Roles of FGFs as adipokines in adipose tissue development
... White adipose tissue (WAT), a lipid storage site, plays a critical role in energy homeostasis. Obesity, the excessive development of WAT, is a well-known risk factor for several diseases including diabetes, hypertension, and atherosclerosis (Wang et al., 2008; Galic et al., 2010). Brown adipose tiss ...
... White adipose tissue (WAT), a lipid storage site, plays a critical role in energy homeostasis. Obesity, the excessive development of WAT, is a well-known risk factor for several diseases including diabetes, hypertension, and atherosclerosis (Wang et al., 2008; Galic et al., 2010). Brown adipose tiss ...
lecture1
... Differences between catabolism and anabolism They are not the reverse of each other They are independently regulated They often take place in different locations in the cells (compartmentalization β-oxidation-mutochondria syn of fatty acids – cytosol. Cellular regulation of metabolic pathways Metabo ...
... Differences between catabolism and anabolism They are not the reverse of each other They are independently regulated They often take place in different locations in the cells (compartmentalization β-oxidation-mutochondria syn of fatty acids – cytosol. Cellular regulation of metabolic pathways Metabo ...
Genetic pathway analysis
... But can artificially create gain-of-function ced-3 or ced-4 by overexpressing proteins in specific cells. ...
... But can artificially create gain-of-function ced-3 or ced-4 by overexpressing proteins in specific cells. ...
KOSMOS 65, 1, 33–41, 2016 PROPHENOLOXIDASE SYSTEM (pro
... of covalent links in damaged tissues resulting in sclerotization (e.g. in insects). Recent evidence also strongly implies that the melanization cascade (the prophenoloxidase activating system) provides, or is intimately associated with, the appearance of factors stimulating cellular defense by aidin ...
... of covalent links in damaged tissues resulting in sclerotization (e.g. in insects). Recent evidence also strongly implies that the melanization cascade (the prophenoloxidase activating system) provides, or is intimately associated with, the appearance of factors stimulating cellular defense by aidin ...
Ribosome biogenesis and cell growth: mTOR coordinates
... yeast which have shown that the TOR signaling pathway broadly controls nutrient metabolism by sequestering several transcription factors in the cytoplasm (Di Como and Arndt, 1996; Beck and Hall, 1999; Jiang and Broach, 1999). Together, these results demonstrate that inhibition of mTOR signaling down ...
... yeast which have shown that the TOR signaling pathway broadly controls nutrient metabolism by sequestering several transcription factors in the cytoplasm (Di Como and Arndt, 1996; Beck and Hall, 1999; Jiang and Broach, 1999). Together, these results demonstrate that inhibition of mTOR signaling down ...
Bio 216 Exam 1 Name Date 1. The study of how disease or injury
... 84. Osmoreceptors are involved in the regulation of blood volume. A. True B.False 85. Protein carrier mediated transport of molecules display A. specificity. B. competition. C. saturation. D. All of these choices are correct. 86. Facilitated diffusion of a molecule into a cell would be more rapid if ...
... 84. Osmoreceptors are involved in the regulation of blood volume. A. True B.False 85. Protein carrier mediated transport of molecules display A. specificity. B. competition. C. saturation. D. All of these choices are correct. 86. Facilitated diffusion of a molecule into a cell would be more rapid if ...
BSN/Briefing 24 - British Society for Neuroendocrinology
... receptors. Receptors also recruit ATPdependent chromatin remodelling complexes. These complexes enzymatically alter the contacts between DNA and histones to promote accessible chromatin and receptor binding. The alteration in chromatin structure is highly dynamic, paralleling transcriptional output ...
... receptors. Receptors also recruit ATPdependent chromatin remodelling complexes. These complexes enzymatically alter the contacts between DNA and histones to promote accessible chromatin and receptor binding. The alteration in chromatin structure is highly dynamic, paralleling transcriptional output ...
407_lecture_9
... Insulin First protein to be fully sequenced; Fred Sanger, 1953. For this, he won his first Nobel Prize (his second was for the Sanger dideoxy method of DNA sequencing). ...
... Insulin First protein to be fully sequenced; Fred Sanger, 1953. For this, he won his first Nobel Prize (his second was for the Sanger dideoxy method of DNA sequencing). ...
CKIP-1, a proinflammatory protein in macrophages interferes with
... Tumor necrosis factor (TNF) is the prototype molecule of the TNF superfamily (TNFSF), exerting a broad spectrum of activities through its membrane bound or soluble form. TNF is a pleiotropic cytokine as it is able to induce differentiation, gene-expression, apoptosis or necrosis depending on the typ ...
... Tumor necrosis factor (TNF) is the prototype molecule of the TNF superfamily (TNFSF), exerting a broad spectrum of activities through its membrane bound or soluble form. TNF is a pleiotropic cytokine as it is able to induce differentiation, gene-expression, apoptosis or necrosis depending on the typ ...
Transcriptome profiling of Heterobasidion annosum in saprotrophic
... to abiotic stresses (salts, oxidative, temperature, and nutrient starvation) indicating the activation of genes which are specifically involved in saprotrophic growth. On the other hand, activation of basic intracellular pathways and up-regulation of protein kinases suggest a fast adaptation respons ...
... to abiotic stresses (salts, oxidative, temperature, and nutrient starvation) indicating the activation of genes which are specifically involved in saprotrophic growth. On the other hand, activation of basic intracellular pathways and up-regulation of protein kinases suggest a fast adaptation respons ...
