Hypersensitivities – 17/03/03
... lymphocytes reacting, usually against self antigens resulting in autoimmune diseases. Most autoimmune diseases are Type IV Hypersensitivity reactions. Mechanisms of Tissue Injury Host is exposed to tissue antigen, which is broken down and is presented on APCs Naïve CD4+ cells recognise these p ...
... lymphocytes reacting, usually against self antigens resulting in autoimmune diseases. Most autoimmune diseases are Type IV Hypersensitivity reactions. Mechanisms of Tissue Injury Host is exposed to tissue antigen, which is broken down and is presented on APCs Naïve CD4+ cells recognise these p ...
T cells
... Functions of NKT cells Secretion of both, Th1 and Th2 cytokines Impact on Th1/Th2 differentiation of naive T cells Activation of B cells Activation of NK cells ...
... Functions of NKT cells Secretion of both, Th1 and Th2 cytokines Impact on Th1/Th2 differentiation of naive T cells Activation of B cells Activation of NK cells ...
Logic of the Immune System - Cancer Immunology Research
... proteasome is the key protease responsible for generation of peptides in the cytosol, which are then delivered via specific peptide transporters to the endoplasmic reticulum, where they are assembled together with the class I MHC subunits to yield a stable class I MHC molecule. All nucleated cells sy ...
... proteasome is the key protease responsible for generation of peptides in the cytosol, which are then delivered via specific peptide transporters to the endoplasmic reticulum, where they are assembled together with the class I MHC subunits to yield a stable class I MHC molecule. All nucleated cells sy ...
BIO SEMINAR PPT FINAL
... An Application of Immunological Memory: Vaccines Immunization – inoculation with antigenic proteins, pathogen fragments, or other molecular antigens Vaccination – inoculation with whole pathogens that have been modified so that they can’t cause disease *both initiate primary immune response (making ...
... An Application of Immunological Memory: Vaccines Immunization – inoculation with antigenic proteins, pathogen fragments, or other molecular antigens Vaccination – inoculation with whole pathogens that have been modified so that they can’t cause disease *both initiate primary immune response (making ...
IMMUNE SYSTEM
... 4 Major Characteristics of Adaptive Immunity 3. cell proliferation triggered by activation greatly increases the # of B and T cells 4. there is a stronger & more rapid response to agn previously encountered – immunological memory occurs after mature lymphocyte encounters & binds to a specific agn ...
... 4 Major Characteristics of Adaptive Immunity 3. cell proliferation triggered by activation greatly increases the # of B and T cells 4. there is a stronger & more rapid response to agn previously encountered – immunological memory occurs after mature lymphocyte encounters & binds to a specific agn ...
Supplementary Figure Legends (doc 38K)
... anti-CD4 mAbs, fixed and permeabilized, and intracellularly labeled with anti-IFN-γ and antiIL17A, and analyzed by FACS. Dot plots of different splenic cell subsets (upper panel). Data are pooled from 3 individual experiments. Data represents mean. *<0.05, **<0.01. Cells from mesenteric lymph nodes ...
... anti-CD4 mAbs, fixed and permeabilized, and intracellularly labeled with anti-IFN-γ and antiIL17A, and analyzed by FACS. Dot plots of different splenic cell subsets (upper panel). Data are pooled from 3 individual experiments. Data represents mean. *<0.05, **<0.01. Cells from mesenteric lymph nodes ...
A Novel Approach in Kidney Transplantation: Costimulation
... The Intricacy of the B7/CD28/CTLA4 Conduit • The B7/CD28/CTLA4 pathway is characterized by the dual affinity of B7-1 and B7-2 for both the stimulatory receptor CD28 and the inhibitory receptor (cytotoxic Tlymphocyteassociated antigen 4 (CTLA4) or CD152). • The CD28 molecule, which is constitutively ...
... The Intricacy of the B7/CD28/CTLA4 Conduit • The B7/CD28/CTLA4 pathway is characterized by the dual affinity of B7-1 and B7-2 for both the stimulatory receptor CD28 and the inhibitory receptor (cytotoxic Tlymphocyteassociated antigen 4 (CTLA4) or CD152). • The CD28 molecule, which is constitutively ...
Document
... plasma B cells , memory B cells, macrophages, dendritic cells know how Helper T cells (TH) regulate entire immune system know what monoclonal antibodies are what what immunity is, difference between active and passive immunity, how smallpox vaccine and snake antivenom are related know the function o ...
... plasma B cells , memory B cells, macrophages, dendritic cells know how Helper T cells (TH) regulate entire immune system know what monoclonal antibodies are what what immunity is, difference between active and passive immunity, how smallpox vaccine and snake antivenom are related know the function o ...
Supplemental Figures 1
... two time points of hormone measurements (0:30 and 2 AM) that were associated with SWS-rich sleep. Means ± SEM, n = 26 for both groups; ** P < 0.01, * P < 0.05 for comparisons between Sleep and Wake condition. ...
