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Pharmacology Basics
Pharmacology Basics

... – Effective concentration (EC50) is the concentration of an agonist needed to elicit half of the maximum biological response of the agonist – The potency of an agonist is inversely related to its EC50 value ...
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... – In 2003, the Centers for Medicare and Medicaid Services (CMS) reduced rates of reimbursement to hospitals and doctors for most orphan drugs • Compassionate Use of Experimental Drugs – Criticism of the FDA’s conservative stance led to the adoption of a new drug approval procedure in the 1980s, wher ...
Simulations of an Extrinsic Stochastic Model of the
Simulations of an Extrinsic Stochastic Model of the

... biological system developed by Rui de Figueiredo. • An extrinsic stochastic model for the development, as a functions of age, of the average neuron/synapse population densities in cortical regions of the human brain. • The model describes the behavior of neurons and synapses during neuron-genesis ba ...
extrapyramidal reactions - Prescrire International
extrapyramidal reactions - Prescrire International

... suggested an autoimmune reaction: antinuclear antibodies (2  cases), and antineutrophil cytoplasmic antibodies (1 case). Certain patients received corticosteroids, methotrexate or another immunosuppressant to treat their joint pain. Gliptins inhibit dipeptidyl dipeptidase (DPP-4) and thereby prolong ...
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Sedatives, Hypnotics & Anxiolytics

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How Neurons Talk to Each Other
How Neurons Talk to Each Other

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1 Neurons 2 Electrical activity of neurons at rest.
1 Neurons 2 Electrical activity of neurons at rest.

... Neurons are electrically active. They produce large electrical signals called “action potentials” or “spikes” or “nerve impulses” that can travel down the axon and are reliably transmitted to other neurons. Action potentials are considered to be stereotypical and are the main communication units in ...
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Pharmacodynamics - obsidian

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Chapter 33 Nervous System
Chapter 33 Nervous System

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Computers are getting faster, capable of performing massive

... The idea started as early as the 17th century with Rene Descartes envisioning animals in the future being complex machines, at least partly. The idea evolved as the 1900s approached, and in the 1950s, algorithms began to be produced. The 60s and 70s brought promising ideas and mechanical methods of ...
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The Loss of Glutamate-GABA Harmony in Anxiety Disorders

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Chapter 10 Slides

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Divisions of the Nervous System

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Nervous System Chapter 11 Answers

... 15. What is the all-or-nothing phenomenon? An action potential occurs completely, or not at all (THRESHOLD must be reached to open up sodium channels) 16. What variables influence the conduction velocity of a neuron?  Axon diameter (Larger diameter results in faster conduction of impulse)  Degr ...
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amnesia(短暂性记忆缺失)

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PoNS Fact Sheet - Helius Medical Technologies

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PHARMACOKINETICS

... amitriptyline 1050 amiodarone ~5000 ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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