoral artery and vein were cannulated for measurement of arterial pressure and systemic administration of drugs, respectively. The trachea was cannulated and all cats were artificially ventilated with room air. Animals then were immobi ...
Drug-Induced Diseases: Depression
... between clonidine and depression is supported by case-report data. However, larger evaluative studies suggest that the incidence of depression in patients taking clonidine is similar to that in the general population.15 The risk of depression associated with β -blocker therapy remains somewhat contr ...
... between clonidine and depression is supported by case-report data. However, larger evaluative studies suggest that the incidence of depression in patients taking clonidine is similar to that in the general population.15 The risk of depression associated with β -blocker therapy remains somewhat contr ...
(PSD) July 2016 PBAC Meeting
... In both arms of trial CA209-025, patients were able to continue receiving treatment beyond progression if they were assessed as still deriving clinical benefit and tolerating treatment. The submission claimed that progression based on discontinuation of treatment would be more clinically representat ...
... In both arms of trial CA209-025, patients were able to continue receiving treatment beyond progression if they were assessed as still deriving clinical benefit and tolerating treatment. The submission claimed that progression based on discontinuation of treatment would be more clinically representat ...
to the Akten FAQs PDF
... have been performed in both rats and rabbits. There was no evidence of harm to the fetus at subcutaneous doses up to 50 mg/kg lidocaine (more than 800 fold greater than the human dose on a body weight basis) in the rat model. There are however, no adequate and well controlled studies in pregnant wom ...
... have been performed in both rats and rabbits. There was no evidence of harm to the fetus at subcutaneous doses up to 50 mg/kg lidocaine (more than 800 fold greater than the human dose on a body weight basis) in the rat model. There are however, no adequate and well controlled studies in pregnant wom ...
RISK PROFILE of acetanilide
... dose for adults and children over 40 kg depends on the treatment cause; for analgesic effect: 800-1200 mg/day divided on 3-4 doses, anti-inflammatory effect: 2400 mg or more per day. Recommended doses for children less than 40 kg range from 100-200 mg 4 times a day, depending on body weight. Gel-pre ...
... dose for adults and children over 40 kg depends on the treatment cause; for analgesic effect: 800-1200 mg/day divided on 3-4 doses, anti-inflammatory effect: 2400 mg or more per day. Recommended doses for children less than 40 kg range from 100-200 mg 4 times a day, depending on body weight. Gel-pre ...
Astaxanthin - Pure Encapsulations
... Are There Any Potential Drug Interactions? At this time, there are no known adverse reactions when taken in conjunction with medications. ...
... Are There Any Potential Drug Interactions? At this time, there are no known adverse reactions when taken in conjunction with medications. ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.