(or summary of product characteristics) for fixed-dose
... single-component products and it is difficult to imagine a case in which essentially the same standards would not apply. 5.1.2 Medical considerations are more complex and sometimes contradictory, for example, when increased efficacy is accompanied by increased toxicity. The decision as to whether to ...
... single-component products and it is difficult to imagine a case in which essentially the same standards would not apply. 5.1.2 Medical considerations are more complex and sometimes contradictory, for example, when increased efficacy is accompanied by increased toxicity. The decision as to whether to ...
Guide to Good Prescribing - World Health Organization
... At the start of clinical training most medical students find that they don't have a very clear idea of how to prescribe a drug for their patients or what information they need to provide. This is usually because their earlier pharmacology training has concentrated more on theory than on practice. Th ...
... At the start of clinical training most medical students find that they don't have a very clear idea of how to prescribe a drug for their patients or what information they need to provide. This is usually because their earlier pharmacology training has concentrated more on theory than on practice. Th ...
spc-doc_PL 20416-0081 - Medicines and Healthcare products
... Antiparkinson drugs of the anticholinergic type may be prescribed as required, but should not be prescribed routinely as a preventive measure. If concomitant anti-parkinson medication is required, it may have to be continued after stopping haloperidol if its excretion is faster than that of haloperi ...
... Antiparkinson drugs of the anticholinergic type may be prescribed as required, but should not be prescribed routinely as a preventive measure. If concomitant anti-parkinson medication is required, it may have to be continued after stopping haloperidol if its excretion is faster than that of haloperi ...
Site-specific conjugation of a cytotoxic drug to an antibody improves
... auristatin E, an antibody against the ovarian cancer antigen MUC16 is as efficacious as a conventional conjugate in mouse xenograft models. Moreover, it is tolerated at higher doses in rats and cynomolgus monkeys than the same conjugate prepared by conventional approaches. The favorable in vivo prop ...
... auristatin E, an antibody against the ovarian cancer antigen MUC16 is as efficacious as a conventional conjugate in mouse xenograft models. Moreover, it is tolerated at higher doses in rats and cynomolgus monkeys than the same conjugate prepared by conventional approaches. The favorable in vivo prop ...
1 EVALUATION OF ANTIDIABETIC ACTIVITY OF LEAF EXTRACT
... Alloxan monohydrate is commonly used to induce non insulin dependent diabetes mellitus in many experimental animals. The mechanism of action of Alloxan has been thoroughly studied. Alloxan, a cytotoxic agent induces diabetes in various animal species through destruction of islets of Langerhans of th ...
... Alloxan monohydrate is commonly used to induce non insulin dependent diabetes mellitus in many experimental animals. The mechanism of action of Alloxan has been thoroughly studied. Alloxan, a cytotoxic agent induces diabetes in various animal species through destruction of islets of Langerhans of th ...
Research Article www.ijrap.net
... Ayurvedic medicines were done by the Acharyas themselves; so drugs made by them were more efficacious, authentic and genuine. In the present age the suppliers make the collection. There are so many drugs; which lost their effectiveness with the passage of time. This causes the lowering the genuine c ...
... Ayurvedic medicines were done by the Acharyas themselves; so drugs made by them were more efficacious, authentic and genuine. In the present age the suppliers make the collection. There are so many drugs; which lost their effectiveness with the passage of time. This causes the lowering the genuine c ...
NIH Public Access
... outcomes. Two approaches are commonly used to identify the contribution of underlying genetic variation to a given drug-response phenotype. The first, a hypothesis-driven “candidate gene” approach, is one in which an understanding of underlying pharmacokinetics or pharmacodynamics drives selection o ...
... outcomes. Two approaches are commonly used to identify the contribution of underlying genetic variation to a given drug-response phenotype. The first, a hypothesis-driven “candidate gene” approach, is one in which an understanding of underlying pharmacokinetics or pharmacodynamics drives selection o ...
Abstrakty Lublin
... specified by law are nearly universal for people with epilepsy. A patient must have controlled seizures to be allowed to drive. Some types of epilepsies (with auras or nocturnal seizures only during sleep) may reduce the risk of seizure-related crashes. The seizure-free periods that determinate whet ...
... specified by law are nearly universal for people with epilepsy. A patient must have controlled seizures to be allowed to drive. Some types of epilepsies (with auras or nocturnal seizures only during sleep) may reduce the risk of seizure-related crashes. The seizure-free periods that determinate whet ...