Gene Section RASL11B (RAS-like, family 11, member B) in Oncology and Haematology
... According to Stolle et al., RASL11B expression is induced during maturation of THP-1 monocytic cells into macrophages and in coronary artery smooth muscle cells after treatment with TGF-beta1 suggesting that RASL11B may play a role in developmental processes or in pathophysiologies such as inflammat ...
... According to Stolle et al., RASL11B expression is induced during maturation of THP-1 monocytic cells into macrophages and in coronary artery smooth muscle cells after treatment with TGF-beta1 suggesting that RASL11B may play a role in developmental processes or in pathophysiologies such as inflammat ...
Access Slides - Science Signaling
... trisphosphate, which mobilizes Ca2+, and diacylglycerol (DAG), which activates protein kinase C (PKC). PAR1 can activate the mitogen-activated protein kinase cascade by transactivation of the EGF receptor, through activation of PKC, phosphatidylinositol 3kinase (PI3K), Pyk2, and other mechanisms. G ...
... trisphosphate, which mobilizes Ca2+, and diacylglycerol (DAG), which activates protein kinase C (PKC). PAR1 can activate the mitogen-activated protein kinase cascade by transactivation of the EGF receptor, through activation of PKC, phosphatidylinositol 3kinase (PI3K), Pyk2, and other mechanisms. G ...
FUNCTIONS OF CELL ORGANELLES
... Transcription of DNA – RNA synthesis. Translation of DNA- Protein synthesis. NUCLEOLUS- involved in the processing of rRNA and ribosomal units ...
... Transcription of DNA – RNA synthesis. Translation of DNA- Protein synthesis. NUCLEOLUS- involved in the processing of rRNA and ribosomal units ...
functions of cell organelles
... Transcription of DNA – RNA synthesis. Translation of DNA- Protein synthesis. NUCLEOLUS- involved in the processing of rRNA and ribosomal units ...
... Transcription of DNA – RNA synthesis. Translation of DNA- Protein synthesis. NUCLEOLUS- involved in the processing of rRNA and ribosomal units ...
as Adobe PDF - Edinburgh Research Explorer
... is essential for maintenance of a regulatory phenotype [37]. Additionally, TGF-b is capable of promoting a tolerant state through Foxp3-independent mechanisms, such as upregulation of CD73 [38], an ectoenzyme that acts to increase the local extracellular concentration of adenosine. The combination o ...
... is essential for maintenance of a regulatory phenotype [37]. Additionally, TGF-b is capable of promoting a tolerant state through Foxp3-independent mechanisms, such as upregulation of CD73 [38], an ectoenzyme that acts to increase the local extracellular concentration of adenosine. The combination o ...
Gene Section SCAF1 (SR related CTD associated factor 1)
... Various putative post-translational modification sites have been identified, including numerous potential sites for either O- or N-glycosylation, and several possible sites of phosphorylation by cAMP-dependent protein kinase (PKA), protein kinase C (PKC), and casein kinase 2 (Scorilas et al., 2001). ...
... Various putative post-translational modification sites have been identified, including numerous potential sites for either O- or N-glycosylation, and several possible sites of phosphorylation by cAMP-dependent protein kinase (PKA), protein kinase C (PKC), and casein kinase 2 (Scorilas et al., 2001). ...
Text S1.
... of isoprenoids. The latter are the most ancient and diverse class of natural products and ...
... of isoprenoids. The latter are the most ancient and diverse class of natural products and ...
fillable MS-Word version of the In Silico Kinase Match
... A human protein kinase name or P-site peptide amino acid (AA) sequence provided by the client is required ...
... A human protein kinase name or P-site peptide amino acid (AA) sequence provided by the client is required ...
Poster
... anchoring proteins (AKAPs) bind and help localize PKA to specific areas. The RIIa domain in PKA provides a shallow groove for an amphipathic helix of AKAP to bind via interactions of hydrophobic side chains. A similar binding motif is found in the DPY-30 domain, which suggests this domain may also p ...
... anchoring proteins (AKAPs) bind and help localize PKA to specific areas. The RIIa domain in PKA provides a shallow groove for an amphipathic helix of AKAP to bind via interactions of hydrophobic side chains. A similar binding motif is found in the DPY-30 domain, which suggests this domain may also p ...
Proteins - TC Online
... Digestion and absorption Roles of proteins in the body Protein quality Protein recommendations Health effects ...
... Digestion and absorption Roles of proteins in the body Protein quality Protein recommendations Health effects ...
Local Anaesthetic Toxicity
... rate phase IV depolarisation duration action potential effective refactory period conduction velocity slight in SVR (slight in BP) ...
... rate phase IV depolarisation duration action potential effective refactory period conduction velocity slight in SVR (slight in BP) ...
Characterization and prediction of drug binding sites in proteins
... functional and computational unit in the cell. They are able to bind other molecules specifically and tightly. ...
... functional and computational unit in the cell. They are able to bind other molecules specifically and tightly. ...
Anti-HSP90 Catalog# SMC-149 A/B Size: 50/200µg This product is
... Furthermore, Hsp90 is highly conserved between species; having 60% and 78% amino acid similarity between mammalian and the corresponding yeast and Drosophila proteins, respectively. Hsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. Despite its label ...
... Furthermore, Hsp90 is highly conserved between species; having 60% and 78% amino acid similarity between mammalian and the corresponding yeast and Drosophila proteins, respectively. Hsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. Despite its label ...
Paracrine signalling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.Although paracrine signaling elicits a diverse array of responses in the induced cells, most paracrine factors utilize a relatively streamlined set of receptors and pathways. In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. The highly conserved receptors and pathways can be organized into four major families based on similar structures: Fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates signal transduction cascades, eliciting different responses.