bioavailability enhancdement of poorly soluble drugs by smedds
... soft gelatin capsules, which have some disadvantages especially in the manufacturing process. An alternative method is the incorporation of liquid self emulsifying ingredients into a powder in order to create a solid dosage form (tablets, capsules). A pellet ...
... soft gelatin capsules, which have some disadvantages especially in the manufacturing process. An alternative method is the incorporation of liquid self emulsifying ingredients into a powder in order to create a solid dosage form (tablets, capsules). A pellet ...
4: Drug Prescribing Information in the United States and Other Countries
... efficacy of a new drug (in addition to its safety) before the FDA would approve it for marketing (170). Because of the large number of OTC drugs on the market (estimates varied from 100,000 to 500,000) (100), it was impractical to review efficacy data for each one. Instead, the FDA established panel ...
... efficacy of a new drug (in addition to its safety) before the FDA would approve it for marketing (170). Because of the large number of OTC drugs on the market (estimates varied from 100,000 to 500,000) (100), it was impractical to review efficacy data for each one. Instead, the FDA established panel ...
Drug Effects on the Fetus and Breast-Fed Infant
... the active component (eg, leflunomide, oxcarbazepine, sulindac). If metabolism of a prodrug is markedly different in an experimental species, then animal reproduction studies should be conducted with the active metabolite if they are to have any meaning in human reproduction. For the newer agents, t ...
... the active component (eg, leflunomide, oxcarbazepine, sulindac). If metabolism of a prodrug is markedly different in an experimental species, then animal reproduction studies should be conducted with the active metabolite if they are to have any meaning in human reproduction. For the newer agents, t ...
a review: advances in drug delivery
... treatments started plenty of decades, or even centuries ago either with the oral administration of solid pills and liquids, or with injectable active chemical drugs. When either of these methods is applied, drug dose maintenance in the body is achieved by repeated administrations. Despite the effect ...
... treatments started plenty of decades, or even centuries ago either with the oral administration of solid pills and liquids, or with injectable active chemical drugs. When either of these methods is applied, drug dose maintenance in the body is achieved by repeated administrations. Despite the effect ...
Cannabinoids
... (CESAMET, a synthetic cannabinoid) have been used to treat nausea during chemotherapy Appetite stimulant Glaucoma: can lower intraocular pressure ...
... (CESAMET, a synthetic cannabinoid) have been used to treat nausea during chemotherapy Appetite stimulant Glaucoma: can lower intraocular pressure ...
You Should Continue Breastfeeding
... baby’s merely getting exposed to a drug, say an antidepressant, then the baby is getting exposed to much more drug at a more sensitive time during pregnancy than during breastfeeding. Recent studies about withdrawal symptoms in newborn babies exposed to SSRI type antidepressants during pregnancy som ...
... baby’s merely getting exposed to a drug, say an antidepressant, then the baby is getting exposed to much more drug at a more sensitive time during pregnancy than during breastfeeding. Recent studies about withdrawal symptoms in newborn babies exposed to SSRI type antidepressants during pregnancy som ...
Importance of in -vitro in -vivo studies in pharmaceutical
... to such an extent that their safety and efficacy can be assumed to be substantially equal. Therapeutic equivalents are interchangeable. Essential similar products: if it has the same qualitative and quantitative composition in terms of active substances and the pharmaceutical form is the same and, w ...
... to such an extent that their safety and efficacy can be assumed to be substantially equal. Therapeutic equivalents are interchangeable. Essential similar products: if it has the same qualitative and quantitative composition in terms of active substances and the pharmaceutical form is the same and, w ...
Medicinal Profile of a Scared Drug in Ayurveda: Crataeva religiosa
... detailed pharmacological and chemical studies on this plant. According to Varalakshmi et al. [38], decoction of bark also lowers the intestinal Na+ and K+ATPase levels. Reports of Singh et al. [39] showed the effectiveness of Crataeva bark in prophylaxis of oxalate urolithiasis induced by simultaneo ...
... detailed pharmacological and chemical studies on this plant. According to Varalakshmi et al. [38], decoction of bark also lowers the intestinal Na+ and K+ATPase levels. Reports of Singh et al. [39] showed the effectiveness of Crataeva bark in prophylaxis of oxalate urolithiasis induced by simultaneo ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... Forty five adult female Wister albino rats (120 - 170 gm) were used in this study, purchased from the Animal House, EL- Nile chemical company, Egypt. Rats were housed in a wire mesh plastic cage, in the animal care center of Mansoura faculty of Pharmacy Mansoura University and left to acclimatize fo ...
