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- Dr. Robert Fox
- Dr. Robert Fox

... 1. Assess for (true) disability- medical/legal, especially if they are seeking disability benefits (although rare to find organic brain syndrome, the results are used to help patients alter their lifestyle) 2. Assess for depression- (duloxetene/milnicaprin or pregabalin approved therapy for fibromya ...
antiparkinsonian drugs
antiparkinsonian drugs

... Mechanism of action: • Selective irreversible inhibitors of monoamine oxidase B (retards the breakdown of dopamine). Given alone, it has a weak action. It is therefore used as adjunctive therapy for patients with a declining response to levodopa. They allow dose of Ldopa to be reduced. Side effects: ...
False Positive Urine Screens for Phencyclidine
False Positive Urine Screens for Phencyclidine

... Antibody-based enzyme-mediated immunoassays are used in the emergency department for screening of the urine for substances of abuse. These immunoassays have become the prevailing technology despite limitations such as the weak specificity for phencyclidine (PCP). Tramadol is a centrally acting synth ...
Risperdal Consta (Risperdal Long Acting Injection)
Risperdal Consta (Risperdal Long Acting Injection)

... this drug. FDA ALERT [07/2006] – Infant Persistent Pulmonary Hypertension The results of a study that looked at the use of antidepressant medicines during pregnancy in mothers of babies born with a serious condition called persistent pulmonary hypertension of the newborn (PPHN) was recently publishe ...
Adverse reactions
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... • Five dopaminergic systems or pathways are important for understanding schizophrenia and the mechanism of action of antipsychotic drugs: 1) Mesolimbic-mesocortical pathway: the one most closely related to behavior and psychosis 2) Nigrostriatal pathway: it is involved in the coordination of volunta ...
B-8 - New Psychiatric Medications
B-8 - New Psychiatric Medications

... • Relatively small metabolic side effects • Higher rates of sedation and akathisia than other agents ...
ECSTASY, GHB, KETAMINE, PCP , h h d Dextromethorphan and
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... • Serious acute illness are relatively rare Serious acute illness are relatively rare • Dilutional hyponatremia – cerebral edema • Liver failure Liver failure – In some cases it is a function of hyperpyrexia,  shock and DIC shock and DIC – Other case reports of liver failure independent of  hyperthe ...
The Characteristics and Application of New Antipsychotic Drugs
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... Abstract: The characteristics of new antipsychotic drugs (atypical antipsychotic drugs) and their effective use are discussed. Atypical antipsychotic drugs can be considered modified drugs that resulted when the dopamine D2 receptor-blocking effect of typical antipsychotic drugs was either lowered i ...
ANAFRANIL® 25 mg Coated tablets, 75 mg Sustained
ANAFRANIL® 25 mg Coated tablets, 75 mg Sustained

... Summary of the safety profile Unwanted effects are usually mild and transient, disappearing under continued treatment or with a reduction in the dosage. They do not always correlate with plasma drug levels or dose. It is often difficult to distinguish certain undesirable effects from symptoms of dep ...
2004 Guide to Psychiatric Drug Interactions
2004 Guide to Psychiatric Drug Interactions

... Why should physicians be concerned about drug-drug interactions (DDIs)? DDIs have the potential for causing untoward outcomes, including morbidity and even mortality for the patient, liability for the prescriber, and increased costs for the healthcare system. The risk of unintended and untoward DDIs ...
Proceedings of the 33rd World Small Animal Veterinary
Proceedings of the 33rd World Small Animal Veterinary

... chloramphenicol, lidocaine, etodolac, theophylline, digoxin, propranolol, and many others… However, phenobarbital causes minimal cytochrome P450 enzyme induction in the cat, and therefore these P450-mediated drug interactions are unlikely in the cat. Clomipramine As a tricyclic antidepressant that i ...
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Cilansetron - Open Access Journals
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... relief of IBS symptoms in 50% or more of the responses to the weekly questions on abdominal pain/discomfort and abnormal bowel habits. The ITT population consisted of 792 patients meeting the ROME criteria for IBS-D (358 men and 434 women). With respect to abdominal pain/discomfort, a greater propor ...
Drug-induced sleepiness and insomnia: an update
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... intentionally used due to their effects on sleep, grouping them according to the diseases for which they are recommended, and we will describe their potential to induce sleepiness or insomnia in more detail. For drugs without such potential, we will only cite them as not possessing either property; ...
Antidepressants - Dr BL Lim Centre for Psychological Wellness
Antidepressants - Dr BL Lim Centre for Psychological Wellness

