Angiotensin I Converting Enzyme and the Changes
... confirmed the existence of a hydrophobic C-termlnal peptide that forms the short transmembrane domain of this plasma membrane-bound enzyme. The much longer external portion contains two homologous active site domains but probably only one functional active center. Finally, in spite of the great prog ...
... confirmed the existence of a hydrophobic C-termlnal peptide that forms the short transmembrane domain of this plasma membrane-bound enzyme. The much longer external portion contains two homologous active site domains but probably only one functional active center. Finally, in spite of the great prog ...
Malic acid production by Aspergillus oryzae
... in high initial concentration, as a direct correlation between the carbon source concentration and the specific production rate of citric acid was found [106]. Another important factor is the nitrogen source, which in industrial settings is usually provided through molasses that are used as carbon s ...
... in high initial concentration, as a direct correlation between the carbon source concentration and the specific production rate of citric acid was found [106]. Another important factor is the nitrogen source, which in industrial settings is usually provided through molasses that are used as carbon s ...
Carbamate Transport in Carbamoyl Phosphate Synthetase: A Theoretical and Experimental Investigation
... The two narrow parts render two free energy barriers of 6.7 and 8.4 kcal/mol, respectively. Three water pockets were filled with about 21, 9, and 9 waters, respectively, and the corresponding relative free energies of carbamate residing in these free energy minima are 5.8, 0, and 1.6 kcal/mol, respe ...
... The two narrow parts render two free energy barriers of 6.7 and 8.4 kcal/mol, respectively. Three water pockets were filled with about 21, 9, and 9 waters, respectively, and the corresponding relative free energies of carbamate residing in these free energy minima are 5.8, 0, and 1.6 kcal/mol, respe ...
Selective 15N labeling and direct observation by NMR
... larger proteins, circumventing increased resonance overlap and increasingly laborious total assignment when a few well-chosen resonances are sufficient to address the questions of interest. Fe-SOD is a particularly difficult case, as its (dimer) molecular weight is 42 kDa and the active site contain ...
... larger proteins, circumventing increased resonance overlap and increasingly laborious total assignment when a few well-chosen resonances are sufficient to address the questions of interest. Fe-SOD is a particularly difficult case, as its (dimer) molecular weight is 42 kDa and the active site contain ...
chapter 18 - HCC Learning Web
... hydrogen in HCl is +1. To be reduced, the oxidation state of H must decrease. The obvious choice for the hydrogen product is H2(g), where hydrogen has a zero oxidation state. The balanced reaction is Mg(s) + 2HCl(aq) MgCl2(aq) + H2(g). Mg goes from the 0 to the +2 oxidation state by losing two ele ...
... hydrogen in HCl is +1. To be reduced, the oxidation state of H must decrease. The obvious choice for the hydrogen product is H2(g), where hydrogen has a zero oxidation state. The balanced reaction is Mg(s) + 2HCl(aq) MgCl2(aq) + H2(g). Mg goes from the 0 to the +2 oxidation state by losing two ele ...
An Investigation of Acetobacter aceti N5
... about biosynthetic pathways that employ acid-labile intermediates. To examine how A. aceti metabolism may have adapted to function under acidic conditions, a biosynthetic conversion involving an acid-labile metabolite has been selected for study. The enzyme N5-carboxyaminoimidazole ribonucleotide mu ...
... about biosynthetic pathways that employ acid-labile intermediates. To examine how A. aceti metabolism may have adapted to function under acidic conditions, a biosynthetic conversion involving an acid-labile metabolite has been selected for study. The enzyme N5-carboxyaminoimidazole ribonucleotide mu ...
Free radical scavenging and antioxidant effects of lactate ion: an in
... at concentrations usually found at rest or during exercise. Lactate concentrations ranged up to 60 mM because such high lactate levels can be found in muscle (22, 29). Different methods were employed to test the lactate effect on free radicals. Two methods were used to determine its scavenging activ ...
... at concentrations usually found at rest or during exercise. Lactate concentrations ranged up to 60 mM because such high lactate levels can be found in muscle (22, 29). Different methods were employed to test the lactate effect on free radicals. Two methods were used to determine its scavenging activ ...
