The Medical Marijuana Movement Reflects an Indifference to Public
... • It lacks accepted safety for use under medical supervision. • There is sound evidence that smoked marijuana is harmful. • A past evaluation by HHS agencies, FDA, SAMHSA and NIDA, concluded that no sound scientific studies supported medical use of marijuana for treatment in the United States. • No ...
... • It lacks accepted safety for use under medical supervision. • There is sound evidence that smoked marijuana is harmful. • A past evaluation by HHS agencies, FDA, SAMHSA and NIDA, concluded that no sound scientific studies supported medical use of marijuana for treatment in the United States. • No ...
ASAM: Safe Methadone Induction and Stabilization
... Objectives: Methadone is a well-studied, safe, and effective medication when dispensed and consumed properly. However, a number of studies have identified elevated rates of overdose and death in patients being treated with methadone for either addiction or chronic pain. Among patients being treated ...
... Objectives: Methadone is a well-studied, safe, and effective medication when dispensed and consumed properly. However, a number of studies have identified elevated rates of overdose and death in patients being treated with methadone for either addiction or chronic pain. Among patients being treated ...
Guidance For The Community Management Of Benzodiazepine And
... withdrawal effects. They can put patients at increased risk of overdose, especially when combined with other depressant drugs such as methadone, heroin and alcohol. • There is very little evidence to suggest that long-term substitute prescribing for dependence reduces harm. There is clear evidence t ...
... withdrawal effects. They can put patients at increased risk of overdose, especially when combined with other depressant drugs such as methadone, heroin and alcohol. • There is very little evidence to suggest that long-term substitute prescribing for dependence reduces harm. There is clear evidence t ...
Pr VIAGRA*
... Women, Nursing Mothers, Pregnancy: VIAGRA is not indicated for use in women. There are no adequate and well-controlled studies in pregnant or lactating women. Pediatrics: VIAGRA is not indicated for use in children. Geriatrics (> 65 years of age): Healthy elderly volunteers had a reduced clearance o ...
... Women, Nursing Mothers, Pregnancy: VIAGRA is not indicated for use in women. There are no adequate and well-controlled studies in pregnant or lactating women. Pediatrics: VIAGRA is not indicated for use in children. Geriatrics (> 65 years of age): Healthy elderly volunteers had a reduced clearance o ...
drug-supplement interactions: a counter-offensive
... supplements have been reported: gastrointestinal toxicity, antiplatelet effects and relief of pain and inflammation. Table 1 lists six supplements that may diminish GI side effects of aspirin or NSAIDs, based upon controlled experiments with healthy humans. The protective effect of vitamin C is note ...
... supplements have been reported: gastrointestinal toxicity, antiplatelet effects and relief of pain and inflammation. Table 1 lists six supplements that may diminish GI side effects of aspirin or NSAIDs, based upon controlled experiments with healthy humans. The protective effect of vitamin C is note ...
Expanded Access Programs
... Serious Disease: Evidence from phase 3 trial or compelling data from phase 2 clinical trials Immediately Life-threatening Disease: Available evidence provides reasonable basis to conclude drug may be effective for the use and would “not expose patients to an unreasonable and significant risk of illn ...
... Serious Disease: Evidence from phase 3 trial or compelling data from phase 2 clinical trials Immediately Life-threatening Disease: Available evidence provides reasonable basis to conclude drug may be effective for the use and would “not expose patients to an unreasonable and significant risk of illn ...
Opioid Drugs in Patients With Liver Disease: A Systematic Review
... P450 enzyme system and metabolizes most opioids. Clearance of opioids decreases in liver failure and their bioavailability increases. These changes may be considered as secondary outcomes of the reduction in liver blood flow (the limitation of primary route of metabolism) or the reduction of the cyt ...
... P450 enzyme system and metabolizes most opioids. Clearance of opioids decreases in liver failure and their bioavailability increases. These changes may be considered as secondary outcomes of the reduction in liver blood flow (the limitation of primary route of metabolism) or the reduction of the cyt ...