... 1-Least, 3- moderate, 5-most Stephen M. Stahl, M. (2008). Stahl’s Essential Psychopharmacology (3rd ed.). New York, NY: Cambridge University Press. ...
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Prozac, Prozac Weekly, and Sarafem (fluoxetine)
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... Like other SSRIs, Prozac is much safer in overdose than the older TCAs and some of the newer antidepressants. However, unlike the other SSRIs, Prozac has a very long duration of action, and therefore it takes much longer to eliminate Prozac from the body. Deaths from massive overdoses of Prozac have ...
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... • 42F brought to ED after being found confused by roomate. C/o cough and chills x1wk. Last night out “partying” with friends, and this a.m. difficult to awaken. • O/e: 38.5 HR 124 BP 98/72 sats 91%r/a ...
Effects and Risks Associated with Novel Psychoactive Substances
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... The psychotic manifestations of synthetic cathinone use often consist of paranoia with auditory and visual hallucinations (23), which can persist for up to four weeks and take a more severe course than with other amphetamines (23, 24). In most cases of intoxication with psychotic symptoms, MDPV is t ...
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as a PDF

... suggestion that an excess of 5-HT at some receptors, probably the 5-HT 2 type, could be involved in depressive illness. The 5-HT1A agonist 8-OH-DPAT has been found to selectively reduce brain 5-HT synthesis ~s by activation of autoreceptors located on serotonergic cell bodies. 8-OH-DPAT also produce ...
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... Rare but serious reaction, 0.2% of patients on neuroleptics High fever, autonomic instability, mental status changes, leaden rigidity, elevated CK, WBC, myoglobinuria Management  Discontinue antipsychotic  Paracetamol for hyperthermia  IV fluids for hydration  Benzodiazepines for anxiety  Dantr ...
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new recreational drug use

... MDMA use.18 These increases are usually due to rhabdomyolysis (secondary to hyperthermia, prolonged dancing, or seizures) but can take place in the absence of muscular damage. Presentation varies but could include diarrhoea and general muscle aches. Urinalysis shows dark urine, proteinuria, and no e ...
EFFEXOR XR INSTRUCTION SHEET EFFEXOR XR
EFFEXOR XR INSTRUCTION SHEET EFFEXOR XR

... Partial dosing: During transition, (if less than 37.5 or between 37.5 and 75mg is needed), capsules may be opened and used as a sprinkle form on any soft food. Sprinkled granules remain slow release unless bitten into. PANIC PATIENTS NOTE: This step is especially important in panic disorder where in ...
IBS
IBS

... • A 40-year-old man presents for the evaluation of abdominal pain and diarrhea. He states that for about 8 months he has had progressively worsening cramping pains, bloating and diarrhea (3 times/day). with loose stools. However, stools never contained blood. He has tried over-the-counter antidiarrh ...
Antenatal Maternal Antidepressants Drugs Affect S100B
Antenatal Maternal Antidepressants Drugs Affect S100B

... amniotic fluid; T6: venous cord blood, T7: arterial cord blood; T8: at 24-h after birth) maternal, fetal and neonatal biological fluids were collected for standard laboratory assessment and for S100B assessment. Control group was composed by 231 physiological pregnancies whose deliveries were betwee ...
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Serotonin syndrome



Serotonin syndrome is a potential symptom of any number of life-threatening drug interactions which may follow therapeutic drug use, combination, overdose of particular drugs, or the recreational use of certain drugs. Serotonin syndrome is not an idiopathic drug reaction; it is a predictable consequence of excess serotonin on the CNS and/or peripheral nervous system. For this reason, some experts strongly prefer the terms serotonin toxicity or serotonin toxidrome which more accurately reflect that it is a form of poisoning. Other names include serotonin sickness, serotonin storm, serotonin poisoning, hyperserotonemia, or serotonergic syndrome.Excessive levels of serotonin produce a spectrum of specific symptoms including cognitive, autonomic, and somatic effects. Symptoms may range from barely perceptible to fatal. Numerous drugs and drug combinations have been reported to produce serotonin syndrome, though the exact mechanism is not well understood in many instances.Diagnosis includes observing symptoms and investigating patient history for causal factors (interacting drugs). The syndrome has a characteristic picture but can be mistaken for other illnesses in some people, particularly those with neuroleptic malignant syndrome. No laboratory tests can currently confirm the diagnosis. Hence it is diagnosed based on symptoms, disease course (that is, the progression of the disease) and the exclusion of other possible causes of the presenting symptoms.Treatment consists of discontinuing medications which may contribute and in moderate to severe cases administering a serotonin antagonist. An important adjunct treatment includes controlling agitation with benzodiazepine sedation. The high-profile case of Libby Zion, who is generally accepted to have died from serotonin syndrome, resulted in changes to graduate medical education in New York State.
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