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Nature`s
Nature`s

GOUT The term gout describes a disease associated with
GOUT The term gout describes a disease associated with

... Therapeutic uses: Allopurinol is effective in the treatment of primary and secondary hyperuricemia of gout and other conditions, such as that associated with certain malignancies or in renal disease. This agent is the drug of choice in those with a history of kidney stones or if the creatinine clea ...
Dimethyl MEA - Mattilsynet
Dimethyl MEA - Mattilsynet

... levels governed by maternal toxicity. Medicinal products DMAE as a drug was discontinued from the US market in 1983, not because of safety issues, but because more efficient drugs became available. In Europe, DMAE is a main ingredient in a commonly prescribed drug, “Centrophenoxine”. Manufacturers' ...
CLINICAL PHARMACOLOGY Dr. P. Oh Aman Hussain, chapter editor
CLINICAL PHARMACOLOGY Dr. P. Oh Aman Hussain, chapter editor

... proprietary name: the brand name or registered trademark street name: drugs of abuse ...
Pharmacology Test #1 Outline Lec. 1: Intro to Principles of
Pharmacology Test #1 Outline Lec. 1: Intro to Principles of

... o pka-pH= log [protinated]/[unprotinated] Bioavailability (F): amount of extravascular administered drug that reaches systemic circulation (due to incomplete absorption and 1st pass effect/metabolism in liver ) Rate of absorption: fastest (IVIMSC) slowest ...
BHF Factfile: The Use of Digoxin
BHF Factfile: The Use of Digoxin

... and exercise tolerance deteriorated after withdrawal in about a quarter of cases, suggesting long-term benefit, there are other effective treatments for heart failure, including ACE inhibitors, beta blockers and spironolactone, all of which reduce mortality. Furthermore, the DIG study, a large prosp ...
CONCERTA Extended-Release Tablets
CONCERTA Extended-Release Tablets

... Metabolism: In humans, methylphenidate is metabolised primarily by de-esterification to -phenylpiperidine acetic acid (PPAA) which has little or no pharmacologic activity. In adults the metabolism of CONCERTA once daily, as evaluated by metabolism to PPAA, is similar to that of methylphenidate thre ...
SUMMARY OF PRODUCT CHARACTERISTICS 1 NAME OF THE
SUMMARY OF PRODUCT CHARACTERISTICS 1 NAME OF THE

... The volume, strength and rate of infusion will depend upon the requirements of individual patients as perceived by the physician. Administration should be effected cautiously and gradually. In less urgent forms of metabolic acidosis, an average dose for adults and older children is 2-5 mmol of bicar ...
The use of rapid onset opioids for breakthrough cancer pain - e-ESO
The use of rapid onset opioids for breakthrough cancer pain - e-ESO

... Breakthrough cancer pain (BTcP) has been defined as a transitory increase in pain intensity on a baseline pain of moderate intensity in patients on analgesic treatment regularly administered. This review provides updated information about the use of opioids for the treatment of BTcP, with special em ...
Recommendations of advisory committee on immunization practices
Recommendations of advisory committee on immunization practices

... (*) Vaccination recommended even in the case of previous vaccination for any indication, and should be administered no less than 5 years after the previous dose (•) Revaccination recommended 5 years after the first dose PCV13, a 13-valent conjugate pneumococcal vaccine, approved in 2010 by the FDA f ...
Aishea omar youiens elkady_rev 1
Aishea omar youiens elkady_rev 1

... the physiologic renal insufficiency in the elderly and so reduction of the observed clearance and this fall in total clearance is responsible for the rise in terminal elimination half life. These modifications in the biodisposition of rilmenidine in the elderly do not require an adaptation of the do ...
Anxiety Disorders Drug Treatment Guidelines
Anxiety Disorders Drug Treatment Guidelines

... The risks and benefits of using benzodiazepines should be carefully considered in each patient. Benzodiazepines have rapid onset, relatively low toxicity, and anxiolytic potency but these benefits should be weighed against potential for motor impairment, dependence and withdrawal symptoms. All p ...
Exam-Objectives
Exam-Objectives

