Adenine Nucleotides Undergo Rapid, Quantitative Conversion to
... slower time scale than any of the other nucleotides tested. These experiments demonstrate that fast, localized release of AMP, ADP, or ATP can result in a transient activation of adenosine receptors but that this is unlikely to occur with cAMP. The existence of a highly active ecto-nucleotidase path ...
... slower time scale than any of the other nucleotides tested. These experiments demonstrate that fast, localized release of AMP, ADP, or ATP can result in a transient activation of adenosine receptors but that this is unlikely to occur with cAMP. The existence of a highly active ecto-nucleotidase path ...
Adjunct Treatments for Schizophrenia and Bipolar Disorder
... The pharmacological treatment of serious psychiatric disorders is unsatisfactory for many patients. Psychotic symptoms are often only partially resolved (1, 2), and the cognitive and negative symptoms of schizophrenia (3) and the depressive symptoms of bipolar disorder (4) have proven to be especial ...
... The pharmacological treatment of serious psychiatric disorders is unsatisfactory for many patients. Psychotic symptoms are often only partially resolved (1, 2), and the cognitive and negative symptoms of schizophrenia (3) and the depressive symptoms of bipolar disorder (4) have proven to be especial ...
Intersegmental synchronization of spontaneous activity of dorsal
... discharges showed the highest incidence of overlapping receptive fields. However, in these studies, very little information was presented on mechanisms and/or pathways contributing to the intersegmental synchronization of the spontaneous activity of these neurons. One question that emerged from the ...
... discharges showed the highest incidence of overlapping receptive fields. However, in these studies, very little information was presented on mechanisms and/or pathways contributing to the intersegmental synchronization of the spontaneous activity of these neurons. One question that emerged from the ...
Measurement of variability dynamics in cortical spike trains
... spike trains. We propose to test neuronal spike trains for deviations from the null-hypothesis FF = CV2 . We show that cortical pyramidal neurons, recorded under controlled stationary input conditions in vitro, comply with this assumption. Performing a time-resolved joint analysis of CV2 and FF of a ...
... spike trains. We propose to test neuronal spike trains for deviations from the null-hypothesis FF = CV2 . We show that cortical pyramidal neurons, recorded under controlled stationary input conditions in vitro, comply with this assumption. Performing a time-resolved joint analysis of CV2 and FF of a ...
Combination Antibiotic Therapy for Infective Endocarditis
... endocarditis (IE) is still associated with high morbidity and mortality rates. Use of synergistic antibiotic combinations is an appealing way to optimize therapy for IE. This review focuses on evidence-based recommendations for combination antimicrobial therapy for IE due to the most common etiologi ...
... endocarditis (IE) is still associated with high morbidity and mortality rates. Use of synergistic antibiotic combinations is an appealing way to optimize therapy for IE. This review focuses on evidence-based recommendations for combination antimicrobial therapy for IE due to the most common etiologi ...
Pharmaceuticals and the Elderly - WHO archives
... Current "Pipeline" of Products ......................................................................................................... 17 Opportunities for Research into New Pharmaceutical Interventions ......................................... 17 Conclusion ....................................... ...
... Current "Pipeline" of Products ......................................................................................................... 17 Opportunities for Research into New Pharmaceutical Interventions ......................................... 17 Conclusion ....................................... ...
J. Clin. Invest.
... bind divalent metal ions, such as Ca2+ rapidly cleared from the circulation and bind to areas undergoing osteoclastic resorption ...
... bind divalent metal ions, such as Ca2+ rapidly cleared from the circulation and bind to areas undergoing osteoclastic resorption ...
Calcineurin Inhibitors FK506 and SDZ ASM 981 Alleviate the
... vehicle were injected i.v. as a bolus in the tail vein. For the rapamycin study, where animals received two injections of vehicle or drug solution, the total amount of injected ethanol/polyethylene glycol 200 (1:2) (v/v) was the same as in the other experiments; for this, it was diluted 1:1 with 0.9 ...
... vehicle were injected i.v. as a bolus in the tail vein. For the rapamycin study, where animals received two injections of vehicle or drug solution, the total amount of injected ethanol/polyethylene glycol 200 (1:2) (v/v) was the same as in the other experiments; for this, it was diluted 1:1 with 0.9 ...
Orientation Preference Patterns in Mammalian Visual Cortex: A Wire
... the fact that each individual neuron is well tuned for orientation. The situation in rat V1 raises a question about the relation between the tuning of neuronal response and the tuning of the connection function. Although they are related, these two tunings do not have to coincide. This is because co ...
