A General Method Applicable to the Search for Similarities in the
... Comparisons are made from the smallest unit of significance, a pair of amino acids, one from each protein. All possible pairs are represented by a two-dimensional array, and all possible comparisons are representod by pathways through the array. For this maximum match only cerhain ofthe possible pat ...
... Comparisons are made from the smallest unit of significance, a pair of amino acids, one from each protein. All possible pairs are represented by a two-dimensional array, and all possible comparisons are representod by pathways through the array. For this maximum match only cerhain ofthe possible pat ...
Biochem-EnzymesL
... The enzyme does not actually form a chemical bond with the substrate. After the reaction, the products are released and the enzyme returns to its normal shape. Because the enzyme does not form chemical bonds with the substrate, it remains unchanged. The enzyme molecule can be reused repeatedly Only ...
... The enzyme does not actually form a chemical bond with the substrate. After the reaction, the products are released and the enzyme returns to its normal shape. Because the enzyme does not form chemical bonds with the substrate, it remains unchanged. The enzyme molecule can be reused repeatedly Only ...
Amino Acids of the Sulfolobus solfataricus Mini-chromosome
... 194 and at histidine 146 to alanine by PCR-based mutagenesis of the corresponding gene (30). The synthetic oligonucleotides used to create the site-directed mutant proteins are available on request. The amplification products were subcloned back into the SsoMCM-pET19b vector and sequenced to check i ...
... 194 and at histidine 146 to alanine by PCR-based mutagenesis of the corresponding gene (30). The synthetic oligonucleotides used to create the site-directed mutant proteins are available on request. The amplification products were subcloned back into the SsoMCM-pET19b vector and sequenced to check i ...
Hidden Markov Model for protein secondary structure
... a succession of two polar residues and two apolar residues. This motif occurs when an helix has a side facing the solvent (thus preferentially supporting polar residues) while the other side faces the core of the protein (preferentially supporting apolar residues). This motif is very frequent. With ...
... a succession of two polar residues and two apolar residues. This motif occurs when an helix has a side facing the solvent (thus preferentially supporting polar residues) while the other side faces the core of the protein (preferentially supporting apolar residues). This motif is very frequent. With ...
Different packing of external residues can explain differences in the
... A residue was called internal if the area of its surface accessible to the solvent was equal to zero, and external if its accessible surface area was more than 25% of the maximal accessible surface area observed in PDB for this type of residue (see Table 1). The other amino acid residues were called ...
... A residue was called internal if the area of its surface accessible to the solvent was equal to zero, and external if its accessible surface area was more than 25% of the maximal accessible surface area observed in PDB for this type of residue (see Table 1). The other amino acid residues were called ...
Chap. 3A Amino Acids, Peptides, and Proteins Topics Amino acids
... specified by the genetic code and polymerized into proteins by ribosomal translation. All amino acids contain an a carbon to which typically 4 different substituent groups are attached (Fig. 3-2). These groups are the aamino group, the a-carboxyl group, hydrogen, and the variable R group (side-chain ...
... specified by the genetic code and polymerized into proteins by ribosomal translation. All amino acids contain an a carbon to which typically 4 different substituent groups are attached (Fig. 3-2). These groups are the aamino group, the a-carboxyl group, hydrogen, and the variable R group (side-chain ...
lec27_2013 - Andrew.cmu.edu
... General Enzyme Nomenclature: Name - usually consists of three parts: i) the substrate is used to name the enzyme, Keep in mind that many enzymatic reactions run in both directions in metabolism, consequently the “product” may be used to name the enzyme. ii) the nature of the chemical reaction. iii) ...
... General Enzyme Nomenclature: Name - usually consists of three parts: i) the substrate is used to name the enzyme, Keep in mind that many enzymatic reactions run in both directions in metabolism, consequently the “product” may be used to name the enzyme. ii) the nature of the chemical reaction. iii) ...
Selective Binding of Lisinopril in Angiotensin
... the phenylpropyl group and the lysine of lisinopril.7 Glu162 binds via hydrogen bonding to the lysine chain of lisinopril.7 Lys511 and Tyr520 binds via hydrogen binding to the C-terminal proline carboxyl group of lisinopril.7 The zinc ion plays an important catalytic role in ACE. This ion is deep wi ...
... the phenylpropyl group and the lysine of lisinopril.7 Glu162 binds via hydrogen bonding to the lysine chain of lisinopril.7 Lys511 and Tyr520 binds via hydrogen binding to the C-terminal proline carboxyl group of lisinopril.7 The zinc ion plays an important catalytic role in ACE. This ion is deep wi ...
