consumer medicine information
... No evidence of teratogenicity or embryotoxicity was observed when erythromycin base was given by oral gavage to pregnant rats and mice at 700 mg/kg/day (approximately 9 times the maximum human dose), and to pregnant rabbits at 125 mg/kg/day (approximately 1.5 times the maximum human dose). A slight ...
... No evidence of teratogenicity or embryotoxicity was observed when erythromycin base was given by oral gavage to pregnant rats and mice at 700 mg/kg/day (approximately 9 times the maximum human dose), and to pregnant rabbits at 125 mg/kg/day (approximately 1.5 times the maximum human dose). A slight ...
1598 Dermatological Drugs and Sunscreens
... consistent with a toxic effect of a drug with a low therapeutic index, rather than an idiosyncratic reaction. The data revealed that even preparations with hydroquinone 2% or less with a sun- ...
... consistent with a toxic effect of a drug with a low therapeutic index, rather than an idiosyncratic reaction. The data revealed that even preparations with hydroquinone 2% or less with a sun- ...
Cardiovascular Drugs - Cardiovascular Nursing Education Associates
... Maintenance dose: 75 mg daily for up to 12 months following stent placement; at least 1 month and preferably up to 1 year for medically treated UA/NSTEMI. Discontinue at least 5 days prior to CABG whenever possible ...
... Maintenance dose: 75 mg daily for up to 12 months following stent placement; at least 1 month and preferably up to 1 year for medically treated UA/NSTEMI. Discontinue at least 5 days prior to CABG whenever possible ...
Word Version - Student Blogs
... NAC in managing IPF would appear to have some scientific basis. This is ...
... NAC in managing IPF would appear to have some scientific basis. This is ...
Selective Suppression of Cocaine- versus Food
... dose-dependent and sustained reduction in cocaine self-administration under second order and progressive-ratio schedules while producing smaller and transient effects on responding maintained by food delivery (Negus and Mello, 2003a,b). Moreover, under a concurrent-choice schedule of cocaine and foo ...
... dose-dependent and sustained reduction in cocaine self-administration under second order and progressive-ratio schedules while producing smaller and transient effects on responding maintained by food delivery (Negus and Mello, 2003a,b). Moreover, under a concurrent-choice schedule of cocaine and foo ...
PRODUCT MONOGRAPH Pr ZYLOPRIM® Allopurinol Tablets USP
... can occur in renal failure and the dose of ZYLOPRIM® should consequently be reduced. With a creatinine clearance of 20 to 10 mL/min, a daily dosage of 200 mg of ZYLOPRIM® is suitable. When the creatinine clearance is less than 10 mL/min, the daily dosage should not exceed 100 mg. With extreme renal ...
... can occur in renal failure and the dose of ZYLOPRIM® should consequently be reduced. With a creatinine clearance of 20 to 10 mL/min, a daily dosage of 200 mg of ZYLOPRIM® is suitable. When the creatinine clearance is less than 10 mL/min, the daily dosage should not exceed 100 mg. With extreme renal ...
Optimization of Protein Therapies by Polymer
... spleen cause adverse reactions [34-36], the improved retention of IL-6 in the blood and the resultant decrease in the transfer and accumulation of IL-6 to these tissues is expected to reduce the side effects of IL-6 therapy. Thus, we attempted the conjugation of IL-6 with PEG, to increase in the act ...
... spleen cause adverse reactions [34-36], the improved retention of IL-6 in the blood and the resultant decrease in the transfer and accumulation of IL-6 to these tissues is expected to reduce the side effects of IL-6 therapy. Thus, we attempted the conjugation of IL-6 with PEG, to increase in the act ...
Drug Interaction and Food - KSU Faculty Member websites
... interaction. A herb can potentially mimic, increase, or reduce the effects of coadministered drugs and the consequences of these interactions can be beneficial, undesirable or harmful effects (Fugh-Berman, 2000). It should be pointed out that both the putative active ingredient(s) and other constitu ...
... interaction. A herb can potentially mimic, increase, or reduce the effects of coadministered drugs and the consequences of these interactions can be beneficial, undesirable or harmful effects (Fugh-Berman, 2000). It should be pointed out that both the putative active ingredient(s) and other constitu ...
S A M P L E C H...
... angina, heart failure or a history of MI. Beta-blockers are also useful in patients who have migraine headaches, tachycardia or essential tremor. However, beta-blockers are not as effective as angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs) or diuretics as initial therapy fo ...
... angina, heart failure or a history of MI. Beta-blockers are also useful in patients who have migraine headaches, tachycardia or essential tremor. However, beta-blockers are not as effective as angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs) or diuretics as initial therapy fo ...
