Gene, environment, microbiome and mucosal immune tolerance in
... Mucosal structure and function There are a variety of mucosal sites in humans, including the eye, respiratory tract, gastrointestinal tract and genitourinary tract, as well as mammary glands and serosal sites such as the pleural and peritoneal cavities [1416]. In addition, there are multiple subsit ...
... Mucosal structure and function There are a variety of mucosal sites in humans, including the eye, respiratory tract, gastrointestinal tract and genitourinary tract, as well as mammary glands and serosal sites such as the pleural and peritoneal cavities [1416]. In addition, there are multiple subsit ...
Giuliana Magri Characterization of natural killer cell response to human cytomegalovirus
... the ability of HCMV to persist in the host is associated to different immune evasion strategies. Yet, information on the nature of NK cell receptor-ligand interactions involved in the response to HCMV infected cells is scarce and most studies have been performed in infected fibroblasts. Our work pro ...
... the ability of HCMV to persist in the host is associated to different immune evasion strategies. Yet, information on the nature of NK cell receptor-ligand interactions involved in the response to HCMV infected cells is scarce and most studies have been performed in infected fibroblasts. Our work pro ...
Photochemotherapy induces the apoptosis of - HAL
... Extracorporeal photopheresis (ECP), a therapy initially developed for the treatment of cutaneous T-cell lymphoma (CTCL)(1), is now currently employed for various hematological disorders involving pathogenic T-lymphocyte clones such as in GVHD(2). In latter, ECP proved very effective with impressive ...
... Extracorporeal photopheresis (ECP), a therapy initially developed for the treatment of cutaneous T-cell lymphoma (CTCL)(1), is now currently employed for various hematological disorders involving pathogenic T-lymphocyte clones such as in GVHD(2). In latter, ECP proved very effective with impressive ...
The interleukin-23 axis in intestinal inflammation
... The inflammatory bowel diseases (IBDs), Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal (GI) tract affecting 0.2% of the population. The etiology of IBD is unknown, but results from clinical and experimental studies indicate a breakdown in ...
... The inflammatory bowel diseases (IBDs), Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal (GI) tract affecting 0.2% of the population. The etiology of IBD is unknown, but results from clinical and experimental studies indicate a breakdown in ...
Increased Susceptibility to Salmonella Infection in Signal Regulatory
... self-limiting in WT controls. Defects in Salmonella-specific CD4 T cell response in Sirpa2/2 mice Our laboratory and others have previously documented a similar inability to resolve Salmonella infection in MHC class II-deficient, CD282/2, and T-bet2/2 mice (8, 10, 13), suggesting that SIRPa deficien ...
... self-limiting in WT controls. Defects in Salmonella-specific CD4 T cell response in Sirpa2/2 mice Our laboratory and others have previously documented a similar inability to resolve Salmonella infection in MHC class II-deficient, CD282/2, and T-bet2/2 mice (8, 10, 13), suggesting that SIRPa deficien ...
Ginkgo biloba extract EGb 761 has anti
... recognized and engulfed by phagocytes as a means to clear them from the body in vivo (10), it was necessary to culture 1 106 CD4þ T cells in complete media for 24 h before examination of apoptosis by Annexin V or TUNEL methods as described above. Statistical analysis For prevention and treatment s ...
... recognized and engulfed by phagocytes as a means to clear them from the body in vivo (10), it was necessary to culture 1 106 CD4þ T cells in complete media for 24 h before examination of apoptosis by Annexin V or TUNEL methods as described above. Statistical analysis For prevention and treatment s ...
Here - European Macrophage and Dendritic Cell Society
... the category “immunology, microbiology and virology”. All this is meant to emphasize that immunology is very close to our hearts. Needless to say that many of us have had a strong and long-standing interest in macrophages and dendritic cells. This year´s EMDS meeting focusses on the interaction of m ...
... the category “immunology, microbiology and virology”. All this is meant to emphasize that immunology is very close to our hearts. Needless to say that many of us have had a strong and long-standing interest in macrophages and dendritic cells. This year´s EMDS meeting focusses on the interaction of m ...
Natural Antimicrobial Peptides: Pleiotropic Molecules in Host Defense
... called antimicrobial peptides (AMPs) can be found in almost all forms of life, in organisms like bacteria or plants and also in invertebrate and vertebrate species, including mammals. Among the latter, humans have several cell types that synthesize and secrete AMPs, such as epithelial cells, epiderm ...
... called antimicrobial peptides (AMPs) can be found in almost all forms of life, in organisms like bacteria or plants and also in invertebrate and vertebrate species, including mammals. Among the latter, humans have several cell types that synthesize and secrete AMPs, such as epithelial cells, epiderm ...
Thesis - KI Open Archive
... Natural Killer (NK) cells are members of the innate lymphoid cell (ILC) family and take part in the detection and eradication of virus-infected and transformed cells. In this thesis, together with my colleagues I have investigated how NK cells and other ILCs develop and function during human fetal d ...
