Methysergide Potentiates the Hyperactivity Produced by MDMA in
... preloaded rat striatal slices but is less effective at increasing [sI-I]-dopamine release [23]. In this same report, [aH]5-HT uptake by a synaptosomal preparation was found to be significantly reduced one week following a single injection of MDMA. These studies suggest that although MDMA LThis is pu ...
... preloaded rat striatal slices but is less effective at increasing [sI-I]-dopamine release [23]. In this same report, [aH]5-HT uptake by a synaptosomal preparation was found to be significantly reduced one week following a single injection of MDMA. These studies suggest that although MDMA LThis is pu ...
On the Role of Biophysical Properties of Cortical Neurons in Binding
... eral, however, the inclusion of voltage-dependent channels may cancel or even reverse this effect (Softky, 1994). Furthermore, because the somatic membrane potential, the variable modeled here, has an upper limit at the threshold for the generation of action potentials below the reversal potential o ...
... eral, however, the inclusion of voltage-dependent channels may cancel or even reverse this effect (Softky, 1994). Furthermore, because the somatic membrane potential, the variable modeled here, has an upper limit at the threshold for the generation of action potentials below the reversal potential o ...
Efficacy of Articaine over Lidocaine – A Review
... of injectable local anesthetics and has been present even before articaine was available (18,19). An article by Haas and Lennon published in 1993 (20) seems to be the original source for the controversy surrounding articaine. This paper, analyzed 143 cases reported in to the Royal College of Dental ...
... of injectable local anesthetics and has been present even before articaine was available (18,19). An article by Haas and Lennon published in 1993 (20) seems to be the original source for the controversy surrounding articaine. This paper, analyzed 143 cases reported in to the Royal College of Dental ...
RIA Reaching Others: `Molly` Who? The New Ecstasy
... Recently, organizers of a New York City music festival cancelled the last day of performances when two people died—and four more were hospitalized in critical condition—due to ingesting the club drug “Molly.” ...
... Recently, organizers of a New York City music festival cancelled the last day of performances when two people died—and four more were hospitalized in critical condition—due to ingesting the club drug “Molly.” ...
Viewpoint - Columbia University
... robustly realized by the LIP circuit and how this realization then explains why even neurons that are not part of the same local network should have a common crossing time. But first, we examine the data for evidence of this one-dimensional dynamics. Figure 2. Concept of One-Dimensional Dynamics An ...
... robustly realized by the LIP circuit and how this realization then explains why even neurons that are not part of the same local network should have a common crossing time. But first, we examine the data for evidence of this one-dimensional dynamics. Figure 2. Concept of One-Dimensional Dynamics An ...
Sparse Coding in the Neocortex
... that the ultimate goal is to have one neuron for every object—and certainly not for a particular view of every object. We believe that sparseness helps learning and prediction even at early stages of sensory processing, like those found in V1. But too much specificity or sparseness can actually make ...
... that the ultimate goal is to have one neuron for every object—and certainly not for a particular view of every object. We believe that sparseness helps learning and prediction even at early stages of sensory processing, like those found in V1. But too much specificity or sparseness can actually make ...
The cutaneous sensory system Neuroscience and Biobehavioral
... movement is executed fluently via elegant feedback and feedforward mechanisms. This review paper will focus on sensory inputs arising from the skin, namely cutaneous sensibility. Sensory modalities operate within interconnecting, intermodal and crossmodal networks, ensuring that interactions with the ...
... movement is executed fluently via elegant feedback and feedforward mechanisms. This review paper will focus on sensory inputs arising from the skin, namely cutaneous sensibility. Sensory modalities operate within interconnecting, intermodal and crossmodal networks, ensuring that interactions with the ...
View/Open - Oregon State University
... disorder that affects physical activity level as well as perception and cognition and is often accompanied by secondary disorders (Rosenbaum, 2006). In order to gain the most health benefits, research shows that meeting the physical activity requirements of strength and cardiorespiratory training sh ...
... disorder that affects physical activity level as well as perception and cognition and is often accompanied by secondary disorders (Rosenbaum, 2006). In order to gain the most health benefits, research shows that meeting the physical activity requirements of strength and cardiorespiratory training sh ...