Metformin and Cancer: Mounting Evidence Against
... of metformin (10). Time-related biases, such as immortal time bias, time window bias, and time lag bias, have been previously described in studies of diabetes treatment (10) and in other therapeutic areas (11–14). These biases result from not properly classifying exposure during the followup of a co ...
... of metformin (10). Time-related biases, such as immortal time bias, time window bias, and time lag bias, have been previously described in studies of diabetes treatment (10) and in other therapeutic areas (11–14). These biases result from not properly classifying exposure during the followup of a co ...
A review of available cholesterol- lowering medicines in South Africa
... participants reported a significant reduction in LDL cholesterol levels, together with a 40-50% decrease in cardiovascular events, when higher doses of statin therapy were utilised.12 More intense statin therapy appears to be well tolerated and can be prescribed to patients with coronary artery dise ...
... participants reported a significant reduction in LDL cholesterol levels, together with a 40-50% decrease in cardiovascular events, when higher doses of statin therapy were utilised.12 More intense statin therapy appears to be well tolerated and can be prescribed to patients with coronary artery dise ...
MHRA recommendations on simvastatin interactions: What are the
... Atorvastatin (20mg or 40mg daily) is an option if a more potent statin is needed. The risk of an interaction with amlodipine is much lower with atorvastatin than simvastatin. 4. Change to an alternative calcium channel blocker- do not change therapy in patients who are well controlled with amlodip ...
... Atorvastatin (20mg or 40mg daily) is an option if a more potent statin is needed. The risk of an interaction with amlodipine is much lower with atorvastatin than simvastatin. 4. Change to an alternative calcium channel blocker- do not change therapy in patients who are well controlled with amlodip ...
Asthma - The Rx Consultant
... drugs of first choice for patients with persistent mild, moderate or severe asthma.2 Treatment with ICS for 2 to 8 weeks significantly reduces the signs of airway inflammation, the frequency and severity of symptoms, and the need for symptom relief with an inhaled bronchodilator.5 The optimal daily ...
... drugs of first choice for patients with persistent mild, moderate or severe asthma.2 Treatment with ICS for 2 to 8 weeks significantly reduces the signs of airway inflammation, the frequency and severity of symptoms, and the need for symptom relief with an inhaled bronchodilator.5 The optimal daily ...
Colchicine for Prevention of Postoperative Atrial Fibrillation:
... Chi-squared test, Fischer’s exact tests, Kaplan-Meier method, logistic regression 360 patients, mean age 67.5 years, 68.9% male, 36.4% had heart valve surgery, 33.9% had CABG ...
... Chi-squared test, Fischer’s exact tests, Kaplan-Meier method, logistic regression 360 patients, mean age 67.5 years, 68.9% male, 36.4% had heart valve surgery, 33.9% had CABG ...
Report of the Psychiatric Drug Safety Expert Advisory Panel
... the medication and the adverse report could be made only in a small proportion of case reports. In these cases there was usually clear evidence of a temporal relationship between the onset of symptoms (e.g. akathisia or suicidal ideation) and the use of medication and evidence that the symptom impro ...
... the medication and the adverse report could be made only in a small proportion of case reports. In these cases there was usually clear evidence of a temporal relationship between the onset of symptoms (e.g. akathisia or suicidal ideation) and the use of medication and evidence that the symptom impro ...
Therapy of peptic ulcer
... The oral dose in peptic ulcer is 300 mg for 4-8 weeks, then, 150 mg daily for 6 months or more as maintenance dose. )Ranitidine doesn’t significantly affect the cytochrome oxidase P-450, thus the subsequent drug interactions are not reported. The risk of untoward antiandrogenic effects and hyperprol ...
... The oral dose in peptic ulcer is 300 mg for 4-8 weeks, then, 150 mg daily for 6 months or more as maintenance dose. )Ranitidine doesn’t significantly affect the cytochrome oxidase P-450, thus the subsequent drug interactions are not reported. The risk of untoward antiandrogenic effects and hyperprol ...
J=” m -1- w
... experiences with IGF-I. IGF-I is a recombinant biological product; however, this approval process was taken by CDER that requires two independent clinical trials. All other neurotrophic factors, such as CNTF, BDNF, or GDNF, were to be evaluated by CBER that requires only one clinical trial. I do not ...
... experiences with IGF-I. IGF-I is a recombinant biological product; however, this approval process was taken by CDER that requires two independent clinical trials. All other neurotrophic factors, such as CNTF, BDNF, or GDNF, were to be evaluated by CBER that requires only one clinical trial. I do not ...
