Determining When Human Subject Research
... to IRB review, the file will move to Checklist 1.C for further review. A written confirmation of the determination will be sent to the investigator after completion of the review process. Automatic Recording: When the reviewer SAVES the document, the system will automatically create an “Electronic S ...
... to IRB review, the file will move to Checklist 1.C for further review. A written confirmation of the determination will be sent to the investigator after completion of the review process. Automatic Recording: When the reviewer SAVES the document, the system will automatically create an “Electronic S ...
Acetylcysteine
... New Acetylcysteine Trial ? THE PROBLEM Contrast-induced nephropathy is associated with mortality and prolonged hospitalization. The incidence in patients with risk factors (such as renal failure, diabetes, age > 70 y) varies between 9% and ...
... New Acetylcysteine Trial ? THE PROBLEM Contrast-induced nephropathy is associated with mortality and prolonged hospitalization. The incidence in patients with risk factors (such as renal failure, diabetes, age > 70 y) varies between 9% and ...
U.S. Prescribing Information
... 250 and 1000 mg/kg/day (rabbits). The high doses resulted in maternal toxicity in both rats and rabbits. No effects on embryo-fetal development were observed in either species. In a peri- and post-natal developmental study, female rats received oral carglumic acid from organogenesis through day 21 p ...
... 250 and 1000 mg/kg/day (rabbits). The high doses resulted in maternal toxicity in both rats and rabbits. No effects on embryo-fetal development were observed in either species. In a peri- and post-natal developmental study, female rats received oral carglumic acid from organogenesis through day 21 p ...
to open the MS Word version of the Quarterly Action Agenda
... to use that information to prevent similar problems at your practice site. To promote such a process, the following selected items from the July– September 2016 issues of the ISMP Medication Safety Alert! have been prepared for an interdisciplinary committee to stimulate discussion and action to red ...
... to use that information to prevent similar problems at your practice site. To promote such a process, the following selected items from the July– September 2016 issues of the ISMP Medication Safety Alert! have been prepared for an interdisciplinary committee to stimulate discussion and action to red ...
Synergistic Interaction between the Two Mechanisms of Action of
... systemic as well as spinal combination of morphine with the ␣2-adrenoceptor agonist clonidine resulted in synergistic antinociception (Ossipov et al., 1990; Fairbanks and Wilcox, 1999). In clinical settings, morphine analgesia was potentiated by systemic tricyclic antidepressants (Levine et al., 198 ...
... systemic as well as spinal combination of morphine with the ␣2-adrenoceptor agonist clonidine resulted in synergistic antinociception (Ossipov et al., 1990; Fairbanks and Wilcox, 1999). In clinical settings, morphine analgesia was potentiated by systemic tricyclic antidepressants (Levine et al., 198 ...
31-07-12 ALLERGY: • BIOLOGICAL AND GENETIC
... by ibuprofen and other strong COX 1 inhibitors, and positive skin tests to HDM. ...
... by ibuprofen and other strong COX 1 inhibitors, and positive skin tests to HDM. ...
Ref: SAMHSA - Temple University Sites
... buprenorphine products. The medication is administered when a person with an opioid dependency has abstained from using opioids for 12 to 24 hours and is in the early stages of opioid withdrawal. It is important to note that buprenorphine can bring on acute withdrawal for patents who are not in the ...
... buprenorphine products. The medication is administered when a person with an opioid dependency has abstained from using opioids for 12 to 24 hours and is in the early stages of opioid withdrawal. It is important to note that buprenorphine can bring on acute withdrawal for patents who are not in the ...
Hemolytic Anemia: Can occur if glucose 6-phosphate
... placebo. All of these events were self-treated. In a randomized, double-blind, placebo-controlled monotherapy trial of 22 weeks duration, patients received a starting dose of either 1 mg AMARYL or placebo daily. The dose of AMARYL was titrated to a target fasting plasma glucose of 90–150 mg/dL. Fina ...
