Chapter 9: Empirical Evidence of the Effects of Amphetamine on
... and pain-induced aggression, as well as intruder–resident models. The problem is that both fear and anger can elicit attack. Pain-induced aggressive behavior is fear induced and thus neurologically very specific. Intruderinduced aggressive behavior is anger induced and thus neurologically very diffe ...
... and pain-induced aggression, as well as intruder–resident models. The problem is that both fear and anger can elicit attack. Pain-induced aggressive behavior is fear induced and thus neurologically very specific. Intruderinduced aggressive behavior is anger induced and thus neurologically very diffe ...
State of the evidence from oral and topical PrEP efficacy
... Javier R. Lama, MD, MPH Director, HIV Prevention Intervention Studies IMPACTA PERU Clinical Trials Unit Lima, Peru ...
... Javier R. Lama, MD, MPH Director, HIV Prevention Intervention Studies IMPACTA PERU Clinical Trials Unit Lima, Peru ...
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... increase the language performance among individuals with aphasia. In this vein, Hemphill (1951) reported findings of short-term improvements (three hours) with an increase in speech fluency and sentence copying after administration of Priscol. Given the short-term effects of Priscol, Hemphill hypoth ...
... increase the language performance among individuals with aphasia. In this vein, Hemphill (1951) reported findings of short-term improvements (three hours) with an increase in speech fluency and sentence copying after administration of Priscol. Given the short-term effects of Priscol, Hemphill hypoth ...
Mitigation of calcium channel blocker-related oedema
... incidence on the method of data collection may also hold true for the rates of oedema reported in clinical trials involving CCBs, as it is evident that very different oedema incidence rates have been reported in CCB-treated groups in different clinical trials.6,17,49–51 Moreover, the data in Table 1 ...
... incidence on the method of data collection may also hold true for the rates of oedema reported in clinical trials involving CCBs, as it is evident that very different oedema incidence rates have been reported in CCB-treated groups in different clinical trials.6,17,49–51 Moreover, the data in Table 1 ...
Several hospitals are participating in a study to test the efficacy of a
... The correct answer is E. Phase III trials consist of large, double-blind, controlled studies using patients for whom the drug is targeted. Typically, 500–5000 patients participate in the study, which is designed to determine whether the drug is more efficacious than placebo, and to compare it ...
... The correct answer is E. Phase III trials consist of large, double-blind, controlled studies using patients for whom the drug is targeted. Typically, 500–5000 patients participate in the study, which is designed to determine whether the drug is more efficacious than placebo, and to compare it ...
Etopophos and associated names - Art. 30 referral
... during etoposide therapy. Etoposide has been shown to be teratogenic in mice and rats (see section 5.3). Given the mutagenic potential of etoposide, an effective contraceptive is required for both male and female patients during treatment and up to 6 months after ending treatment (see section 4.4). ...
... during etoposide therapy. Etoposide has been shown to be teratogenic in mice and rats (see section 5.3). Given the mutagenic potential of etoposide, an effective contraceptive is required for both male and female patients during treatment and up to 6 months after ending treatment (see section 4.4). ...
Dopamine Agonists and the Risk of Cardiac
... • Detection bias could be a concern, since pergolide was discussed in September 2003 by the British Committee on Safety of Medicines as a possible cause of cardiac valvulopathy before the end of the study period leading to an increase in use of diagnostic measures in patients receiving this drug; ho ...
... • Detection bias could be a concern, since pergolide was discussed in September 2003 by the British Committee on Safety of Medicines as a possible cause of cardiac valvulopathy before the end of the study period leading to an increase in use of diagnostic measures in patients receiving this drug; ho ...
The Case Against Antipsychotics
... narrative about the drugs’ merits, we could expect that the arrival of chlorpromazine and other antipsychotics would lead to an improvement in this spectrum of outcomes, a leap forward that would be captured by the research literature. The percentage of first episode patients who recovered and could ...
... narrative about the drugs’ merits, we could expect that the arrival of chlorpromazine and other antipsychotics would lead to an improvement in this spectrum of outcomes, a leap forward that would be captured by the research literature. The percentage of first episode patients who recovered and could ...
TABLE I MEDICATION ISSUES OF PARTICULAR RELEVANCE This
... Since medication issues continue to evolve and new medications are being approved regularly, it is important to refer to a current authoritative source for detailed medication information such as indications and precautions, dosage, monitoring, or adverse consequences. The listed doses for psychopha ...
... Since medication issues continue to evolve and new medications are being approved regularly, it is important to refer to a current authoritative source for detailed medication information such as indications and precautions, dosage, monitoring, or adverse consequences. The listed doses for psychopha ...
