Safety and Side Effects of CBD
... of chronic CBD incubation also showed that 25 µM CBD led to morphological changes in the cell lines but not to a directly cytotoxic effect, whereas 1 µM did neither affect cell nor placenta viability. The authors consider this effect cytostatic. Nicardipine was used as the BCRP-substrate in the in v ...
... of chronic CBD incubation also showed that 25 µM CBD led to morphological changes in the cell lines but not to a directly cytotoxic effect, whereas 1 µM did neither affect cell nor placenta viability. The authors consider this effect cytostatic. Nicardipine was used as the BCRP-substrate in the in v ...
- Boehringer Ingelheim (Canada)
... (e.g. ischaemic heart disease, arrhythmia or severe heart failure) who are receiving DUOVENT, should be warned to seek immediate medical advice if they experience chest pain or other symptoms of worsening heart disease. Attention should be paid to assessment of symptoms such as dyspnoea and chest pa ...
... (e.g. ischaemic heart disease, arrhythmia or severe heart failure) who are receiving DUOVENT, should be warned to seek immediate medical advice if they experience chest pain or other symptoms of worsening heart disease. Attention should be paid to assessment of symptoms such as dyspnoea and chest pa ...
Hepatotoxicity associated with illicit use of anabolic androgenic
... have been observed and reported in the literature8,23. Nevertheless, the prevalence of toxic effects following AAS administration could and cannot be defined due to underreporting and lack of specific studies24. However, it seems that in some cases AAS-induced hepatotoxicity might be overestimated b ...
... have been observed and reported in the literature8,23. Nevertheless, the prevalence of toxic effects following AAS administration could and cannot be defined due to underreporting and lack of specific studies24. However, it seems that in some cases AAS-induced hepatotoxicity might be overestimated b ...
GPAT-2012 PAPER
... drug target for the management of Type-2 diabetes mellitus? (A) Sodium glucose linked transporter-2 (SGLT2) (B) Glucose transporter-1 (GLUT1) (C) Sodium glucose linked transporter-1 (SGLT1) (D) Glucose transporter-2 (GLUT2) Q.5 Which one of the following modes of HIV transmission carries highest rel ...
... drug target for the management of Type-2 diabetes mellitus? (A) Sodium glucose linked transporter-2 (SGLT2) (B) Glucose transporter-1 (GLUT1) (C) Sodium glucose linked transporter-1 (SGLT1) (D) Glucose transporter-2 (GLUT2) Q.5 Which one of the following modes of HIV transmission carries highest rel ...
attenuation of hemodynamic response to extubation with injection
... pulmonary oedema if lung volumes are less than vital capacity. They also cause ...
... pulmonary oedema if lung volumes are less than vital capacity. They also cause ...
GPAT-2012 PAPER
... drug target for the management of Type-2 diabetes mellitus? (A) Sodium glucose linked transporter-2 (SGLT2) (B) Glucose transporter-1 (GLUT1) (C) Sodium glucose linked transporter-1 (SGLT1) (D) Glucose transporter-2 (GLUT2) Q.5 Which one of the following modes of HIV transmission carries highest rel ...
... drug target for the management of Type-2 diabetes mellitus? (A) Sodium glucose linked transporter-2 (SGLT2) (B) Glucose transporter-1 (GLUT1) (C) Sodium glucose linked transporter-1 (SGLT1) (D) Glucose transporter-2 (GLUT2) Q.5 Which one of the following modes of HIV transmission carries highest rel ...
united states district court
... first year medical students in the Primary Care Mentorship Program at Harvard Medical School and also as a Preceptor in the Primary Care Clerkship Program at Harvard Medical School. I continue to serve as a tutor in the Primary Care Clerkship Program there. In these roles, I have ...
... first year medical students in the Primary Care Mentorship Program at Harvard Medical School and also as a Preceptor in the Primary Care Clerkship Program at Harvard Medical School. I continue to serve as a tutor in the Primary Care Clerkship Program there. In these roles, I have ...
Doxylamine Succinate - IARC Monographs on the Evaluation of
... > 90%, regardless of sex and dose. The identified unconjugated urinary metabolites (representing 36–44% of the radiolabel) included doxylamine N-oxide, N-desmethyldoxylamine, N,N-didesmethyldoxylamine and ring-hydroxylated products of doxylamine and desmethyldoxylamine (Holder et al., 1987). The ide ...
... > 90%, regardless of sex and dose. The identified unconjugated urinary metabolites (representing 36–44% of the radiolabel) included doxylamine N-oxide, N-desmethyldoxylamine, N,N-didesmethyldoxylamine and ring-hydroxylated products of doxylamine and desmethyldoxylamine (Holder et al., 1987). The ide ...