... Forty five adult female Wister albino rats (120 - 170 gm) were used in this study, purchased from the Animal House, EL- Nile chemical company, Egypt. Rats were housed in a wire mesh plastic cage, in the animal care center of Mansoura faculty of Pharmacy Mansoura University and left to acclimatize fo ...
Herbal Medicines
... frequent used therapies worldwide and 80% (4 billion) of world population uses them for primary health care • Dietary supplements, including herbal products, are regulated under the Dietary Supplement Health and Education Act of 1994 as food product. – Does not require these products to be shown eff ...
... frequent used therapies worldwide and 80% (4 billion) of world population uses them for primary health care • Dietary supplements, including herbal products, are regulated under the Dietary Supplement Health and Education Act of 1994 as food product. – Does not require these products to be shown eff ...
Antiseizure Drugs
... CNS is accomplished without major disturbances in the normal electrical activity. • In fact antiseizure drugs inhibit sustained, high-frequency, repetitive firing much more effectively than low-frequency, nonrepetitive firing. ...
... CNS is accomplished without major disturbances in the normal electrical activity. • In fact antiseizure drugs inhibit sustained, high-frequency, repetitive firing much more effectively than low-frequency, nonrepetitive firing. ...
MYX receives first generic approval of Tikosyn
... the Company’s first generic product to receive 180-days of market exclusivity, the approval and launch of dofetilide is a significant milestone for our Company. Today’s approval accelerates our growth and underscores our investment and commitment to bringing complex generic products to the marketpla ...
... the Company’s first generic product to receive 180-days of market exclusivity, the approval and launch of dofetilide is a significant milestone for our Company. Today’s approval accelerates our growth and underscores our investment and commitment to bringing complex generic products to the marketpla ...
CAMPHOR
... Camphor oil preparations have been used both internally and externally in many countries, for a variety of ailments, ranging from respiratory problems to rheumatic pain (Adame and Adame, 2000; Chevalier, 2000; Ody, 2000; Berdoncés, 1998; Martinez 1989; Lewis and Elvin-Lewis, 1977). Chemically speaki ...
... Camphor oil preparations have been used both internally and externally in many countries, for a variety of ailments, ranging from respiratory problems to rheumatic pain (Adame and Adame, 2000; Chevalier, 2000; Ody, 2000; Berdoncés, 1998; Martinez 1989; Lewis and Elvin-Lewis, 1977). Chemically speaki ...
7. Cholinergic drugs
... intravenously) will produce no relief or even worsen weakness if the patient is receiving excessive cholinesterase inhibitor therapy. On the other hand, if the patient improves with edrophonium, an increase in cholinesterase inhibitor dosage may be indicated. ...
... intravenously) will produce no relief or even worsen weakness if the patient is receiving excessive cholinesterase inhibitor therapy. On the other hand, if the patient improves with edrophonium, an increase in cholinesterase inhibitor dosage may be indicated. ...
High Altitude Notes - Global Adventure Challenges
... allergic to sulfa medicines should not take it. Taking Diamox If a personal choice is made to take Diamox, then it is advised that 250mg (one tablet) is taken twice daily as a trial at sea level for two days several weeks before a visit to altitude. Assuming no unpleasant side effects are experience ...
... allergic to sulfa medicines should not take it. Taking Diamox If a personal choice is made to take Diamox, then it is advised that 250mg (one tablet) is taken twice daily as a trial at sea level for two days several weeks before a visit to altitude. Assuming no unpleasant side effects are experience ...
Anti Epileptic Drugs
... • Reduced in liver to the active metabolite, monohydroxy derivative (MHD) • 27 % excreted unchanged by kidneys • Peak serum drug level 4 – 6 hours • Peak serum metabolite level 8 hours • Elimination half life 8 – 10 hours • Time to steady state – 2 days • Protein binding 38 % ...
... • Reduced in liver to the active metabolite, monohydroxy derivative (MHD) • 27 % excreted unchanged by kidneys • Peak serum drug level 4 – 6 hours • Peak serum metabolite level 8 hours • Elimination half life 8 – 10 hours • Time to steady state – 2 days • Protein binding 38 % ...
TERMINALIA CHEBULA, TERMINALIA BELLERICA Research Article
... activity between two extracts were calculated by Welch’s t‐test. Differences were considered statistically significant if p<0.05. IC50 value (concentration of extract required to scavenge 50% enzyme activity) was calculated from the regression equation prepared from ...
... activity between two extracts were calculated by Welch’s t‐test. Differences were considered statistically significant if p<0.05. IC50 value (concentration of extract required to scavenge 50% enzyme activity) was calculated from the regression equation prepared from ...