A Short Course in Pharmacokinetics
... – IV/Oral PK study (in efficacy species) – Microsomal stability (efficacy & other species) • Metabolite ID work for very unstable compounds ...
... – IV/Oral PK study (in efficacy species) – Microsomal stability (efficacy & other species) • Metabolite ID work for very unstable compounds ...
Pharmacological Management of Pediatric Patients With Sepsis
... while often used in clinical practice, combination therapy has not been well studied in clinical trials. Despite the possible need for initial empiric combination therapy, it should generally not be continued for more than 3 to 5 days if the infecting pathogen and susceptibility results are known. T ...
... while often used in clinical practice, combination therapy has not been well studied in clinical trials. Despite the possible need for initial empiric combination therapy, it should generally not be continued for more than 3 to 5 days if the infecting pathogen and susceptibility results are known. T ...
Update on Statins
... compared with other studies. Statins in Hypertensive Patients The lipid-modification arm of the larger Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT) hypertension trial sought to determine whether pravastatin compared with usual care reduces allcause mortali ...
... compared with other studies. Statins in Hypertensive Patients The lipid-modification arm of the larger Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT) hypertension trial sought to determine whether pravastatin compared with usual care reduces allcause mortali ...
2 review of literature 28.06.2013
... 2.2. MEDICINAL PLANTS AS ANTI-INFECTIVE AGENTS Research efforts in herbal remedies have contributed in developing outstanding new drugs against many parasitic diseases (Li and Vederas, 2009). There are a number of plants which have been shown to contain anti-infective potential. An extract, commonly ...
... 2.2. MEDICINAL PLANTS AS ANTI-INFECTIVE AGENTS Research efforts in herbal remedies have contributed in developing outstanding new drugs against many parasitic diseases (Li and Vederas, 2009). There are a number of plants which have been shown to contain anti-infective potential. An extract, commonly ...
Perioperative High-Dose Amiodarone Elevates
... levels in patients undergoing coronary artery bypass surgery (CABG). Twenty patients undergoing CABG were included in the study. The patients were divided into control and amiodarone groups (n=10 in each group). The patients in group 1 did not receive any drugs. The patients in group II received 4X4 ...
... levels in patients undergoing coronary artery bypass surgery (CABG). Twenty patients undergoing CABG were included in the study. The patients were divided into control and amiodarone groups (n=10 in each group). The patients in group 1 did not receive any drugs. The patients in group II received 4X4 ...
(PSD) March 2015 PBAC meeting
... same diagnostic criteria for multiple sclerosis, had similar baseline characteristics, and similar relapse rates in the placebo arm. Relapse rate reduction: Glatiramer acetate 20 mg/mL versus 40 mg/mL Glatiramer acetate 20 mg/mL versus placebo Glatiramer acetate Placebo 20 mg/mL ...
... same diagnostic criteria for multiple sclerosis, had similar baseline characteristics, and similar relapse rates in the placebo arm. Relapse rate reduction: Glatiramer acetate 20 mg/mL versus 40 mg/mL Glatiramer acetate 20 mg/mL versus placebo Glatiramer acetate Placebo 20 mg/mL ...
TITLE: 1000 mg versus 600/650 mg Acetaminophen for Pain or
... Two systematic reviews of reviews,12,13 and one RCT14 were included. One systematic review12 included systematic reviews or meta-analyses comparing ibuprofen and different doses of oral acetaminophen in different pain conditions in adults and children. One systematic review13 included Cochrane revie ...
... Two systematic reviews of reviews,12,13 and one RCT14 were included. One systematic review12 included systematic reviews or meta-analyses comparing ibuprofen and different doses of oral acetaminophen in different pain conditions in adults and children. One systematic review13 included Cochrane revie ...
Theracurmin | Information Sheet
... for Theracurmin was 29.5 ng/ml, compared to 1.8 ng/ml for standard curcumin. Theracurmin reached Tmax in one hour, compared to six hours for standard curcumin. Following this study, it remained to be determined whether higher doses of Theracurmin could increase plasma curcumin levels in a dose-depen ...
