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EBOLA and FDA: reviewing the response to the 2014 outbreak, to
EBOLA and FDA: reviewing the response to the 2014 outbreak, to

... transcriptase polymerase chain reaction and antigen detection by enzyme linked immunosorbent assay—are only available in referral centers or national reference laboratories.13 Outbreaks are thought to originate from an animal reservoir, most likely a fruit bat, although that linkage has not been con ...
CYCLODEXTRINS
CYCLODEXTRINS

... surface and a lipophilic central cavity. Cyclodextrin molecules are relatively large with a number of hydrogen donors and acceptors and, thus, in general they do not permeate lipophilic membranes. In the pharmaceutical industry cyclodextrins have mainly been used as complexing agents to increase aqu ...
Clinical pharmacokinetic equations and calculations
Clinical pharmacokinetic equations and calculations

... succinylcholine is given by IV infusion for sustained muscle relaxation. A typical initial dose is 20 mg followed by continuous infusion of 4 mg/min. the infusion must be individualized because of variation in the kinetics of metabolism of suucinylcholine. Estimate the elimination half-lives of succ ...
Prodrugs for Amines
Prodrugs for Amines

... hydrolysis of a pentyl carbamate mediated by liver carboxylesterase (CES-1). Significant species differences were observed when a panel of homologous carbamates was subjected to hydrolysis by human, monkey and mouse carboxylesterases and the discovery scientists point out that the correct analogue w ...
enzyme induction and inhibition
enzyme induction and inhibition

... dietary constituents, smoking and drugs (Fig. 1). The metabolizing activity of the enzymes may be increased following administration of certain xenobiotics. When this results from the selective increase in the concentration of enzyme the term enzyme induction is used to describe the process (Goldber ...
Pharmacological drugs inducing ototoxicity, vestibular symptoms
Pharmacological drugs inducing ototoxicity, vestibular symptoms

... amounts of drugs in their system. There is also a need to consider other factors like self-medication, very common among the elderly who often use drugs unnecessarily or don’t seek medical advice, either because of lack of knowledge or just carelessness, and other age-related factors like loss of me ...
Herbal Remedies: The Design of a New Course in Pharmacy
Herbal Remedies: The Design of a New Course in Pharmacy

... need for training our students in the area of herbal remedies but also the positive impact that this training will have on pharmaceutical care practice well into the 21st century. The idea for designing this new course originated following a continuing education program, entitled “The Risks of Herba ...
Curcuminoid drug interactions
Curcuminoid drug interactions

... valuable in the prevention and treatment of many different degenerative diseases. As curcuminoids are often taken as supplements by some population groups, it may be asked whether this can lead to changes in the pharmacokinetics or pharmacodynamics of other drugs taken at the same time. It is partic ...
domperidone domperidone
domperidone domperidone

... and colostrum has occurred. If leakage should occur and foaling does not take place within 24 hours, half the recommended dose should be administered twice daily at approximately 12-hour intervals and continued until foaling. If leakage continues, the dose should be reduced to one third of the recom ...
March 2017 PBAC Meeting Agenda (Word 67KB)
March 2017 PBAC Meeting Agenda (Word 67KB)

... circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be listed in alphabetical order by drug name. There is no provision for consumer comments to the PBAC on agenda item 8 which relates to pricing matters. Pharmaceu ...
formulation and evaluation of meloxicam gels
formulation and evaluation of meloxicam gels

... and anti-inflammatory activity after oral administration (1). NSAIDs have been widely used in the treatment of rheumatoid arthritis and other related conditions. However, they carry the risk of undesirable systemic side effects and gastrointestinal irritation at the usual dose of oral administration ...
A SURVEY BASED STUDY IN CURRENT SCENARIO OF GENERIC AND... Research Article
A SURVEY BASED STUDY IN CURRENT SCENARIO OF GENERIC AND... Research Article

... [5]. While manufacturing generic drugs, the drug companies use the same active ingredients and are shown to work the same way in the body, they have the same risks and benefits as their brand name counterparts. Also, generic drugs have the same quality, strength, purity and stability as brand name d ...
Abuse Liability & Drug Scheduling: Role of FDA
Abuse Liability & Drug Scheduling: Role of FDA

... The transformation of a stigmatized person into one who is not stigmatized will have significant effects on the person and the society within which the individual lives as it allows for personal growth and the possibility of a greater contribution to society. This dynamic is expressed within the act ...
Ibogaine as an Alternative and Efficacious Treatment for Heroin
Ibogaine as an Alternative and Efficacious Treatment for Heroin

322 PHT Tablet
322 PHT Tablet

... The methods used to improve flow are summarized below i) Addition of glidants ii) Addition of fines: Addition of fines up to certain extent improves flow. This is because of filling of void space and decrease in surface roughness. ...
pharmaceutical informations on the web
pharmaceutical informations on the web