... Natural Killer (NK) cells are members of the innate lymphoid cell (ILC) family and take part in the detection and eradication of virus-infected and transformed cells. In this thesis, together with my colleagues I have investigated how NK cells and other ILCs develop and function during human fetal d ...
iiiiiiiiii - Cancer Research
... titre of agglutination is estimated microscopically, with a % inch objective. The results are tabulated in accordance with the following scale. In recording these, wherever doubt existed as to the degree of agglutination the lower estimate was assigned. ...
... titre of agglutination is estimated microscopically, with a % inch objective. The results are tabulated in accordance with the following scale. In recording these, wherever doubt existed as to the degree of agglutination the lower estimate was assigned. ...
PD-1 Blockade in Chronically HIV-1
... difficult to study in animal models. In efforts to ‘‘humanize’’ mice to render them permissive for HIV infection, investigators began to engraft human immune cells and/or tissues into immunodeficient mice that are unable to reject xenogeneic grafts [19]. Early versions of humanized mice used for HIV ...
... difficult to study in animal models. In efforts to ‘‘humanize’’ mice to render them permissive for HIV infection, investigators began to engraft human immune cells and/or tissues into immunodeficient mice that are unable to reject xenogeneic grafts [19]. Early versions of humanized mice used for HIV ...
Bovine Endometrial Epithelial Cells Scale Their Pro
... postpartum uterine diseases caused by uterine bacterial infections after parturition (Sheldon et al., 2009). During the postpartum period, up to 50% of all dairy cows develop uterine inflammatory diseases, such as metritis, and clinical or subclinical endometritis (Sheldon et al., 2009). The inciden ...
... postpartum uterine diseases caused by uterine bacterial infections after parturition (Sheldon et al., 2009). During the postpartum period, up to 50% of all dairy cows develop uterine inflammatory diseases, such as metritis, and clinical or subclinical endometritis (Sheldon et al., 2009). The inciden ...
Specific Control of Immunity by Regulatory CD8 T Cells
... (regulatory T cells or Treg) (4-10). Since the identification of CD25 as a marker for a naturally occurring CD4+ suppressor T cell, there has been a renewal of interest in the area of active T cell-mediated suppression (11, 12). The suppression of immunity by the naturally occurring CD4+CD25+ regula ...
... (regulatory T cells or Treg) (4-10). Since the identification of CD25 as a marker for a naturally occurring CD4+ suppressor T cell, there has been a renewal of interest in the area of active T cell-mediated suppression (11, 12). The suppression of immunity by the naturally occurring CD4+CD25+ regula ...
Cutaneous Lymphoma at Injection Sites
... presented either as a single nodule or localized disease. Of the 30 cases not included, 24 developed at noninjection cutaneous sites, while in 6 cases, site and history were not retrieved; only one of these had microscopic features resembling those described in this caseload but was not included. Al ...
... presented either as a single nodule or localized disease. Of the 30 cases not included, 24 developed at noninjection cutaneous sites, while in 6 cases, site and history were not retrieved; only one of these had microscopic features resembling those described in this caseload but was not included. Al ...
Chapter 50 - Tripod.com
... The clinical significance of the paranasal sinuses is well known to anyone who has suffered from acute or chronic sinusitis. The functional significance of the sinuses has, however, eluded physiologists and physicians alike since the sinuses were first described some 1800 years ago. Blanton and Bigg ...
... The clinical significance of the paranasal sinuses is well known to anyone who has suffered from acute or chronic sinusitis. The functional significance of the sinuses has, however, eluded physiologists and physicians alike since the sinuses were first described some 1800 years ago. Blanton and Bigg ...
A monoclonal antibody against lymphocyte function-associated antigen-1 decreases HIV-1
... MAb). It recognizes an epitope within CD11a known as S6F1. This epitope is preferentially expressed on CD8+ T cells and can be used to distinguish killer effector cells from suppressor effector cells [3]. In HIV-1 infected individuals, CD8+ T cells play a central role in controlling viral replicatio ...
... MAb). It recognizes an epitope within CD11a known as S6F1. This epitope is preferentially expressed on CD8+ T cells and can be used to distinguish killer effector cells from suppressor effector cells [3]. In HIV-1 infected individuals, CD8+ T cells play a central role in controlling viral replicatio ...
Population dynamics of immune repertoires
... resources [39–42]. More recent works have analysed very similar models [36, 43]. All these previous models can be encompassed within a common mathematical framework, which we describe now. The general idea behind this class of models is that one important signal for which lymphocytes compete comes f ...
... resources [39–42]. More recent works have analysed very similar models [36, 43]. All these previous models can be encompassed within a common mathematical framework, which we describe now. The general idea behind this class of models is that one important signal for which lymphocytes compete comes f ...
A B - Padis
... through protein-protein interactions and activates promoter activity. Clearly, IRF8 can act either as a repressor or activator, depending on the target DNA sequence, presumably by interacting with different proteins (Tamura et al., 2002). One of the proteins that directly interacts with IRF8 is the ...
... through protein-protein interactions and activates promoter activity. Clearly, IRF8 can act either as a repressor or activator, depending on the target DNA sequence, presumably by interacting with different proteins (Tamura et al., 2002). One of the proteins that directly interacts with IRF8 is the ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.