Uppers, Downers & All Arounders
... – Liver converts morphine into metabolites – Can be detected in urine fro several days – Therapeutic pain control – Patient become more sensitive to pain after long-term use because the body produces fewer of its own painkillers – Down regulates opioid receptor sites ...
... – Liver converts morphine into metabolites – Can be detected in urine fro several days – Therapeutic pain control – Patient become more sensitive to pain after long-term use because the body produces fewer of its own painkillers – Down regulates opioid receptor sites ...
Intracellular Modulation of NMDA Receptor Function by
... gene expression in vivo in the rat striatum and ex vivo in primary striatal culture. Gene expression may be important for some of the therapeutic actions of antipsychotic drugs (Hyman, 1993). We chose to analyze the regulation of two genes in the striatum: the immediate early gene c-fos, which is ra ...
... gene expression in vivo in the rat striatum and ex vivo in primary striatal culture. Gene expression may be important for some of the therapeutic actions of antipsychotic drugs (Hyman, 1993). We chose to analyze the regulation of two genes in the striatum: the immediate early gene c-fos, which is ra ...
Cranberries May Improve Chemotherapy for Ovarian Cancer
... and morbidity associated with platinum therapy. For the first time, we have shown in our in-vitro studies that cranberry extracts and its actives proanthocyanidin can sensitize resistant human ovarian cancer cell lines. This has opened up exciting possibilities for therapeutic intervention associate ...
... and morbidity associated with platinum therapy. For the first time, we have shown in our in-vitro studies that cranberry extracts and its actives proanthocyanidin can sensitize resistant human ovarian cancer cell lines. This has opened up exciting possibilities for therapeutic intervention associate ...
Motivation - Blackwell Publishing
... What motivates us to work for food when we are hungry, or water when we are thirsty? How do these motivational control systems ensure that we eat approximately the right amount of food to maintain our body weight, or drink enough to quench our thirst? And how do we explain overeating and obesity? In ...
... What motivates us to work for food when we are hungry, or water when we are thirsty? How do these motivational control systems ensure that we eat approximately the right amount of food to maintain our body weight, or drink enough to quench our thirst? And how do we explain overeating and obesity? In ...
Possible Mechanism Underlying
... which leads to dysphoria or anxiety during withdrawal (32). Yin and Yang theory may explain these seemingly opposite proponent and opponent theories underlying drug addiction and relapse to drug seeking. Koob and Moal Le (33) proposed a conceptual framework of allostasis which focused on abnormal ch ...
... which leads to dysphoria or anxiety during withdrawal (32). Yin and Yang theory may explain these seemingly opposite proponent and opponent theories underlying drug addiction and relapse to drug seeking. Koob and Moal Le (33) proposed a conceptual framework of allostasis which focused on abnormal ch ...
Molecular imaging with SPECT as a tool for drug
... [2,3]. The situation is rather common with the development of the new so-called molecularly targeted agents for cancer treatment, whereas the availability of validated biomarker signals that correlate with clinical endpoints could predict which new drugs will have clinical efficacy before moving to h ...
... [2,3]. The situation is rather common with the development of the new so-called molecularly targeted agents for cancer treatment, whereas the availability of validated biomarker signals that correlate with clinical endpoints could predict which new drugs will have clinical efficacy before moving to h ...
Chapter 5 for PSYC 2301
... 2. Activation-synthesis hypothesis = dreams are the brain’s way of making sense of random electrical stimulation occurring during REM 3. Cognitive view = dreams organize and interpret information from waking experience into memories © 2014 John Wiley & Sons, Inc. All rights reserved. ...
... 2. Activation-synthesis hypothesis = dreams are the brain’s way of making sense of random electrical stimulation occurring during REM 3. Cognitive view = dreams organize and interpret information from waking experience into memories © 2014 John Wiley & Sons, Inc. All rights reserved. ...