... According to the legislations in Hungary it is not allowed to trade with medicinal products online, these products can only be sold at pharmacies. In more and more countries, for example in the US, Canada and the United Kingdom, patients are able to buy their drugs from the web. As the internet and ...
as PDF
as PDF

... Sulfonate impurities comprise the most investigated group of genotoxic impurities (GIs). Initially in 2007, sulfonate impurities raised major concern when over a period of three months (March to May 2007), several thousand HIV patients in Europe were exposed to ViraceptR (nelfinavir mesylate) tablet ...
Dow Corning Silicones in Pharmaceutical Applications
Dow Corning Silicones in Pharmaceutical Applications

... are stored separately before use and the crosslinking reaction will only start upon mixing the parts A and B in a defined ratio, usually 50:50. The reaction can take place at room temperature or be heat accelerated to crosslink the elastomer in a few minutes after extrusion, injection or moulding. H ...
The New High: Designer Drugs and New Trends
The New High: Designer Drugs and New Trends

... Dr. David E. Nichols is a researcher of psychedelic agents with emphasis in developing medicines to assist people by improving their physical conditions, such as alleviating the symptoms of Parkinson’s disease, or improve memory and cognition in patients having schizophrenia. ...
Pharmaceuticals: Focussing on Appropriate Utilization
Pharmaceuticals: Focussing on Appropriate Utilization

... Indicators of pharmaceutical use within the current environment do not reflect a strategy for assessing the effectiveness or outcomes of prescription drugs. The assumption is that, other than death and other catastrophic events like heart attack or hip fracture, we have few population-based measures ...
Archive 2014
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... It gives me immense pleasure to be a part of the beautiful journey that made ’The Nest 2013-2014’, with the theme ETHICS. The job of the editors is a daunting task and I am really very thankful to my team - Sahana Ray, Ankita Satoor and Dipali Nagila who worked with dedication and hard work to nurtu ...
Guideline on the investigation of bioequivalence - EMA
Guideline on the investigation of bioequivalence - EMA

... Conduct of a multiple dose study in patients is acceptable if a single dose study cannot be conducted in healthy volunteers due to tolerability reasons, and a single dose study is not feasible in patients. In the rare situation where problems of sensitivity of the analytical method preclude sufficie ...
RIVM rapport 370030002 Trends in drug substances detected in
RIVM rapport 370030002 Trends in drug substances detected in

... analysis. Genuine medicines were further classified as ‘approved’ or ‘unapproved’ for the Dutch market: legal medicines or illegal medicines. The distinction between ‘approved’ and ‘unapproved’ was made to enable categorizing authentic foreign medicines that are not available on the official Dutch m ...
What is Methamphetamine? Pushback Fact Sheet
What is Methamphetamine? Pushback Fact Sheet

... Unlike drugs such as marijuana, cocaine, and heroin, which are derived from plants, meth can be manufactured using a variety of store bought chemicals. The most common ingredient in meth is pseudoephedrine or ephedrine, commonly found in cold medicine. Through a cooking process the pseudoephedrine o ...
DANGERS OF PHARMACEUTICAL SUBSTITUTES FOR NICOTINE
DANGERS OF PHARMACEUTICAL SUBSTITUTES FOR NICOTINE

... Bupropion (aka Wellbutrin, Zyban) have been approved for treatment of tobacco addiction. Used alone or in combination with other drugs it is claimed that they increase quit rates when compared to placebo, however research results tend to have been primarily provided by the drug manufacturers and the ...
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Compounding

Pharmaceutical compounding (done in compounding pharmacies) is the creation of a particular pharmaceutical product to fit the unique need of a patient. To do this, compounding pharmacists combine or process appropriate ingredients using various tools. This may be done for medically necessary reasons, such as to change the form of the medication from a solid pill to a liquid, to avoid a non-essential ingredient that the patient is allergic to, or to obtain the exact dose(s) needed or deemed best of particular active pharmaceutical ingredient(s). It may also be done for more optional reasons, such as adding flavors to a medication or otherwise altering taste or texture. Compounding is most routine in the case of intravenous/parenteral medication, typically by hospital pharmacists, but is also offered by privately owned compounding pharmacies and certain retail pharmacies for various forms of medication. Whether routine or rare, intravenous or oral, etc., when a given drug product is made or modified to have characteristics that are specifically prescribed for an individual patient, it is known as ""traditional"" compounding.Due to the rising cost of compounding and the shortage of drugs, many hospitals have shown a tendency to rely more upon large-scale compounding pharmacies to meet their regular requirement, particularly of sterile-injectable medications. When compounding is done on bulk production of a given formulation rather than patient-specific production, it is known as ""non-traditional"" compounding (which, as discussed below, is arguably not ""compounding"" but rather ""manufacturing""). This development raises concerns about patient safety and makes a case for proper regulatory control and monitoring.
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