MICROMEDEX® Healthcare Series - Law Project for Psychiatric
... the initial recommended dose is 12.5 mg daily with a maximum recommended dose of 50 mg daily; these dosing guidelines also apply to debilitated patients (Prod Info Paxil CR(TM), 2002). 2) Although considerable interindividual variation in paroxetine pharmacokinetics has been observed, higher plasma ...
... the initial recommended dose is 12.5 mg daily with a maximum recommended dose of 50 mg daily; these dosing guidelines also apply to debilitated patients (Prod Info Paxil CR(TM), 2002). 2) Although considerable interindividual variation in paroxetine pharmacokinetics has been observed, higher plasma ...
MICROMEDEX® Healthcare Series OXCARBAZEPINE
... 1.4.1.A.1 Partial seizure, monotherapy a) Conversion 1) For conversion of therapy from other antiepileptic drugs (AEDs) to oxcarbazepine monotherapy in children 4 to 16 years, oxcarbazepine therapy should be initiated with a dose of 8 to 10 milligrams/kilogram/day (mg/kg/day in two divided doses; si ...
... 1.4.1.A.1 Partial seizure, monotherapy a) Conversion 1) For conversion of therapy from other antiepileptic drugs (AEDs) to oxcarbazepine monotherapy in children 4 to 16 years, oxcarbazepine therapy should be initiated with a dose of 8 to 10 milligrams/kilogram/day (mg/kg/day in two divided doses; si ...
St John`s wort (Hypericum perforatum L.): a review of its
... antidepressants, particularly newer antidepressant agents, such as the selective serotonin reuptake inhibitors (recent comparative studies with fluoxetine and sertraline have been conducted). Also, there is a need for further studies in well-defined groups of patients, in different types of depressi ...
... antidepressants, particularly newer antidepressant agents, such as the selective serotonin reuptake inhibitors (recent comparative studies with fluoxetine and sertraline have been conducted). Also, there is a need for further studies in well-defined groups of patients, in different types of depressi ...
St. John`s Wort - American Botanical Council
... The absolute increased response rate with SJW ranged from 23% to 55% higher than with placebo, but ranged from 6% to 18% lower compared with tricyclic antidepressants. Treatment with SJW and fluoxetine, was compared in patients with mild to moderate depression. Results showed that SJW and fluoxetine ...
... The absolute increased response rate with SJW ranged from 23% to 55% higher than with placebo, but ranged from 6% to 18% lower compared with tricyclic antidepressants. Treatment with SJW and fluoxetine, was compared in patients with mild to moderate depression. Results showed that SJW and fluoxetine ...
Effects of different doses of venlafaxine on serotonin and
... plasma protein binding of venlafaxine when compared to those of paroxetine and desipramine, being y30 % for venlafaxine vs. 95 % for the latter two drugs (Ereshefsky and Dugan, 2000 ; Puozzo and Leonard, 1996). Presumably, the greater free fraction of venlafaxine may allow greater brain penetration. ...
... plasma protein binding of venlafaxine when compared to those of paroxetine and desipramine, being y30 % for venlafaxine vs. 95 % for the latter two drugs (Ereshefsky and Dugan, 2000 ; Puozzo and Leonard, 1996). Presumably, the greater free fraction of venlafaxine may allow greater brain penetration. ...
What’s special about methadone?
... FDA has reviewed reports of death and life-threatening side effects such as slowed or stopped breathing, and dangerous changes in heart beat in patients receiving methadone. These serious side effects may occur because methadone may build up in the body to a toxic level if it is taken too often, if ...
... FDA has reviewed reports of death and life-threatening side effects such as slowed or stopped breathing, and dangerous changes in heart beat in patients receiving methadone. These serious side effects may occur because methadone may build up in the body to a toxic level if it is taken too often, if ...
Hypericum perforatum Monograph
... constituent hyperforin to inhibit synaptosomal reuptake of serotonin, norepinephrine, and dopamine.11,12 Two human pharmacological studies demonstrating an increase in cortisol levels following administration of two different St. John’s wort extracts have recently been reported to support this propo ...
... constituent hyperforin to inhibit synaptosomal reuptake of serotonin, norepinephrine, and dopamine.11,12 Two human pharmacological studies demonstrating an increase in cortisol levels following administration of two different St. John’s wort extracts have recently been reported to support this propo ...
Update on Serotonin - Mayo Medical Laboratories
... intravenous therapy, careful monitoring) and removal of the offending agent(s). Once the inciting agent(s) has been removed, recovery is usually rapid. Other agents may be used to shorten the duration of symptoms, although most patients recover in 24 hours with supportive care alone. Prevention is t ...
... intravenous therapy, careful monitoring) and removal of the offending agent(s). Once the inciting agent(s) has been removed, recovery is usually rapid. Other agents may be used to shorten the duration of symptoms, although most patients recover in 24 hours with supportive care alone. Prevention is t ...