Effects of clozapine and typical antipsychotic drugs on
... and financially costly. Emotionally, these events and those leading up to them disturb not only the patient, but also other patients on the ward and the staff who must impose seclusion or restraint. Financially, they are a possible source of injury for staff and other patients. Pharmacological restr ...
... and financially costly. Emotionally, these events and those leading up to them disturb not only the patient, but also other patients on the ward and the staff who must impose seclusion or restraint. Financially, they are a possible source of injury for staff and other patients. Pharmacological restr ...
Clenbuterol and the Horse
... severity of airway obstruction) from 35.5 to 25.2 cm H2O (SEM ⫽ 2.9). In practical terms, these horses would have moderate signs of heaves before treatment. After treatment, their signs would be somewhat less but not gone. A large clinical trial of clenbuterol syrup was conducted in COPD-affected ho ...
... severity of airway obstruction) from 35.5 to 25.2 cm H2O (SEM ⫽ 2.9). In practical terms, these horses would have moderate signs of heaves before treatment. After treatment, their signs would be somewhat less but not gone. A large clinical trial of clenbuterol syrup was conducted in COPD-affected ho ...
The Family Practice Newsletter
... million prescriptions are filled annually. However, all inhalers which contain CFCs are affected by this ruling. HFA inhalers will not only be more expensive, but the new devices may be unreliable in determining the remaining medication, as well as decreased expiration dates. Due to the extensive us ...
... million prescriptions are filled annually. However, all inhalers which contain CFCs are affected by this ruling. HFA inhalers will not only be more expensive, but the new devices may be unreliable in determining the remaining medication, as well as decreased expiration dates. Due to the extensive us ...
slides
... MTN-020/ASPIRE was a multi-center, randomized, double-blind, placebo-controlled phase III trial of a vaginal matrix ring containing the non-nucleoside reverse transcriptase inhibitor dapivirine. The primary objectives were to determine the effectiveness and safety of dapivirine (25 mg) administered ...
... MTN-020/ASPIRE was a multi-center, randomized, double-blind, placebo-controlled phase III trial of a vaginal matrix ring containing the non-nucleoside reverse transcriptase inhibitor dapivirine. The primary objectives were to determine the effectiveness and safety of dapivirine (25 mg) administered ...
Medications Development for Nicotine Dependence
... • Inhibition of nicotine metabolism • Based on observations of differences in nicotine metabolism ( CYP 2A6) and risk of dependence formation – Pianezza et al Nature (1998) • Clinical study with Methoxsalen ( CYP2A6 inhibitor ) reduced CO and smoking – Sellers et al CPT (2000) ...
... • Inhibition of nicotine metabolism • Based on observations of differences in nicotine metabolism ( CYP 2A6) and risk of dependence formation – Pianezza et al Nature (1998) • Clinical study with Methoxsalen ( CYP2A6 inhibitor ) reduced CO and smoking – Sellers et al CPT (2000) ...
Deadly pediatric poisons: nine common agents that kill at low doses
... substances than older children and perform hand-mouth behaviors nearly 10 times an hour [4,5]. Physical environmental change plays a significant role in the epidemiology of accidental ingestion [6]. In approximately half of all accidental poisonings, the product either was in use at the time of inges ...
... substances than older children and perform hand-mouth behaviors nearly 10 times an hour [4,5]. Physical environmental change plays a significant role in the epidemiology of accidental ingestion [6]. In approximately half of all accidental poisonings, the product either was in use at the time of inges ...
Publication
... for Vietnam, where injecting drug users (IDUs) account for approximately 45% of the total 190,000 HIV cases in the country [2-4]. According to the 2007 – 2012 HIV/AIDS Estimates and Projections for Vietnam, the HIV epidemic in the country remains concentrated, with high prevalence rates among high r ...
... for Vietnam, where injecting drug users (IDUs) account for approximately 45% of the total 190,000 HIV cases in the country [2-4]. According to the 2007 – 2012 HIV/AIDS Estimates and Projections for Vietnam, the HIV epidemic in the country remains concentrated, with high prevalence rates among high r ...
Management of malignant ventricular arrhythmias and cardiac arrest
... 82% for amiodarone-treated patients and 69% for conventionally treated patients. After 4 yrs of follow-up, these survival values were 66% vs. 52%, respectively (p ⫽ .007). This study suggested that amiodarone given empirically was more effective than other antiarrhythmic agents guided by the results ...
... 82% for amiodarone-treated patients and 69% for conventionally treated patients. After 4 yrs of follow-up, these survival values were 66% vs. 52%, respectively (p ⫽ .007). This study suggested that amiodarone given empirically was more effective than other antiarrhythmic agents guided by the results ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.