Psychopharmacology
... • The study of the effects of drugs on the nervous system and on behavior. Drug effects: • The changes a drug produces in an animal’s physiological processes and behavior. Sites of Action: • The locations at which molecules of drugs interact with molecules located on or in cells of the body, thu ...
... • The study of the effects of drugs on the nervous system and on behavior. Drug effects: • The changes a drug produces in an animal’s physiological processes and behavior. Sites of Action: • The locations at which molecules of drugs interact with molecules located on or in cells of the body, thu ...
Opioid Receptors - Science Mission
... Reinforcing or “Reward” Effects of Drugs of Abuse Initial exposure to a drug of abuse may produce effects which are interpreted by the individual as “desirable” or “pleasurable”, i.e., “rewarding”. These effects may lead to “craving” or “hunger” for the drug, with resultant spontaneous activity or ...
... Reinforcing or “Reward” Effects of Drugs of Abuse Initial exposure to a drug of abuse may produce effects which are interpreted by the individual as “desirable” or “pleasurable”, i.e., “rewarding”. These effects may lead to “craving” or “hunger” for the drug, with resultant spontaneous activity or ...
Body Temperature and Analgesic Effects of Selective Mu and Kappa
... sour et al., 1987), and opioids alter the activities of the thermosensitive neurons within this region (Baldino et al., 1980; Lin et al., 1984). The PAG is known to be one of the most important regions involved in pain modulation (Basbaum and Fields, 1984). It has also been reported to be involved i ...
... sour et al., 1987), and opioids alter the activities of the thermosensitive neurons within this region (Baldino et al., 1980; Lin et al., 1984). The PAG is known to be one of the most important regions involved in pain modulation (Basbaum and Fields, 1984). It has also been reported to be involved i ...
Association study of 37 genes related to serotonin and dopamine
... cocaine. Both environmental and genetic factors underlie this disorder. Although some studies have estimated a heritability of cocaine dependence around 60–70% (Kendler & Prescott 1998; Kendler et al . 2000), genetic susceptibility factors are not well understood. Several processes, such as reward a ...
... cocaine. Both environmental and genetic factors underlie this disorder. Although some studies have estimated a heritability of cocaine dependence around 60–70% (Kendler & Prescott 1998; Kendler et al . 2000), genetic susceptibility factors are not well understood. Several processes, such as reward a ...
the PDF
... this new method of treatment immediately (Becker et al., 1997; Becker et al., 1995; Dralle et al., 1985; Gianino et al., 1998; Ochs, 1993; Ochs et al., 1989; Rawlins, 1998). Quantitative measurements by Leisen et al. (2003) showed that intrathecal administration of doses up to 600 mg resulted in loc ...
... this new method of treatment immediately (Becker et al., 1997; Becker et al., 1995; Dralle et al., 1985; Gianino et al., 1998; Ochs, 1993; Ochs et al., 1989; Rawlins, 1998). Quantitative measurements by Leisen et al. (2003) showed that intrathecal administration of doses up to 600 mg resulted in loc ...
5-Hydroxytryptamine2C Receptor Contribution to m
... Animal Surgery and Preparation. All procedures were approved by the Vanderbilt University Medical Center Institutional Animal Care and Use Committees and were conducted according to the NIH Guide for the Care and Use of Laboratory Animals. Adult male Sprague-Dawley rats (n ⫽ 6 per group) were housed ...
... Animal Surgery and Preparation. All procedures were approved by the Vanderbilt University Medical Center Institutional Animal Care and Use Committees and were conducted according to the NIH Guide for the Care and Use of Laboratory Animals. Adult male Sprague-Dawley rats (n ⫽ 6 per group) were housed ...
Effects of the putative dopamine D receptor antagonist PNU 99194A
... were measured using a set of four Digiscan Animal Activity Monitors ŽOmnitech, Colombus, OH, USA.. The monitors consisted of a 41.9 = 41.9 cm Plexiglas enclosure with two rows of 16 photocell beams to measure horizontal activity, one row being located front to back and the other side to side. These ...
... were measured using a set of four Digiscan Animal Activity Monitors ŽOmnitech, Colombus, OH, USA.. The monitors consisted of a 41.9 = 41.9 cm Plexiglas enclosure with two rows of 16 photocell beams to measure horizontal activity, one row being located front to back and the other side to side. These ...
Functional Characterization of GABAA Receptors in Neonatal
... molecular architecture of native GABAA receptors is extremely heterogeneous (Bonnert et al. 1999; Hevers and Lüddens 1998). Pharmacological studies of recombinant receptors have shown that individual subunits and their subtypes confer different sensitivities to GABAA receptor modulators (Hevers and ...
... molecular architecture of native GABAA receptors is extremely heterogeneous (Bonnert et al. 1999; Hevers and Lüddens 1998). Pharmacological studies of recombinant receptors have shown that individual subunits and their subtypes confer different sensitivities to GABAA receptor modulators (Hevers and ...
Respiratory-pharmacology
... Due to the possibility of cardiovascular disease, epinephrine should be administered with caution in patients over 35 years of age (with respiratory problems or if they are conscious) The patient should be carefully monitored for changes in pulse, blood pressure, and ECG after administration of epin ...
... Due to the possibility of cardiovascular disease, epinephrine should be administered with caution in patients over 35 years of age (with respiratory problems or if they are conscious) The patient should be carefully monitored for changes in pulse, blood pressure, and ECG after administration of epin ...
Click here for handout
... Additional subtypes of serotonin receptors, such as 5-HT1A, may also contribute. Noradrenergic CNS hyperactivity may play l a critical iti l role, l since i the th degree d to t which CNS norepinephrine concentrations are increased in the serotonin syndrome may correlate with the clinical outcome. ...