Structure of chicken calcitonin predicted by partial nucleotide
... m lower vertebrates by the ultrmobranchial gland, shows important differences in its amino acid sequence. Based on structure, three groups of calcitonins can be distinguished: (i) human and murine [1,2] (Primate and Rodentia); (n) bovine, porcine and ovine [3-51 (Artiodactyls); (iii) salmon and eel ...
... m lower vertebrates by the ultrmobranchial gland, shows important differences in its amino acid sequence. Based on structure, three groups of calcitonins can be distinguished: (i) human and murine [1,2] (Primate and Rodentia); (n) bovine, porcine and ovine [3-51 (Artiodactyls); (iii) salmon and eel ...
DFT Analysis into the Intermediates of Nickel
... singlet spin state can be assumed, however transition metal complexes are more complicated.43,44 Six coordinate Ni(II) is octahedral d8 so 1− and 2N have a triplet ground state with two unpaired electrons. When 2N was optimized as a singlet, the geometry changed to square planar with dechelation of ...
... singlet spin state can be assumed, however transition metal complexes are more complicated.43,44 Six coordinate Ni(II) is octahedral d8 so 1− and 2N have a triplet ground state with two unpaired electrons. When 2N was optimized as a singlet, the geometry changed to square planar with dechelation of ...
chapter 10: coordination chemistry ii: bonding
... If we assume that each low spin configuration will have the maximum number of paired electrons, then the configurations with asymmetrically occupied degenerate orbitals are those for d1, d3, d5, and d7 metals. These are expected to give rise to Jahn-Teller distortion. ...
... If we assume that each low spin configuration will have the maximum number of paired electrons, then the configurations with asymmetrically occupied degenerate orbitals are those for d1, d3, d5, and d7 metals. These are expected to give rise to Jahn-Teller distortion. ...
Lecture 27
... N-acetylglutamate is synthesized from glutamate and acetylCoA by N-acetylglutamate synthase, it is hydrolyzed by a specific hydrolase. Rate of urea production is dependent on [N-acetylglutamate]. When aa breakdown rates increase, excess nitrogen must be excreted. This results in increase in Glu thro ...
... N-acetylglutamate is synthesized from glutamate and acetylCoA by N-acetylglutamate synthase, it is hydrolyzed by a specific hydrolase. Rate of urea production is dependent on [N-acetylglutamate]. When aa breakdown rates increase, excess nitrogen must be excreted. This results in increase in Glu thro ...
Translation is simply the decoding of nucleotide sequences on
... Fig. 2. a-‐Structure of prokaryotic (70S) and eukaryotic (80S) ribosomes; b-‐Genetic code showing t aminoacids base sequence in the mRNA by means of a set of adaptor molecules known as tRNA . The tRNA binds to the mRNA codons (group of three adjac ...
... Fig. 2. a-‐Structure of prokaryotic (70S) and eukaryotic (80S) ribosomes; b-‐Genetic code showing t aminoacids base sequence in the mRNA by means of a set of adaptor molecules known as tRNA . The tRNA binds to the mRNA codons (group of three adjac ...
Metal Fluorides: Tools for Structural and Computational Analysis of
... anionic oxygen. These comprise two sub-groups: over 70 have Be coordinated to an aspartate carboxylate while some 50 have Be coordinated to a terminal phosphate oxygen of a nucleotide. Just two have Be coordinated to a histidine ring nitrogen, while one has BeF2 bridging two phosphates. 3.1.1 Aspart ...
... anionic oxygen. These comprise two sub-groups: over 70 have Be coordinated to an aspartate carboxylate while some 50 have Be coordinated to a terminal phosphate oxygen of a nucleotide. Just two have Be coordinated to a histidine ring nitrogen, while one has BeF2 bridging two phosphates. 3.1.1 Aspart ...
as a PDF
... sized and characterized by physicochemical methods and X-ray crystallography. The crystal structure of [CC13C02PdOO-tB u ] was ~ determined. The molecule crystallizes with four formula units in the monoclinic space group C2/c with a = 17.867 (7) A, b = 14.371 (4) A, c = 21.126 (3) A, and p = 112.63 ...
... sized and characterized by physicochemical methods and X-ray crystallography. The crystal structure of [CC13C02PdOO-tB u ] was ~ determined. The molecule crystallizes with four formula units in the monoclinic space group C2/c with a = 17.867 (7) A, b = 14.371 (4) A, c = 21.126 (3) A, and p = 112.63 ...
Effects of Enzyme Concentration, Temperature, pH
... 2005; Liceaga-Gesualdo & Li-Chan 1999). The functional properties of fish protein hydrolysates prepared may be improved through partial hydrolysis where the proteins are hydrolyzed to the desired extent by the use of specific enzymes and by choosing a defined set of hydrolysis conditions. Parameters ...