Kratom and Other Mitragynines
... Morphine and other opioid drugs are extracts or analogs of compounds isolated from a single source, the opium poppy (Papaver somniferum). However, it seems that biological diversity has given rise to an alternative source. Specifically, at least two alkaloids isolated from the plant Mitragyna specio ...
... Morphine and other opioid drugs are extracts or analogs of compounds isolated from a single source, the opium poppy (Papaver somniferum). However, it seems that biological diversity has given rise to an alternative source. Specifically, at least two alkaloids isolated from the plant Mitragyna specio ...
Evaluation of Naltrexone as a Treatment for Amphetamine
... Amphetamine addiction is a disease that affects millions of people worldwide and lacks effective treatment. An estimated 35 million persons are reported to abuse amphetamines, which is more than the total number of cocaine and heroin abusers combined. A majority of intravenous drug users in Sweden a ...
... Amphetamine addiction is a disease that affects millions of people worldwide and lacks effective treatment. An estimated 35 million persons are reported to abuse amphetamines, which is more than the total number of cocaine and heroin abusers combined. A majority of intravenous drug users in Sweden a ...
Answer key 2012
... Choose the correct statement about the use of corticosteroids for the treatment of these disease. a) P, Q and S are treated while R is NOT b) P, R and S are treated while Q is NOT c) Q, R and S are treated while P is NOT d) P, Q and R are treated while S is NOT Q.26 Which one of the followings is st ...
... Choose the correct statement about the use of corticosteroids for the treatment of these disease. a) P, Q and S are treated while R is NOT b) P, R and S are treated while Q is NOT c) Q, R and S are treated while P is NOT d) P, Q and R are treated while S is NOT Q.26 Which one of the followings is st ...
CASSIA ALATA Research Article MULHAM ALFATAMA, KAUSAR AHMAD, FARAHIDAH MOHAMED
... microencapsulated drug delivery systems for medical and pharmaceutical uses have also been widely explored and some successfully used clinically. The micro-carrier systems have clinically demonstrated its ability to improve bioavailability of conventional drugs by prolonging the release of drug from ...
... microencapsulated drug delivery systems for medical and pharmaceutical uses have also been widely explored and some successfully used clinically. The micro-carrier systems have clinically demonstrated its ability to improve bioavailability of conventional drugs by prolonging the release of drug from ...
Diminished Cocaine-Like Effects in Dopamine Transporter Ligands
... vitro, their behavioral effects are generally different from those of the typical dopamine uptake inhibitors, for which cocaine is a prototype (Katz et al., 1999). Many of these compounds have relatively high affinity for muscarinic M1 Portions of this research were presented at the 1999 Annual Meet ...
... vitro, their behavioral effects are generally different from those of the typical dopamine uptake inhibitors, for which cocaine is a prototype (Katz et al., 1999). Many of these compounds have relatively high affinity for muscarinic M1 Portions of this research were presented at the 1999 Annual Meet ...
Histones Differentially Modulate the Anticoagulant and
... depolymerization of UFH; pentasaccharide represents the smallest heparin sequence with inhibitory activity. These compounds mainly differ in selectivity, UFH exerting equal activity against FXa and thrombin, LMWHs showing a preference for FXa, and pentasaccharide being specific for FXa. It is renown ...
... depolymerization of UFH; pentasaccharide represents the smallest heparin sequence with inhibitory activity. These compounds mainly differ in selectivity, UFH exerting equal activity against FXa and thrombin, LMWHs showing a preference for FXa, and pentasaccharide being specific for FXa. It is renown ...
Decreased Serum Concentrations of Tamoxifen
... tamoxifen, but because of more frequent side effects aminoglu tethimide is generally used after tamoxifen as a second line endocrine treatment (12). Combination therapy with tamoxifen plus aminoglutethi mide should afford both estrogen receptor blockade and reduced plasma estrogen levels, and becaus ...
... tamoxifen, but because of more frequent side effects aminoglu tethimide is generally used after tamoxifen as a second line endocrine treatment (12). Combination therapy with tamoxifen plus aminoglutethi mide should afford both estrogen receptor blockade and reduced plasma estrogen levels, and becaus ...
What’s special about methadone?
... receiving methadone. These serious side effects may occur because methadone may build up in the body to a toxic level if it is taken too often, if the amount taken is too high, or if it is taken with certain other medicines or supplements. Methadone has specific toxic effects on the heart (QT prolon ...
... receiving methadone. These serious side effects may occur because methadone may build up in the body to a toxic level if it is taken too often, if the amount taken is too high, or if it is taken with certain other medicines or supplements. Methadone has specific toxic effects on the heart (QT prolon ...
Phenylpropanolamine There are four optical isomers of
... of hypotension from spinal/epidural anaesthesia.[4] It is also used in other hypotensive states, including overdose with ganglionic blocking agents, antiadrenergic agents, or other medications that lower blood pressure.[5] It can be used in narcolepsy and nocturnal enuresis. In traditional Chinese m ...