Pharmaceuticals and Personal Care Products (PPCPs)
... The data on medication sales provide some perspective on how we use medications. For example, throughout the last decade the percentage of Americans who indicated they had used one prescription medication in the previous month increased by 4%, the use of multiple prescription medications increased b ...
... The data on medication sales provide some perspective on how we use medications. For example, throughout the last decade the percentage of Americans who indicated they had used one prescription medication in the previous month increased by 4%, the use of multiple prescription medications increased b ...
In Pursuit of Science-based Regulation: FDA, FTC, and the
... undiagnosed, and untreated.24 While it may be incumbent upon physicians to ask their patients what supplements they are using, full disclosure by the patients does not guarantee an accurate appraisal. Supplement doses can also vary wildly from their labels, and with dangerous results. For example, a ...
... undiagnosed, and untreated.24 While it may be incumbent upon physicians to ask their patients what supplements they are using, full disclosure by the patients does not guarantee an accurate appraisal. Supplement doses can also vary wildly from their labels, and with dangerous results. For example, a ...
Drugs Salbutamol (Ventolin) SLB
... Salbutamol is less effective in children <12 months and a single dose of 2.5 milligrams should be administered. If this is ineffective, further doses should not be given. In severe attacks nebulisation may need to be repeated as necessary. The pulse rate in children may exceed 140 after significant ...
... Salbutamol is less effective in children <12 months and a single dose of 2.5 milligrams should be administered. If this is ineffective, further doses should not be given. In severe attacks nebulisation may need to be repeated as necessary. The pulse rate in children may exceed 140 after significant ...
Amphetamines
... cause the release of dopamine from axon terminals. block dopamine reuptake. inhibit the storage of dopamine in vesicles. inhibit the destruction of dopamine by enzymes. ...
... cause the release of dopamine from axon terminals. block dopamine reuptake. inhibit the storage of dopamine in vesicles. inhibit the destruction of dopamine by enzymes. ...
Nincs diacím
... reacts with the receptor, opens the channel and depolarizes the end-plate). Depolarization spreads to and depolarizes adjacent membranes generalized, disorganized contraction of muscle motor unit. SUCH is metabolised slower than Ach the depolarized membrane remains unresponsive to additional sti ...
... reacts with the receptor, opens the channel and depolarizes the end-plate). Depolarization spreads to and depolarizes adjacent membranes generalized, disorganized contraction of muscle motor unit. SUCH is metabolised slower than Ach the depolarized membrane remains unresponsive to additional sti ...
Inspections, Compliance, Enforcement, and Criminal Investigations
... The intended uses of your products, Trans-D Tropin, TD-DMPS, and Progesterone-3/.3, make clear that they are drugs as defined in section 201(g)(1) of the Act [21 U.S.C. §321(g) (1)]. Moreover, these products are new drugs as defined in section 201(p) of the Act [21 U.S.C. §321(p)] because your drugs ...
... The intended uses of your products, Trans-D Tropin, TD-DMPS, and Progesterone-3/.3, make clear that they are drugs as defined in section 201(g)(1) of the Act [21 U.S.C. §321(g) (1)]. Moreover, these products are new drugs as defined in section 201(p) of the Act [21 U.S.C. §321(p)] because your drugs ...
September 2015 - Institute For Safe Medication Practices
... A separate and distinct forum for evaluating drug safety exists in the U.S. court systems, where thousands of patient claims of injury for a drug are litigated at cost of millions of dollars in an elaborate process that may take years to complete. When legal claims reach a drug manufacturer they are ...
... A separate and distinct forum for evaluating drug safety exists in the U.S. court systems, where thousands of patient claims of injury for a drug are litigated at cost of millions of dollars in an elaborate process that may take years to complete. When legal claims reach a drug manufacturer they are ...
Relative Reinforcing Effects of Three Opioids with Different
... served as subjects in this part of the study. The apparatus used was similar to that described previously (Howell et al., 1988; France and Woods, 1990; Butelman et al., 1993). The monkey was seated in a restraint chair that was placed in a ventilated, sound-attenuating chamber. A helmet was placed o ...
... served as subjects in this part of the study. The apparatus used was similar to that described previously (Howell et al., 1988; France and Woods, 1990; Butelman et al., 1993). The monkey was seated in a restraint chair that was placed in a ventilated, sound-attenuating chamber. A helmet was placed o ...
Pharmacognosy
Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. The American Society of Pharmacognosy defines pharmacognosy as ""the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.""It is also defined as the study of crude drugs.