... 2005; Liceaga-Gesualdo & Li-Chan 1999). The functional properties of fish protein hydrolysates prepared may be improved through partial hydrolysis where the proteins are hydrolyzed to the desired extent by the use of specific enzymes and by choosing a defined set of hydrolysis conditions. Parameters ...
SAMPLE QUESTION PAPER SIR.S.M.TAHIR CHEMISTRY Mob: 9557076999
... Give chemical reaction for the following observations. (a) Potassium permanganate is a good oxidizing agent in basic medium. (b) Interconvertibility of chromate ion and dichromate ion in aqueous solution depends upon pH of the solutions. (c) Potassium permanganate is thermally unstable at 513 K. ...
... Give chemical reaction for the following observations. (a) Potassium permanganate is a good oxidizing agent in basic medium. (b) Interconvertibility of chromate ion and dichromate ion in aqueous solution depends upon pH of the solutions. (c) Potassium permanganate is thermally unstable at 513 K. ...
Nutritional Requirements for Rabbits
... enzymes and is involved in cell division processes. Higher levels are required for reproduction and fur production than for maintenance and meat production. Impaired fertility, hair loss and dermatitis are common signs of iron deficiency. Manganese is a coenzyme in amino acid metabolism and cartilag ...
... enzymes and is involved in cell division processes. Higher levels are required for reproduction and fur production than for maintenance and meat production. Impaired fertility, hair loss and dermatitis are common signs of iron deficiency. Manganese is a coenzyme in amino acid metabolism and cartilag ...
Statistical analysis of DNA microarray data
... structure atomic representation of the protein template in fold recognition. Today, the terms threading and fold recognition are frequently (though somewhat incorrectly) used interchangeably. The basic idea is that the target sequence (the protein sequence for which the structure is being predicted) ...
... structure atomic representation of the protein template in fold recognition. Today, the terms threading and fold recognition are frequently (though somewhat incorrectly) used interchangeably. The basic idea is that the target sequence (the protein sequence for which the structure is being predicted) ...
here - Dr. Alan Dombkowski
... are the estimated χ3 torsion angle and an energy value in kcal/mol. χ3 angles of known disulfides have a bimodal distribution with peaks observed at +100 and -80 (Petersen et al., 1999), see figure in technical details. These values provide useful selection criteria for disulfide design. The estimat ...
... are the estimated χ3 torsion angle and an energy value in kcal/mol. χ3 angles of known disulfides have a bimodal distribution with peaks observed at +100 and -80 (Petersen et al., 1999), see figure in technical details. These values provide useful selection criteria for disulfide design. The estimat ...
Biosynthesis of the dystonia-associated AAA ATPase torsinA at the
... presence of membranes (Figure 1B, compare lanes 1 and 2). The presence of this product in the absence of ER membranes suggests that it is a non-glycosylated, uncleaved form of torsinA. TorsinA contains two N-glycosylation sites [4,12], and treatment with endo H caused a decrease in the intensity of ...
... presence of membranes (Figure 1B, compare lanes 1 and 2). The presence of this product in the absence of ER membranes suggests that it is a non-glycosylated, uncleaved form of torsinA. TorsinA contains two N-glycosylation sites [4,12], and treatment with endo H caused a decrease in the intensity of ...
Structural biology and drug design
... variables (X) to the potency of the response variable (Y) • In QSAR, X is the “molecular structure” of the ligands, and Y is the biological response • For a good QSAR model, the biological response for new molecules can be estimated from the “molecular structure” without testing • The difficult part ...
... variables (X) to the potency of the response variable (Y) • In QSAR, X is the “molecular structure” of the ligands, and Y is the biological response • For a good QSAR model, the biological response for new molecules can be estimated from the “molecular structure” without testing • The difficult part ...
Amino Acids - Portal UniMAP
... which an amino group, a carboxylate group, a hydrogen atom and an R (side chain) group are attached ...
... which an amino group, a carboxylate group, a hydrogen atom and an R (side chain) group are attached ...
Topic 4 Proteins as Drug Targets
... 3. G-protein-coupled receptors (7-TM receptors) 3.7 Glycogen metabolism - triggered by adrenaline in liver cells Coordinated effect - activation of glycogen metabolism - inhibition of glycogen synthesis Adrenaline has different effects on different cells - activates fat metabolism in fat cells ...
... 3. G-protein-coupled receptors (7-TM receptors) 3.7 Glycogen metabolism - triggered by adrenaline in liver cells Coordinated effect - activation of glycogen metabolism - inhibition of glycogen synthesis Adrenaline has different effects on different cells - activates fat metabolism in fat cells ...
Metalloprotein
Metalloprotein is a generic term for a protein that contains a metal ion cofactor. A large number of all proteins are part of this category.