Cannabinoid Abuse and Addiction
... acid amide hydrolase genes have been linked to cannabis addiction phenotypes.19 In a recent study, functional connectivity magnetic resonance imaging demonstrated that cannabis users with genetic variation in CNR1 (rs1406977 G carriers) had greater functional connectivity in the left ventrolateral p ...
... acid amide hydrolase genes have been linked to cannabis addiction phenotypes.19 In a recent study, functional connectivity magnetic resonance imaging demonstrated that cannabis users with genetic variation in CNR1 (rs1406977 G carriers) had greater functional connectivity in the left ventrolateral p ...
National Adult Clozapine Titration Chart User Guide
... adverse drug events. Research shows that many adverse events reported in Australian hospitals are associated with medications. It also demonstrates that improvements to medication chart design can improve the safety of medication processes in hospitals. The following are general requirements regardi ...
... adverse drug events. Research shows that many adverse events reported in Australian hospitals are associated with medications. It also demonstrates that improvements to medication chart design can improve the safety of medication processes in hospitals. The following are general requirements regardi ...
In vivo evaluation of 2-adrenoceptors in cats with
... In the present study, no differences were detected between the 2 groups in regards to sedation and blood pressure after medetomidine administration. Sedative effects of α2-AR agonists are mediated from stimulation of the presynaptic α2-AR located primarily on the LC in the pons and lower portion of ...
... In the present study, no differences were detected between the 2 groups in regards to sedation and blood pressure after medetomidine administration. Sedative effects of α2-AR agonists are mediated from stimulation of the presynaptic α2-AR located primarily on the LC in the pons and lower portion of ...
2
... anephric patients, the average half-life of elimination is 7.5 days. The distribution coefficient is from 03 to 0.43 Llkg. There is no apparent metabolism of the drug. About 60% of an intraperitoneal dose of vancomycin administered during peritoneal dialysis is absorbed systemically in six hours. Se ...
... anephric patients, the average half-life of elimination is 7.5 days. The distribution coefficient is from 03 to 0.43 Llkg. There is no apparent metabolism of the drug. About 60% of an intraperitoneal dose of vancomycin administered during peritoneal dialysis is absorbed systemically in six hours. Se ...
Corticosteroids in the treatment of dengue shock syndrome
... The earliest evidence of possible benefit of corticosteroids in dengue came from a small randomized controlled trial, in which children with dengue shock syndrome were treated with a tapering dose of hydrocortisone for 3 days; a statistically significant mortality benefit was seen in older children ...
... The earliest evidence of possible benefit of corticosteroids in dengue came from a small randomized controlled trial, in which children with dengue shock syndrome were treated with a tapering dose of hydrocortisone for 3 days; a statistically significant mortality benefit was seen in older children ...
The use of cannabinoids in animals and therapeutic implications for
... their psychoactive effects and addictive potential. Attempts by pharmaceutical companies in the sixth decade of the twentieth century to produce cannabinoids with pharmacological effects and without psychotropic activity were not successful (Fisar 2009; Pertwee 2009), although cannabinoids with very ...
... their psychoactive effects and addictive potential. Attempts by pharmaceutical companies in the sixth decade of the twentieth century to produce cannabinoids with pharmacological effects and without psychotropic activity were not successful (Fisar 2009; Pertwee 2009), although cannabinoids with very ...
6- Diuretics
... 1- -SO2NH2 group hypersensitivity 2- Ototoxicity So care must be noticed when used with aminoglycosides. 3-NSAIDs may blunt the natriuresis produced by loop diuretics in patients with preexisting impaired renal function who are on diuretic therapy NSAIDs may increase the risk of renal ...
... 1- -SO2NH2 group hypersensitivity 2- Ototoxicity So care must be noticed when used with aminoglycosides. 3-NSAIDs may blunt the natriuresis produced by loop diuretics in patients with preexisting impaired renal function who are on diuretic therapy NSAIDs may increase the risk of renal ...
Effects of rimonabant on body weight, glucose control
... “as an adjunct to diet and exercise for the treatment of obese patients (BMI ≥30 kg/m²), or overweight patients (BMI >27 kg/m²) with associated risk factor(s), such as type 2 diabetes or dyslipidaemia” [37]. In addition to rimonabant, several other CB1 receptor antagonists have been synthesized and ...
... “as an adjunct to diet and exercise for the treatment of obese patients (BMI ≥30 kg/m²), or overweight patients (BMI >27 kg/m²) with associated risk factor(s), such as type 2 diabetes or dyslipidaemia” [37]. In addition to rimonabant, several other CB1 receptor antagonists have been synthesized and ...