... 1. What is the relationship between a drug effect and the degree of stimulus control over behavior? (i.e., is behavior more likely, or less likely, to be disrupted by a drug if it is strongly controlled by a stimulus?) 2. Describe some pharmacological variables that might influence drug effects.**** ...
Medicine is a constantly changing field that demands breakthroughs
Medicine is a constantly changing field that demands breakthroughs

... differences in the responses to drugs have been identified, for example among the drugs currently used in the treatment of cardiovascular diseases, psychiatric disorders and in many anti-infective agents. Researchers have identified three main types of pharmacogenetic variations among individuals:4 ...
Advisory Committee Mtgs. Sample PPT
Advisory Committee Mtgs. Sample PPT

... • Incomplete or lack of reference for dosimetry calculations. • Inconsistency in dosimetry among investigators within an RDRC – obvious failure of RDRC to standardize. Greater New York City RDRC Meeting, December 2007 ...
Parnate - GSK.ca
Parnate - GSK.ca

... In patients with a previous history of hypersensitivity to tranylcypromine or excipients. In patients with cerebrovascular or cardiovascular disorders or a history of recurrent or frequent headaches. PARNATE® should not be administered to patients with confirmed or suspected cerebrovascular defect, ...
two approaches to ketamine move forward for complex regional pain
two approaches to ketamine move forward for complex regional pain

... ketamine (0.5 mg/kg) and midazolam (2.5-5 mg) until deep sedation is reached. Therapy is maintained with infusions of ketamine (3-7 mg/kg/h) and midazolam (0.15-0.3 mg/kg/h) over five days. On the fifth day infusions are slowly tapered. So far, nine of the 30 patients have experienced complete and p ...
beta lactam antibiotics and other cell wall synthesis
beta lactam antibiotics and other cell wall synthesis

...  3. impaired penetration of drug to target PBPs  4. presence of an efflux pump  Kinetics:  - absorption vary with the preparation depending ...
[acute trust logo] - Coastal West Sussex Formulary
[acute trust logo] - Coastal West Sussex Formulary

... No additional benefit has been demonstrated for doses higher than 1.2mg/kg/day. The safety of doses above 1.8mg/kg has not been systematically evaluated. Dosing of children/adolescents over 70 kg body weight: Initial dose of 40mg per day. This should be maintained for a minimum of 7 days, before tit ...
requip xl extended-release tablets
requip xl extended-release tablets

... Among the 613 patients who received REQUIP XL in clinical trials, there were 5 cases of sudden onset of sleep and 2 cases of motor vehicle accident in which it is not known if falling asleep was a contributing factor. During the 6-month trial in advanced Parkinson’s disease, somnolence was reported ...
Multiple Drug Ingestion For Suicidal Purpose Alprazolam
Multiple Drug Ingestion For Suicidal Purpose Alprazolam

... and bipolar disorder. Minimum lethal level of its blood concentration was reported 5200 mg. After using with other CNS depressant agent risk of arrhythmia and convulsion increases. Acute toxicity with this drug results in rhabdomyolysis, renal failure, hypoxia and seizures (12). Oxcarbazepine (Trile ...
Kyowa Hakko Kirin and Bristol-Myers Squibb Announce Immuno
Kyowa Hakko Kirin and Bristol-Myers Squibb Announce Immuno

... Tumors in the U.S. (NEW YORK and TOKYO, July 29, 2015) - Kyowa Hakko Kirin Co., Ltd. (Tokyo: 4151,“Kyowa Hakko Kirin”) and Bristol-Myers Squibb Company (NYSE: BMY, “BristolMyers Squibb”) today announced that the companies have entered into a clinical trial collaboration agreement to conduct a Phase ...
New Approaches to Chronic Anticoagulation
New Approaches to Chronic Anticoagulation

... • Rivaroxaban was well tolerated, with similar incidence of AEs as enoxaparin • Rivaroxaban did not affect ECG parameters • Rivaroxaban did not have any substance-specific effects on laboratory parameters (except for clotting tests) • LFT increases with BAY 597939 did not exceed the level observed w ...
Antimycobacterial drugs
Antimycobacterial drugs

... Pharmacokinetics ...
March 2008
March 2008

... † The Approval Date is established by the FDA, but does not necessarily mean a generic product is available as of that date, or that such product is available. ‡ This Launch Date/Anticipated Launch Date may not reflect the date of availability for this medication. Due to circumstances beyond the con ...
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Bilastine



Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.
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