IBM Research Report - Dharmendra S Modha`s Brain
... Since the final submission of our work on the Compass scalable simulator for the IBM TrueNorth Cognitive Computing architecture [1], we have simulated an unprecedented 2.084 billion neurosynaptic cores containing 53 × 1010 neurons and 1.37 × 1014 synapses running at only 1542× slower than real time. ...
... Since the final submission of our work on the Compass scalable simulator for the IBM TrueNorth Cognitive Computing architecture [1], we have simulated an unprecedented 2.084 billion neurosynaptic cores containing 53 × 1010 neurons and 1.37 × 1014 synapses running at only 1542× slower than real time. ...
Antibacterials
... Resistance to Beta-Lactam antibiotics is a serious issue, however. Gram-negative organisms change the porins in their outer cell wall, inhibiting entry of the drug. Some bacteria produce a penicillinase that inactivates the drug; gram-positives secrete it while gram negatives contain it in their pe ...
... Resistance to Beta-Lactam antibiotics is a serious issue, however. Gram-negative organisms change the porins in their outer cell wall, inhibiting entry of the drug. Some bacteria produce a penicillinase that inactivates the drug; gram-positives secrete it while gram negatives contain it in their pe ...
CENTRAL NERVOUS SYSTEM Sensory Pathway (PNS
... The cells of each organ controlled by the ANS have both ACh and NE receptors organs are dually controlled The response of the organ is determined by the identity of the neurotransmitter released the binding of ACh to its receptor will cause the effector to respond in one way the binding of NE ...
... The cells of each organ controlled by the ANS have both ACh and NE receptors organs are dually controlled The response of the organ is determined by the identity of the neurotransmitter released the binding of ACh to its receptor will cause the effector to respond in one way the binding of NE ...
SNS-314, a selective Aurora kinase inhibitor with potent, pre
... Background: SNS-314, a selective small-molecule inhibitor of Aurora kinases, has entered a phase 1 clinical trial for the treatment of patients with advanced solid cancers. Aurora kinases play critical roles during mitosis and cytokinesis. SNS314 demonstrates significant in vivo activity in a wide r ...
... Background: SNS-314, a selective small-molecule inhibitor of Aurora kinases, has entered a phase 1 clinical trial for the treatment of patients with advanced solid cancers. Aurora kinases play critical roles during mitosis and cytokinesis. SNS314 demonstrates significant in vivo activity in a wide r ...
ALZHEIMER DISEASE
... Alzheimer’s is the most common cause of dementia in adult life and is associated with the selective damage of brain regions and neural circuits critical for memory and cognition The pathogenesis of this disease is complex, and involves many molecular, cellular, and physiological pathologies The neur ...
... Alzheimer’s is the most common cause of dementia in adult life and is associated with the selective damage of brain regions and neural circuits critical for memory and cognition The pathogenesis of this disease is complex, and involves many molecular, cellular, and physiological pathologies The neur ...
Neurological Clinicopathologic Case Presentation Dr. Eileen Vallin
... Faculty members are required to inform the audience when they are discussing off-label, unapproved uses of devices and drugs. Physicians should consult full prescribing information before using any product mentioned during this educational activity. Learner Assurance Statement The University of Cinc ...
... Faculty members are required to inform the audience when they are discussing off-label, unapproved uses of devices and drugs. Physicians should consult full prescribing information before using any product mentioned during this educational activity. Learner Assurance Statement The University of Cinc ...
Sensory receptors - E
... Overview: Sensing and Acting • Bats use sonar to detect their prey. • Moths, a common prey for bats, can detect the bat’s sonar and attempt to flee. • Both organisms have complex sensory systems that facilitate survival. • These systems include diverse mechanisms that sense stimuli and generate ...
... Overview: Sensing and Acting • Bats use sonar to detect their prey. • Moths, a common prey for bats, can detect the bat’s sonar and attempt to flee. • Both organisms have complex sensory systems that facilitate survival. • These systems include diverse mechanisms that sense stimuli and generate ...
VolkowandLi Drug Addiction.2004
... a myocardial infarction. The images were obtained with positron emission tomography (PET) and [18F]fluoro2-deoxyglucose (FDG–PET) to measure glucose metabolism, which is a sensitive indicator of damage to the tissue in the brain and the heart. Note the decreased glucose metabolism in the OFC (orbito ...
