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SP Koppikar Clinical Experiences of 70 Years in
SP Koppikar Clinical Experiences of 70 Years in

... antihistamine syrup. From then, almost every 3 weeks the child was down for 4 to 6 days, each time a bronchitis threatening broncho-pneumonia and wheezing dyspnoea, (expiratory wheezing more) and needing stronger and stronger and different antibiotic every time. The cough used to be severe with chok ...
ADVERSE DRUG REACTIONS
ADVERSE DRUG REACTIONS

... i) Toxicity of overdose (Drug overdose) An adverse drug reaction caused by excessive dosing e.g., hepatic failure with dose of paracetamol Headache with antihypertensives hypoglycemia with sulfonylurea; ...
Newer anti anginals
Newer anti anginals

Major Depressive Disorders
Major Depressive Disorders

... Mirtazapine (Remeron, Organon)  Receptors: -5HT2 and 5HT3 antagonist, histamine 1, ...
for the treatment of atrial fibrillation
for the treatment of atrial fibrillation

... 0.89, p = 0.002). Furthermore, dronedarone significantly reduced the ventricular rate response when compared to placebo during the recurrence of arrhythmia in both European and non-European trials (102.3 ± 24.7 vs 117.5 ± 29.1 and 104.6 ± 27.1 vs 116.6 ± 31.9 in EURIDIS and ADONIS, respectively). In ...
Successful Drug Discovery, Volume 1 Brochure
Successful Drug Discovery, Volume 1 Brochure

... The first volume of the book series Successful Drug Discovery is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small–molecule–, peptide–, and protein–based drugs. The role of serendipity is analyzed in some very successful ...
Overview of Vinca Alkaloids
Overview of Vinca Alkaloids

... stopped and motor neurotoxicity may be irreversible  Autonomic polyneuropathy ...
Vol. 8, No. 3, March 2012 “Happy Trials to You” Adverse Event and
Vol. 8, No. 3, March 2012 “Happy Trials to You” Adverse Event and

... Proper coding is complete. For example, if an investigator reports a sign or symptom of “gold,” which is not in the MedDRA database, the report should not be ignored. Instead, the sponsor should send a data query to the investigator asking for clarification. Proper coding is accurate. Investigator’s ...
Clinical Pharmacology
Clinical Pharmacology

... – Clearance: rate of elimination of drug from the body = dose AUC – Half-life: time required for drug concentration in plasma to  by half • alpha -rate of distribution into tissues • beta - rate of elimination from body • gamma - in case of slow, delayed elimination ...
mycophenolate mofetil mycophenolic acid (mye-koe-fee-noe-lik)
mycophenolate mofetil mycophenolic acid (mye-koe-fee-noe-lik)

... Cholestyramine and colestipolpthe absorption of MPA (avoid concurrent use). Maypthe effectiveness of oral contraceptives (additional contraceptive method should be used). Maypthe antibody response to andqrisk of adverse reactions from live-virus vaccines, although influenza vaccine may be useful. Am ...
Elicited Behavior and Classical Conditioning
Elicited Behavior and Classical Conditioning

... cells in the body. Some of the dose molecules may bind to inactive sites such as plasma proteins or storage depots (3) and some to receptors in target tissue. Blood-borne dose molecules also enter the liver (4), where they may be transformed into metabolites and travel to the kidneys and other disch ...
Alzheimer`s Disease
Alzheimer`s Disease

... Reserve drug treatment for situations where nonpharmacological interventions have failed or in situations with dangerous risk,(agitation, hitting). ...
Name of Medication - Ark Veterinary Centre
Name of Medication - Ark Veterinary Centre

... Potential side effects such as diarrhoea may occur; contact your veterinary surgeon. Other side effects may occur. If you notice anything unusual, contact your veterinary surgeon. Possible Drug Interactions Make sure to tell your veterinary surgeon what other medication you are giving to your pet. Q ...
SPIRIVA® 18 microgram, inhalation powder, hard capsule
SPIRIVA® 18 microgram, inhalation powder, hard capsule

