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the pharmacokinetics of a thiazole benzenesulfonamide
the pharmacokinetics of a thiazole benzenesulfonamide

Inhaled  clemastine,  an  H
Inhaled clemastine, an H

... immediate effect compared with oral administration. The aim of this study was to examine the effect of an histamine 1 receptor antagonist, delivered as an aerosol, on responses to changes in airway osmolarity. We chose clemastine because it is available in an injectable form and can easily be nebuli ...
current use of analgesics for colic
current use of analgesics for colic

... progressive motility of the small intestine and colon while potentially increasing mixing movements and increasing sphincter tone. This can delay transit of ingesta. The disadvantages of morphine and oxymorphone in the horse with abdominal disease are sufficient to discourage their use. Epidural mor ...
PHARMACOKINETICS OF FELODIPINE AFTER SINGLE ORAL
PHARMACOKINETICS OF FELODIPINE AFTER SINGLE ORAL

... of the University of Medicine and Pharmacy “Iuliu Hatieganu”, ClujNapoca, Romania.  Study protocol The study consisted in two clinical periods, cross-over, with a wash-out period between. In each period, after an overnight fast, the volunteers received a single dose of 10 mg felodipine (either Plen ...
URCC U1202 - Southeast Clinical Oncology Research
URCC U1202 - Southeast Clinical Oncology Research

... National Cancer Institute (NCI) Food and Drug Administration (FDA) Office for Human Research Protections (OHRP) Institutional Review Board (IRB) at your hospital Qualified Representative of applicable drug manufacturers Possible other federal or state government agencies If your record is used or gi ...
Clinically significant drug interactions
Clinically significant drug interactions

... damage, because most NSAIDs do not produce a hypothrombinemic response. When given to or withdrawn from patients maintained on warfarin, NSAIDs may actually alter anticoagulant control as a result of changes in the amount of circulating warfarin released from plasma albumin binding sites. Preliminar ...
Accumulation of phytosterols in food. Evaluation of the adverse
Accumulation of phytosterols in food. Evaluation of the adverse

... was 12%, although it was much greater in some individual patients. Sterol balance data showed that plant sterols inhibit cholesterol absorption with a maximal negative cholesterol balance in adults at a dose of 3 g/day of a tall oil sterol suspension [16]. Another example is the study of Miettinen e ...
Active International Research into Cardiometabolic and Liver Effects
Active International Research into Cardiometabolic and Liver Effects

... been shown to lower LDL- cholesterol , raise HDL-cholesterol and favorably improve the dangerous lipoprotein particle characteristics seen in most Americans who consume excessive carbohydrates. Dietary polyphenols (especially bioflavonoids) may prevent atherosclerosis due to their anti-oxidative and ...
Barbiturate
Barbiturate

... Other sedative and hypnotic agents:Buspirone: The actions of buspirone appear to be mediated by serotonin (5-HT1A) receptors, although other receptors could be involved. Because buspirone displays some affinity for DA2 dopamine receptors and 5-HT2A serotonin receptors. Thus, its mode of action diffe ...
Pharmacodynamics
Pharmacodynamics

... ¾ most drugs act through receptors ¾ there are 4 common signal transduction methods ¾ the interaction between drug and receptor can be described mathematically and graphically ¾ agonists have both affinity and intrinsic activity. ¾ antagonists have affinity only ¾ antagonists can be competitive or ...
Beta Blockers in Mental Retardation and Developmental Disorders
Beta Blockers in Mental Retardation and Developmental Disorders

... Other uses of ß-blockers Substance Withdrawal. Withdrawal symptoms from alcohol and many other drugs involve hyperadrenergic states that might be expected to be at least partially alleviated by β-blockers. The literature now shows only equivocal clinical results (Carlsson 1976, Carlsson and Johansso ...
1/5 PATIENT INFORMATION LEAFLET KLOBATE 0.05% ointment
1/5 PATIENT INFORMATION LEAFLET KLOBATE 0.05% ointment

... is achieved once or twice a day over a period of 4 weeks. Then, the frequency of administration is reduced or the treatment is replaced by a less potent drug. Sufficient time should be waited for absorption before an emollient is applied after each administration Treatment and diagnosis should be re ...
Hydrochlorothiazide - Developing Anaesthesia
Hydrochlorothiazide - Developing Anaesthesia

... Natriuresis may be also be accompanied by some loss of potassium and magnesium. See also Appendix 1 below. Hydrochlorothiazide has properties qualitatively similar to chlorothiazide, although it is about 10 times as potent, on a weight basis When used in recommended low doses for hypertension, the t ...
Tips and tricks in hypertension
Tips and tricks in hypertension