... for Theracurmin was 29.5 ng/ml, compared to 1.8 ng/ml for standard curcumin. Theracurmin reached Tmax in one hour, compared to six hours for standard curcumin. Following this study, it remained to be determined whether higher doses of Theracurmin could increase plasma curcumin levels in a dose-depen ...
Herbal supplements and the geriatric population
... Retail sales of herbal products increased from $8.8 billion in 1994 to $14.7 billion in ...
... Retail sales of herbal products increased from $8.8 billion in 1994 to $14.7 billion in ...
Benzydamine Oral Spray Inhibiting Parasympathetic Function of
... used in our experiments were excised from rats without damaging the endothelium or smooth muscle. Therefore, it is reasonable to assume that tracheal responses to test agents in our study are comparable to those observed after application of a spray to the trachea during an asthmatic attack. It was ...
... used in our experiments were excised from rats without damaging the endothelium or smooth muscle. Therefore, it is reasonable to assume that tracheal responses to test agents in our study are comparable to those observed after application of a spray to the trachea during an asthmatic attack. It was ...
PDF hosted at the Radboud Repository of the Radboud University
... published in 1992 by Hanlon et al.[30] and a modified version was presented by the same group in 1997.[31] The index raises a number of important issues that are incompletely or not considered at all by the Beers criteria. For example, has each medication an indication? Is it expected to be effectiv ...
... published in 1992 by Hanlon et al.[30] and a modified version was presented by the same group in 1997.[31] The index raises a number of important issues that are incompletely or not considered at all by the Beers criteria. For example, has each medication an indication? Is it expected to be effectiv ...
Summary: Although, dramatic advances in the prevention and
... Tolerance has been shown to develop with all types of organic nitrates when they are administered using dosing patterns or ...
... Tolerance has been shown to develop with all types of organic nitrates when they are administered using dosing patterns or ...
General Outline for Antibiotics (a good study guide)
... 3. active transport out of cell (efflux pumps) 4. poor penetration into cell (intrinsic resistance) III. Pharmacology of Penicillins A. absorbance- administered orally, intramuscularly, or intravenously B. fate after absorption 1. after oral dose, widely distributed in tissues and secretions 2. do n ...
... 3. active transport out of cell (efflux pumps) 4. poor penetration into cell (intrinsic resistance) III. Pharmacology of Penicillins A. absorbance- administered orally, intramuscularly, or intravenously B. fate after absorption 1. after oral dose, widely distributed in tissues and secretions 2. do n ...
Treating Chronic Pain
... Methadone (synthetic opioid) ½ life 20-36 hrs. NMDA antagonist and inhibits serotonin and norepinephrine and therefore helpful in neuropathic pain syndromes Cheap CLOSE MONITORING. QT prolongation a risk as are mult. drug interactions (rare if <50 mg/day) ...
... Methadone (synthetic opioid) ½ life 20-36 hrs. NMDA antagonist and inhibits serotonin and norepinephrine and therefore helpful in neuropathic pain syndromes Cheap CLOSE MONITORING. QT prolongation a risk as are mult. drug interactions (rare if <50 mg/day) ...
Treatment and Prevention of Respiratory Syncytial Virus Disease Janet A. Englund, M.D.
... pathogenesis well studied Conservation of F protein and function among RSV strains well documented Impact of monoclonal Ab on prevention of RSV disease clinically documented ...
... pathogenesis well studied Conservation of F protein and function among RSV strains well documented Impact of monoclonal Ab on prevention of RSV disease clinically documented ...
Annex I : CSP – final clean version
... Linezolid should be used with special caution in patients with severe renal insufficiency and only when the anticipated benefit is considered to outweigh the theoretical risk (see sections 4.2 and 5.2). It is recommended that linezolid should be given to patients with severe hepatic insufficiency on ...
... Linezolid should be used with special caution in patients with severe renal insufficiency and only when the anticipated benefit is considered to outweigh the theoretical risk (see sections 4.2 and 5.2). It is recommended that linezolid should be given to patients with severe hepatic insufficiency on ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.