Risk Management Plan Rasagiline tablets
... CYP1A2) did not affect the pharmacokinetics of either product. Thus, potent CYP1A2 inhibitors may alter rasagiline plasma levels and should be administered with caution”. Section 4.8: “Serious adverse reactions are known to occur with the concomitant use of SSRIs, SNRIs, tricyclic/tetracyclic antide ...
... CYP1A2) did not affect the pharmacokinetics of either product. Thus, potent CYP1A2 inhibitors may alter rasagiline plasma levels and should be administered with caution”. Section 4.8: “Serious adverse reactions are known to occur with the concomitant use of SSRIs, SNRIs, tricyclic/tetracyclic antide ...
The substituted amphetamines 3,4
... The abilities of the substituted amphetamines 3,4-methylenedioxymethamphetamine (MDMA), methamphetamine, p-chloroamphetamine(PCA) and fenfluramine to induce synaptosomal [3H]serotonin (5-HT) release were compared using a novel microassaysystem. The rank order of release potencies was found to be (+) ...
... The abilities of the substituted amphetamines 3,4-methylenedioxymethamphetamine (MDMA), methamphetamine, p-chloroamphetamine(PCA) and fenfluramine to induce synaptosomal [3H]serotonin (5-HT) release were compared using a novel microassaysystem. The rank order of release potencies was found to be (+) ...
Serotonin Transporter Occupancy of Five Selective Serotonin
... protocol in the second group, were poorly responsive to treatment, and reenrolled in the protocol to join the third group; they are therefore included in both the second and third groups. The subjects did not take any other medications during SSRI treatment. Overall, the combined ranges covered subt ...
... protocol in the second group, were poorly responsive to treatment, and reenrolled in the protocol to join the third group; they are therefore included in both the second and third groups. The subjects did not take any other medications during SSRI treatment. Overall, the combined ranges covered subt ...
Hyperforin - International Journal of Pharmacy and Pharmaceutical
... SJW significantly altered gliclazide pharmacokinetics by a decreased gliclazide AUC, t1/2, and apparent oral clearance. There were no significant changes in glucose or insulin AUC after SJW treatment and no significant differences according to CYP2C9 genotype. Thus, treatment with SJW significantly ...
... SJW significantly altered gliclazide pharmacokinetics by a decreased gliclazide AUC, t1/2, and apparent oral clearance. There were no significant changes in glucose or insulin AUC after SJW treatment and no significant differences according to CYP2C9 genotype. Thus, treatment with SJW significantly ...
Selective serotonin reuptake inhibitors and risk for gastrointestinal
... tract were more susceptible to adverse effects. This suggests that the use of high-affinity SSRIs may increase the risk of bleeding from the upper gastrointestinal tract in psychiatric patients4. A systematic review of 34 studies about the association of antidepressants with the risk of bleeding con ...
... tract were more susceptible to adverse effects. This suggests that the use of high-affinity SSRIs may increase the risk of bleeding from the upper gastrointestinal tract in psychiatric patients4. A systematic review of 34 studies about the association of antidepressants with the risk of bleeding con ...
GENERIC NAME: nefazodone
... PREGNANCY: There are no adequate studies of nefazodone in pregnant women. Studies in animals have not demonstrated any adverse effects on the developing fetus, but some studies in animals found that the animal offspring were of low weight and died more frequently than those whose mothers were not ex ...
... PREGNANCY: There are no adequate studies of nefazodone in pregnant women. Studies in animals have not demonstrated any adverse effects on the developing fetus, but some studies in animals found that the animal offspring were of low weight and died more frequently than those whose mothers were not ex ...
Stahl_3rd_ch12_Part1..
... children and adolescents also suggest increased risk of suicidality; this, coupled with a lack of data demonstrating clear antidepressant efficacy, gives children between the ages of 6 to 12 the worst risk/benefit ratio, with adolescents intermediate between young adults and children. Elderly patien ...
... children and adolescents also suggest increased risk of suicidality; this, coupled with a lack of data demonstrating clear antidepressant efficacy, gives children between the ages of 6 to 12 the worst risk/benefit ratio, with adolescents intermediate between young adults and children. Elderly patien ...
Psychopharmacotherapy of anorexia nervosa, bulimia nervosa and
... observed in patients with anorexia nervosa,39,40 are also reported to thwart central serotonergic activity.40 These findings suggest reduced serotonergic activity that could be a state-related phenomenon because dieting is known to reduce the availability of tryptophan, the precursor of serotonin.41 ...
... observed in patients with anorexia nervosa,39,40 are also reported to thwart central serotonergic activity.40 These findings suggest reduced serotonergic activity that could be a state-related phenomenon because dieting is known to reduce the availability of tryptophan, the precursor of serotonin.41 ...
PR OZA C - Family Guardian
... explain their behavior: The men were missing an enzyme called monoamine oxidase A, or MAO-A, which breaks down serotonin leading to high levels of serotonin just as the mutant mice have. [Keep in mind that the SSRIs and SNRIs work by INCREASING serotonin and DECREASING the ability to metabolize sero ...
