Leukaemia Section t(11;19)(q23;p13.3) MLL/ACER1 Atlas of Genetics and Cytogenetics in Oncology and Haematology
... catalyze hydrolysis of ceramide to generate sphingosine (SPH), which is phosphorylated to form sphingosine-1phosphate (S1P). Ceramide, SPH, and S1P are bioactive lipids that mediate cell proliferation, differentiation, apoptosis, adhesion and migration (Mao and Obeid, 2008). ...
... catalyze hydrolysis of ceramide to generate sphingosine (SPH), which is phosphorylated to form sphingosine-1phosphate (S1P). Ceramide, SPH, and S1P are bioactive lipids that mediate cell proliferation, differentiation, apoptosis, adhesion and migration (Mao and Obeid, 2008). ...
The codon adaptation index-a measure of directional synonymous
... This seems to be confirmed by contrasting the distribution of CAI values for T7 genes with those of E.coli (Figure 1). However, the difference seen in Figure 1 could arise in part because the genes contrasted encode different products; for example, T7 encodes no ribosomal proteins. It has been repor ...
... This seems to be confirmed by contrasting the distribution of CAI values for T7 genes with those of E.coli (Figure 1). However, the difference seen in Figure 1 could arise in part because the genes contrasted encode different products; for example, T7 encodes no ribosomal proteins. It has been repor ...
Evaluation of Nyholt`s Procedure for Multiple Testing Correction
... describing a way of overcoming this. The suggestion is to exclude all SNPs but one from any set of SNPs that are in perfect LD. This is, however, somewhat contrary to the theoretical justification for the method, given that it is based on the formula for Meff being correct when all SNPs are in perfe ...
... describing a way of overcoming this. The suggestion is to exclude all SNPs but one from any set of SNPs that are in perfect LD. This is, however, somewhat contrary to the theoretical justification for the method, given that it is based on the formula for Meff being correct when all SNPs are in perfe ...
Lab_36 - PCC - Portland Community College
... Ss = sickle-cell trait (both aberrant and normal Hb is made) ss = sickle-cell anemia (only aberrant Hb is made) ...
... Ss = sickle-cell trait (both aberrant and normal Hb is made) ss = sickle-cell anemia (only aberrant Hb is made) ...
Survey of Biodata Analysis from a Data Mining Perspective
... BLAST: For a protein or DNA sequence S, BLAST will find all similar sequences S’ in the database such that the aggregate mutation score from S to S’ is above some user-specified threshold. Tandem repeat detection: A segment that occurs more than a certain number of times within a ...
... BLAST: For a protein or DNA sequence S, BLAST will find all similar sequences S’ in the database such that the aggregate mutation score from S to S’ is above some user-specified threshold. Tandem repeat detection: A segment that occurs more than a certain number of times within a ...
Tweak to molecular scissors cuts path to turn on genes —
... multiple activators bound to CRISPR to turn on two developmental genes in induced pluripotent stem cells. This allowed them to consistently transform the cells into neurons in just four days, besting the efficiency of the standard technique. Both techniques lead to higher levels of gene expression t ...
... multiple activators bound to CRISPR to turn on two developmental genes in induced pluripotent stem cells. This allowed them to consistently transform the cells into neurons in just four days, besting the efficiency of the standard technique. Both techniques lead to higher levels of gene expression t ...
Presentation
... Multialignments • Select BLAST alignments to be multialigned • Clustal-W performs multialignment • Aligns – The originating IMAS gene sequence – The “Full” sequence found by BLAST • Not just the high-quality section – Useful to align entire genes, or entire corresponding segments of DNA ...
... Multialignments • Select BLAST alignments to be multialigned • Clustal-W performs multialignment • Aligns – The originating IMAS gene sequence – The “Full” sequence found by BLAST • Not just the high-quality section – Useful to align entire genes, or entire corresponding segments of DNA ...
A virulence-associated gene microarray: a tool for
... regulatory genes including the agr and sar operons (Chien & Cheung, 1998; Sabersheikh & Saunders, 2004). Strain variation in these regulatory mechanisms may be an important factor influencing the switch from colonization to disease. Such variations may also contribute towards the success of the spec ...
... regulatory genes including the agr and sar operons (Chien & Cheung, 1998; Sabersheikh & Saunders, 2004). Strain variation in these regulatory mechanisms may be an important factor influencing the switch from colonization to disease. Such variations may also contribute towards the success of the spec ...
Lab_36_old - PCC - Portland Community College
... Ss = sickle-cell trait (both aberrant and normal Hb is made) ss = sickle-cell anemia (only aberrant Hb is made) ...
... Ss = sickle-cell trait (both aberrant and normal Hb is made) ss = sickle-cell anemia (only aberrant Hb is made) ...
Biocatalytic potential of thermophilic bacteria and actinomycetes
... proof reading capacity of the enzyme [73]. Some of the issues that have stimulated scientists, are improvements required in the fidelity of the PCR, development of strategies for more economical use of the enzymes and ensuring rapid multiplication from fewer strands. A thermostable DNA polymerase ha ...
... proof reading capacity of the enzyme [73]. Some of the issues that have stimulated scientists, are improvements required in the fidelity of the PCR, development of strategies for more economical use of the enzymes and ensuring rapid multiplication from fewer strands. A thermostable DNA polymerase ha ...
The dark side of ribosome biogenesis
... course of this project, several other genetic diseases have been associated with such defects, leading to the definition of a new class of diseases (ribosomopathies) for which DBA is a central model. We are currently trying to define simple protocols to detect anomalies in ribosome production and to ...