Experimental and Theoretical EPR Study of JahnTeller-
... examine the isoelectronic [Mo]CO complex, which can be considered to be a model for COinhibited state(s) of FeMo-co, finding a remarkable equivalence in the electronic properties of the L = N2 and CO complexes that can be understood through considerations of JT effects. Parallel study of the [Mo]NH3 ...
... examine the isoelectronic [Mo]CO complex, which can be considered to be a model for COinhibited state(s) of FeMo-co, finding a remarkable equivalence in the electronic properties of the L = N2 and CO complexes that can be understood through considerations of JT effects. Parallel study of the [Mo]NH3 ...
Catalytic Mechanism and Regulation of Mammalian Adenylyl Cyclases
... odorants, and autocrines) require at least three membrane components to modulate intracellular cAMP: a heptahelical receptor, a heterotrimeric G protein, and adenylyl cyclase. The main stimulatory effect of adenylyl cyclase by hormones and neurotransmitters is mediated by Gsa, the a subunit of Gs pr ...
... odorants, and autocrines) require at least three membrane components to modulate intracellular cAMP: a heptahelical receptor, a heterotrimeric G protein, and adenylyl cyclase. The main stimulatory effect of adenylyl cyclase by hormones and neurotransmitters is mediated by Gsa, the a subunit of Gs pr ...
06_Metabolism of lipid
... Transport of Fatty Acids and Glycerol • Fatty acids and glycerol diffuse through the adipocyte membrane and enter bloodstream. • Glycerol is transported via the blood in free state and oxidized or converted to glucose in liver. • Fatty acids are traveled bound to albumin. • In heart, skeletal muscl ...
... Transport of Fatty Acids and Glycerol • Fatty acids and glycerol diffuse through the adipocyte membrane and enter bloodstream. • Glycerol is transported via the blood in free state and oxidized or converted to glucose in liver. • Fatty acids are traveled bound to albumin. • In heart, skeletal muscl ...
Quantitative Analysis of the Kinetics of End
... ssDNA, the process that is inhibited by SSB. The nucleation that does occur is described by the second-order rate constant kNUC. Each nucleation event rapidly results in the formation of a new ®lament from that point extending 50 to 30 up to the disassembling end of the preexisting ®lament, and disa ...
... ssDNA, the process that is inhibited by SSB. The nucleation that does occur is described by the second-order rate constant kNUC. Each nucleation event rapidly results in the formation of a new ®lament from that point extending 50 to 30 up to the disassembling end of the preexisting ®lament, and disa ...
A study of complexes Mg(NH3)n and Ag(NH3)n , where n 1–8
... only found in small amounts relative to the fourth adduct at high NH3 flow rates and, if all five ammonia molecules are directly coordinated to the metal, then formally there are 11 valence electrons around the magnesium. Also our collision induced dissociation spectra provided some indication that ...
... only found in small amounts relative to the fourth adduct at high NH3 flow rates and, if all five ammonia molecules are directly coordinated to the metal, then formally there are 11 valence electrons around the magnesium. Also our collision induced dissociation spectra provided some indication that ...
Developement of strategies for the isotopic labeling of methyl
... To make an efficient use of the obtained high quality NMR spectra using this protocol, assignment of the methyl groups signals is mandatory. Two strategies were then proposed. The first is suitable for systems whose molecular weight does not exceed 100 kDa. It relies on the use of isotopically linea ...
... To make an efficient use of the obtained high quality NMR spectra using this protocol, assignment of the methyl groups signals is mandatory. Two strategies were then proposed. The first is suitable for systems whose molecular weight does not exceed 100 kDa. It relies on the use of isotopically linea ...
Identification of the Amino Terminus of Neuronal Ca2
... al., 1997; Qin et al., 1997). It is of interest that these effects are attenuated by the presence of accessory V DCC b subunits, suggesting f unctional competition, as previously hypothesized (Campbell et al., 1995b). In contrast, rat brain a1E(rbEII) (Soong et al., 1993) shows no G-protein modulati ...