... a myocardial infarction. The images were obtained with positron emission tomography (PET) and [18F]fluoro2-deoxyglucose (FDG–PET) to measure glucose metabolism, which is a sensitive indicator of damage to the tissue in the brain and the heart. Note the decreased glucose metabolism in the OFC (orbito ...
Acetylcholine - American College of Neuropsychopharmacology
... lacking the ␣3 (6), ␣4 (7), ␣5 (8), ␣7 (9), ␣9 (10), 2 (11), 3 (12), or 4 (13) subunit of the nAChR have been reported. In addition, mice lacking the M1 (14), M2 (15), and M4 (16) subtypes of the muscarinic receptor have been generated. These mice have already been used to demonstrate the role of ...
... lacking the ␣3 (6), ␣4 (7), ␣5 (8), ␣7 (9), ␣9 (10), 2 (11), 3 (12), or 4 (13) subunit of the nAChR have been reported. In addition, mice lacking the M1 (14), M2 (15), and M4 (16) subtypes of the muscarinic receptor have been generated. These mice have already been used to demonstrate the role of ...
The population modeling of neuronal cell fractions for the use of
... It is described in many research studies that single neurons are very noisy. For example, when one single neuron of a visual cortex is investigated, it is difficult to reconstruct what an eye of a person under research sees. The information is processed in the brain by a neuron population, and this ...
... It is described in many research studies that single neurons are very noisy. For example, when one single neuron of a visual cortex is investigated, it is difficult to reconstruct what an eye of a person under research sees. The information is processed in the brain by a neuron population, and this ...
Psych Ch. 7 Powerpoint
... i. That it’s a by-product of stimulating brain cells during sleep ii. Another says that dreaming allows people the chance to review and address some of the problems they faced during the day iii. Another says dreams are the brain’s way of removing certain unneeded memories c) Daydreams i. Requires a ...
... i. That it’s a by-product of stimulating brain cells during sleep ii. Another says that dreaming allows people the chance to review and address some of the problems they faced during the day iii. Another says dreams are the brain’s way of removing certain unneeded memories c) Daydreams i. Requires a ...
pharm 22 A [4-20
... (via DAG)--> PKC activates PLA2 leading to expression of GPIIb-IIIa on platelets so they can aggregate 3. 2 G-protein receptors for ADP? 3 drugs that target P2Y(ADP)? GPIIb-IIIa w/ what is critical for aggregation? a. P2Y1 (Gq coupled- increases Ca++ and PKC like TxA2) and P2Y(ADP) (Gidecreases cAMP ...
... (via DAG)--> PKC activates PLA2 leading to expression of GPIIb-IIIa on platelets so they can aggregate 3. 2 G-protein receptors for ADP? 3 drugs that target P2Y(ADP)? GPIIb-IIIa w/ what is critical for aggregation? a. P2Y1 (Gq coupled- increases Ca++ and PKC like TxA2) and P2Y(ADP) (Gidecreases cAMP ...
clinical trials
... “Sometimes, you have little or no safety or efficacy information about a drug in the pediatric population and there is no other hospital using it, then a doctor will ask the institutional review board to use the drug as part of a study,” explained Dr. Paul Offit, Chief of Infectious Diseases at The ...
... “Sometimes, you have little or no safety or efficacy information about a drug in the pediatric population and there is no other hospital using it, then a doctor will ask the institutional review board to use the drug as part of a study,” explained Dr. Paul Offit, Chief of Infectious Diseases at The ...
FIRST BRAIN-TO-BRAIN INTERFACE ALLOWS TRANSMISSION
... "neurophysiology of social interaction." "To understand social interaction, we could record from animals' brains while they are socializing and analyze how their brains adapt—for example when a new member of the colony is introduced," he said. Such complex experiments will be enabled by the laborato ...
... "neurophysiology of social interaction." "To understand social interaction, we could record from animals' brains while they are socializing and analyze how their brains adapt—for example when a new member of the colony is introduced," he said. Such complex experiments will be enabled by the laborato ...
Monoallelic deletion of the microRNA biogenesis
... functional miRNAs. The activity of DGCR8 can control cellular levels of miRNAs and it has been demonstrated that haploinsufficiency or ablation of DGCR8 protein can cause a ‘bottleneck’ in miRNA production, leading to significant increases in primary-microRNAs and concomitant decreases in functional ...
