Allergy - British Society for Immunology
... seen in anaphylaxis. The type of symptoms depends mainly on how the person is exposed to the allergen. Every year in the UK, the number of allergy cases increases by approximately 5%, and half of those are in children. The ‘Hygiene Hypothesis’, the idea that increased exposure to microorganisms corr ...
... seen in anaphylaxis. The type of symptoms depends mainly on how the person is exposed to the allergen. Every year in the UK, the number of allergy cases increases by approximately 5%, and half of those are in children. The ‘Hygiene Hypothesis’, the idea that increased exposure to microorganisms corr ...
match! - Bone Marrow Donor Programme
... Are there likely to be any long term effects on my health after making a donation? All of our donors have returned to their normal routine after donating their bone marrow and none have had any long term side effects. Bone marrow is fully restored within 4-6 weeks and there is a possibility that you ...
... Are there likely to be any long term effects on my health after making a donation? All of our donors have returned to their normal routine after donating their bone marrow and none have had any long term side effects. Bone marrow is fully restored within 4-6 weeks and there is a possibility that you ...
Listeria Impair Innate Defenses against 1
... modifying the supply of oxygen and metabolites required for a successful “fight or flight” response (11). In addition to controlling cardiovascular functions, energy metabolism, and thermoregulation, stress factors are known to influence immune cell functions. Numerous neuroendocrine factors, such a ...
... modifying the supply of oxygen and metabolites required for a successful “fight or flight” response (11). In addition to controlling cardiovascular functions, energy metabolism, and thermoregulation, stress factors are known to influence immune cell functions. Numerous neuroendocrine factors, such a ...
Emerging microengineered tools for functional analysis
... [30]. Thus, detection of cytokine secretion from WBCs is of great importance both for fundamental understanding of human immunity and for immune monitoring in healthy humans and in those with allergy, asthma, autoimmunity, acquired or primary immunodeficiency, transplantation, or infection. In infla ...
... [30]. Thus, detection of cytokine secretion from WBCs is of great importance both for fundamental understanding of human immunity and for immune monitoring in healthy humans and in those with allergy, asthma, autoimmunity, acquired or primary immunodeficiency, transplantation, or infection. In infla ...
Full Text PDF - J
... DNP-BSA and TNP were purchased from Sigma-Aldrich (St Louis, MO). TNP-BSA, TNP-OVA, and TNP-HSA were prepared according to the method of Bondada and Robertson (2003), but with slight modifications as described by Wu et al. (2010). Briefly, 50 mg of OVA (or 80 mg of BSA or HSA) was dissolved in 2.5 m ...
... DNP-BSA and TNP were purchased from Sigma-Aldrich (St Louis, MO). TNP-BSA, TNP-OVA, and TNP-HSA were prepared according to the method of Bondada and Robertson (2003), but with slight modifications as described by Wu et al. (2010). Briefly, 50 mg of OVA (or 80 mg of BSA or HSA) was dissolved in 2.5 m ...
NRT.010 Acid Elution
... The yield of antibody obtained upon elution from coated cells is dependent on the following variable factors: 8.7.1 The amount of antibody bound to the cells. 8.7.2 The degree of dissociation of antibody that occurs during the washing procedure. 8.7.3 Red cells that have a positive DAT due to bound ...
... The yield of antibody obtained upon elution from coated cells is dependent on the following variable factors: 8.7.1 The amount of antibody bound to the cells. 8.7.2 The degree of dissociation of antibody that occurs during the washing procedure. 8.7.3 Red cells that have a positive DAT due to bound ...
Taking Advantage: High-Affinity B Cells in the Germinal Center Have
... Shih et al. elegantly showed that when placed in direct juxtaposition, high-affinity cells will dramatically outcompete low-affinity cells in the GC (20). However, whether there is an intrinsic difference between high- and low-affinity B cells in the GC, apart from influences of competition, is much ...
... Shih et al. elegantly showed that when placed in direct juxtaposition, high-affinity cells will dramatically outcompete low-affinity cells in the GC (20). However, whether there is an intrinsic difference between high- and low-affinity B cells in the GC, apart from influences of competition, is much ...