These highlights do not include all the information needed to
... FLECTOR PATCH until a serious GI adverse event is ruled out. In the setting of concomitant use of low-dose aspirin for cardiac prophylaxis, monitor patients more closely for evidence of GI bleeding [see Drug Interactions (7)]. 5.3 Hepatotoxicity In clinical trials of oral diclofenac containing produ ...
... FLECTOR PATCH until a serious GI adverse event is ruled out. In the setting of concomitant use of low-dose aspirin for cardiac prophylaxis, monitor patients more closely for evidence of GI bleeding [see Drug Interactions (7)]. 5.3 Hepatotoxicity In clinical trials of oral diclofenac containing produ ...
Cannabidiol as a Potential Treatment for Anxiety Disorders
... CB1R activation are anxiogenic [35], and individuals with eCB system gene polymorphisms that reduce eCB tone— for example, FAAH gene polymorphisms—exhibit physiological, psychological, and neuroimaging features consistent with impaired fear regulation [36]. Reduction of AEA–CB1 R signaling in the am ...
... CB1R activation are anxiogenic [35], and individuals with eCB system gene polymorphisms that reduce eCB tone— for example, FAAH gene polymorphisms—exhibit physiological, psychological, and neuroimaging features consistent with impaired fear regulation [36]. Reduction of AEA–CB1 R signaling in the am ...
Ibuprofen Overdose: 126 Cases - Annals of Emergency Medicine
... oped renal failure with elevated BUN and creatinine. One patient died after ingesting both ibuprofen and salicylates, and was found to have plasma levels of 240 &g/mL of salicylates and 170 ~g/mL of ibuprofen at postmortem examination.a, s Some ibuprofen plasma levels were obtained in this series, b ...
... oped renal failure with elevated BUN and creatinine. One patient died after ingesting both ibuprofen and salicylates, and was found to have plasma levels of 240 &g/mL of salicylates and 170 ~g/mL of ibuprofen at postmortem examination.a, s Some ibuprofen plasma levels were obtained in this series, b ...
Sinemet® CR Product Monograph
... carbidopa) and other dopaminergic agents have reported suddenly falling asleep while engaged in activities of daily living, including the driving of a car, which has sometimes resulted in accidents. Although some of the patients reported somnolence while on SINEMET® CR, others perceived that they ha ...
... carbidopa) and other dopaminergic agents have reported suddenly falling asleep while engaged in activities of daily living, including the driving of a car, which has sometimes resulted in accidents. Although some of the patients reported somnolence while on SINEMET® CR, others perceived that they ha ...
Zyprexa/Zyprexa Zydis (olanzapine)
... the medication develops, these side effects usually subside. Taking Zyprexa in a single bedtime dose may minimize daytime sedation. For dry mouth, chewing sugarless gum or sucking on sugarless candy may promote salivation. To prevent constipation, patients should increase fluid intake and dietary fi ...
... the medication develops, these side effects usually subside. Taking Zyprexa in a single bedtime dose may minimize daytime sedation. For dry mouth, chewing sugarless gum or sucking on sugarless candy may promote salivation. To prevent constipation, patients should increase fluid intake and dietary fi ...
A systems model of altered consciousness: Integrating natural and
... likely to be responsible for a group of disorders that have sufficiently overlapping symptomatology to be classified phenomenologically as schizophrenia. Second, even within one of these etiologically distinct subtypes of schizophrenia, multiple neurotransmitter systems are likely to be functionally ...
... likely to be responsible for a group of disorders that have sufficiently overlapping symptomatology to be classified phenomenologically as schizophrenia. Second, even within one of these etiologically distinct subtypes of schizophrenia, multiple neurotransmitter systems are likely to be functionally ...
Facilitative effects of an adenosine A1/A2 receptor blockade on
... over a long phase of time and impairments of RM are reflected by choices of arms that are never baited. Therefore, an RM error was defined as an entry in a never baited arm for the first time. We counted RM errors starting with the second block of trials (i.e. on day 2 of acquisition), because the p ...
... over a long phase of time and impairments of RM are reflected by choices of arms that are never baited. Therefore, an RM error was defined as an entry in a never baited arm for the first time. We counted RM errors starting with the second block of trials (i.e. on day 2 of acquisition), because the p ...
A comparative bioequivalence study of two prolonged
... almost completely absorbed after oral administration. Only negligible amounts of metoprolol are absorbed in the stomach, and the duodenum, jejunum, ileum and colon have similar capacities for absorption by firstorder kinetics [17-19]. Regional absorption decreases in anatomical order with approximat ...
... almost completely absorbed after oral administration. Only negligible amounts of metoprolol are absorbed in the stomach, and the duodenum, jejunum, ileum and colon have similar capacities for absorption by firstorder kinetics [17-19]. Regional absorption decreases in anatomical order with approximat ...
