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of virus infection
of virus infection

... – IL-12, IL-18: stimulate NK cells to release IFN γ to activate macrophages Induction of lymphocyte-mediated response (innate to acquired) – Immature DCs in periphery migrate to draining lymph nodes to prime T cells – Activated macrophages at site of infection act as APC to further activate effector ...
Delivery of Epitopes by the Salmonella Type III Secretion System for
Delivery of Epitopes by the Salmonella Type III Secretion System for

...  Address the difference in the survivability of mice inoculated with a control and a SipDmutant strain ...
Slide 1
Slide 1

... What is the extracellular matrix? • Extracellular space is filled with a mesh of proteins and polysaccharides organized and assembled by the cells. • Two main classes of molecules – Glucoseaminoglycans associated with protein to form proteoglycans – fibrous proteins - the major fibrous proteins are ...
Cell Mediated Immunity
Cell Mediated Immunity

... membrane bound, TCR only membrane Bound 2.Both have their variabilities 2. TCR has one binding site, Ab has two 3. TCR is shorter and wider than Fab portion of located in one part of the Ab. molecule that bind antigen (V-region) 4. B-cells/antibodies recognize circulating antibodies. T-cells require ...
The immune system may be viewed as one aspect of the lymphatic
The immune system may be viewed as one aspect of the lymphatic

... become functional, in various parts of the body such as thymus and spleen. In Figure 42.2 focus on macrophages and lymphocytes. These cells secrete (i.e. produce and release) cytokines, which serve as chemical signals (molecular communication) among the cells to coordinate the activities of WBC in ...
Lecture schedule of Biochemistry 2015
Lecture schedule of Biochemistry 2015

... 05.02.15 Features of lambda phage as cloning vector, Insertional and replacement vectors based on lambda phage 06.02.15 Insertional and replacement vectors based on lambda phage (continued) Cosmids as cloning vectors 22.02.15 BAC as cloning vector 13.02.15 Ligation of insert DNA with the vector for ...
lec#5 done by Haneen Al-Khateeb
lec#5 done by Haneen Al-Khateeb

... In this case we should look for 2 things : the receptor of( B lymphocyte & immunoglobulin) & ( receptor of T lymphocyte) , both have variable regions ,the difference is that B cell has 2 acting binding site & T cell has only one, but the principle is the same , both have variable & constant regions ...
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06 Immunity

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B Cells and Antibodies
B Cells and Antibodies

... • Some activated B cells develop into memory cells, which recirculate and do not secrete antibody but can be rapidly reactivated to become plasma cells ...
Anti-HSP90 Catalog# SMC-149 A/B Size: 50/200µg This product is
Anti-HSP90 Catalog# SMC-149 A/B Size: 50/200µg This product is

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T4 helper cell

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Notes on Acquired Immunity
Notes on Acquired Immunity

... o Mouse C is also resistant to listeria because T cells specific for the tubercule bacilli activate macrophages that mediate resistance to listeria as well (macrophage killing is NOT specific) o However, if infected with listeria alone, Mouse C would become infected (as would Mouse A and B) ...
Immune System - Uplift Education
Immune System - Uplift Education

... antigen will undergo clonal selection so that they, and their multitude of offspring, can fulfill their destiny by participating in the humoral or cell-mediated immune response. ...
Immunity and Vaccination: biology homework revision question
Immunity and Vaccination: biology homework revision question

... A new technique for vaccinating people involves injecting them with DNA. Viruses have proteins on their coats that are coded for by their DNA. The genes for producing viral proteins can be isolated and inserted into loops of DNA (plasmids). Plasmids can enter human cells which will then produce the ...
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... survive inside cells. Macrophages are a common targets for intracellular bacteria (e.g. Salmonella spp.) that live inside cell compartments. These bacteria cannot be detected by complement or antibody but, instead, are eliminated using a cell-mediated response. Infected macrophages present bacterial ...
Study Guide for Exam 1
Study Guide for Exam 1

... 1. Be familiar with different scientists and their contributions to the field of immunology (only those covered in class): small pox, Pasteur, Lady Montagu, Jenner, etc. 2. Be familiar with the historical contributions that allowed the discovery of humoral and cellular immunities. Be familiar with t ...
Virulence Factors of Pathogens Toxin: Botulism toxin Botulism: case
Virulence Factors of Pathogens Toxin: Botulism toxin Botulism: case

... • Substances generated by pathogens that enhance their ability to cause disease • Four categories of virulence factors correspond to the different mechanisms pathogens used to cause disease ...
immune response
immune response

... partially or completely  Present some of the organism antigens on its surface  ...
Biologics as an Adjunct for Chemotherapy
Biologics as an Adjunct for Chemotherapy

... – Cell mediated components • Neutrophils, monocytes, macrophages, dendritic cells, natural killer cells, mast cells, phagocytes, and complementary proteins (cytokines) ...
WK11-RhoJared
WK11-RhoJared

... slight amount of IgG1. Compare this to varying but similar levels of IgG subclasses, such as IgG2a, and IgA, produced from CNF1 and CT stimulation. The amounts of IgA were low in both of these conditions; the amounts of all the varieties of IgGs were more or less significantly higher than those of I ...
T helper cell polarization_150305.indd
T helper cell polarization_150305.indd

... • Serum-free T cell culture medium for standardized cell culture conditions • Comprehensive technical support from the experts in T cells ...
IGG - Institute for Responsible Technology
IGG - Institute for Responsible Technology

... In humans: elevated in asthma, in the IELs of children with untreated food allergies, in the duodenum (small intestine) of children with juvenile arthritis or connective tissue diseases with gastrointestinal symptoms. ...
Immune responses to bacteria
Immune responses to bacteria

... survive inside cells. Macrophages are a common targets for intracellular bacteria (e.g. Salmonella spp.) that live inside cell compartments. These bacteria cannot be detected by complement or antibody but, instead, are eliminated using a cell-mediated response. Infected macrophages present bacterial ...
Immune Responses to Bacteria
Immune Responses to Bacteria

... survive inside cells. Macrophages are a common targets for intracellular bacteria (e.g. Salmonella spp.) that live inside cell compartments. These bacteria cannot be detected by complement or antibody but, instead, are eliminated using a cell-mediated response. Infected macrophages present bacterial ...
T cell-mediated immune response
T cell-mediated immune response

... parasitic, viral (if they are ingested in IC or during the processing of infected cells) - hydrolysed in endosomes to linear peptides → presentation on the cell surface together with class II MHC to CD4+ T lymphocytes ...
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Monoclonal antibody



Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.
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