... two time points of hormone measurements (0:30 and 2 AM) that were associated with SWS-rich sleep. Means ± SEM, n = 26 for both groups; ** P < 0.01, * P < 0.05 for comparisons between Sleep and Wake condition. ...
Defense Lecture Study ppt File
... Adaptive Immunity: Summary • Uses lymphocytes, APCs, and specific molecules to identify and destroy nonself substances • Depends upon the ability of its cells to – Recognize antigens by binding to them – Communicate with one another so that the whole system mounts a specific response ...
... Adaptive Immunity: Summary • Uses lymphocytes, APCs, and specific molecules to identify and destroy nonself substances • Depends upon the ability of its cells to – Recognize antigens by binding to them – Communicate with one another so that the whole system mounts a specific response ...
defence mechanism of gingiva
... Pashley developed a model where gingival fluid production is modulated by the passage of fluid from capillaries into the tissues and by removal of this interstitial fluid by lymphatic of gingival. When the production of fluid from capillaries is greater than lymphatic uptake, fluid will accumulate ...
... Pashley developed a model where gingival fluid production is modulated by the passage of fluid from capillaries into the tissues and by removal of this interstitial fluid by lymphatic of gingival. When the production of fluid from capillaries is greater than lymphatic uptake, fluid will accumulate ...
PowerPoint - MediVet Biologics
... • MSCs have the ability to migrate to the sites of injury (express a variety of adhesion and chemokine receptors). • Potential for tissue repair (Proliferation and matrix production) • Potential for immunomodulatory effect (both innate and adaptive immunity) ...
... • MSCs have the ability to migrate to the sites of injury (express a variety of adhesion and chemokine receptors). • Potential for tissue repair (Proliferation and matrix production) • Potential for immunomodulatory effect (both innate and adaptive immunity) ...
Powerpoint Presentation: The Monoclonal Antibodies
... • Developing specific antibodies would be useful in fighting particular diseases • Diagnosing infections • Identifying molecules with antigenic properties. ...
... • Developing specific antibodies would be useful in fighting particular diseases • Diagnosing infections • Identifying molecules with antigenic properties. ...
Eman Mohamed Ali Hassan_Pathogenesis2
... were higher in the subjects with immediate reactions than in those without immediate reactions. The mean lymphocyte proliferation stimulation index was higher in the subjects with delayed reactions ...
... were higher in the subjects with immediate reactions than in those without immediate reactions. The mean lymphocyte proliferation stimulation index was higher in the subjects with delayed reactions ...
Hypersensitivity
... • Can mediated cell destruction by activating the complement system to create pores in the membrane of the foreign cell • Can also mediated by Antibody-Dependent CellMediated Cytotoxicity (ADCC) where the Fc receptors bind to Fc receptor of antibody on the target cell and promote killing ...
... • Can mediated cell destruction by activating the complement system to create pores in the membrane of the foreign cell • Can also mediated by Antibody-Dependent CellMediated Cytotoxicity (ADCC) where the Fc receptors bind to Fc receptor of antibody on the target cell and promote killing ...
Autoimmunity - the IID and GHTP
... • The MHC accomplishes its major role in immune recognition by satisfying two distinct molecular functions: – Binding of peptides (or in some cases non-peptidic molecules) – Interaction with T cells, usually via the αβ T-cell receptor (TCR). MHC PEPTIDE ...
... • The MHC accomplishes its major role in immune recognition by satisfying two distinct molecular functions: – Binding of peptides (or in some cases non-peptidic molecules) – Interaction with T cells, usually via the αβ T-cell receptor (TCR). MHC PEPTIDE ...
Tumour Immunology fi..
... D. NATURAL KILLER CELL after activation, directly killing tumor cell Do not recognize tumor cell via antigen specific cell surface receptor, but rather through receptors that recognize loss of expression of MHC I molecules, therefore detect “missing self” common in cancer. ...
... D. NATURAL KILLER CELL after activation, directly killing tumor cell Do not recognize tumor cell via antigen specific cell surface receptor, but rather through receptors that recognize loss of expression of MHC I molecules, therefore detect “missing self” common in cancer. ...
chapter_01 - Welcome to people.pharmacy.purdue.edu!
... infection site they get activated - to divide into functional effector cells. Some T-cells stay in the lymph node and become Thelper cells - secrete cytokines (soluble proteins) and have receptors that contact B-cells. This helps the Bcells differentiate into plasma cells. Plasma cells stay in the l ...
... infection site they get activated - to divide into functional effector cells. Some T-cells stay in the lymph node and become Thelper cells - secrete cytokines (soluble proteins) and have receptors that contact B-cells. This helps the Bcells differentiate into plasma cells. Plasma cells stay in the l ...
07. Immunology
... MHC To minimise rejection, the MHC of donor and recipient are matched as closely as possible i.e. tissue typing Siblings usually provide the closest match MHC do not play a role in transfusion reactions because red blood cells do not have MHC. ...
... MHC To minimise rejection, the MHC of donor and recipient are matched as closely as possible i.e. tissue typing Siblings usually provide the closest match MHC do not play a role in transfusion reactions because red blood cells do not have MHC. ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.