... of hypotension from spinal/epidural anaesthesia.[4] It is also used in other hypotensive states, including overdose with ganglionic blocking agents, antiadrenergic agents, or other medications that lower blood pressure.[5] It can be used in narcolepsy and nocturnal enuresis. In traditional Chinese m ...
The use of natural and synthetic phospholipids as pharmaceutical
... at pH values of about 7, whereas, e.g., PG is negatively charged. The most common phospholipid is PC, and PC is the main component of lecithin. Lecithin is described, e.g., in the United States Pharmacopoeia (USP) as a “complex mixture of acetone‐insoluble phosphatides, which consists chiefly of PC, ...
... at pH values of about 7, whereas, e.g., PG is negatively charged. The most common phospholipid is PC, and PC is the main component of lecithin. Lecithin is described, e.g., in the United States Pharmacopoeia (USP) as a “complex mixture of acetone‐insoluble phosphatides, which consists chiefly of PC, ...
cannabis 2009 - addiction education home
... to use one drug (legal or illicit) instead of, or in conjunction with, another due to issues such as: perceived safety; level of addiction potential; effectiveness in relieving symptoms; access and level of acceptance. This practice of substitution has been observed among individuals using cannabis ...
... to use one drug (legal or illicit) instead of, or in conjunction with, another due to issues such as: perceived safety; level of addiction potential; effectiveness in relieving symptoms; access and level of acceptance. This practice of substitution has been observed among individuals using cannabis ...
Yohimbine enhances the effect of sildenafil on erectile
... Combining the centrally acting drug yohimbine with the peripheral conditioner sildenafil might be an approach to erectile dysfunction cases in which sildenafil alone failed. This work aimed to investigate the effect of yohimbine on sildenafil-induced facilitation of erectile process. Erectile respon ...
... Combining the centrally acting drug yohimbine with the peripheral conditioner sildenafil might be an approach to erectile dysfunction cases in which sildenafil alone failed. This work aimed to investigate the effect of yohimbine on sildenafil-induced facilitation of erectile process. Erectile respon ...
Thyroxine Sodium - Therapeutic Goods Administration
... prescribed. In the US, the leading brand of thyroxine is the third most widely prescribed pharmaceutical product. It has been formulated into tablets to treat thyroid disease for more than 50 years. It is known to be difficult to manufacture; it can be sensitive to seemingly minor changes in process ...
... prescribed. In the US, the leading brand of thyroxine is the third most widely prescribed pharmaceutical product. It has been formulated into tablets to treat thyroid disease for more than 50 years. It is known to be difficult to manufacture; it can be sensitive to seemingly minor changes in process ...
cocaine 68, 111, 145, 150, 164, 192, 201, 208, 209, 226, 270, 274
... community survey (531); and (2) ratio-estimation multiplier, using an estimate of number of injecting drug users and proportion that use crack cocaine. Findings: After matching, 4117 individuals aged 15-44 were identified. The best-fitting model estimated 16 855 unobserved crack cocaine users, givin ...
... community survey (531); and (2) ratio-estimation multiplier, using an estimate of number of injecting drug users and proportion that use crack cocaine. Findings: After matching, 4117 individuals aged 15-44 were identified. The best-fitting model estimated 16 855 unobserved crack cocaine users, givin ...
Australian public assessment for Thyroxine Sodium
... There are British Pharmacopeia (BP), European Pharmacopeia (EP) and US Pharmacopeia (USP) monographs for the drug substance and BP and USP monographs for the tablets. 1 Drug substance (active ingredient) Thyroxine is a naturally occurring thyroid hormone. This product is formulated with the sodium s ...
... There are British Pharmacopeia (BP), European Pharmacopeia (EP) and US Pharmacopeia (USP) monographs for the drug substance and BP and USP monographs for the tablets. 1 Drug substance (active ingredient) Thyroxine is a naturally occurring thyroid hormone. This product is formulated with the sodium s ...
Evaluation of the use of static and dynamic models to predict drug
... than Simcyp (84% compared to 58% of the interactions predicted within 2-fold). Differences in the prediction outcomes between the static and dynamic models are attributable to differences in first-pass contribution to DDI. The inclusion of AUCRhfp in static equations leads to systematic overpredicti ...
... than Simcyp (84% compared to 58% of the interactions predicted within 2-fold). Differences in the prediction outcomes between the static and dynamic models are attributable to differences in first-pass contribution to DDI. The inclusion of AUCRhfp in static equations leads to systematic overpredicti ...
Pharmacognosy
Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. The American Society of Pharmacognosy defines pharmacognosy as ""the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.""It is also defined as the study of crude drugs.