AusPAR: Metformin HCI / Linagliptin
... currently registered for twice daily dosing, linagliptin is only registered as a once daily treatment. This is unlikely to alter the toxicity assessment of linagliptin made previously (see III. Nonclinical Findings; Toxicity below). Other drugs (sitagliptin, vildagliptin, saxagliptin) in the same cl ...
... currently registered for twice daily dosing, linagliptin is only registered as a once daily treatment. This is unlikely to alter the toxicity assessment of linagliptin made previously (see III. Nonclinical Findings; Toxicity below). Other drugs (sitagliptin, vildagliptin, saxagliptin) in the same cl ...
Chapter 4 Lesson 2 - ROP Pharmacology for Health Care
... can be attached quickly to the patient's existing I.V. line. This I.V. bag contains the trade name antibiotic drug Zosyn, a combination of two different generic antibiotic drugs; it is used to treat severe infections. The drug will run quickly through the intravenous line, and the entire drug dose w ...
... can be attached quickly to the patient's existing I.V. line. This I.V. bag contains the trade name antibiotic drug Zosyn, a combination of two different generic antibiotic drugs; it is used to treat severe infections. The drug will run quickly through the intravenous line, and the entire drug dose w ...
Success and limitations of methadone and drug free treatment
... Furthermore: The clients of the low threshold or harm reduction program profited more from their crimes and were involved in more complex criminal activities than those from the other groups as can be seen in table 2 (Leuw, 1998). It can be concluded that large-scale distribution of methadone withou ...
... Furthermore: The clients of the low threshold or harm reduction program profited more from their crimes and were involved in more complex criminal activities than those from the other groups as can be seen in table 2 (Leuw, 1998). It can be concluded that large-scale distribution of methadone withou ...
Anaesthesia of Wild Carnivores and Primates
... Cardiorespiratory parameters and body temperature were monitored in all animals. Arterial blood samples were analysed for blood gases, acid-base status and selected haematological and plasma parameters in lions and wolverines. For primates and lions the developed anaesthetic protocols, including low ...
... Cardiorespiratory parameters and body temperature were monitored in all animals. Arterial blood samples were analysed for blood gases, acid-base status and selected haematological and plasma parameters in lions and wolverines. For primates and lions the developed anaesthetic protocols, including low ...
BAOJ Pharmaceutical Sciences
... most widely studied enhancers of this group. Pyrrolidones have been used as permeation promoters for numerous molecules including hydrophilic (e.g. mannitol, 5-fluorouracil and sulphaguanidine) and lipophilic (betamethasone-17-benzoate, hydrocortisone and progesterone) permeants. As with many studie ...
... most widely studied enhancers of this group. Pyrrolidones have been used as permeation promoters for numerous molecules including hydrophilic (e.g. mannitol, 5-fluorouracil and sulphaguanidine) and lipophilic (betamethasone-17-benzoate, hydrocortisone and progesterone) permeants. As with many studie ...
Ada_Dekhtyar
... discuss issues related to providing oral contraceptives without prescription.20 The issues scheduled for discussion at the Feb. 4-5 session were to include whether labeling can provide adequate instruction on the use of oral contraceptives, whether an over-the-counter Pill would place women at a hig ...
... discuss issues related to providing oral contraceptives without prescription.20 The issues scheduled for discussion at the Feb. 4-5 session were to include whether labeling can provide adequate instruction on the use of oral contraceptives, whether an over-the-counter Pill would place women at a hig ...
List of Figures - The University of Tennessee, Knoxville
... Background and Characterization of the Agouti Mouse: The melanocyte is the principal cell type involved in coat color pigmentation. During embryonic development melanocyte precursors (melanoblasts) migrate from the neural tube to the base of developing hair follicles (Billingham and Silvers, 1960; S ...
... Background and Characterization of the Agouti Mouse: The melanocyte is the principal cell type involved in coat color pigmentation. During embryonic development melanocyte precursors (melanoblasts) migrate from the neural tube to the base of developing hair follicles (Billingham and Silvers, 1960; S ...
ii. immunosuppressive drugs - The University of Tennessee, Knoxville
... Background and Characterization of the Agouti Mouse: The melanocyte is the principal cell type involved in coat color pigmentation. During embryonic development melanocyte precursors (melanoblasts) migrate from the neural tube to the base of developing hair follicles (Billingham and Silvers, 1960; S ...