EMBRYOLOGY
... source of epithelial cells for the intestinal surface. When the stem cell divides, one of the progeny retains stem cell qualities and the other continues to proliferate as it migrates up the villus. These migrating cells differentiate into four different mature cell types: Paneth cells (in small int ...
... source of epithelial cells for the intestinal surface. When the stem cell divides, one of the progeny retains stem cell qualities and the other continues to proliferate as it migrates up the villus. These migrating cells differentiate into four different mature cell types: Paneth cells (in small int ...
File
... recognize components of different types of microbes. Thus far 10 mammalian TLRs have been identified, and each seems to be required for responses to different classes of infectious pathogens. 2- G protein–coupled receptors found on neutrophils, macrophages, and most other types of leukocytes recogni ...
... recognize components of different types of microbes. Thus far 10 mammalian TLRs have been identified, and each seems to be required for responses to different classes of infectious pathogens. 2- G protein–coupled receptors found on neutrophils, macrophages, and most other types of leukocytes recogni ...
Implications of CTL-Mediated Killing of HIV
... in viral set-point levels while the observed death rate of virusproducing cells during antiretroviral therapy would remain largely invariant. This characteristic behavior is depicted by the solid lines in Fig. 4A, where the set-point viral load varies over orders of magnitude when the saturation con ...
... in viral set-point levels while the observed death rate of virusproducing cells during antiretroviral therapy would remain largely invariant. This characteristic behavior is depicted by the solid lines in Fig. 4A, where the set-point viral load varies over orders of magnitude when the saturation con ...
A Hypomorphic IgH-Chain Allele Affects Development of B
... BAFF-R expression we like to suggest to omit these data in the revised version. We will provide the FACS data as separate 'referee-only' supplementary material, however. 4) Fig. 5D: lacks a negative staining control to discriminate whether or not LPS-treated B cells from EmuGFP/EmuGFP mice express m ...
... BAFF-R expression we like to suggest to omit these data in the revised version. We will provide the FACS data as separate 'referee-only' supplementary material, however. 4) Fig. 5D: lacks a negative staining control to discriminate whether or not LPS-treated B cells from EmuGFP/EmuGFP mice express m ...
Cells - Home
... signal, which is antigen-specific, is provided through the T cell receptor which interacts with peptide-MHC molecules on the membrane of antigen presenting cells (APC). A second signal, the co-stimulatory signal, is antigen nonspecific and is provided by the interaction between co-stimulatory molecu ...
... signal, which is antigen-specific, is provided through the T cell receptor which interacts with peptide-MHC molecules on the membrane of antigen presenting cells (APC). A second signal, the co-stimulatory signal, is antigen nonspecific and is provided by the interaction between co-stimulatory molecu ...
Cytochrome P450s in human immune cells regulate IL-22
... The mechanisms how environmental compounds influence the human immune system are unknown. The environmentally sensitive transcription factor aryl hydrocarbon receptor (AHR) has immunemodulating functions and responds to small molecules. Cytochrome P4501 enzymes (CYP1) act downstream of the AHR and m ...
... The mechanisms how environmental compounds influence the human immune system are unknown. The environmentally sensitive transcription factor aryl hydrocarbon receptor (AHR) has immunemodulating functions and responds to small molecules. Cytochrome P4501 enzymes (CYP1) act downstream of the AHR and m ...
PHS 398 (Rev. 9/04), Biographical Sketch Format Page
... vaccine development and therapy. The major goals of this project are to determine whether development of broadly neutralizing antibodies is correlated with less disrupted B lymphocyte compartments and follicular helper CD4 T cells (Tfh) in two cohorts of longitudinally studied HIV+ patients. 5R01 AI ...
... vaccine development and therapy. The major goals of this project are to determine whether development of broadly neutralizing antibodies is correlated with less disrupted B lymphocyte compartments and follicular helper CD4 T cells (Tfh) in two cohorts of longitudinally studied HIV+ patients. 5R01 AI ...
the lymphatic system and immunity
... The lymphatic system consists of the fluid lymph flowing within lymphatic vessels. It also consists of lymphatic tissue composed of aggregates of lymphocytes and macrophages scattered throughout the body or forming dense lymphatic nodules such as the tonsils, appendix, and peyer’s patches. The lymph ...