Drugs that affect the fetus and newborn infant via the placenta or
... during pregnancy can cross the placenta and reach the fetus. Whether knowingly or not, a mother is exposed to several drugs during pregnancy; the number can range from one to as many as six to eight drugs [6 – 8]. The drugs can be prescribed, obtained over the counter, or obtained illicitly (eg, dru ...
... during pregnancy can cross the placenta and reach the fetus. Whether knowingly or not, a mother is exposed to several drugs during pregnancy; the number can range from one to as many as six to eight drugs [6 – 8]. The drugs can be prescribed, obtained over the counter, or obtained illicitly (eg, dru ...
journal
... The traditional style of practice has evolved over the years. In many countries practices used to be mixed, treating all species, large and small, and they were at one time predominantly single-vet practices. Over the years, practice size has grown to multi-vet and multi-branch in many countries and ...
... The traditional style of practice has evolved over the years. In many countries practices used to be mixed, treating all species, large and small, and they were at one time predominantly single-vet practices. Over the years, practice size has grown to multi-vet and multi-branch in many countries and ...
Clinical Pharmacy Department Clinical Pharmacy Modul 3
... Which of the following antibiotics is a tetracycline? A. Chloramphenicol B. Doxycycline C. Streptomycin D. Erythromycin E. None of the above ANSWER: B In the treatment of acute diarrhea A. antibiotics are worst avoided in non-pathogenic diarrhea B. antibiotics are worst avoided in viral gastroenteri ...
... Which of the following antibiotics is a tetracycline? A. Chloramphenicol B. Doxycycline C. Streptomycin D. Erythromycin E. None of the above ANSWER: B In the treatment of acute diarrhea A. antibiotics are worst avoided in non-pathogenic diarrhea B. antibiotics are worst avoided in viral gastroenteri ...
A Brief History of Great Discoveries in Pharmacology: In Celebration
... Although pharmacology is a discipline with a rich and enduring heritage, present-day pharmacology is quite a different discipline than the more traditional subject I studied as a graduate student in the early 1960s. The discipline is now deeply rooted in molecular biology and molecular genetics, bot ...
... Although pharmacology is a discipline with a rich and enduring heritage, present-day pharmacology is quite a different discipline than the more traditional subject I studied as a graduate student in the early 1960s. The discipline is now deeply rooted in molecular biology and molecular genetics, bot ...
Lemon Balm - Longwood Herbal Task Force
... to mice caused sedative and narcotic effects31. iii. Human data: Most studies on lemon balm’s sedative effects have used herbal combinations including proven sedatives such as valerian, and have not been published in English. The data presented here are largely drawn from the English abstracts of th ...
... to mice caused sedative and narcotic effects31. iii. Human data: Most studies on lemon balm’s sedative effects have used herbal combinations including proven sedatives such as valerian, and have not been published in English. The data presented here are largely drawn from the English abstracts of th ...
Determination and validation of hydrazine content by
... detection(LOD) and Limit of quantification(LOQ) values were 0.2 µg/g and 0.6 µg/g respectively. The average accuracy value is 97.8%-100.0%.And also determination of hydrazine in different drug substances like zinc carnosine, aprepitant. In zinc carnosine and aprepitant with slight modification in me ...
... detection(LOD) and Limit of quantification(LOQ) values were 0.2 µg/g and 0.6 µg/g respectively. The average accuracy value is 97.8%-100.0%.And also determination of hydrazine in different drug substances like zinc carnosine, aprepitant. In zinc carnosine and aprepitant with slight modification in me ...
2012 Drug Trend Report
... Drug Trend Report provides the healthcare industry’s most detailed analysis of prescription drug costs and utilization. In recent years, we created an online report for a more interactive experience. In 2013 and going forward, we’re updating the site regularly for timely access to critical informati ...
... Drug Trend Report provides the healthcare industry’s most detailed analysis of prescription drug costs and utilization. In recent years, we created an online report for a more interactive experience. In 2013 and going forward, we’re updating the site regularly for timely access to critical informati ...
Amebic meningoencephalitides and keratitis: challenges
... against different Acanthamoeba isolates [2,23]. For example, miltefosine (hexadecylphosphocholine) was found to be effective in vitro against Acanthamoeba isolates [24,25] and was found to be useful in systemic infections [21] and amebic keratitis [26]. In a recent article, Walochnik et al. [27] h ...
