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Stage 1 hypertension
Stage 1 hypertension

... changed, partly reflecting the move to ambulatory BP monitoring.  Diuretics have moved to third line drugs after ACE inhibitors and calcium channel blockers  The thiazide-like diuretic of choice is now indapamide or chlortalidone rather than bendroflumethiazide or hydrochlorothiazide. NICE say tha ...
Responding to an Opiate Overdose
Responding to an Opiate Overdose

... 4. “Solo Drugs”  Using opiates alone is a cause on unnecessary opiate ...
Distribution and characterisation of Glucagon-like peptide
Distribution and characterisation of Glucagon-like peptide

Biological Theories of Aging
Biological Theories of Aging

... • Recent research suggests that cerebral cell loss with aging is LESS PRONOUNCED than previously thought • Hippocampal atrophy < 2%/year in healthy elderly vs. 4-8%/year in Alzheimer’s ...
Modulation of Cortical Activation and Behavioral Arousal by
Modulation of Cortical Activation and Behavioral Arousal by

... FIGURE 1. Cholinergic, orexinergic, and other neurons involved in sleep–wake state control. Sagittal schematic view of the rat brain depicting neurons with their chemical neurotransmitters and pathways by which they influence cortical activity or behavior across the sleep–wake cycle. Wake (W) is cha ...
Chapter 12, Hallucinogens PowerPoint
Chapter 12, Hallucinogens PowerPoint

...  Multiple mechanisms are involved in the actions of these drugs, which contribute to the array of responses that they can cause. These drugs influence the complex inner workings of the human mind and have been described as a psychedelic, psychotogenic, or psychotomimetic. Psychedelics- substances t ...
Exam-Objectives
Exam-Objectives

... 13. Give a brief explanation (e.g., fast-off theory) of why the typicals have more motor side effects than the atypicals. 14. Know the following about antipsychotics: a. Tolerance? b. W/D ? c. Subjective effects d. Abuse potential e. Effects on sexual activity - think about what kind of behavior pro ...
Studying the impact on vision of silencing cells - Find a team
Studying the impact on vision of silencing cells - Find a team

... brain. This code is composed of electrical impulses (« spikes ») emitted by specific cells in the retina, the retinal ganglion cells (RGCs). A human retina contains ~1 million RGCs (45,000 in mouse) and each of these cells sends information (shape, motion, color, ...) from its immediate surrounding ...
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- Wiley Online Library

... across all arrays. The results show a ratio of around 0 on a log-scale, which is expected as most probe-sets should remain invariant across the array. Percentage of present calls plots using Affymetrix MAS 5.0 show good consistency across arrays. Positive and negative controls distributions were plo ...
Extracellular-vesicle type of volume transmission and tunnelling
Extracellular-vesicle type of volume transmission and tunnelling

... One of the best examples is CSF-delivered beta-endorphin (2500 pmol in 5 ml) which could accumulate in nerve cell body populations and their dendrites all over the paraventricular hypothalamus as seen 15 min after CSF injection [37]. Striatally microinjected beta-endorphin can also reach the CSF as ...
intracellular recordings
intracellular recordings

... Intracellular recordings have been obtained from five binocularly activated dLGN neurons. Four of these cells were sampled among more than 400 penetrated dLGN neurons in experiments devoted to other problems. They were all located near or within the interlaminar layers between lamina A, Al and C. On ...
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23. Parasympathetic nervous system

... Visceral sensory and autonomic neurons participate in visceral reflex arcs • Many are spinal reflexes such as defecation and micturition reflexes • Some only involve peripheral neurons: spinal cord not involved (not shown)* *e.g. “enteric” nervous system: 3 neuron reflex arcs entirely within the wa ...
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FUNCTIONAL COGNITIVE NETWORKS IN PRIMATES
FUNCTIONAL COGNITIVE NETWORKS IN PRIMATES

... The telencephalon, the anterior most region of the brain, arose evolutionarily in the olfactory system, as an invagination of the olfactory bulb, a laminated structure. The olfactory system uses a persistent analysis mode for detecting odor signals. The telencephalon initially played an essential ro ...
Music and Evolution
Music and Evolution

... common ancestor • Homoplasy: A trait with distinct lineages, lacking a common ancestor Powerful tool for evolutionary arguments • Can control exposure • Animals do not naturally produce music, thus any perceptual effects cannot be part of adaptation for music ...
Sleep/Neurology-The Orexin System
Sleep/Neurology-The Orexin System

... Two papers were published within 3 weeks of one another in early 1998 ...
Cognition without a Neural Code: How a Folded Electromagnetic Fields
Cognition without a Neural Code: How a Folded Electromagnetic Fields

... ulation after round-trips between two sets of coordinated neurons (a small number of round-trips, since any one center is already modulated by third parties before it receives news back from a center it just signaled). In addition, there is the time spent conducting along axons. Even if we assume op ...
06 trauma
06 trauma

... • Angular acceleration alone, in the absence of impact, may cause axonal injury as well as hemorrhage • As many as 50% of patients who develop coma shortly after trauma, even without cerebral contusions, are believed to have white matter damage and diffuse axonal injury • Although these changes may ...
What is mindfulness
What is mindfulness

... When practicing mindfulness, everyone, however much they practice, will experience thoughts creeping in to their heads uninvited. This is fine - its just what brains do, but how we respond to these thoughts is important. If we start to think about the thought, or get annoyed with ourselves for not b ...
Music and the Brain: Areas and Networks
Music and the Brain: Areas and Networks

... (who rely more on visual cues) during the integration of audiovisual information (Paraskevopoulos, Kraneburg, Herholz, Bamidis & Pantev, 2015), suggesting that long-term musical training can affect visual as well as auditory processing. Enhanced multisensory perception While audiovisual integration ...
Structure and function in the cerebral ganglion
Structure and function in the cerebral ganglion

... that some procerebral neurons are true projection neurons. They receive functional inputs within the procerebrum and they transmit to locations outside the procerebrum, presumably in a manner that generates behaviors appropriate to the olfactory signal. Other cells have neurites that are confined to ...
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PDF 2

... Parkinsonism is a movement disorder characterized by the triad of bradykinesia, tremor at rest, and muscular rigidity, which results from a decreased dopaminergic tone in the motor portions of the putamen. In idiopathic Parkinson disease (PD), these motor features are often accompanied by nonmotor i ...
ISIS 301012: The Reduction of Atherogenic Lipids in
ISIS 301012: The Reduction of Atherogenic Lipids in

...  Not well studied in children; no registration  Mechanism of action is complex and largely unknown  Decreased production of very low-density lipoprotein cholesterol (VLDL-C) and an increased clearance of triglycerides  Adverse reactions are similar to those of statins  In children, fibrates are ...
PGX Test Monographs
PGX Test Monographs

... CYP286 enzyme activity defines a normal or an abnormal (intermediate or poor) metabolizer status for a given individual. Several variant alleles have been identified and result in different CYP286 isoforms that functionally are fully active, partially active, inactive, or have increased activity. Th ...
Neurobiology of Behaviour
Neurobiology of Behaviour

... An animals response to the environment will be influenced by their underlying nervous system ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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