CASE REPORT ERYTHROMYCIN INDUCED TORSADE DE
... prolonging drugs such as methadone can be prevented by avoiding its use in patients with pre-existing heart disease or risk factors as mentioned above, and/or electrolyte imbalance such as hypokalaemia. It should be emphasized that the risk of cardiac arrhythmia arises with the concurrent presence o ...
... prolonging drugs such as methadone can be prevented by avoiding its use in patients with pre-existing heart disease or risk factors as mentioned above, and/or electrolyte imbalance such as hypokalaemia. It should be emphasized that the risk of cardiac arrhythmia arises with the concurrent presence o ...
2120 Sex Hormones and their Modulators
... contraceptives containing older progestogens such as norethisterone appear to be associated with a lower incidence of venous thromboembolism than desogestrel- or gestodene-containing preparations, see p.2063. ...
... contraceptives containing older progestogens such as norethisterone appear to be associated with a lower incidence of venous thromboembolism than desogestrel- or gestodene-containing preparations, see p.2063. ...
The importance of residence and recognition time of drug
... 3. Compounds with slow off-rates need only a peak in bioavailable concentration to have a broader therapeutic window 4. You cannot properly judge pharmacokinetic data without knowing the binding kinetics of the interaction 5. High residence time selectivity is important to minimize side effects ...
... 3. Compounds with slow off-rates need only a peak in bioavailable concentration to have a broader therapeutic window 4. You cannot properly judge pharmacokinetic data without knowing the binding kinetics of the interaction 5. High residence time selectivity is important to minimize side effects ...
2: Cardiovascular system - Gateshead Health NHS Foundation Trust
... - Disopyramide capsules 100mg: orally 300-800mg daily in divided doses - Lidocaine injection 10mg/mL (1%), 20mg/mL (2%); infusion 1mg/mL (0.1%) and 2mg/mL (0.2%) in glucose 5%, 500mL. - Flecainide tablets 50mg, 100mg; injection 10mg/mL: orally, ventricular arrhythmias, 100mg twice daily; max 400mg d ...
... - Disopyramide capsules 100mg: orally 300-800mg daily in divided doses - Lidocaine injection 10mg/mL (1%), 20mg/mL (2%); infusion 1mg/mL (0.1%) and 2mg/mL (0.2%) in glucose 5%, 500mL. - Flecainide tablets 50mg, 100mg; injection 10mg/mL: orally, ventricular arrhythmias, 100mg twice daily; max 400mg d ...
xanax xanax ts
... XANAX and XANAX TS are indicated for the treatment of Generalized Anxiety Disorder (GAD). GAD is characterized by unrealistic or excessive anxiety and worry (apprehensive expectation) about two or more life circumstances, for a period of six months or longer, during which the person has been bothere ...
... XANAX and XANAX TS are indicated for the treatment of Generalized Anxiety Disorder (GAD). GAD is characterized by unrealistic or excessive anxiety and worry (apprehensive expectation) about two or more life circumstances, for a period of six months or longer, during which the person has been bothere ...
... which was correlated with the behavioural signs of social defeat stress, and with the ensuing establishment of social hierarchy, was a change in the activity of the neurosympathetic system and the hypothalamo-pituitary-adrenal axis, with variations in the levels of testosterone, corticosterone, prol ...
Advocate Patent Ductus Arteriosus in Preterm Infants—Debating the Treatment Options
... and renal blood flow and a decrease in platelet function. The changes in organ blood flow are thought to be caused by vasoconstriction that can lead to spontaneous gastrointestinal (GI) perforation or NEC. Because the mesenteric blood flow is rate-related, the extent of reduced flow may be lessened ...
... and renal blood flow and a decrease in platelet function. The changes in organ blood flow are thought to be caused by vasoconstriction that can lead to spontaneous gastrointestinal (GI) perforation or NEC. Because the mesenteric blood flow is rate-related, the extent of reduced flow may be lessened ...
DOI: 10.1161/CIRCULATIONAHA.106.181424 published online Feb
... trials of cyclooxygenase (COX)-2–selective agents have been reported and summarized in meta-analyses, which has reinforced the concern about cardiovascular events with COX-2 inhibitors (coxibs; Figure 1). (2) Several reports have appeared that have identified an increased risk of cardiovascular even ...
... trials of cyclooxygenase (COX)-2–selective agents have been reported and summarized in meta-analyses, which has reinforced the concern about cardiovascular events with COX-2 inhibitors (coxibs; Figure 1). (2) Several reports have appeared that have identified an increased risk of cardiovascular even ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.