... significantly longer dissociation half-life than ipratropium. As an N-quaternary anticholinergic, tiotropium bromide is topically (broncho-) selective when administered by inhalation, demonstrating an acceptable therapeutic range before systemic anticholinergic effects may occur. Pharmacodynamic eff ...
product monograph
product monograph

... PHARMACOLOGY, Pharmacodynamics). The potential for delayed effects on the QT interval was not evaluated. Isolated cases of ECG changes (including QT prolongation) have been observed in patients administered TREANDA at a dose higher than recommended for NHL and CLL patients (see DOSAGE AND ADMINISTRA ...
TOXICOLOGY Case: DRESS Syndrome LETTER 1-800-222-1222
TOXICOLOGY Case: DRESS Syndrome LETTER 1-800-222-1222

... In addition the use of MDAC may facilitate reverse diffusion of drug from the circulation into the gastrointestinal tract by binding drug in the gut, setting up a concentration gradient. This is referred to as “gut-dialysis.1” In a pig model MDAC had no effect on clearance of 300 mg/kg IV aspirin de ...
Searching For Novel Biomarkers in Alzheimer`s Disease
Searching For Novel Biomarkers in Alzheimer`s Disease

... Medications that prevent acetylcholine breakdown often produce side effects including nausea, vomiting, excess saliva and tear production, and sweating. Other than dizziness, no severe side effects were reported in clinical trials investigating huperzine A. Further clinical trials need to be perform ...
Cardiology Review: HTN - Wayne State University
Cardiology Review: HTN - Wayne State University

... Cause decreased peripheral resistance by by inhibiting the actions of angiotensin II at its cell surface receptor Side effect profile similar to ACE-I but decreased likelihood of cough Avoid in pregnancy ...
Efficacy and safety of ipragliflozin as add‐on therapy to insulin in
Efficacy and safety of ipragliflozin as add‐on therapy to insulin in

... treatment period. Patients using oral antidiabetic drugs other than DPP-4 inhibitors entered an additional 4-week washout period before screening. The randomization list was prepared by the patient registration centre and patients were allocated to study groups at a 2:1 ratio by the investigator. To ...
Sodium Nitroprusside - Nottingham University Hospitals NHS Trust
Sodium Nitroprusside - Nottingham University Hospitals NHS Trust

... Calcium chloride Dobutamine Dopamine Esmolol ...
PATIENT INFORMATION ORACEA (Or-RAY
PATIENT INFORMATION ORACEA (Or-RAY

... Pseudotumor cerebri (benign intracranial hypertension) in adults has been associated with the use of tetracyclines. The usual clinical manifestations are headache and blurred vision. Bulging fontanels have been associated with the use of tetracyclines in infants. While both of these conditions and r ...
Revised: December 2016 AN: 00745/2016 SUMMARY OF
Revised: December 2016 AN: 00745/2016 SUMMARY OF

... As for the subject of malignancy, please see sections 4.3 “Contraindications” and 4.5 “Special precautions for use”. Side effects may be severe in individual animals. 4.7 Use during pregnancy, lactation or lay In laboratory animals, at doses which induce maternal toxicity (rats at 30 mg/kg bw and ra ...
what is itchiness?
what is itchiness?

... Rare s/e unmasking systemic infections e.g. fungal infections and Toxoplasmosis – In humans may increase risk for lymphoma (cancer) – not proven in dogs ...
Antivirus agents. Agents used in AIDs treatment. Immunomodulators
Antivirus agents. Agents used in AIDs treatment. Immunomodulators

... reactions in clinic: 1. reactions of immediate type (I, II, III, V types after Cumbs) 2. reactions of delayed type (IV type after Cumbs) ...
Antihypertensive Agents
Antihypertensive Agents

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Bilastine



Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.
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