... The lymphatic system consists of the fluid lymph flowing within lymphatic vessels. It also consists of lymphatic tissue composed of aggregates of lymphocytes and macrophages scattered throughout the body or forming dense lymphatic nodules such as the tonsils, appendix, and peyer’s patches. The lymph ...
1 Negative regulation of primitive hematopoiesis by
... induction and migration defects (data not shown). No obvious defect or delay in embryonic development was seen with the concentration used (DMSO: Figs. 4G, I; SU5402: Figs. 4H, J; Insets in I, J: Paraxis staining). Control treated embryos showed normal ρ expression (Figs. 4G, K). SU5402 caused drama ...
... induction and migration defects (data not shown). No obvious defect or delay in embryonic development was seen with the concentration used (DMSO: Figs. 4G, I; SU5402: Figs. 4H, J; Insets in I, J: Paraxis staining). Control treated embryos showed normal ρ expression (Figs. 4G, K). SU5402 caused drama ...
Macrophages, pathology and parasite persistence in
... macrophages studied in vitro) to third party stimuli, through pathways including; (i) activation of the suppressor of cytokine signalling (SOCS)-3 [24]; (ii) inhibition of p38 mitogen-activated protein kinase (MAPK) [25]; (iii) local activation of latent transforming growth factor (TGF)-b [26]; and/ ...
... macrophages studied in vitro) to third party stimuli, through pathways including; (i) activation of the suppressor of cytokine signalling (SOCS)-3 [24]; (ii) inhibition of p38 mitogen-activated protein kinase (MAPK) [25]; (iii) local activation of latent transforming growth factor (TGF)-b [26]; and/ ...
properties of the amniotic membrane
... ectodermal, endodermal, and mesodermal lineage. This differentiation was determined using the formation of embryoid bodies in vitro and teratomas in vivo (Thomson et al., 1998). Teratomas form when embryonic stem cells are injected into severe combined immunodeficient (SCID) mice and tissue types fo ...
... ectodermal, endodermal, and mesodermal lineage. This differentiation was determined using the formation of embryoid bodies in vitro and teratomas in vivo (Thomson et al., 1998). Teratomas form when embryonic stem cells are injected into severe combined immunodeficient (SCID) mice and tissue types fo ...
17-26
... s the largest immune organ, the spleen would play an important role in pathogenesis and development of many diseases because of the close relationship between the spleen and other organs, which even could contribute to the important functions of other This ...
... s the largest immune organ, the spleen would play an important role in pathogenesis and development of many diseases because of the close relationship between the spleen and other organs, which even could contribute to the important functions of other This ...
Fig 5 - Journal of Allergy and Clinical Immunology
... To study a possible association between sIgE levels, IL-41 cell frequency, and blockade of allergen-sIgE binding to B cells in patients’ sera, we evaluated these variables using the Pearson correlation coefficient. Comparison of the x-fold change in inhibition of allergen–sIgE–B-cell binding correla ...
... To study a possible association between sIgE levels, IL-41 cell frequency, and blockade of allergen-sIgE binding to B cells in patients’ sera, we evaluated these variables using the Pearson correlation coefficient. Comparison of the x-fold change in inhibition of allergen–sIgE–B-cell binding correla ...
Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma
... expression of co-stimulatory molecules and surface HLA class I and II molecules. This renders them a difficult target for the host T cell compartment.3 In contrast, it has been shown that NK cells are able to lyse neuroblastoma cells in vitro and inhibit neuroblastoma growth in mice and humans.4–6 Ne ...
... expression of co-stimulatory molecules and surface HLA class I and II molecules. This renders them a difficult target for the host T cell compartment.3 In contrast, it has been shown that NK cells are able to lyse neuroblastoma cells in vitro and inhibit neuroblastoma growth in mice and humans.4–6 Ne ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.