... functional miRNAs. The activity of DGCR8 can control cellular levels of miRNAs and it has been demonstrated that haploinsufficiency or ablation of DGCR8 protein can cause a ‘bottleneck’ in miRNA production, leading to significant increases in primary-microRNAs and concomitant decreases in functional ...
汤慧芳
... Significant and at times treatment-limiting adverse effects, including bone marrow suppression and irreversible peripheral and optic neuropathy, have been reported with the prolonged courses of therapy that are necessary for treatment of tuberculosis. Although linezolid may eventually prove to be an ...
... Significant and at times treatment-limiting adverse effects, including bone marrow suppression and irreversible peripheral and optic neuropathy, have been reported with the prolonged courses of therapy that are necessary for treatment of tuberculosis. Although linezolid may eventually prove to be an ...
Powerpoint
... The five senses - the meaning of the terms stimuli and respond (0.25 hr) The eye - mechanism of vision: function of rods and cones, color vision (0.5 hr) The ear - the structure of the ear, the mechanism of hearing: the role of the organ of Corti, investigation on senses (0.75 hr) The sensory functi ...
... The five senses - the meaning of the terms stimuli and respond (0.25 hr) The eye - mechanism of vision: function of rods and cones, color vision (0.5 hr) The ear - the structure of the ear, the mechanism of hearing: the role of the organ of Corti, investigation on senses (0.75 hr) The sensory functi ...
Introduction to Psychology
... b) Explain why REM sleep is called paradoxical sleep. c) Distinguish between REM and NREM dreams. d) Describe the role of the reticular formation, locus coeruleus, and basal forebrain in arousal. e) Explain how caffeine increases arousal. f) Identify the parts of the brain that are activated in REM ...
... b) Explain why REM sleep is called paradoxical sleep. c) Distinguish between REM and NREM dreams. d) Describe the role of the reticular formation, locus coeruleus, and basal forebrain in arousal. e) Explain how caffeine increases arousal. f) Identify the parts of the brain that are activated in REM ...
CORTEX I. GENERAL CONSIDERATIONS a. Cerebral cortex = grey
... iv. Inhibitory, use GABA (can use Gly – in spinal cord) v. Chandelier cells: powerful inhibitors, axon-axon synapses, horizontal with little vertical branches (like a chandelier), pleiomorphic residues vi. Others: bitufted cells, basket cells, double-bouquet cells c. Interneurons i. Layers 1-6 ii. W ...
... iv. Inhibitory, use GABA (can use Gly – in spinal cord) v. Chandelier cells: powerful inhibitors, axon-axon synapses, horizontal with little vertical branches (like a chandelier), pleiomorphic residues vi. Others: bitufted cells, basket cells, double-bouquet cells c. Interneurons i. Layers 1-6 ii. W ...
PDF file
... of neurotransmitters [5], [9], [23]. For example, glutamate is a type of neurotransmitter. Nerve impulses trigger release of glutamate from the pre-synaptic cell. Once released, the glutamate neurotransmitter binds a glutamate receptor, such as the NMDA receptor, in the post-synaptic neuron. A suffi ...
... of neurotransmitters [5], [9], [23]. For example, glutamate is a type of neurotransmitter. Nerve impulses trigger release of glutamate from the pre-synaptic cell. Once released, the glutamate neurotransmitter binds a glutamate receptor, such as the NMDA receptor, in the post-synaptic neuron. A suffi ...
Axon 轴突
... The shape of the cell body is dependent on the number of processes arising from it. The most common type of neuron gives off several processes from the cell body is, therefore, multipolar. Some neurons have only one axon and one dendrite and are bipolar. ...
... The shape of the cell body is dependent on the number of processes arising from it. The most common type of neuron gives off several processes from the cell body is, therefore, multipolar. Some neurons have only one axon and one dendrite and are bipolar. ...
Prescription_Medications
... A: Choosing a medication to treat obesity is a decision between you and your health care provider. You will consider the drug’s side effects, your family’s medical history, and your current health issues and medicines. Q: How long will I need to take weight-loss drugs? A: The answer depends upon ...
... A: Choosing a medication to treat obesity is a decision between you and your health care provider. You will consider the drug’s side effects, your family’s medical history, and your current health issues and medicines. Q: How long will I need to take weight-loss drugs? A: The answer depends upon ...