... the fact that each individual neuron is well tuned for orientation. The situation in rat V1 raises a question about the relation between the tuning of neuronal response and the tuning of the connection function. Although they are related, these two tunings do not have to coincide. This is because co ...
\\Appganim\Fda\Mt\Alonim\1921.doc PRAMIN INJECTION TABLETS
... Metoclopramide has been reported to induce tardive dyskinesia and dysarthria, especially in geriatric patients. This may develop during administration and/or following discontinuation of use. These effects, although possibly reversible, are extremely distressing and their resolution is often slow. M ...
... Metoclopramide has been reported to induce tardive dyskinesia and dysarthria, especially in geriatric patients. This may develop during administration and/or following discontinuation of use. These effects, although possibly reversible, are extremely distressing and their resolution is often slow. M ...
PDF
... In addition to dopamine, primarily involved in hedonic experience are endogenous opioids, like endorphins, enkephalins, dynorphins, and orphanin FG as well as their various receptor subtypes (μ, δ, κ, and ORL1; Cooper et al., 2003), which are widely expressed in the ventral striatum (particularly th ...
... In addition to dopamine, primarily involved in hedonic experience are endogenous opioids, like endorphins, enkephalins, dynorphins, and orphanin FG as well as their various receptor subtypes (μ, δ, κ, and ORL1; Cooper et al., 2003), which are widely expressed in the ventral striatum (particularly th ...
Predictive Coding: A Possible Explanation of Filling
... blind spot, filling-in also occurs in other visual input deficit conditions, e.g. filling-in at the artificial and natural retinal scotoma [2, 3]. In addition to the deficit of input, filling-in also occurs in visual illusions such as Neon color spreading, Craik-O’Brien-Cornsweet illusion, Kanizsa s ...
... blind spot, filling-in also occurs in other visual input deficit conditions, e.g. filling-in at the artificial and natural retinal scotoma [2, 3]. In addition to the deficit of input, filling-in also occurs in visual illusions such as Neon color spreading, Craik-O’Brien-Cornsweet illusion, Kanizsa s ...
a review of the adverse side effects associated with antipsychotics
... drugs have been developed while their side effects have become evident. The side effects of both the typical and atypical generation of antipsychotics have important consequences for the quality of life of recipients, stigma experienced and also the level of care of patients. It is well acknowledged ...
... drugs have been developed while their side effects have become evident. The side effects of both the typical and atypical generation of antipsychotics have important consequences for the quality of life of recipients, stigma experienced and also the level of care of patients. It is well acknowledged ...
Dynamic Stochastic Synapses as Computational Units
... an excitatory neuron to an inhibitory neuron, which sends feedback directly to the presynaptic terminals. They showed through computer simulations that tuning the relative contributions of excitatory and inhibitory mechanisms can selectively increase the network output cross-correlation for certain ...
... an excitatory neuron to an inhibitory neuron, which sends feedback directly to the presynaptic terminals. They showed through computer simulations that tuning the relative contributions of excitatory and inhibitory mechanisms can selectively increase the network output cross-correlation for certain ...
Microglial Phagocytosis Induced by FibrillarЯ
... Phagocytosis stimulated by fA was not affected by the presence of IL-1 for 1 h or less, suggesting that proinflammatory inhibition of fA-stimulated phagocytosis might be transcriptionally regulated. We further evaluated a role for transcriptional regulation in IL-1-inhibited fA-stimulated phago ...
... Phagocytosis stimulated by fA was not affected by the presence of IL-1 for 1 h or less, suggesting that proinflammatory inhibition of fA-stimulated phagocytosis might be transcriptionally regulated. We further evaluated a role for transcriptional regulation in IL-1-inhibited fA-stimulated phago ...
Realizing Biological Spiking Network Models in a Configurable
... this hardware architecture: First, a continuous-time serial bus system using on-chip and post-processing lines for intrawafer communication (“Layer-1”). Second, a packet-based dynamic routing network implemented by separate custom hardware components which interface the network chips via contacts on ...
... this hardware architecture: First, a continuous-time serial bus system using on-chip and post-processing lines for intrawafer communication (“Layer-1”). Second, a packet-based dynamic routing network implemented by separate custom hardware components which interface the network chips via contacts on ...
Applied physiology: neuropathic pain
... for good ethical reasons, most animal models of neuropathic pain study the animals for a period of weeks, whereas the clinical course of neuropathic pain presenting to a pain relief clinic is often measured in years. Finally, as with all animal models, it is difficult to know what is actually percei ...