... explain their behavior: The men were missing an enzyme called monoamine oxidase A, or MAO-A, which breaks down serotonin leading to high levels of serotonin just as the mutant mice have. [Keep in mind that the SSRIs and SNRIs work by INCREASING serotonin and DECREASING the ability to metabolize sero ...
O R I G I N A L A R T I C L E
... and immediately placed to ice-cold buffered sucrose (0.32 mol/l sucrose, 4 mmol/l HEPES; pH 7.4). All subsequent procedures were performed at 0–4 °C. Brain cortex was separated without cerebellum, gently homogenized in ten volumes (w/v) of ice-cold 0.32 mol/l buffered sucrose supplemented with aprot ...
... and immediately placed to ice-cold buffered sucrose (0.32 mol/l sucrose, 4 mmol/l HEPES; pH 7.4). All subsequent procedures were performed at 0–4 °C. Brain cortex was separated without cerebellum, gently homogenized in ten volumes (w/v) of ice-cold 0.32 mol/l buffered sucrose supplemented with aprot ...
March - Behavioral Health Care Services
... Two large, randomized, multicenter, double-blind, placebocontrolled trials of 18 months’ duration compared the efficacy and tolerability of lamotrigine and lithium to placebo in delaying relapse or recurrence of mood episodes in patients with bipolar I disorder. Both studies were supported by GlaxoS ...
... Two large, randomized, multicenter, double-blind, placebocontrolled trials of 18 months’ duration compared the efficacy and tolerability of lamotrigine and lithium to placebo in delaying relapse or recurrence of mood episodes in patients with bipolar I disorder. Both studies were supported by GlaxoS ...
Studies - The British Journal of Psychiatry
... Self-poisoning is a common method of suicide, especially in women.1 Antidepressants are frequently used for self-poisoning, being involved in around 20% of all poisoning suicides in the UK1 and in 20–30% of non-fatal overdoses.2 This reflects the facts that depression is the most frequent psychiatri ...
... Self-poisoning is a common method of suicide, especially in women.1 Antidepressants are frequently used for self-poisoning, being involved in around 20% of all poisoning suicides in the UK1 and in 20–30% of non-fatal overdoses.2 This reflects the facts that depression is the most frequent psychiatri ...
Antidepressants and Insomnia
... for depression rather than a first-line monotherapy.49 Second, sales of nefazodone have been discontinued in several countries including the United States (branded version) due to concerns of liver toxicity. The process of elimination leaves trazodone as the most likely candidate for monotherapy in ...
... for depression rather than a first-line monotherapy.49 Second, sales of nefazodone have been discontinued in several countries including the United States (branded version) due to concerns of liver toxicity. The process of elimination leaves trazodone as the most likely candidate for monotherapy in ...
Central nervous system activity of the hydroalcoholic extract of
... extract caused considerable reduction of locomotor and exploratory activities and increased the exploration of the EPM open arms in a similar way that diazepam. In the FST, the extract was as effective as fluoxetine in inducing shortening of immobility, along with a significant increase on climbing ...
... extract caused considerable reduction of locomotor and exploratory activities and increased the exploration of the EPM open arms in a similar way that diazepam. In the FST, the extract was as effective as fluoxetine in inducing shortening of immobility, along with a significant increase on climbing ...
References - Specialist Pharmacy Service
... at the right dose for an appropriate duration of time, or the presence of intolerable side effects. When switching between antidepressants there is the potential for interaction between the two agents and/or for the patient to experience drug discontinuation symptoms from withdrawal of the first dru ...
... at the right dose for an appropriate duration of time, or the presence of intolerable side effects. When switching between antidepressants there is the potential for interaction between the two agents and/or for the patient to experience drug discontinuation symptoms from withdrawal of the first dru ...
COMMONLY PRESCRIBED PSYCHOTROPIC MEDICATIONS
... Is the patient taking the medication? Poor adherence is common with all medications and antidepressants are no exception. Are there side effects that are limiting adherence (e.g., sexual side effects) or other concerns (e.g., cost, getting addicted)? Is the dosage high enou ...
... Is the patient taking the medication? Poor adherence is common with all medications and antidepressants are no exception. Are there side effects that are limiting adherence (e.g., sexual side effects) or other concerns (e.g., cost, getting addicted)? Is the dosage high enou ...
Fluoxetine
Fluoxetine (also known by the trade names Prozac, and Sarafem, among others) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Fluoxetine was discovered and developed by scientists from Eli Lilly and Company. It was approved by the U.S. Food and Drug Administration for the treatment of major depressive disorder in December 1987. The U.S. fluoxetine patent expired in August 2001, so generic formulations are now available in the U.S.Fluoxetine is used for the treatment of major depressive disorder (including pediatric depression), obsessive–compulsive disorder (in both adults and children), bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. In addition, it is used to treat trichotillomania if cognitive behaviour therapy has been unsuccessful.In 2010, over 24.4 million prescriptions for generic formulations of fluoxetine were filled in the United States, making it the third-most prescribed antidepressant after sertraline and citalopram. In 2011, 6 million prescriptions for fluoxetine were filled in the United Kingdom. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.