... Increase in serum creatinine with an ACE inhibitor Small increases in serum creatinine, in the order of 0.1 to 0.3-mg/dL are common with an ACE inhibitor that correcting with stopping the drug. Increases > 0.3-mg/dL typically reflect underlying renal micro or macrovascular disease and/or volume con ...
Fuzeon® Prescribing Information
Fuzeon® Prescribing Information

... Because it was unclear whether the higher incidence rate of pneumonia was related to FUZEON use, an observational study in 1850 HIV-infected patients (740 FUZEON treated patients and 1110 non-FUZEON treated patients) was conducted to evaluate the risk of pneumonia in patients treated with FUZEON. A ...
Effectively treating cats with FHM
Effectively treating cats with FHM

... are complicating factors. A significant number of cats with FHM are also feline leukemia virus (FeLV) positive, and it has been shown that concurrent infection with M. haemofelis and FeLV exacerbates the anemia.1,7 Interestingly, simultaneous infection with feline immunodeficiency virus does not app ...
Stribild
Stribild

... antiretrovirals [See Warnings and Precautions (5.1)]. STRIBILD is not approved for the treatment of chronic hepatitis B virus (HBV) infection, and the safety and efficacy of STRIBILD have not been established in patients coinfected with HBV and human immunodeficiency virus-1 (HIV-1). Severe acute ex ...
Tricyclic Antidepressants
Tricyclic Antidepressants

... used to treat depression, but more frequently these agents are used to treat conditions outside of their approved indications, such as for the treatment of insomnia, chronic pain syndromes, generalized anxiety disorder, panic disorder, eating disorders (e.g., bulimia nervosa), and premenstrual dysph ...
A TRANSDERMAL GLUCOSAMINE FORMULATION IMPROVES OSTEOARTHRITIC SYMPTOMS  IN AN OPEN CLINICAL SURVEY Research Article   
A TRANSDERMAL GLUCOSAMINE FORMULATION IMPROVES OSTEOARTHRITIC SYMPTOMS  IN AN OPEN CLINICAL SURVEY Research Article   

... and the cyclo‐oxygenase‐2 (COX‐2) inhibitors  4. The failure of these  conventional  medications  to  satisfactorily  treat  OA  has  resulted  in  increasing search for superior treatment options. Many OA patients  resort  to  the  use  of  unconventional  treatment  methods  such  as  herbal  or  ...
iron isomaltoside 1000, 100mg/mL solution for injection/infusion
iron isomaltoside 1000, 100mg/mL solution for injection/infusion

... or possibly related to study treatment. The numbers of patients with abnormalities on electrocardiogram (ECG) which were classified as clinically significant by the investigator were: four at baseline, two at week 1, two at week 2, one at week 4 and four at week 8. All ECG abnormalities could be exp ...
Clinical study on the efficacy of Amoebex (coded herbal drug
Clinical study on the efficacy of Amoebex (coded herbal drug

... open intervention. All patients examined by the general physician and given either herbal or allopathic medicine for amoebiasis. All patients were divided into two groups, control group and test group on the basis of treatment. ...
Antidepressant agents - به سامانه مديريت
Antidepressant agents - به سامانه مديريت

... only as new enzyme is biosynthesized) Have a rapid rate of elimination, excess drug is rapidly metabolized Inhibition occurs slowly  Ex: phenelzine ,tranylcypomine, isocarboxazid ...
over the counter drugs
over the counter drugs

... abilities are more likely to take gingko. • For example, higher scores on the memory and learning tests may come from subjects who could read and understood articles suggesting gingko might help them, or who were better able remember to take the drug. • Researchers need to give tests both before and ...
Sodium oxybate - Coastal West Sussex Formulary
Sodium oxybate - Coastal West Sussex Formulary

... Sodium oxybate has been shown to significantly reduce cataplexy within four weeks, with near abolition within six months. It also significantly reduces drowsiness and improves nocturnal sleep which is fragmented in narcolepsy. In cataplexy, sodium oxybate also has the advantage of fewer side effects ...
Anticancer efficacy and toxicokinetics of a novel paclitaxel-clofazimine nanoparticulate co- formulation
Anticancer efficacy and toxicokinetics of a novel paclitaxel-clofazimine nanoparticulate co- formulation

... anaesthetised tail veins of 6 mice each at an equivalent PTX dose of 10 mg/kg using a 30-gauge needle over ~1 min using a 1 ml syringe. After administration the animals were observed daily for clinical evidence of toxicity and local tolerance. All surviving animals were weighed every second day for ...
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Bilastine



Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.
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