... against different Acanthamoeba isolates [2,23]. For example, miltefosine (hexadecylphosphocholine) was found to be effective in vitro against Acanthamoeba isolates [24,25] and was found to be useful in systemic infections [21] and amebic keratitis [26]. In a recent article, Walochnik et al. [27] h ...
PLA MICROGRANULES USED AS CARRIERS OF ACTIVE
... considerable amount of the organic solvent in this phase. Due to the fact that ethyl acetate is an undesireable component of the system it was evaporated during 10 hours in the vacuum chamber (Artvac) under the pressure of 0.15 bar and at the temperature of 50 °C. 2.2. Coacervation of mPLA-IBU/CS Th ...
... considerable amount of the organic solvent in this phase. Due to the fact that ethyl acetate is an undesireable component of the system it was evaporated during 10 hours in the vacuum chamber (Artvac) under the pressure of 0.15 bar and at the temperature of 50 °C. 2.2. Coacervation of mPLA-IBU/CS Th ...
The Seventh Report of the Joint National Committee on Prevention
... at 115/75 mm Hg, doubles with each increment of 20/10 mm Hg; individuals who are normotensive at 55 years of age have a 90% lifetime risk for developing hypertension; (3) Individuals with a systolic BP of 120 to 139 mm Hg or a diastolic BP of 80 to 89 mm Hg should be considered as prehypertensive an ...
... at 115/75 mm Hg, doubles with each increment of 20/10 mm Hg; individuals who are normotensive at 55 years of age have a 90% lifetime risk for developing hypertension; (3) Individuals with a systolic BP of 120 to 139 mm Hg or a diastolic BP of 80 to 89 mm Hg should be considered as prehypertensive an ...
Non-prescription and Household Substances of Abuse
... lethal dose for humans is estimated at 150-200 mg/kg.48 In one case report, a 19-year old female had died after ingesting an estimate of 18 grams of caffeine from an over-the-counter appetite suppressant. 49 Abuse of other products have also been identified in dieters and patients with eating disord ...
... lethal dose for humans is estimated at 150-200 mg/kg.48 In one case report, a 19-year old female had died after ingesting an estimate of 18 grams of caffeine from an over-the-counter appetite suppressant. 49 Abuse of other products have also been identified in dieters and patients with eating disord ...
et al. Madhu E. Nicholas* , Shanker Panaganti , L. Prabakaran
... Radio-telemetry shows the highest pH level (7.5±0.5) in the terminal ileum. On entry into the colon, the pH drop to 6.4+0.6. The pH in the mid colon is 6.6+0.8 and in the left colon 7.0+0.7. Since there is minimal variation in the pH from ileum to colon, apparently pH dependent polymer drug delivery ...
... Radio-telemetry shows the highest pH level (7.5±0.5) in the terminal ileum. On entry into the colon, the pH drop to 6.4+0.6. The pH in the mid colon is 6.6+0.8 and in the left colon 7.0+0.7. Since there is minimal variation in the pH from ileum to colon, apparently pH dependent polymer drug delivery ...
Frequency of Sodium Valproate-Induced Hair Loss and Curly Hair
... curling of hair were found between sodium valproate users. Three cases were female and three were male. This side effect observed at least 3 months after its first initial drug therapy. The estimated frequency of curly hair along with hair loss in our study is lower than previously-reported frequenc ...
... curling of hair were found between sodium valproate users. Three cases were female and three were male. This side effect observed at least 3 months after its first initial drug therapy. The estimated frequency of curly hair along with hair loss in our study is lower than previously-reported frequenc ...
An Epidemic of Clandestine Labs and Health Risk
... apparent and the task of its synthesis was given to a British UCLA graduate student named Gordon Alles. Alles attempt to synthesize ephedrine was unsuccessful, but on the way he discovered the properties of a product later called dextroamphetamine. He found this substance to have potential for incre ...
... apparent and the task of its synthesis was given to a British UCLA graduate student named Gordon Alles. Alles attempt to synthesize ephedrine was unsuccessful, but on the way he discovered the properties of a product later called dextroamphetamine. He found this substance to have potential for incre ...
Pharmacognosy
Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. The American Society of Pharmacognosy defines pharmacognosy as ""the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.""It is also defined as the study of crude drugs.