... placebo. All of these events were self-treated. In a randomized, double-blind, placebo-controlled monotherapy trial of 22 weeks duration, patients received a starting dose of either 1 mg AMARYL or placebo daily. The dose of AMARYL was titrated to a target fasting plasma glucose of 90–150 mg/dL. Fina ...
Academic paper: A Diarylquinoline Drug Active on the ATP
... TB control programs (6). We report on the antimycobacterial properties of the diarylquinolines (DARQs). The lead compound, R207910, not only has several properties, both in vitro and in vivo, that may improve the treatment of TB, but also appears to act at a new target, providing an antimycobacteria ...
... TB control programs (6). We report on the antimycobacterial properties of the diarylquinolines (DARQs). The lead compound, R207910, not only has several properties, both in vitro and in vivo, that may improve the treatment of TB, but also appears to act at a new target, providing an antimycobacteria ...
Methamphetamine
... Long-term methamphetamine abuse results in many damaging effects, including addiction. Addiction is a chronic, relapsing disease, characterized by compulsive drug-seeking and drug use which is accompanied by functional and molecular changes in the brain. In addition to being addicted to methamphetam ...
... Long-term methamphetamine abuse results in many damaging effects, including addiction. Addiction is a chronic, relapsing disease, characterized by compulsive drug-seeking and drug use which is accompanied by functional and molecular changes in the brain. In addition to being addicted to methamphetam ...
NICE TA 315. Shared Care available
... 2. NICE Clinical Guideline 87. Type 2 diabetes: The management of Type 2 diabetes. May 2009. Available at: http://publications.nice.org.uk/type-2-diabetes-cg87/guidance#oral-glucose-controltherapies-2-other-oral-agents-and-exenatide Accessed <04.11.13> 3. NICE Technology Appraisal TA315: Canaglifloz ...
... 2. NICE Clinical Guideline 87. Type 2 diabetes: The management of Type 2 diabetes. May 2009. Available at: http://publications.nice.org.uk/type-2-diabetes-cg87/guidance#oral-glucose-controltherapies-2-other-oral-agents-and-exenatide Accessed <04.11.13> 3. NICE Technology Appraisal TA315: Canaglifloz ...
Full Text - Molecular Cancer Therapeutics
... Therapeutics Online (http://mct.aacrjournals.org/). K. Elkins, B. Zheng, and M.A. Go contributed equally to this work. Corresponding Author: Andrew G. Polson, Genentech Research and ...
... Therapeutics Online (http://mct.aacrjournals.org/). K. Elkins, B. Zheng, and M.A. Go contributed equally to this work. Corresponding Author: Andrew G. Polson, Genentech Research and ...
Medical Emergencies
... Monitor for re-sedation, repeat doses at 20 min intervals Max 3mg/hr. Mechanism: Antagonizes effect of BDZ at GABA receptor Does not antagonize non BDZ GABA agonists, I.e., ethanol, barbiturates. ...
... Monitor for re-sedation, repeat doses at 20 min intervals Max 3mg/hr. Mechanism: Antagonizes effect of BDZ at GABA receptor Does not antagonize non BDZ GABA agonists, I.e., ethanol, barbiturates. ...
Transport Proteins and Intestinal Metabolism
... COREGULATION OF P-GLYCOPROTEIN AND CYP3A EXPRESSION The pregnane X receptor/steroid and xenobiotic receptor (PXR/SXR) mediates induction of both CYP4503A and MDR genes, the genes responsible for P-glycoprotein expression.5,6 High intracellular free radical concentrations (eg, in diabetic patients), ...
... COREGULATION OF P-GLYCOPROTEIN AND CYP3A EXPRESSION The pregnane X receptor/steroid and xenobiotic receptor (PXR/SXR) mediates induction of both CYP4503A and MDR genes, the genes responsible for P-glycoprotein expression.5,6 High intracellular free radical concentrations (eg, in diabetic patients), ...
Approach to Poisonings
... • In general, activated charcoal is the sole intervention necessary to treat serious poisonings. This may be used with or ...
... • In general, activated charcoal is the sole intervention necessary to treat serious poisonings. This may be used with or ...