... for good ethical reasons, most animal models of neuropathic pain study the animals for a period of weeks, whereas the clinical course of neuropathic pain presenting to a pain relief clinic is often measured in years. Finally, as with all animal models, it is difficult to know what is actually percei ...
Decozol, Oral gel
... vitro and in vivo. In studies miconazole and amphotericin combination were also shown to be antagonistic in antifungal activity against Candida albicans. HIV protease inhibitors (such as saquinavir): In vitro inhibition of the metabolism of saquinavir has been demonstrated. Therefore, the dosage may ...
... vitro and in vivo. In studies miconazole and amphotericin combination were also shown to be antagonistic in antifungal activity against Candida albicans. HIV protease inhibitors (such as saquinavir): In vitro inhibition of the metabolism of saquinavir has been demonstrated. Therefore, the dosage may ...
Role of the basal ganglia in conditional associative learning
... The arbitrary mapping of sensory information onto action forms an important element of the intelligent behavior of primates (also called conditional associative learning). The cortico-basal ganglia-thalamo-cortical loops are thought to play a key role in such behavior. The present research was under ...
... The arbitrary mapping of sensory information onto action forms an important element of the intelligent behavior of primates (also called conditional associative learning). The cortico-basal ganglia-thalamo-cortical loops are thought to play a key role in such behavior. The present research was under ...
Quinto trabajo
... processes in some injury models. However, targeted disruption of this protein produces limited phenotypic abnormalities during development, but excitotoxic cell death can be partially prevented in adult striatum. Here, we have examined the compensatory mechanisms activated by the lack of Bax during ...
... processes in some injury models. However, targeted disruption of this protein produces limited phenotypic abnormalities during development, but excitotoxic cell death can be partially prevented in adult striatum. Here, we have examined the compensatory mechanisms activated by the lack of Bax during ...
Multimodal Integration in Rostral Fastigial Nucleus Provides an
... to determine whether the average of two measured parameters differed significantly from each other. Note that only data for which the firing rate was ⬎20 sp/s were included in the optimization. To determine whether each individual cell was better fit with the vestibular or summation model linear reg ...
... to determine whether the average of two measured parameters differed significantly from each other. Note that only data for which the firing rate was ⬎20 sp/s were included in the optimization. To determine whether each individual cell was better fit with the vestibular or summation model linear reg ...
Receptive fields and suppressive fields in the
... Initial models proposed that these operations are weighted sums, with weights given by a neuron’s receptive field. These models explain the basic features of response selectivity. They were later extended to explain a number of suppressive effects originating within and outside the region of the rec ...
... Initial models proposed that these operations are weighted sums, with weights given by a neuron’s receptive field. These models explain the basic features of response selectivity. They were later extended to explain a number of suppressive effects originating within and outside the region of the rec ...
Projections of the median raphe nucleus in the rat
... reticular formation, we (Vertes and Martin, 1988) examined the ascending projections of the MR to the diencephalon, basal forebrain, and hippocampal formation by using the autoradiographic technique. Although our report described projections to these regions, it also was incomplete in that certain a ...
... reticular formation, we (Vertes and Martin, 1988) examined the ascending projections of the MR to the diencephalon, basal forebrain, and hippocampal formation by using the autoradiographic technique. Although our report described projections to these regions, it also was incomplete in that certain a ...
the electron microscopic localization of
... extracellular spaces of considerable extent. These spaces contribute to the large "inulin space" of 18.6 per cent (Treherne, 1962 a): this total extracellular phase is very large compared with that of the vertebrate (Horstmann and Meves, 1959; et al., 1962) or leech (Coggeshall and Fawcett, 1964) ce ...
... extracellular spaces of considerable extent. These spaces contribute to the large "inulin space" of 18.6 per cent (Treherne, 1962 a): this total extracellular phase is very large compared with that of the vertebrate (Horstmann and Meves, 1959; et al., 1962) or leech (Coggeshall and Fawcett, 1964) ce ...
This Guidance updates a Faculty ... Professional Development Topic (FACT) on ...
... drugs which may be toxic if serum concentrations increase, and on commonly used drugs (prescription and non-prescription) which do and do not affect contraceptive efficacy. Further research into drug interactions and hormonal contraception is needed to guide clinical practice and should be encourage ...
... drugs which may be toxic if serum concentrations increase, and on commonly used drugs (prescription and non-prescription) which do and do not affect contraceptive efficacy. Further research into drug interactions and hormonal contraception is needed to guide clinical practice and should be encourage ...