... course of this project, several other genetic diseases have been associated with such defects, leading to the definition of a new class of diseases (ribosomopathies) for which DBA is a central model. We are currently trying to define simple protocols to detect anomalies in ribosome production and to ...
Latest bill text (Draft #1)
... If a person making his or her initial appearance before a judge pursuant to an arrest, indictment, summons, or other process for committing a felony offense has not previously had a sample of his or her DNA collected under this subsection, it shall be the duty of the sheriff to have a DNA sample col ...
... If a person making his or her initial appearance before a judge pursuant to an arrest, indictment, summons, or other process for committing a felony offense has not previously had a sample of his or her DNA collected under this subsection, it shall be the duty of the sheriff to have a DNA sample col ...
Primordial Germ Cells
... definitively argued that egg numbers are determined at birth, shutting the door to further work for the next half century. "People were viewing ovaries very differently than we do now," Tilly reflects. "The technology was just based on histological analysis." Although biological markers for germline ...
... definitively argued that egg numbers are determined at birth, shutting the door to further work for the next half century. "People were viewing ovaries very differently than we do now," Tilly reflects. "The technology was just based on histological analysis." Although biological markers for germline ...
Mutations Article (use this to answer questions)
... Mutations may also take the form of insertions or deletions, which are together known as indels. Indels can have a wide variety of lengths. At the short end of the spectrum, indels of one or two base pairs within coding sequences have the greatest effect, because they will inevitably cause a framesh ...
... Mutations may also take the form of insertions or deletions, which are together known as indels. Indels can have a wide variety of lengths. At the short end of the spectrum, indels of one or two base pairs within coding sequences have the greatest effect, because they will inevitably cause a framesh ...
PENTOSE PHOSPHATE PATHWAY
... The hexose monophosphate pathway has several names just to confuse you. It’s called the hexose monophosphate shunt or pathway (HMP shunt or pathway), or the pentose phosphate pathway, or the phosphogluconate pathway (Fig. 15-1). The pathway in its full form is complicated and has complicated stoichi ...
... The hexose monophosphate pathway has several names just to confuse you. It’s called the hexose monophosphate shunt or pathway (HMP shunt or pathway), or the pentose phosphate pathway, or the phosphogluconate pathway (Fig. 15-1). The pathway in its full form is complicated and has complicated stoichi ...
A dioxin sensitive gene, mammalian WAPL, is implicated in
... DSB repair [14,15] and the alterations in recombination promote carcinogenesis by causing genomic instability. Therefore, unscheduled expression of mammalian WAPL by human pappilloma virus (HPV) [16], TCDD or other agents may cause an inaccurately repaired or unrepaired DSB and result in mutations o ...
... DSB repair [14,15] and the alterations in recombination promote carcinogenesis by causing genomic instability. Therefore, unscheduled expression of mammalian WAPL by human pappilloma virus (HPV) [16], TCDD or other agents may cause an inaccurately repaired or unrepaired DSB and result in mutations o ...
ppt file
... Both proteins are either belong to the same complex or are parts of the same functional pathway. The same trend is generally true for the larger data set. By manually inspecting the top 100 pairs, the author found that in >95% of them both proteins have similar functions. ...
... Both proteins are either belong to the same complex or are parts of the same functional pathway. The same trend is generally true for the larger data set. By manually inspecting the top 100 pairs, the author found that in >95% of them both proteins have similar functions. ...
The bacterial two-hybrid system based on adenylate cyclase
... Since the output is a diffusible cAMP, interactions can take place anywhere in the cell, making it possible to study a large variety of proteins including membrane proteins. Using an indirect method to detect protein interaction based on a complicated signal cascade allows for the use of minimal med ...
... Since the output is a diffusible cAMP, interactions can take place anywhere in the cell, making it possible to study a large variety of proteins including membrane proteins. Using an indirect method to detect protein interaction based on a complicated signal cascade allows for the use of minimal med ...
Kinoshita, T et al.
... flowering plants, it is not yet clear whether a long-distance control of genomic imprinting occurs. However, a recent report showed that the DNA methylation status of a 3 -tandem repeat about 2.5 kb downstream from the PHE1 locus affected the imprinted expression of the gene [25]. PHE1 encodes a MAD ...
... flowering plants, it is not yet clear whether a long-distance control of genomic imprinting occurs. However, a recent report showed that the DNA methylation status of a 3 -tandem repeat about 2.5 kb downstream from the PHE1 locus affected the imprinted expression of the gene [25]. PHE1 encodes a MAD ...
Thrombocytopenia
... – ESPECIALLY MDS and AML • 40% of affected individual • Mean age of onset 33 years ...
... – ESPECIALLY MDS and AML • 40% of affected individual • Mean age of onset 33 years ...
The Role of Mismatch Repair in Bacterial Evolution
... The spread of mutators occurs because they can create or acquire a beneficial mutation (e.g. antibiotic resistance) that gives them advantage over non-adapted bacteria. In an asexual population, the mutator may then spread with the advantageous gene, by a phenomenon called »hitch-hiking« (29) and in ...
... The spread of mutators occurs because they can create or acquire a beneficial mutation (e.g. antibiotic resistance) that gives them advantage over non-adapted bacteria. In an asexual population, the mutator may then spread with the advantageous gene, by a phenomenon called »hitch-hiking« (29) and in ...
Constraint and divergence of global gene expression in
... Developmental biology and stem cells | Genomics and evolutionary biology ...
... Developmental biology and stem cells | Genomics and evolutionary biology ...