... Additional subtypes of serotonin receptors, such as 5-HT1A, may also contribute. Noradrenergic CNS hyperactivity may play l a critical iti l role, l since i the th degree d to t which CNS norepinephrine concentrations are increased in the serotonin syndrome may correlate with the clinical outcome. ...
Toxicant – Receptor Interactions: Fundamental - UNC
... receptor causes a specific and predictable biological response. The obvious question, then, is whether the receptor of interest is one to which endogenous ligands bind or, rather, an opportunistic site for which the toxicant has affinity. Since this distinction is of general importance, several exam ...
... receptor causes a specific and predictable biological response. The obvious question, then, is whether the receptor of interest is one to which endogenous ligands bind or, rather, an opportunistic site for which the toxicant has affinity. Since this distinction is of general importance, several exam ...
Diphenhydramine (Benadryl)
... Diphenhydramine demonstrates both stimulant and depressant effects on the central nervous system although stimulation is only occasionally seen in patients given conventional doses with accompanying restlessness, nervousness and inability to sleep. Companies have capitalized on the depressant effect ...
... Diphenhydramine demonstrates both stimulant and depressant effects on the central nervous system although stimulation is only occasionally seen in patients given conventional doses with accompanying restlessness, nervousness and inability to sleep. Companies have capitalized on the depressant effect ...
Histamine and Antihistamines
... GI: agonists down regulate histamine. Thereby decreasing gastrin Lung: agonists have a bronchodilatory effect ...
... GI: agonists down regulate histamine. Thereby decreasing gastrin Lung: agonists have a bronchodilatory effect ...
- Acta Medica Iranica
... the latter. For example, because one action of dopamine receptors is to inhibit glutamate release (21), a primary defect in the dopamine system that causes dopamine hyperactivity could result in excessive suppression of glutamate release at NMDA receptors, with consequential hypofunction of the NMDA ...
... the latter. For example, because one action of dopamine receptors is to inhibit glutamate release (21), a primary defect in the dopamine system that causes dopamine hyperactivity could result in excessive suppression of glutamate release at NMDA receptors, with consequential hypofunction of the NMDA ...
the-serotonergic-hallucinogen-5-meo-dmt-disrupts
... dimethyltryptamine (5-MeO-DMT) which bind with high affinity to several 5-HT receptors (5-HT-R), namely phenylalkylamines such as mescaline and 2,5-dimethoxy-4- ...
... dimethyltryptamine (5-MeO-DMT) which bind with high affinity to several 5-HT receptors (5-HT-R), namely phenylalkylamines such as mescaline and 2,5-dimethoxy-4- ...
Zolmitriptan and human aggression: interaction
... to become aggressive under the influence of alcohol and have been called “aggressive drunks” (Ito et al. 1996); aggressive drunks tend to have higher trait levels of aggression (Giancola et al. 2005). Fifty-four percent of men and forty-three percent of women arrested for any crime reported recent a ...
... to become aggressive under the influence of alcohol and have been called “aggressive drunks” (Ito et al. 1996); aggressive drunks tend to have higher trait levels of aggression (Giancola et al. 2005). Fifty-four percent of men and forty-three percent of women arrested for any crime reported recent a ...
Psychopharmacology
... • Test with a variety of samples between 2- and 4-s • Those on marjiuana were more likely to judge time samples as long. – Indicating that time had sped up for the individual making short intervals seem long ...
... • Test with a variety of samples between 2- and 4-s • Those on marjiuana were more likely to judge time samples as long. – Indicating that time had sped up for the individual making short intervals seem long ...
New pharmacological technologies in the clinical management of
... A compound that has an affinity for & stimulates physiological activity at the same cell receptors as opioid agonists but that produces only a partial (i.e., submaximal) bodily response. ...
... A compound that has an affinity for & stimulates physiological activity at the same cell receptors as opioid agonists but that produces only a partial (i.e., submaximal) bodily response. ...
Histamine receptor antagonists
... Nervous system—Histamine is a powerful stimulant of sensory nerve endings, especially those mediating pain and itching. This H1-mediated effect is an important component of the urticarial response and reactions to insect and nettle stings. H1 and H3 receptors play important roles in appetite and sat ...
... Nervous system—Histamine is a powerful stimulant of sensory nerve endings, especially those mediating pain and itching. This H1-mediated effect is an important component of the urticarial response and reactions to insect and nettle stings. H1 and H3 receptors play important roles in appetite and sat ...
Pharmacology of Muscarinic Receptor Blockade
... M1Receptor Blockade Eliminates the Negative Feedback Effect and Increases ACh Release in Response to Nerve Impulse Flow ...
... M1Receptor Blockade Eliminates the Negative Feedback Effect and Increases ACh Release in Response to Nerve Impulse Flow ...
Pharmacological treatment of schizophrenia–a review of progress
... trial to further assess its efficacy (NCT02469155). RP5063 is a dopamine/serotonin system stabiliser, which completed a phase II clinical trial with promising results. At all therapeutic doses it demonstrated superior efficacy compared with aripiprazole, with a side-effect profile comparable with ...
... trial to further assess its efficacy (NCT02469155). RP5063 is a dopamine/serotonin system stabiliser, which completed a phase II clinical trial with promising results. At all therapeutic doses it demonstrated superior efficacy compared with aripiprazole, with a side-effect profile comparable with ...
Adverse effects
... dosing, avoid driving etc. Counsel patient regarding risk for increased appetite and weight gain. Monitor cholesterol and CBCs. Monitor for suicidal ideation. ...
... dosing, avoid driving etc. Counsel patient regarding risk for increased appetite and weight gain. Monitor cholesterol and CBCs. Monitor for suicidal ideation. ...