NMDA Receptors Subserve Persistent Neuronal Firing during
... sensory-motor systems regarding the response (Funahashi et al., 1991). Response-like cells appear to predominate in the rodent PFC (Caetano et al., 2012), and it is likely that the higher representational operations performed by Delay cells can only be studied in primate dlPFC (Preuss, 1995). The wo ...
... sensory-motor systems regarding the response (Funahashi et al., 1991). Response-like cells appear to predominate in the rodent PFC (Caetano et al., 2012), and it is likely that the higher representational operations performed by Delay cells can only be studied in primate dlPFC (Preuss, 1995). The wo ...
Stimulation Within the Rostral Ventrolateral Medulla Can Evoke
... the upper thoracic segments of the spinal cord in a neonatal rat brain stem-spinal cord preparation. Neurons were identified as SPNs on the basis of their antidromic activation after stimulation of the ipsilateral segmental ventral root and their morphology and location in the intermediolateral cell ...
... the upper thoracic segments of the spinal cord in a neonatal rat brain stem-spinal cord preparation. Neurons were identified as SPNs on the basis of their antidromic activation after stimulation of the ipsilateral segmental ventral root and their morphology and location in the intermediolateral cell ...
Malformations of the Cerebral Cortex as a Cause of Mental
... associated with synaptogenesis and apoptosis. This is a dynamic process and more than one stage may occur simultaneously during several gestational weeks. In humans, the proliferation stage ranges from weeks 5-6 to weeks 16-20, migration from weeks 6-7 to weeks 20-24, and organization from week 16 u ...
... associated with synaptogenesis and apoptosis. This is a dynamic process and more than one stage may occur simultaneously during several gestational weeks. In humans, the proliferation stage ranges from weeks 5-6 to weeks 16-20, migration from weeks 6-7 to weeks 20-24, and organization from week 16 u ...
multiple-choice tests in pharmacology
... a) Accumulation of substances in a fat tissue b) Binding of substances with plasma proteins c) Accumulation of substances in a tissue d) Process of physicochemical and biochemical alteration of a drug in the body 026. Biotransformation of the drugs is to render them: a) Less ionized b) More pharmaco ...
... a) Accumulation of substances in a fat tissue b) Binding of substances with plasma proteins c) Accumulation of substances in a tissue d) Process of physicochemical and biochemical alteration of a drug in the body 026. Biotransformation of the drugs is to render them: a) Less ionized b) More pharmaco ...
Ariel FARM 19 5
... SUMMARY. Using a modified Geller and Seifter test in rats the mechanisms of anticonflict effect of carbamazepine was investigated. The purinoceptor antagonist aminophyline (5 m&& blocked the carbamazepine effect in this paradigm. On the other hand, papaverine (5 m&& significantly increased the punis ...
... SUMMARY. Using a modified Geller and Seifter test in rats the mechanisms of anticonflict effect of carbamazepine was investigated. The purinoceptor antagonist aminophyline (5 m&& blocked the carbamazepine effect in this paradigm. On the other hand, papaverine (5 m&& significantly increased the punis ...
Physiology of the Striate Cortex
... • Hierarchy of complex receptive fields • Retinal ganglion cells: Center-surround structure, Sensitive to contrast, and wavelength of light • Striate cortex: Orientation selectivity, direction selectivity, and binocularity • Extrastriate cortical areas: Selective responsive to complex shapes; e.g., ...
... • Hierarchy of complex receptive fields • Retinal ganglion cells: Center-surround structure, Sensitive to contrast, and wavelength of light • Striate cortex: Orientation selectivity, direction selectivity, and binocularity • Extrastriate cortical areas: Selective responsive to complex shapes; e.g., ...
Options for regulating new psychoactive drugs: a review of
... prohibitions; two examples that have been prominent recently are mephedrone and Spice. Many, but not all, of these substances are the creation of entrepreneurial chemists. Some are natural substances, for which new and more dangerous modes of ingestion have been developed or whose intoxicating prope ...
... prohibitions; two examples that have been prominent recently are mephedrone and Spice. Many, but not all, of these substances are the creation of entrepreneurial chemists. Some are natural substances, for which new and more dangerous modes of ingestion have been developed or whose intoxicating prope ...