... Background and Characterization of the Agouti Mouse: The melanocyte is the principal cell type involved in coat color pigmentation. During embryonic development melanocyte precursors (melanoblasts) migrate from the neural tube to the base of developing hair follicles (Billingham and Silvers, 1960; S ...
melatonin - don`t lose sleep over it 1
... ASLEEP is a useful acronym for remembering sleep hygiene tips Alcohol, caffeine and nicotine should be avoided, especially in the evening Sleep and sex should be the only uses of the bed; make sure your bed environment is comfortable Leave laptops, TV and paperwork out of the bedroom and keep clocks ...
... ASLEEP is a useful acronym for remembering sleep hygiene tips Alcohol, caffeine and nicotine should be avoided, especially in the evening Sleep and sex should be the only uses of the bed; make sure your bed environment is comfortable Leave laptops, TV and paperwork out of the bedroom and keep clocks ...
Relationship between objective responses in phase I trials and
... or overall survival than a conventional treatment, or in which an investigational arm showed the same RR, progression-free survival and overall survival, but less toxicity or improved quality of life when compared with a reference arm. A drug was defined as ‘effective’ if at least one positive study ...
... or overall survival than a conventional treatment, or in which an investigational arm showed the same RR, progression-free survival and overall survival, but less toxicity or improved quality of life when compared with a reference arm. A drug was defined as ‘effective’ if at least one positive study ...
Newer Therapies for Chronic Obstructive Pulmonary Disease
... of the ultra-LABAs currently under development. Carmoterol, indacaterol, vilanterol, LAS100977 are faster acting compared to salmeterol. Indacaterol, a promising ultra-LABA has been approved in Europe and USA for bronchodilator treatment. Large clinical trials have shown that indacaterol may be bett ...
... of the ultra-LABAs currently under development. Carmoterol, indacaterol, vilanterol, LAS100977 are faster acting compared to salmeterol. Indacaterol, a promising ultra-LABA has been approved in Europe and USA for bronchodilator treatment. Large clinical trials have shown that indacaterol may be bett ...
CE EN Evidence-based Pharmacy Practice (EBPP): DYSLIPIDAEMIA
... Dyslipidaemia is a disorder of lipoprotein metabolism that alters the concentration or composition of lipoproteins. Atherosclerosis and pancreatitis are the two major complications of dyslipidaemia. The most common dyslipidaemia is hypercholesterolaemia, which is one of the major risk factors for co ...
... Dyslipidaemia is a disorder of lipoprotein metabolism that alters the concentration or composition of lipoproteins. Atherosclerosis and pancreatitis are the two major complications of dyslipidaemia. The most common dyslipidaemia is hypercholesterolaemia, which is one of the major risk factors for co ...
Fluticasone Propionate Ointment, 0.005%
... Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. In a study of 6 healthy volunteers applying 25 g of fluticasone propionate ointment 0.005% twice daily to the trunk and legs for up to 5 days und ...
... Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. In a study of 6 healthy volunteers applying 25 g of fluticasone propionate ointment 0.005% twice daily to the trunk and legs for up to 5 days und ...
Anticancer Potential of Turmeric
... generation of ROS and the JNK pathway. (13) Studies in tissue culture showed that curcumin did inhibit the induction of apoptosis by several agents (camptothecin, mechlorethamme, and doxorubicin). This effect was dose- and time-dependent, but occurred after even brief three-hour exposures. In their ...
... generation of ROS and the JNK pathway. (13) Studies in tissue culture showed that curcumin did inhibit the induction of apoptosis by several agents (camptothecin, mechlorethamme, and doxorubicin). This effect was dose- and time-dependent, but occurred after even brief three-hour exposures. In their ...
Paediatric Advanced Life Support
... The ideal energy level for safe and effective defibrillation in children is unknown. The recommendation of 2 - 4 J kg-1 in Guidelines 2000 was based on a single historical study of effective outcomes. Extrapolation from adult data and experimental studies shows that biphasic shocks are at least as e ...
... The ideal energy level for safe and effective defibrillation in children is unknown. The recommendation of 2 - 4 J kg-1 in Guidelines 2000 was based on a single historical study of effective outcomes. Extrapolation from adult data and experimental studies shows that biphasic shocks are at least as e ...
Kempegowda Institute of Medical Sciences
... sympathetic activity3. Intrathecal morphine provides prolonged postoperative analgesia but is associated with increased risk of nausea, vomiting, itching and respiratory depression4. Short acting opiods like fentanyl and sufentanil have been used intrathecally in elderly population to provide pain r ...
... sympathetic activity3. Intrathecal morphine provides prolonged postoperative analgesia but is associated with increased risk of nausea, vomiting, itching and respiratory depression4. Short acting opiods like fentanyl and sufentanil have been used intrathecally in elderly population to provide pain r ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.