Drug Metabolism
... Liver: principal organ of drug metabolism (although almost all tissues have some capacity for this process) ...
... Liver: principal organ of drug metabolism (although almost all tissues have some capacity for this process) ...
Developments in Community Drug Treatment
... misusers in the community and prison settings Drug Misuse: psychosocial management of drug misusers in the community and prison settings NICE Technology Appraisals (due March 2007) Methadone and buprenorphine for the treatment of opiate drug misuse Naltrexone as a treatment for relapse prevent ...
... misusers in the community and prison settings Drug Misuse: psychosocial management of drug misusers in the community and prison settings NICE Technology Appraisals (due March 2007) Methadone and buprenorphine for the treatment of opiate drug misuse Naltrexone as a treatment for relapse prevent ...
An Advanced Phase 1/2 Study using an XC
... designs [24] combined with a Phase II efficacy phase. For the Phase 1 part of the study, treatment with Rexin-G comprised 6-week cycles that encompassed 4 weeks of treatment followed by a 2-week rest period. Five dose levels were planned, beginning at 1.0 x 10e11 cfu given by intravenous (i.v.) infu ...
... designs [24] combined with a Phase II efficacy phase. For the Phase 1 part of the study, treatment with Rexin-G comprised 6-week cycles that encompassed 4 weeks of treatment followed by a 2-week rest period. Five dose levels were planned, beginning at 1.0 x 10e11 cfu given by intravenous (i.v.) infu ...
Memo - Passport
... efficacy compared to traditional triple highly active antiretroviral therapy (HAART) cannot be found.14 One study divided 42 HIV-positive individuals with suppressed HIV-RNA (the result of prior HAART treatment): one group remained on HAART, and the other received lopinavir/ritonavir monotherapy.15 ...
... efficacy compared to traditional triple highly active antiretroviral therapy (HAART) cannot be found.14 One study divided 42 HIV-positive individuals with suppressed HIV-RNA (the result of prior HAART treatment): one group remained on HAART, and the other received lopinavir/ritonavir monotherapy.15 ...
CEFADROXIL CAPSULES, USP 500 mg
... Urinary tract infections caused by E. coli, P. mirabilis, and Klebsiella species. Skin and skin structure infections caused by staphylococci and/or streptococci. Pharyngitis and/or tonsillitis caused by Streptococcus pyogenes (Group A betahemolytic streptococci). Note: Only penicillin by the intramu ...
... Urinary tract infections caused by E. coli, P. mirabilis, and Klebsiella species. Skin and skin structure infections caused by staphylococci and/or streptococci. Pharyngitis and/or tonsillitis caused by Streptococcus pyogenes (Group A betahemolytic streptococci). Note: Only penicillin by the intramu ...
ToxTidbits (March/April 2013)
... renal damage, fever, hallucinations, coma and seizures. Inhalation of ricin produces symptoms within 4-12 hours. Coughing, dyspnea, bronchoconstriction, pulmonary edema and cyanosis may develop. Other effects such as nausea, diaphoresis, weakness, fever, arthralgias and hypotension may be observed. ...
... renal damage, fever, hallucinations, coma and seizures. Inhalation of ricin produces symptoms within 4-12 hours. Coughing, dyspnea, bronchoconstriction, pulmonary edema and cyanosis may develop. Other effects such as nausea, diaphoresis, weakness, fever, arthralgias and hypotension may be observed. ...
Anticancer efficacy and toxicokinetics of a novel paclitaxel-clofazimine nanoparticulate co- formulation
... A total of sixty seven female BALB/c mice (weighing: 15.9 - 25.8 g) were acclimatized to the laboratory conditions of the University of Pretoria, Biomedical Research Centre for a week prior to experimentation. Mice were individually ear-tagged and fed standard rodent food and water ad libitum. All a ...
... A total of sixty seven female BALB/c mice (weighing: 15.9 - 25.8 g) were acclimatized to the laboratory conditions of the University of Pretoria, Biomedical Research Centre for a week prior to experimentation. Mice were individually ear-tagged and fed standard rodent food and water ad libitum. All a ...