... al., 1997; Qin et al., 1997). It is of interest that these effects are attenuated by the presence of accessory V DCC b subunits, suggesting f unctional competition, as previously hypothesized (Campbell et al., 1995b). In contrast, rat brain a1E(rbEII) (Soong et al., 1993) shows no G-protein modulati ...
Protein Sequencing and Identification With Mass
... A set of ion types _ Parent mass m Output: a peptide with the best match to the spectrum S that is at most k mutations/modifications apart from a database peptide. ...
... A set of ion types _ Parent mass m Output: a peptide with the best match to the spectrum S that is at most k mutations/modifications apart from a database peptide. ...
To remember Sir Hans Krebs: Nobelist, Friend, and Adviser
... with William A. Johnson, a graduate student, the mechanism for the synthesis of citric acid from oxaloacetic acid and pyruvic acid, one of the major steps in ceU metabolism. 2 While much was known about cell metabolism before this work, Hans supplied much missing information and was able to organize ...
... with William A. Johnson, a graduate student, the mechanism for the synthesis of citric acid from oxaloacetic acid and pyruvic acid, one of the major steps in ceU metabolism. 2 While much was known about cell metabolism before this work, Hans supplied much missing information and was able to organize ...
GC-content of synonymous codons profoundly influences amino
... We employed 65 representative genomes from bacteria, plants, and animals to investigate the amino acid usage and codon usage based on GCsyn (Table S1). Our analyses show evidences for a connection between the usage and the number of synonymous codons for each amino acid. First, within each group of ...
... We employed 65 representative genomes from bacteria, plants, and animals to investigate the amino acid usage and codon usage based on GCsyn (Table S1). Our analyses show evidences for a connection between the usage and the number of synonymous codons for each amino acid. First, within each group of ...
Room-temperature-curable resin composition
... The vinyl polymer (A) containing basic nitrogen 55 group-containing vinyl monomers such as p-styrenesul fonic acid or 2-acrylamido-2-methyl-propanesulfonic acid; vinyl esters such as vinyl acetate, vinyl benzoate or “Veova” (a tradename for vinyl esters produced by ...
... The vinyl polymer (A) containing basic nitrogen 55 group-containing vinyl monomers such as p-styrenesul fonic acid or 2-acrylamido-2-methyl-propanesulfonic acid; vinyl esters such as vinyl acetate, vinyl benzoate or “Veova” (a tradename for vinyl esters produced by ...
Characterization of NAD Salvage Pathways and their Role in
... pathogenesis and indicate that PnuC could potentially be a viable small-molecule therapeutic ...
... pathogenesis and indicate that PnuC could potentially be a viable small-molecule therapeutic ...
Development of directly compressible metformin hydrochloride by
... typical example of this type of drugs. Metformin hydrochloride is an oral anti-hyperglycemic agent of the biguanide class used in the treatment of non-insulin dependent diabetes mellitus (2). Metformin hydrochloride is highly water soluble (> 300 mg mL–1 at 25 °C), hygroscopic and shows stability pr ...
... typical example of this type of drugs. Metformin hydrochloride is an oral anti-hyperglycemic agent of the biguanide class used in the treatment of non-insulin dependent diabetes mellitus (2). Metformin hydrochloride is highly water soluble (> 300 mg mL–1 at 25 °C), hygroscopic and shows stability pr ...
Chapter 27 Amino acid
... Objectives Draw a general amino acid and identify the two functional groups common to all. Classify each amino acid according to the chemical nature of its R group. Define the meaning of an essential amino acid. Draw the reaction that joins two amino acids to form a peptide bond. Describe and diffe ...
... Objectives Draw a general amino acid and identify the two functional groups common to all. Classify each amino acid according to the chemical nature of its R group. Define the meaning of an essential amino acid. Draw the reaction that joins two amino acids to form a peptide bond. Describe and diffe ...
Metalloprotein
Metalloprotein is a generic term for a protein that contains a metal ion cofactor. A large number of all proteins are part of this category.